Home Blog

DST affects your sleep and health. Should we get rid of it?

0

Loading

One such system is the glymphatic system, a recently discovered waste disposal pathway in the brain that allows toxins to be flushed out during sleep.

“There is evidence that if sleep is disrupted or of insufficient duration, there could be a buildup of these toxins like beta-amyloid, for example, which is implicated in Alzheimer’s disease,” Rajaratnam said. .

Professor Shantha Rajaratnam, President of the Sleep Health Foundation.

Keeping social time (the time on our phones and watches) more in sync with the sun’s light and dark cycle better suits our circadian rhythm. By delaying sunset, daylight saving time pushes social time and sun time away.

Rajaratnam said a growing body of research shows that an out of whack social and body clock worsens sleep, shortens lifespan and lowers cognitive performance.

Light the way: how to adapt to summer time

For those looking to smoothly adapt to daylight saving time, it all comes down to light. Some might be able to reject a sleeping pill to force an early bedtime, but Rajaratnam recommends a gentler approach.

Loading

“Shift your sleep time by a small amount, quarter or half hour, rather than trying to shift it by an hour,” he said. “Increase your exposure to morning light to get your clock changing as quickly as possible.”

Avoid caffeine, nicotine, and alcohol in the hours before bedtime to have the best chance of getting quality sleep. Setting up a smart globe “alarm light” that lights up in the morning or goes out in the sun as soon as possible will help.

Children and especially teenagers, whose circadian rhythms are already naturally set later than adults, should dim the lights and ditch the screens within an hour of bedtime.

“We have evidence that adolescent circadian clocks may be even more sensitive to the effects of light in the evening and so it is important to try to minimize this light exposure,” Rajaratnam said. “We know that there is also a strong two-way relationship between sleep and mental health, which is critical during these teenage years.”

Should summer time be abolished?

Dr Thomas Sigler, an urban geographer at the University of Queensland, is an advocate for daylight saving time because of the lifestyle and health benefits of brighter evenings. He finds it “ridiculous” that Queensland does not observe daylight saving time and thinks the time zones need an overhaul.

“Drawing an arbitrary line from London may have worked 100 years ago, but it’s no longer useful for people in Brisbane who leave the office in the dark 350 days a year like I do,” he said. he declared. “Australians are active people, aren’t they? Having usable daylight is essential for cycling, for surfing.

Sigler said the brief increase in cardiac arrests and traffic accidents after the clock change is more than offset by a drop in car crashes and fatalities in the following months as roads become lighter later in the year. the day.

Loading

Sigler welcomes the progress of the Sunshine Protection Act in the United States, which would rearrange time zones so that most states are effectively on daylight saving time all the time without needing to change clocks. But Rajaratnam said most international tech bodies disagree with the bill because it would permanently misalign our biological clocks with the movement of the sun.

“Sleep expert bodies around the world have recommended the opposite, which is to stay out of daylight saving time,” he said.

Get the most out of your health, relationships, fitness and nutrition with our Live Well newsletter. Receive it in your mailbox every Monday.

Scientists have created a mechanical uterus that can grow life in the lab

0

The dystopian universe of blade runner features replicants or genetically modified people with sci-fi powers, such as super-strength and advanced intelligence, that far surpass any ordinary individual (albeit with a limited lifespan). Their invention is considered a colossal feat of scientific achievement (and the basis of a pretty messed up society).

But off the big screen, we’re still a long way from creating an organism — let alone a human — entirely from scratch. So far.

In a study published last month in the newspaper Nature, scientists in the United States, United Kingdom and Israel have succeeded in creating a synthetic mouse embryo without using an egg or sperm. Instead, they used an assortment of stem cells.

Compared to natural embryos maturing alongside them, these lab-grown counterparts developed similar features seen nearly nine days after fertilization, such as a beating heart, a very early-stage brain, and an intestinal tract – before abruptly stop growth.

“Essentially, the big question we grapple with in the lab is how do we start our lives?” said Magdalena Zernicka-GoetzPrincipal investigator of the study and a stem cell biologist at the University of Cambridge and the California Institute of Technology, during a press briefing.

Look in the “black box”

Researchers from the Weizmann Institute of Science in Israel have successfully grown synthetic (left) and natural (right) embryos side by side in the lab.Amadei and Handford

When a sperm fertilizes an egg, the fusion sets off a cascade of changes that cause the single cell to multiply, specialize, and organize into distinct cell types, tissues, organs, and other structures that make up a complete organism.

Over the past few decades, scientists have tried to recreate models of embryonic development in the lab to learn how the primordial phenomenon unfolds in real time. But this feat turned out to be extremely difficult. After all, we can’t just peer into a living uterus in the lab to directly observe microscopic events.

Specifically, researchers don’t know exactly what happens in the womb between about 14 days and a month of development, says Max Wilsona molecular biologist from the University of California at Santa Barbara, who was not involved in the study.

During this mysterious period, the brain builds and the heart sets. “It’s called the ‘black box’ of human development,” he explains.

This device took seven grueling years of engineering.

Recent efforts to unravel these mysteries have involved Hug human embryonic stem cells into blastocysts, a hollow, thin-walled ball of dividing cells that gives rise to the embryo during natural development.

This “blastoid” method hasn’t quite got scientists closer to how cells self-organize and specialize into organs. But in 2021, researchers from the Weizmann Institute of Science in Israel – who also worked on the new Nature study – developed a kind of mechanical matrix (image an axolotl tank at Frank Herbert’s Dunes).

This device took seven grueling years of engineering. It included an incubator, which floated and swirled the embryos in vials filled with a special nutrient-rich liquid. Meanwhile, a ventilator provided oxygen and carbon dioxide, meticulously controlling the flow and pressure of the gases.

With this setup, Weizmann researchers were able to grow stem cell-derived synthetic mouse embryos in their artificial mummy for around six days – until they were able to expand it further, according to a published study. earlier this month in the magazine Cell.

The embryos underwent gastrulation (when an early embryo changes into a multi-layered structure) for eight and a half days, but then stalled for unknown reasons. (A mouse pregnancy lasts about 20 days.)

But the experiment was not entirely a failure. He set out the colossal task of the latest study: to show that it was entirely possible to grow mammalian embryos outside the womb.

How to grow a baby

Zernicka-Goetz and her colleagues used embryonic stem cells, as well as those that give rise to the placenta and yolk sac, to grow synthetic embryos.José A. Bernat Bacete/Moment/Getty Images

Zernicka-Goetz, one of the authors of the new Nature study, has spent the past decade researching ways to develop synthetic embryos. She said her lab initially only used embryonic stem cells to mimic early development.

But in 2018, she and her colleagues discovered that if they added two more stem cells that give rise to the placenta (the organ that provides nutrients and removes waste) and the yolk sac (a structure that provides food early in development), the embryos were better prepared for self-assembly.

Here’s the problem with science: there’s always competition. After their 2018 Nature paper, the Zernicka-Goetz team was surprised when the Weizmann group released an incubator-ventilator system, along with subsequent experiments that forged embryos without sperm or eggs — exactly as they were attempting.

But science is also about collaboration. The two groups eventually teamed up to see if combining their techniques could result in the life-creating golden ticket.

The results were impressive: Zernicka-Goetz and her colleagues observed the uterine cells artificially transformed into synthetic “embroids” without any sort of modification or outside guidance.

The embryo model developed a head and a heart – parts of the body that researchers could never study in vitro.

Compared to natural mouse embryos that were cultured separately, these embryonic mice went through the same developmental stages up to eight and a half days after fertilization (just like the Weizmann team’s previous work), which is equivalent to the day 14 of human embryonic development.

The embryo model developed a head and a heart — parts of the body that researchers have never been able to study in vitro, Zernicka-Goetz said.

“This is truly the first demonstration of the forebrain in any model of embryonic development, and it has been a holy grail for the field,” co-author David Gloverprofessor-researcher in biology and biological engineering at Caltech, said during the press briefing.

Zernicka-Goetz’s team also tinkered with a gene called Pax6, which appears to be a key player in brain development and function. After removing Pax6 from mouse stem cell DNA using CRISPR, Zernicka-Goetz and colleagues observed that the heads of these synthetic embryos did not develop properly, mimicking what is seen when natural embryos lack this gene.

In humans, rare Pax6 mutations or deletions can lead to abnormal fetal development and death. They can also stimulate conditions such as aniridia (absence of the colored part of the eye, the iris) or Peters’ anomaly, which hinders the development of eye structures such as the cornea.

A chance for synthetic life?

Concocting synthetic embryos from human stem cells could prove a technical (and ethical) challenge.Westend61/Westend61/Getty Images

The detailed insight into early embryonic development could be a boon to human health. For example, it could help scientists understand why many pregnancies, whether conceived naturally or through assisted reproduction, fail early in the trimester.

Zernicka-Goetz said the research could also advance regenerative medicine. This could help scientists learn how to make viable, fully functioning replacement organs for a transplant patient using their own stem cells (potentially eliminating the need to use lifelong immunosuppressants).

Currently, we have a broad sense of organogenesis – or the development of an organ from embryo to birth – but we do not know all of the microscopic steps and cellular interactions that result in a fully functional organ.

The model system could help in the development of new drugs: it could reveal which drugs can be taken safely during pregnancy without harming the fetus. Now researchers can potentially test them on synthetic embryos, Zernicka-Goetz said.

“It is a breakthrough but at a very early stage of development, a rare event which, while superficially resembling an embryo, bears flaws that should not be overlooked,” Alfonso Martinez Ariasa developmental biologist at Pompeu Fabra University in Spain who was not involved in the study, said in a Press release.

A glaring challenge: While the synthetic mouse embryos look identical to their natural counterparts, their stalled development at eight and a half days makes it hard to say whether they would continue to develop properly.

“This is very strong proof that we will one day have this power, and it will be possible [to create synthetic life].”

So, despite its enormous potential, making synthetic embryos from stem cells is simply not possible at present.

“This blockade is not understood and must be overcome if one wishes to grow synthetic mouse embryos past the eighth day,” Christophe Galicheta stem cell biologist from the Francis Crick Institute in London who was also not involved in the new work, said in the same press release.

Since humans and mice do not share exactly the same characteristics when it comes to embryonic development, the next step is to possibly concoct synthetic embryos from human stem cells.

This is likely to prove complicated, more ethically than technically. But Wilson believes the research marks a major scientific milestone and a tool to add to humanity’s technological toolbox.

“This is very strong proof that we will one day have this power, and it will be possible [to create synthetic life]”Whether we decide to do it or not because of the ethics or even the potential benefits – that’s a question for society as a whole.”

This was HORIZONS, a newsletter that explores today’s innovations shaping the world of tomorrow. Subscribe for free.

Carbon-negative home research wins $2.6 million DOE grant – WSU Insider

0

A two-year, $2.6 million grant from the U.S. Department of Energy will support a team of researchers in designing and building carbon-negative homes to combat climate change in the growing energy sector. residential construction.

The project, a collaboration between Pacific Northwest National Laboratory, Washington State University and Seattle-based company Green Canopy NODE, was one of 18 selected in the area of ​​carbon storage structures. The goal of the DOE program is to support decarbonization through advanced construction processes.

“Society needs the built environment. It’s one of those things in the future that we can’t create less of, so we have to find a way to do it cleanly,” said Adam Phillips, assistant professor of civil engineering and co-principal investigator of the project.

The team will work to develop carbon-negative home designs using renewable resources that can be taken apart and reused for generations. The team’s research is based on the idea of ​​circular design, a broad concept that, when applied to a house, accounts for its demolition before it is built.

“We think about the next house when we design the first house,” Phillips said.

Bio-based wood materials make up the components of the proposed houses, including the floor, wall and roof structures. At the end of their life, they are carefully dismantled and used in the next version of a new house. The carbon sequestered in a tree during its lifetime remains in the wood material throughout the production of the house components, thus maintaining a negative carbon status for each iteration of the house. Phillips estimates that the second iteration of the homes will avoid about 70% of the carbon emissions typically expected from a single-family residence.

The research team will develop and test seals that will allow reusable components to be structurally attached over the 50-year design life and detached without damaging the materials.

Research also has potential in the medium-density housing sector, which can provide more opportunities for living close to urban areas. The reusable single-family housing components are reconfigurable in a manner applicable to multi-family homes, increasing the availability of housing on a single lot of land.

“We’re reinventing how best to use land to meet the needs of a new generation, without having to generate new materials,” Phillips said.

Adam Phillips

As part of the grant, researchers will also study the economy, geographic placement, and energy consumption of homes.

In addition to Phillips, the team is led by lead researcher Chrissi Antonopoulos of PNNL and Darrin Griechen of Green Canopy NODE. It is funded by the Advanced Research Projects Agency-Energy Harnessing Emissions into Structures Taking Inputs from the Atmosphere and includes WSU collaborators Karl Englund and Ji Yun Lee from Voiland College’s Department of Civil and Environmental Engineering.

Bribe to vote: SC to decide whether MPs qualify for immunity: The Tribune India

0


Tribune press service

New Delhi, September 28

Can a lawmaker be prosecuted for accepting bribes to vote in the House? A bench of five Constitutional Justices headed by Justice Abdul Nazeer decided on Wednesday to consider on November 15 whether Articles 194(1) and 105(2) of the Constitution granted immunity to MPs and MPs from prosecution. for accepting or paying bribes to vote in the Loger.

As the bench noted, the issue was covered by a Constitutional Bench decision in the PV Narasimha Rao case in which it was held that a lawmaker was immune from prosecution even if he or she was taking money to vote on the floor of the House, attorney General Tushar Mehta pointed out that it was a 3 to 2 verdict by a bench of the same strength, that is- that is, a bench of five judges.

“The question is … is it the act (of giving or receiving bribes) within the House or the whole scope of the act must be taken into account … immunity is there for the whole act or not,” noted the bench, which also included Justice BR Gavai, Justice AS Bopanna, Justice V Ramasubramanian and Justice BV Nagarathna.

On March 7, 2019, a bench of three judges led by CJI Ranjan Gogoi referred the matter to a larger bench, saying it involved important questions of law.

The 1998 verdict in the PV Narasimha Rao case (popularly known as the JMM MP Corruption Case) was delivered by a bench of five judges. Another bench of five judges in the court had in 2007 ruled in the case of Raja Rampal that those who took money to ask questions in Parliament were liable to be expelled from the House permanently. As the 1998 and 2007 verdicts appear contradictory, the current issue may ultimately be referred to a bench of seven judges.

Sita Soren, who was a member of the Jharkhand Assembly, is being prosecuted by the CBI for allegedly accepting bribes for voting in the 2012 Rajya Sabha poll. She had been accused of receiving bribes. de-vin of a Rajya Sabha candidate for voting for him, but instead voted for another candidate.

His father-in-law and JMM leader Shibu Soren was saved by the 1998 Constitution Bench verdict, in which the Supreme Court ruled that MPs who took money and voted for Rao’s government were immune from prosecution. However, he had ruled that those who had paid the bribe to the JMM deputies were not immune from prosecution.

According to Rule 105(2), “No Member shall be liable in court in respect of anything said or any vote cast by him in Parliament or in any of its panels, and no shall not be responsible for the publication by or under the authority of either House of Parliament of any report, vote or deliberation.The petitioner Sita Soren claimed protection under Article 194(2) which is identical to Article 105(2) and applies to mutual legal assistance.

Past precedents and what the law says

  • Section 105(2) states that “no Member shall be liable to any suit in court in respect of anything said or voted in Parliament”
  • JMM’s Shibu Soren was saved by the 1998 Constitution Bench verdict in which the SC ruled that MPs who took money to vote for Narasimha Rao’s government were immune from prosecution
  • Sita Soren, who was an MP for Jharkhand, is being prosecuted by the CBI for allegedly accepting a bribe for voting in the 2012 RS poll

Won’t stay dismissal of Gujarat IPS officer

Calling it an interim order, the SC refused to interfere with Delhi HC’s order refusing to suspend the Centre’s decision to fire Gujarat IPS officer Satish Chandra Verma on August 30, a month before his retirement. He had helped the SIT in the affair of the meeting with Ishrat Jahan.

Advocacy against DeMo to be heard on October 12

Six years after the Center demonetized the Rs 500 and Rs 1,000 notes, the SC wondered on Wednesday whether it would be an academic exercise to hear pleas challenging the decision. He posted the case for hearing on October 12. There are 58 motions in the case.

RoPower Nuclear will develop SMRs in Romania

0

Nuclearelectrica (SNN) and Nova Power & Gas have launched RoPower Nuclear, the project company for the development of small modular reactors in Romania, on the site of the former coal-fired power plant of Doicesti, in the county of Dambovita.

Jose W. Fernandez, U.S. Under Secretary for Economic Growth, Energy, and Environment, U.S. Department of State, and Romanian Energy Minister Virgil Popescu observed the signing ceremony of the shareholders’ statement, at the Ministry of Energy, Romania.

Project company RoPower Nuclear SA will take steps to deploy the first NuScale VOYGR-6 (462 MWe) power plant in Romania this decade. The plant will use NuScale Power Module technology from NuScale, the only SMR company to have received design approval from the US Nuclear Regulatory Commission. The installed capacity can also be supplemented by renewable energies amounting to a capacity of c. 80MWe, which would make the new energy complex exceed the capacity of the old Doicesti plant. The joint nuclear-renewable solution would represent not only an optimal production capacity, with the possibility of varying the yield, but also a vision of the sources of production for the electricity network of tomorrow.

“We are proud to develop a safe power plant in Romania that offers clean and cost-effective energy, at the same time bringing multiple benefits to the local community. With energy independence and energy security as the highest goals, Romania will be a leader for the deployment of small modular reactors in the region and the new company, RoPower Nuclear, an example of best practices in the implementation of standards highest safety, performance and productivity. , following the lead of Cernavoda NPP for over 25 years,” said Cosmin Ghita, CEO of SNN.

“The RoPower Nuclear shareholder statement, signed today, reaffirms the good faith of the two partners, Nuclearelectrica and Nova Power & Gas, for the deployment in Romania of the NuScale small modular reactors (SMR). At the same time, it is the guarantee that we will treat this project with the utmost seriousness. The long cooperation between the United States and Romania in the nuclear field has a very successful track record. Thus, I am firmly convinced that RoPower Nuclear will have excellent cooperation with the American nuclear industry and the Romanian industry, within the framework of the USA-Romania strategic partnership, providing clean energy and security of supply for our country and the region,” Teodor Chirica, Chairman of the Board, SNN, added.

“RoPower Nuclear, the joint venture between Nuclearelectrica, a Romanian national company and Nova Power & Gas, a Romanian private company, combining the expertise, potential, stability and agility of the parent companies, could be a model for other futures. energy projects. We are very proud to be part of such a transformative project, which will guarantee Romania’s energy security,” said Teofil Mureșan, President of Nova Power & Gas.

Targets to prevent hearing loss caused by certain antibiotics

0

Some life-saving antibiotics cause hearing loss, and now, for the first time, some researchers think they know why and are one step closer to preventing it.

Aminoglycosides (AGs), such as gentamicin, are potent, broad-spectrum antibiotics used to treat a wide variety of life-threatening infections.

However, they do have a downside: they are ototoxic, which means a person taking them may develop hearing or balance problems because they cause irreversible damage to cochlear hair cells.

Until now, scientists knew very little about the molecular pathways critical to hair cell survival that are affected by exposure to these antibiotics.

But in a new study from the journal Development cellAmerican researchers have discovered that the dysfunction of a process within the cell, called autophagy, is linked.

By reducing the expression of a protein involved in autophagy in cochlear hair cells, they were able to prevent hair cell death and subsequent hearing loss caused by systemic exposure to AGs.

“This work identifies several potential therapeutic targets for preventing aminoglycoside-induced hearing loss,” says lead author Bo Zhao, assistant professor of otolaryngology at Indiana University School of Medicine, USA. United States.


Read more: Loss of hair cells may explain hearing loss.


What is autophagy?

Autophagy is the process by which cells “eat” pieces of themselves – hence the name. It comes from the Greek “autos” meaning self and “phageîn” meaning to eat.

Thanks to autophagy, unwanted or damaged molecules are eliminated and recycled from the cell. First, they are marked for disposal, enveloped by a membrane (becoming an autophagosome) which then fuses with a lysosome (an acidic organelle filled with enzymes) which breaks them down into nutrients that the cell can then reuse.

But when autophagy is abnormal or triggered inappropriately, it can cause cell damage and death.

In a cell line from the inner ear of mice, researchers found that FAs bind and trigger the translocation of a protein called RIPOR2.

Usually, this enzyme is found at the base of tiny hair-like structures called stereocilia in the cochlear hair cell. But all the AGs tested, and none of the other types of antibiotics examined, cause it to translocate to another region – the pericuticular collar – inside the cell.

There, RIPOR2 interacts with GABARAP, a component of the autophagy pathway that plays a major role in the elimination and recycling of dysfunctional cellular components.

“As aminoglycosides specifically trigger a rapid localization change of RIPOR2 in hair cells, we hypothesize that RIPOR2 is essential for aminoglycoside-induced hair cell death,” Zhao explains.

“We then discovered that RIPOR2 regulates the autophagy pathway in hair cells. Knowing this, we developed other laboratory models without the expression of several key autophagy proteins that did not show hair cell death or hearing loss when treated with the antibiotic.” Dr. Jinan Li, postdoctoral fellow in Zhao’s lab and first author of the paper. .

Reducing RIPOR2 expression prevents hearing loss in mice

The team then injected AG into mice that had been genetically modified to produce significantly lower levels of the RIPOR2 protein and, surprisingly, no significant loss of hair cells occurred.

These results suggest that reduced RIPOR2 expression protects hair cells from AG-induced death.

Next, auditory brainstem response tests to “click stimuli” were measured in normal and genetically modified mice to determine whether reducing RIPOR2 expression could prevent GA-induced hearing loss.

And while the normal mice were found to be profoundly deaf after treatment with AG, remarkably, there was no significant change in the hearing thresholds of the mice that produced less RIPOR2.

The authors state that the proteins identified in this study could potentially be used as drug targets to prevent aminoglycoside-induced hearing loss in future studies.

Beleaguered crypto firm Helium attempts a second act as users flee and revenue plummets

0

The best thing you could do as a helium miner was to live in a skyscraper. Max Gold discovered this quickly when he installed a hotspot in early 2021 and made around $16,000 in a month.

A friend had told him about the service, where people set up radio devices in their homes to broadcast a decentralized wireless network that linked Internet of Things products like air quality monitors and keg trackers. In exchange for transferring data over the so-called “people’s network”, miners would receive a crypto token called HNT.

When Gold installed his first helium access point, he was working for an offshore drilling company, but he was laid off in May 2021 and decided to focus on helium full-time. As he learned from his own prime location, Helium devices produced more HNT at higher altitudes, so he connected hotspot owners with internet service providers who already had access to different types of tricks, taking a share of the profits. At the peak of his business, which he named Hotspot Rescue, Gold said he was making around six figures.

Helium has become one of the most notorious companies in crypto, something of a weather vane for the trajectory of the industry’s roller coaster. In February, as owners of hotspots like Gold reaped profits, the New York Times published a flattering profile of the company, describing it as one of the few crypto projects with “normed utility”. The following month, the company behind Helium confirmed a $200 million funding round and renamed Nova Labs.

As the overall crypto market plunged, Helium’s outlook fell in tandem. A Mashable July report revealed that helium had lead into error the public on its customers, questioning the practicality of its technology. The previous month, IoT companies had only spent about $6,500 in data transfer over the Helium network – an unpromising figure for a business valued at $1.2 billion. Meanwhile, Helium’s HNT token fell over 90%.

A Fortune An analysis found that the entire Helium network only received about $1,150 in revenue from demand for IoT devices over the past 30 days, a figure confirmed by the nonprofit Helium Foundation.

Meanwhile, as the likes of Gold saturated the hotspot market and the token’s price plummeted, adoption plummeted. Fortune found that only around 15,000 access points have been installed so far in September, compared to a peak of over 90,000 in November 2021. Gold’s access point, the one that originally hit around 16 $000 in HNT per month, now produces about $10 per month.

With miner profits and collapsing facilities, Nova Labs is now attempting a second act. After hint to build a 5G network last year and to acquire hardware companies, Helium announcement it would launch a separate mobile network in June, powered by a different type of hotspot and a new crypto token called MOBILE.

The question, as Nova Labs embarks on 5G, is whether the company can pull off an ambitious new project while its other is mired in turmoil. For reviews like Nicolas Tisserandresearcher at the International Computer Science Institute in Berkeley, Helium Mobile is not another attempt to create a decentralized wireless network, but a distraction.

“They’ve tried to keep the scam going by moving to a model where it’s cellular connectivity because people can understand that better,” he said. “They need to keep the grappling hook.”

“The People’s Network”

Amir Haleem, a game designer, launched Helium with Napster co-founder Shawn Fanning in 2013. Despite funding from major investors such as Khosla Ventures, the company struggled to find a foothold and was making a hemorrhaged money before switching to crypto in 2017. Its decentralized IoT-focused network launched in 2019.

A Forbes survey published this month found that Helium insiders profited greatly from the early days of the network, creating hotspots and mining half of all Helium tokens in the first three months – a practice common among blockchain projects, although contrary to the principles of decentralization.

Consumers like Gold also rushed into the project, buying around $500 million worth of hotspots. Rather than producing the devices themselves, Helium relied on third-party manufacturers, which resulted in varying degrees of quality and longer turnaround times.

“I think since [Helium’s] point of view, they didn’t want to impersonate: “We do all the manufacturing and sell you these overpriced Raspberry Pis that mine our token,” Gold said.

This allowed secondary markets to proliferate. Gold’s first miner came from a company called Emrit, who sent him a free hotspot in exchange for 80% of the winnings. He would later apply elements of this transaction model to his own business.

Even though the network spread across the United States and around the world thanks to people setting up devices, its capabilities didn’t make much sense from an economic perspective. The IoT could transfer data over the network via “data credits”, which were used to purchase HNT. Helium has touted major customers like electric scooter company Lime as using the network, although Lime later denied working with Helium beyond an initial test. (Nova Labs COO Frank Mong said Fortune that Helium had a pilot with Lime.)

Today, Mong said Helium has hundreds of customers using the network. Even so, most revenue comes from other fees, such as onboarding new devices. As Fortune found, only about $1,150 generated last month came from actual data transfers.

In an interview with FortuneHaleem, CEO of Helium, explained that the IoT network is still in its infancy.

“For Helium to be successful over a ten-year period on the IoT network, there must be hundreds of millions of devices using the network worldwide,” he said. “There is no other way to decide the answer to this question that there must be a lot of traffic.”

He declined to estimate the number of devices currently using the network.

$1,151.07

Helium data credit revenue from IoT device demand in the last 30 days
Source: Helium Foundation

Weaver, the Berkeley researcher, expressed skepticism that such an IoT network could attract enough companies to be sustainable. On the one hand, he explained, because the network relies on a decentralized network of access points, it will always be a patchwork. For IoT companies looking for consistent data transfer, Helium would not offer the most reliable service.

“[IoT Companies] also want to pay real money,” he said. Fortune. “You’re not going to want to pay a stupid third-party token that goes up and down in value.”

Enter Helium Mobile.

“Get as many lottery tickets as possible”

Haleem explained that Nova Labs as a company does not collect revenue from people paying for new access points or IoT companies paying for data transfers, which instead go to third-party manufacturers or the protocol. blockchain powering the Helium network. Instead, the company turns to other projects.

“We are now entering a phase where we will focus in the form of revenue,” he said. “Helium Mobile is an example of that.”

The project echoes the IoT network, with people setting up hotspots in their homes or other locations and mining a crypto token as a reward. The main difference is that the main customers of the network will not be IoT companies, but everyday mobile users.

The main challenge, of course, is coverage – for a cellular network to work, it cannot be disparate. Hotspots cost around $2,000 to $3,000. Currently there are only around 5,000 Helium Mobile hotspots operational, and more than two-thirds of these are “indoor radios”, meaning they would have questionable reception outside the buildings in which they are housed. report from PCMag criticized the hotspot technology – powered by Nova Labs-owned software company FreedomFi – questioning whether it could scale.

Haleem explained that Helium faces the limitations of operating in unlicensed spectrum, admitting that hotspots could never compete with cell towers. “You’re not trying to create this apples-to-apples comparison,” he said.

Instead, he argued that most cellular use happens indoors, which would be the target of the network, helping provide coverage through hotspots in places where cellular service struggles. such as rural areas or crowded places. “We’re not trying to compete with the big telecom operators,” he said. Fortune. “This is a cellular network that’s going to exist in places where traditional networks can’t or don’t exist.”

It’s a way for them to start earning real dollars to support their billion dollar valuation.”

Helium Hotspot Power User Max Gold

To help with the rest of the coverage, Helium recently announced a deal with T-Mobile where whenever Helium Mobile customers can’t access the Helium network, their devices automatically revert to T-Mobile. Wong, COO of Helium, said the price would be $5 per month for 1 gigabyte of data usage. No other plans were priced. The company’s targeted launch date is early next year.

“We believe Helium Mobile is pursuing a very nascent and exciting market segment,” Dan Thygesen, T-Mobile’s senior vice president of wholesale, said in a statement. “T-Mobile is thrilled to support Nova Labs’ innovation in this new crypto-powered space.”

Weaver described Helium Mobile as an ordinary MVNO, or mobile virtual network operator, which does not provide its own infrastructure but rather leases a network from a larger carrier.

“As a service, they don’t offer anything on consumer cellular,” he said.

Gold, the IoT hotspot mogul, has scaled back its Helium IoT hotspot business, focusing on other decentralized wireless projects like the crypto-powered rival mobile network Pollen. Rather than onboarding new IoT hotspots, he is focusing on governance issues within Helium, hoping this will lift his HNT holdings. He also founded the People’s Antenna brand, a popular merchandise and equipment platform within the Helium community.

Gold views Helium Mobile the same way Weaver does. “They call it a crypto operator, but it’s an MVNO,” he said. Fortune. “It’s a way for them to start earning real dollars to support their billion dollar valuation.”

That didn’t stop him from buying an access point, two in fact. One is inside and the other is outside of her apartment covering Minute Maid Park in her hometown of Houston.

“There’s so much luck involved in it that it spills over into different projects and you get as many of those lottery tickets as you can,” he said.

Industry Partners Demonstrate New Underwater Technology at Northeast Tech Bridge Demonstration Day at Newport’s NUWC Division

0

Naval Undersea Warfare Center (NUWC) Division Newport’s Northeast Tech Bridge hosted its first demo day with the goal of introducing new underwater technologies from local start-ups to a Navy audience.

The event, which included seven companies, technology demonstrations and information sessions, took place Sept. 1 at the Narragansett Bay Test Facility. Newport Division Technical Director Ron Vien welcomed attendees.

“We are looking for small businesses to come up with new ideas and we learn more about the industry at these events,” Vien said. “We want to connect the engineers and scientists of the NUWC Newport division with industry partners to find dual-use solutions to Navy challenges.”

Several years ago, the Office of Naval Research (ONR) implemented a series of technology, business, and workforce programs to create an effective agility network across the facility. naval research and development and to promote partnerships with government, universities and industrial partners. Tech Bridges are ONR-sponsored entities located around the world that bring together innovative organizations to accelerate results and solutions for the Navy – one way to do this is to increase local access to ecosystems of innovation.

The Northeast Tech Bridge is the government side of the Tech Bridge with focus areas such as underwater vehicles and underwater sensors. The goal of the Northeast Tech Bridge is to connect government, industry, and academia with the goal of helping move ideas, projects, and technologies through the innovation pipeline. The Northeast Tech Bridge is working with the 401 Tech Bridge, a division of the University of Rhode Island (URI) Research Foundation, as a partner to achieve this goal.

Northeast Tech Bridge Director Dr. Steven Bordonaro hosted a demo day to bring several local start-ups to demonstrate their technology on a Navy range in front of an audience of Newport Division engineers and scientists.

“There are barriers to entry when it comes to working with the Navy and there’s a lot going on in the commercial world for us,” Bordonaro said. “We want to continue to reduce these barriers and continue to make it easier for businesses to work with the Navy. The Blue Tech Accelerator program can help start-up companies, it also helps them connect with industry partners. »

“Dual-use applications are really important to us,” said Christian Cowan, who represented both the 401 Tech Bridge and the URI Research Foundation. “The 401 Tech Bridge can help with people, places, and programming. There are incredibly exciting blue economy initiations in Rhode Island, and the NUWC Newport division is a vital partner with its assets and employees. Everything it benefits the state and the nation.

The demo day was held on the waterfront at the Rapid Engineering Experimentation Facility [REEF] is an example of how 401 Tech Bridge can bring non-traditional industry-based companies to partner with the NUWC Newport division and accelerate technology for the benefit of the Navy as well as the private commercialization of these technologies , Cowan said.

Industry participants

A team from Boston Engineering Corp., based in Waltham, Massachusetts, demonstrated two vertical profilers – one in a tube on the deck and one in the bay. Both of these profilers provide vertical water column profiles carrying standard or user-specified payloads in large customizable payload volumes, collecting data and then transmitting it in multiple ways. For Demo Day, the team used satellite communications.

“Our hope for Demo Day is to expose ourselves and the technology to the NUWC team and better understand the incredible capabilities NUWC has to offer,” said David Shane of Boston Engineering Corp. “We are already engaged with NUWC and want to be more involved in collaboratively solving Navy problem sets.”

Darya Blout of Deep Blue Composites, located in Bristol, Rhode Island, shared his company’s line of deep-sea pressure vessels intended to replace the titanium pressure vessels currently used in unmanned underwater vehicles (UUVs). . Deep Blue Composites products reduce weight by using an all-composite option that is cost effective, making them more accessible to UUV manufacturers.

“I hope to increase awareness of composites and their use in Navy and DOD environments,” Blout said. “I think they’re really underutilized, especially in the underwater vehicle space, because they’ve only recently been adopted by the Navy and other defense sectors.”

The Jaia Robotics team, also based in Bristol, launched two of its JaiaBot micro-autonomous underwater vehicles (AUV) to perform diving simulations. JaiaBots can collect sound velocity profiles (SVP), bathymetry and water depth measurements while being able to move at high speeds on the surface.

The company hopes to reach out to future collaborators, show what its staff and robots are capable of, and then spend time on the water as well, said Jessie Paskoski, an engineer at Jaia Robotics.

Juice Robotics, based in Middletown, Rhode Island, showcased its fiber optic coil system, or FOReel system, which was created in partnership with Nautilus Defense and URI. The system includes a lightweight fiber optic fishing line, a commercial mechanical reel, and a camera and lighting system that allows users to view live footage of the bottom of Narragansett Bay.

Juice Robotics was started by Matt Jewell who later teamed up with Christine deSilva after meeting at URI while filming for “Shark Week”. Their goal was to create a vehicle that would move at high speed and “catch people’s attention”.

“We have realized the future of deep sea research and deep sea exploration and the real access to oceanographic data is with these smaller, modular, lighter and more affordable components,” deSilva said. “So what we do at Juice is really bring that passion together.”

Dr. Kevin Rosa started Current Lab, a Newport-based ocean current forecasting company that primarily works with the yacht racing industry to help them find the fastest route on the race course.

“We can provide predictions of what the currents will do and what the speed of sound will do when you plan your mission,” Rosa said. “We do this with very detailed computer models similar to a weather model, but instead of predicting wind and rain, we predict currents and temperature underwater. I hope to speak to people from the NUWC division in Newport and the marine world to understand what their needs are and what we could potentially provide to them in the future.

Will Magruder, Senior Director of Partnerships at Mass Challenge, a nonprofit global nonprofit accelerator program, helped bring Demo Day attendees together with Linda Larson and the 401 Tech Bridge team.

“Mass Challenge has always been an independent industry accelerator program for today’s event purposes, we’ve partnered with 401 Tech Bridge and Northeast Tech Bridge to highlight companies with strong potential in the blue technology space,” Magruder said. “We’re excited to show off some of the best companies from the mass challenge programs at today’s event in Newport.”

Dillon Fournier, Range Manager of the Newport Division’s Underwater Warfare Ranges Engineering and Analysis Department, led the logistics and range support for this event.

“Narragansett Bay Test Center has all the support needed to host events such as Demo Day and ANTX, and can also support smaller test events with companies that need to test their technologies. in water.” Fournier said, “Through work for private parties and collaborative research and development agreements, we are here to help technologies mature.”

Mary Sylvia, Manager of the Newport Division’s Office of Technology Partnerships, answered attendees’ questions about the variety of different agreements available for working with the Newport Division.

“This is the first of many events that we are going to have over the next few months and possibly years,” Sylvia said. “It’s a wonderful opportunity for small businesses to come through our doors and show us the technology they have.”

The Tech Bridge will continue to support efforts throughout New England in the Blue Tech Zone and will continue to offer technology screening for Newport Division engineers and scientists interested in learning more about industry technology. The Tech Bridge will also continue to partner with the URI Research Foundation.

“We want to continue events like these. They’re at the scale where I think conversations are very natural and hosting these fairly small-scale events several times a year is an effective way to work with businesses, especially small ones,” Bordonaro said. “Some of the bigger companies can navigate a bigger event where a smaller company can get lost. If companies are interested, there’s another cohort going on with Mass Challenge and the 401 Tech Bridge in the Blue Tech area, so that’s something they can look into.

Ultimately, the first day of demonstration achieved its goal of connecting the industry to the Newport Division workforce.

“The technologies that were presented were right,” Bordonaro said. “I was really happy to see the conversations that were taking place. I think there will be long-term results, whether it’s projects or collaborative research. We’ve planted seeds that I think will will grow for a long time.

You can find out more about the start-ups that participated in Demo Day at:

NUWC Newport is the nation’s oldest warfare center, tracing its heritage to the naval torpedo station established on Goat Island in Newport Harbor in 1869. Commanded by Captain Chad Hennings, NUWC Newport maintains significant detachments in West Palm Beach, Florida and Andros Island in the Bahamas, as well as testing facilities in Seneca Lake and Fisher’s Island, New York, Leesburg, Florida and Dodge Pond, Connecticut.

Join our team! NUWC Division Newport, one of Rhode Island’s 20 largest employers, employs a diverse, highly skilled, educated, and skilled workforce. We are always looking for engineers, scientists and other STEM professionals, as well as talented experts in business, finance, logistics and other support services who want to be at the forefront of underwater research and development. Please connect with NUWC Division Newport Recruiting on this site- https://www.navsea.navy.mil/Home/Warfare-Centers/NUWC-Newport/Career-Opportunities/ and follow us on LinkedIn @NUWC-Newport and on Facebook @NUWCNewport.

Immunity Booster Supplements Market Will Help Minimize Risk Of Virus Infection

0

Pune, Maharashtra, September 26 2022 (Wiredrelease) Market.Biz –: Immunity Booster Supplements Market: Ginger, Turmeric and Gooseberries (amla) are natural immune supplements. Many herbs can boost immunity, including garlic, Basel leaf, and black cumin. Since the COVID-19 pandemic, sales of cold and immunity supplements have increased significantly. Many consumers now buy dietary supplements online to support or boost their immune system. Determine if dietary supplements claiming to support or enhance the immune system have been properly labeled using the Supplement Facts label. Also, to qualitatively describe product labels in terms of claims.

The growth of the Immunity Booster Supplements market has been analyzed in the research report. This research includes trends, drivers and restraints that can transform the market in a positive or detrimental way. This provides insights into the potential market impact of various segments and applications. Also provides detailed information based on historical milestones and current trends. Immunity Booster Supplement Market Research Study provides information on production volume in global market along with details of each product type from 2014 to 2030. This section provides information on production volume by region from 2014 to 2030. The report includes price analysis for each product type, from 2014 to 2030, by manufacturer from 2014 to 2022, by region from 2014 to 2022, and globally from 2014 to 2030.

Sample request: https://market.biz/report/global-immunity-booster-supplement-market-gm/#requestforsample

The report provides detailed boundary analysis and enables strategic planning. The Immunity Booster Supplement market growth factors are crucial as they can be understood in order to find different ways to take advantage of the profitable opportunities available in this ever-growing market. To better understand the market, the opinions of market experts have also been taken into consideration.

Immunity Booster Supplements Market Segment Analysis:

This research report contains specific segments by type and application. Each type includes production information for the period 2014-2030. The Immunity Booster Supplement application segment provides consumption information for the period 2014-2030. Understanding the segments will help you identify important factors supporting market growth.

Segment by Type: Capsules; Liquid; Pill; Powder

Segment by application: offline; On line

Global Immunity Booster Supplements Market Regional Analysis

This report provides an in-depth analysis of the Immunity Boosting Supplements market in key regions such as US & Canada, Germany and France. It also includes information about North America; Europe; Asia Pacific; Latin America; The Middle East and Africa.

After studying and observing various factors of the Immunity Booster Supplement market, which influence regional growth, such as political, economic, technological, and social status of each region, the report has been drafted. The analysts examined the data regarding revenue, production and manufacturers in each region. This section analyzes revenues by region for the period from 2014 to 2030. These analyzes will allow the reader to assess the value of investing in a specific region.

Competitive Landscape of the Global Immunity Booster Supplements Market

This section of the report lists the major market players. This section helps the readers to understand the collaborations and the strategies that the market players are using to fight the competition. This comprehensive report provides a detailed overview of the market. The global turnover of the manufacturers and their global price can be viewed by the reader.

Key players in the immunity booster supplements market are Airborne; Amway Corp.; Archer-Daniels-Midland Company; ARKOPHARMA Laboratories; Vita fusion; Bayer SA; Pfizer; Suntory Holdings Ltd; Cyanotech Co.; DuPont de Nemours Inc.; Pfizer Inc.; Enterogermine; Assimilate; FANCL Company; Glanbia PLC; GlaxoSmithKline PLC; immunofree; Nature made; The bounty of nature; Sanofi SA; etc

Inquiry: https://market.biz/report/global-immunity-booster-supplement-market-gm/#inquiry

This report has the following objectives:

To analyze global Immunity Booster Supplement status and future forecast, key growth opportunity market, along with key players.

The Immunity Booster supplement was developed in Europe, the United States and China.

Identify and analyze the most important market players and provide a comprehensive analysis of their development strategies and plans.

To describe, forecast and define the market by product type, market, key regions and other factors.

Buy Report Link: https://market.biz/checkout/?reportId=650045&type=Single%20User

Contact number: +1 (857)4450045, +91 9130855334.
Email: [email protected]

Global Immunity-Boosting Food Market by Type (Nuts & Seeds, Fruits & Vegetables, Dairy, Probiotics & Prebiotics), By Application (Online and Offline) by Country & Manufacturing – Industry Segment, Scenario Competition and Forecast by 2030: https://market.biz/report/global-immunity-boosting-food-product-market-gm/

Global Immunity Gums Market by Type (Vitamins and Probiotics), by Application (Children and Adults), by Country and Manufacture – Industry Segment, Competition Scenario and Forecast by 2030: https://market. biz/report/global-immunity-gummies-market-gm/

Global Immunity Boosting Foods Market By Type (Herbs & Spices, Dairy & Probiotics & Prebiotics), By Application (Hypermarkets/Supermarkets, Food & Beverage Specialty Stores, Convenience Stores, Small Independent Grocery Stores and Discount Stores), by Country and Manufacturing – Industry Segment, Competition Scenario and Forecast by 2030: https://market.biz/report/global-immunity-boosting-food-market-gm/

Global Autoimmune Reagents Market by Type (BLOT, ELISA, IFA, and CLIA), by Application (Hospital and Third-Party Testing Agency), by Country, and Manufacture – Industry Segment, Competition Scenario and Forecast by 2030: https:// /market.biz/report/global-autoimmunity-reagents-market-gm/

Global Chemical Luminescence Immunity Analyzers Market by Type (Automatic and Semi-Automatic), by Application (Hospital and Research Institution), by Country and Manufacture – industry segment, competition scenario and forecast by 2030: https ://market. biz/report/global-chemical-luminescence-immunity-analyzer-market-gm/

Global Immune Support Ingredients Market By Type (Vitamin C, Vitamin E, Other Vitamins, Beta-Glucans, Carotenoids, Phytosterols & Omega-3 Fatty Acids), By Application (Nutritional Supplements, Food & Beverages, Pharmaceuticals, Animal Feeds) , Pet Food and Personal Care Products), by Country and Manufacture – Industry Segment, Competition Scenario and Forecast by 2030: https://market.biz/report/global-immunity-support- ingredients-market-gm/

Global Immunity Sleep Supplements Market By Type (Capsule, Powder & Pills), By Application (Elderly, Adults & Children), By Country & Manufacture – Industry Segment, Competition Scenario and Forecast by 2030: https ://market. biz/report/global-immunity-sleep-supplements-market-gm/

This content was published by Market.Biz company. WiredRelease’s news service was not involved in the creation of this content. For press release service inquiries, please contact us at [email protected]

Entergy Louisiana, Entergy New Orleans and Diamond Offshore Wind seek to assess offshore wind potential in Gulf waters | New

0





Companies Partner in Future Offshore Wind Energy Development to Serve Louisiana Customers

JEFFERSON, La. – Entergy Louisiana, Entergy New Orleans and Diamond Offshore Wind, a subsidiary of Diamond Generating Corporation, today announced the signing of a memorandum of understanding regarding the evaluation and potential early development of the production of wind power in the Gulf of Mexico. The deal could put Entergy in a position to provide another source of clean energy to customers while bolstering economic development in the region.

“This is an important first step in eventually bringing wind power to our Louisiana shores,” said Phillip May, president and CEO of Entergy Louisiana. “Although there is still work to be done before this happens, we are delighted at the opportunity to begin this process. We aspire to help our communities prosper for generations to come, and this marks another step in fulfilling that mission.

“Clean, affordable energy is an engine of economic growth, which translates into increased investment and well-paying green jobs in our communities,” added Deanna Rodriguez, President and CEO of Entergy New Orleans. “Entergy New Orleans understands the importance of providing customers with clean energy to reduce the impacts of climate change and doing so in a way that keeps service affordable for New Orleans families and businesses. This agreement creates another possible route to meet these demands.

The MOU provides a legal framework for Entergy and Diamond Offshore Wind to work towards the development of potential offshore wind demonstration projects located in Louisiana waters and will focus in the short term on the evaluation of grid interconnection to determine the optimal size and location of future offshore wind developments.

Earlier this year, Louisiana Governor John Bel Edwards introduced the Louisiana Climate Action Plan, which offered a series of recommendations that could lead Louisiana to net zero greenhouse gas emissions from by 2050 – a key action of this plan is to achieve five gigawatts of offshore wind generation by 2035. Developing wind power in the Gulf of Mexico will accelerate the state’s role as a leader in the development of renewable energy and will stimulate collaboration among state and federal agencies, utilities, the private sector, and colleges and universities in our states. Entergy is proud to be a leader in this exciting future for Louisiana.

“Diamond Offshore Wind is pleased to announce its partnership with Entergy Louisiana and Entergy New Orleans to explore the construction of the first offshore wind project in Louisiana state waters and the Gulf of Mexico,” said Chris Wissemann, CEO. of Diamond Offshore Wind. “Louisiana has a tremendous opportunity to develop an offshore wind industry that serves the entire country, and through this project we hope to accelerate its development, create jobs, provide a renewable energy source for Louisiana customers and help Louisiana meet its climate goals. .”

Entergy Louisiana currently has approximately 280 megawatts of renewable resources, including the Capital Region Solar Facility, which began delivering electricity to the grid in October 2020. Along with nuclear generation, nearly 30 % of the company’s portfolio comes from renewable resources. Additionally, the LPSC recently approved 475 megawatts of solar power with an additional 2,000 megawatts in the queue.

Entergy New Orleans’ diverse generation portfolio includes the 20-megawatt New Orleans Solar Station and the soon-to-be-completed Iris Solar and St. James Solar projects that will add an additional 70 megawatts of clean power. Additionally, the company has 5 megawatts of solar power installed on commercial and residential rooftops. Together with nuclear, these carbon-free resources represent nearly 40% of the company’s generating capacity and will continue to reduce Entergy New Orleans’ carbon emissions, which today are already nearly 40% lower than the national average.

Entergy Corporation has been an industry leader in voluntary climate action for more than two decades. In 2001, the company was the first US electric utility to commit to voluntarily stabilize greenhouse gas emissions. This goal has since been accelerated with a commitment to achieve net zero carbon emissions by 2050.

As a subsidiary of Mitsubishi Corporation, Diamond Offshore Wind, its parent companies and affiliates bring decades of successful experience in the development, construction and operation of major energy assets, both in the United States and overseas, including seven commercial-scale offshore wind projects and 13 offshore wind projects. transportation projects.

About Diamond Offshore Wind

Diamond Offshore Wind is a wholly owned subsidiary of Diamond Generating Corporation (DGC), a wholly owned subsidiary of Mitsubishi Corporation, and was established by DGC to develop, own and operate offshore wind projects in the United States.

Building on MC’s success in the global offshore wind market and DGC’s deep experience and outstanding performance as an independent power producer in the United States, Diamond Offshore Wind is uniquely positioned to to be a strong, long-term leader in the growing offshore wind market in the United States.

About Entergy Louisiana

Entergy Louisiana, LLC provides electric service to more than one million customers in 58 parishes and natural gas service to more than 94,000 customers in Baton Rouge, Louisiana.

About Entergy New Orleans

Entergy New Orleans, LLC provides electricity to more than 209,000 customers and natural gas to more than 110,000 customers in Orleans Parish, Louisiana.

Both Entergy Louisiana and Entergy New Orleans are subsidiaries of Entergy Corporation (NYSE: ETR), a Fortune 500 company headquartered in New Orleans. Entergy Corporation powers the lives of 3 million customers through its operating companies in Arkansas, Louisiana, Mississippi and Texas. Entergy is creating a cleaner, more resilient energy future for all through our diverse power generation portfolio, including increasingly carbon-free energy sources. With roots in the Southern Gulf region for more than a century, Entergy is a recognized leader in corporate citizenship, delivering over $100 million in economic benefits to local communities through efforts to philanthropy and advocacy every year for the past few years. Our approximately 12,000 employees are dedicated to fueling life today and for future generations.

Dementia: chilli peppers could double your risk of brain disease – ‘killer’

0

The number of dementia cases is expected to triple by 2050 as the world’s populations age. However, age is not the only driver of cognitive decline. Research has also linked chili peppers to a higher risk of mental disorder.

Whether you use it as the defining flavor for your curry or as an extra kick for your marinade, capsaicin is the primary pungent ingredient in chili peppers that gives it its pungent taste.

Unfortunately, for heat lovers, this chemical is also what has been linked to cognitive decline.

Nutritionist Rory Batt said: “Capsaicin has been shown in a few studies to cause (neuronal) cell death through a phenomenon known as excitotoxicity.

“Basically, capsaicin in very high doses can cause an excessive and prolonged release of cellular calcium through the activation of a receptor called TRPV1, which triggers a cascade of events that ultimately leads to cell death. This is what this is called excitotoxicity.

READ MORE: Taking two vitamin supplements together increases cancer risk by almost 30% – BMJ

“Because cognitive decline is partly underpinned by neurodegeneration (the death of neuronal cells), then it is possible that capsaicin plays a role [in cognitive decline] through this mechanism.

Moreover, the nutritionist is not the only one to point out the potentially “destructive” effects of peppers.

According to a study published in the journal Nutrients, the spicy ingredient could nearly double your risk of dementia.

By examining more than 4,852 Chinese adults, researchers determined that eating more than 50 grams of chili peppers per day was associated with an increased risk.

Participants’ chili consumption was assessed by a three-day food diary during home visits.

Although the research placed a red flag on chili peppers, the researchers also shared that more studies are needed to come to a firm conclusion.

However, you might not want to throw away your chili stash just yet, according to Batt.

The nutritionist explained that moderate consumption of the spicy ingredient has neutral effects on cognition.

Additionally, he even suggested that consuming 1-20 grams per day may provide some benefits.

READ MORE: Fish may have ‘tumor-promoting’ effects – ‘major risk factor’ for colon cancer

Batt said: “It is very likely that the dose does the poison. A little is protective, too destructive.

“The right amount of TRPV1 activation and calcium release by capsaicin is actually responsible for many very beneficial effects (but as we know from above, too much could lead to cell death-excitotoxicity).

“There’s good reason to believe that capsaicin is good for cognitive health (at the right doses).”

The reason it’s so hard to draw a conclusion about spicy food comes down to the type of research looking at chili peppers and dementia.

Dr Louise Durrant, Head of Nutrition Communications, British Nutrition Foundation, said: “Scientific research into potential associations between chilli consumption and cognitive decline has its limits.

“It is primarily based on observational data which cannot tell us whether a specific food is the direct cause of a health outcome such as cognitive decline, and also provides no clear indication of the underlying mechanisms. underlying how chili consumption might be related to cognitive function.

“The evidence available to date does not indicate the need to alter our average chili consumption for the sake of our cognitive health.”

However, if you want to play it safe, you can follow Batt’s advice by sticking to a dose of between 1 and 20 grams of chili pepper per day.

Insider Sale: Intra-Cellular Therapies, Inc. (NASDAQ: ITCI) CFO Sells 65,164 Shares

0

Intra-Cellular Therapies, Inc. (NASDAQ: ITCI – Get a rating) Chief Financial Officer Lawrence J. Hineline sold 65,164 shares of the company in a trade on Wednesday, September 21. The shares were sold at an average price of $45.63, for a total transaction of $2,973,433.32. The transaction was disclosed in a document filed with the SEC, accessible via this hyperlink.

Price performance of intra-cellular therapies

NASDAQ: ITCI was down $2.20 on Friday, hitting $43.51. The stock had a trading volume of 912,534 shares, compared to an average volume of 940,529. The company has a market capitalization of $4.11 billion, a price-earnings ratio of -11.76 and a beta of 1.19. The company’s fifty-day moving average is $52.24 and its two-hundred-day moving average is $55.50. Intra-Cellular Therapies, Inc. has a 12-month low of $34.43 and a 12-month high of $66.00.

Intra-Cellular Therapies (NASDAQ:ITCI – Get a rating) last reported its quarterly earnings data on Tuesday, August 9. The biopharmaceutical company reported ($0.92) earnings per share for the quarter, missing the consensus estimate of ($0.79) by ($0.13). Intra-Cellular Therapies had a negative return on equity of 53.13% and a negative net margin of 232.11%. The company posted revenue of $55.58 million for the quarter, compared to $48.62 million expected by analysts. In the same quarter of the previous year, the company made ($0.85) earnings per share. The company’s revenue increased 177.2% year over year. As a group, research analysts expect Intra-Cellular Therapies, Inc. to post earnings per share of -3.36 for the current fiscal year.

A Wall Street analyst gives his opinion

Several stock analysts have recently weighed in on ITCI shares. Needham & Company LLC raised its price target on Intra-Cellular Therapies shares from $65.00 to $67.00 and gave the stock a “buy” rating in a Wednesday, August 10 research note . Goldman Sachs Group cut shares of Intra-Cellular Therapies from a ‘buy’ rating to a ‘neutral’ rating and lowered its price target for the company from $64.00 to $49.00 in a report research on Monday August 22. UBS Group began covering the actions of intra-cellular therapies in a research report on Monday, June 13. They set a “buy” rating and a price target of $75.00 for the company. Finally, Mizuho lowered its price target on shares of Intra-Cellular Therapies from $75.00 to $72.00 and set a “buy” rating for the company in a Thursday, August 11 report. One equity research analyst gave the stock a sell rating, two gave the stock a hold rating and six gave the stock a buy rating. According to MarketBeat, the company currently has an average rating of “Moderate Buy” and a consensus target price of $60.88.

Institutional trade in intra-cellular therapies

Hedge funds have recently changed their positions in the stock. US Bancorp DE increased its stake in Intra-Cellular Therapies by 93.8% during the second quarter. US Bancorp DE now owns 496 shares of the biopharmaceutical company worth $28,000 after buying 240 more shares in the last quarter. Assetmark Inc. increased its holdings in intracellular therapies by 410.0% during the second quarter. Assetmark Inc. now owns 510 shares of the biopharmaceutical company worth $29,000 after acquiring an additional 410 shares during the period. Exchange Traded Concepts LLC acquired a new position in intracellular therapies during the first quarter worth approximately $33,000. Northern Oak Wealth Management Inc. acquired a new position in intracellular therapies during the second quarter worth approximately $51,000. Finally, FourThought Financial LLC bought a new position in intra-cellular therapies in Q1 worth approximately $54,000. Institutional investors and hedge funds hold 85.48% of the company’s shares.

Intra-Cellular Therapies Company Profile

(Get a rating)

Intra-Cellular Therapies, Inc, a biopharmaceutical company, is developing novel drugs for the treatment of neuropsychiatric and neurological diseases by targeting intracellular signaling mechanisms in the central nervous system in the United States. The company offers CAPLYTA for the treatment of schizophrenia in adults.

Featured articles

Insider Buying and Selling by Quarter for Intracellular Therapies (NASDAQ:ITCI)

This instant news alert was powered by MarketBeat’s narrative science technology and financial data to provide readers with the fastest and most accurate reports. This story was reviewed by MarketBeat’s editorial team prior to publication. Please send questions or comments about this story to [email protected]

Before you consider intracellular therapies, you’ll want to hear this.

MarketBeat tracks daily the highest rated and most successful research analysts on Wall Street and the stocks they recommend to their clients. MarketBeat has identified the five stocks that top analysts are quietly whispering to their clients to buy now before the market goes higher…and intracellular therapies weren’t on the list.

While Intra-Cellular Therapies currently has a “Moderate Buy” rating among analysts, top-rated analysts believe these five stocks are better buys.

See the five actions here

Vitamins and supplements: your reading in 5 minutes

0

You may decide to take vitamins and supplements for many reasons, including getting your recommended daily nutrient intake or addressing a specific health issue.

Vitamins and supplements offer a range of potential benefits, from boosting immunity to managing stress.

But with so many choices, what should you look for when choosing the right vitamins or supplements for your needs? We collaborated with Swanson Health to provide tips on what to keep in mind when browsing the vitamin aisle.

Do you need to take vitamins and supplements? You may benefit if you have a deficiency. According research 2021, common deficiencies in the United States include vitamin D and vitamin B12. These essential vitamins play a role in bone and brain health.

How do you know if you have a deficiency? Some signs and symptoms may include:

  • visual or skin changes
  • anemia
  • bone changes
  • neurological problems
  • blood clotting problems
  • hair loss or brittle hair
  • brittle nails
  • fatigue

Discuss deficiency testing options with a healthcare professional if you think you are missing an essential vitamin or mineral. Testing can help identify potential deficiencies and determine why you’re lacking in a particular nutrient, whether it’s because of diet or an underlying health condition.

Learn more about magnesium deficiency.

When shopping for vitamins and supplements, you can choose from a wide variety of options. The type you choose depends on the health issue you want to target.

Here are some commonly sold supplements and why people use them often:

  • biotin for hair loss
  • calcium and Vitamin D for bone health
  • fish oil for joint health, eye health, heart health, bone health, depression and inflammation
  • ashwaganda to relieve stress
  • the iron for anemia and low iron levels
  • magnesium for depression, heart health, bone health, migraine and inflammation
  • niacin (vitamin B3) for skin health and digestive health
  • omega-3 fatty acids for heart health, eye health, inflammation and depression
  • vitamin B12 for people who do not get enough of it in their diet, such as vegans and vegetarians
  • vitamin C for antioxidants, healthy skin, healthy bones and boosting immunity
  • Vitamin E for heart health, eye health and inflammation

Learn more about the potential benefits of ashwagandha.

With rows of vitamins and supplements available in stores and even more options online, how do you know which options are effective and trustworthy? Here are some key factors to consider.

Security

It’s important to consult with a healthcare professional to determine which vitamins and supplements are best for your needs and safe to take. Some vitamins and supplements can interact with medications.

A healthcare professional can also help you select the right doses of vitamins and supplements for your needs. Taking inappropriate amounts can be dangerous.

Brand reputation

Buying dietary supplements from a reputable brand that offers a high quality product is crucial.

The Food and Drug Administration (FDA) generally does not approve claims and labeling before a vitamin or supplement hits the market. This means that it is up to the manufacturer to provide accurate information. Unfortunately, not all brands are transparent when it comes to labeling.

A study 2019 reviewed the accuracy of herbal and dietary supplement labels. The researchers found that more than half of the products tested were mislabeled.

When shopping for supplements and vitamins, look for brands that use reputable third-party testing. Looking for a Certificate of Analysis (COA) is one way to ensure that a brand takes the quality of its products seriously.

Some third-party identifications to look for include:

  • NSF Certification: This certificate type uses strict standards to evaluate products and involves regular on-site inspections.
  • USP Verified Mark: This mark verifies that the ingredients, potency and quantities are accurate and free of harmful contaminants. It also verifies that the products are manufactured in accordance with current FDA Good Manufacturing Practices (CGMP), confirming that the products are manufactured in a sanitary and controlled manner.
  • Banned Substances Control Group (BSCG) certified quality and GMP: BSCG certified quality checks ingredients and checks for hazardous substances. BSCG Certified GMP audits manufacturers to ensure they comply with CGMP.
  • USDA Certified Organic: Products with this certification go through rigorous review to ensure that their quality and integrity meet USDA organic regulations.

Swanson Health offers a wide variety of gummies, such as magnesium, zinc, vitamin C and multivitamins for children and adults. Supplements are also tested by in-house and third-party labs.

Labels

A product label can provide a lot of information, including:

  • Ingredients and potency: A clear list of ingredients and information on nutrient content are important. If it’s missing, it’s a red flag.
  • Fillers and additives: Beware of supplements containing heavy fillers, sweeteners and additives.
  • Servings and Serving Size: Look for the number of servings in the container and how the serving size is measured.
  • Certificates: Certifications may state information about the supplement, including whether it is vegan, USDA organic, gluten-free, kosher, etc.

Learn more about how to choose high quality vitamins and supplements.

The right type of vitamin and supplement depends on your preferences and needs.

Do you hate swallowing thick capsules? Do you prefer a convenient single-dose pill? Or maybe you’re looking for a kid-friendly vitamin option.

Common forms of vitamins include:

  • Capsules and liqui-gels: Capsules and liqui-gels can mask unpleasant tastes, but they may contain gelatin, which makes them unsuitable if you’re vegan.
  • Tablets or capsules: Capsule shells and tablets are common and available in vegan and non-vegan formulas.
  • Liquid and mists: These vitamins and supplements are a great choice if you have trouble swallowing pills or capsules.
  • Candy and chewing gum: Chewable vitamins and supplements are a great option for children and people who don’t like swallowing whole capsules.

Vitamins and supplements can provide benefits that can help with various health issues. When choosing the right nutritional supplements for your needs, factors to consider include brand reliability, safety, and your preferences.

Before you start taking any vitamin or supplement, talk to a doctor. They can help you determine if you have a deficiency and give you advice on how to supplement safely.

This university is replacing cheesesteaks with Vegan Patty Melts

0

About 23% of 18-25 year olds follow a vegan or vegetarian diet, but most universities offer few plant-based food options, making it difficult for college-aged students to make sustainable and healthy choices. Today, catering giant Sodexo, which serves around 380 North American universities, announced it was adapting its food selection, starting with Liberty University in Virginia.

This semester, Sodexo is replacing Liberty’s South Street Cheesesteaks with an all-new vegan and gluten-free concept called The Hungry Herbivore. The plant-based restaurant is Sodexo’s first entirely vegetarian and gluten-free concept on a university campus. The new restaurant will provide Liberty students with an allergen-friendly option that completely reduces the risk of cross-contamination.

“Based on my nationwide research, there are few restaurants that focus solely on gluten-free and plant-based, because that’s extremely difficult to do,” District Manager Sarah Falls told Food management. “We are always striving to deliver innovative concepts from Liberty University.”

Hungry Herbivore’s menu includes fudgy hash browns, nachos, meatball marinara bowls, vegan burgers and more. Although it offers some dairy cheese options, the Hungry Herbivore allows all customers to swap it out for a vegan alternative.

“Many gluten-free students have said they haven’t been able to use their meal plans like everyone else, even with our strong Gluten Intolerant Options (GIO) program,” said Duke Davis, director of the Liberty district. “We heard the same thing from vegan and vegetarian students. It was a tough decision as many students loved the cheesesteak concept, but we felt a greater demand to provide more food options for students with dietary restrictions.

Colleges go for plants

Sodexo currently provides catering services to over 1,000 colleges and universities worldwide. With increased demand for plant-based options, the restaurant giant aims to restructure its menus to cater to the growing plant-based population. Last April, the company announced plans to increase plant-based meal offerings by 42% by 2025. Sodexo is partnering with the Humane Society of the United States to ensure its new menu helps reduce its carbon footprint.

Working with colleges nationwide, Sodexo aims to reduce its carbon emissions by 34% by 2025. The company has discovered that 70% of its carbon footprint is associated with its food products. animal origin. By introducing new plant-based offerings, the company hopes to move away from its current meat-heavy menus across the United States.

Last August, Sodexo partnered with Israeli food tech company SavorEat to help bring its new plant-based vending robot to market. The tech company unveiled a vegan burger-serving robot last year, with plans to launch the plant-based mobile vending machine in US colleges in 2022. Using 3D printing technology, the company is preparing burgers with plant-based ingredients.

School systems are introducing vegan meal programs

In May, Illinois Public Schools unveiled a plan to serve vegan meals to two million students. Illinois Governor JB Pritzker has signed a new bill requiring plant-based school lunches to be served statewide. The new law will come into effect on August 1, 2023, ensuring that all students have the opportunity to choose plant-based dishes in their school cafeterias.

Similarly, the New York public school system launched its “Vegan Fridays” program, providing one million students with free plant-based meals. Aimed at teaching kids to eat healthier, the new plant-based program provides students with access to vegan foods they wouldn’t otherwise have access to.

For more plant-based events, check out The Beet’s News articles.

The 13 Best Foods to Boost Your Immune System to Fight COVID-19 Symptoms

Here are the best foods to eat repeatedly, to boost immunity and fight inflammation. And avoid red meat.

Kenya: East African Portland cement resumes manufacturing after kiln upgrade

0

Nairobi – Cement maker East African Portland Cement PLC has resumed manufacturing at its Athi River plant after replacing a faulty kiln jacket that caused frequent process stoppages.

The upgrade saw the cement manufacturer carve out 16 meters of the kiln’s dilapidated shell and replace it with a new one at a cost of 500 million shillings.

The company’s Managing Director (MD), Oliver Kirubai, said the upgrade is in line with East African Portland Cement’s recently launched five-year strategic plan, which is anchored on a long-term performance-driven cycle to turn it around. firmly on the path to profitability.

“We have already started producing our own clinker after upgrading our kiln. With this upgrade, we expect to improve plant reliability and increase production by almost 50%. Blue Triangle cement will be produced in abundance and used throughout the country. said Kirubai.

He further noted that the upgrade and optimal operation of the plant will result in efficient energy consumption resulting in the production of cement at a cost that will enable customers to purchase Blue Triangle Cement at competitive prices. more advantageous.

Kirubai further assured customers that orders from Blue Triangle Cement will be processed within the agreed time frame in accordance with the Customer Service Charter as the company has fully resumed operations.

The company’s plant operations manager, Stanley Irungu, noted that the replaced part of the kiln will ensure constant operation, which will lead to increased production of good quality clinker for grinding cement that will satisfy its market.

“We have been waiting to undertake this project and now that it is complete, we can now guarantee the continued availability of the plant,” Irungu said.

Kenya currently has 13 cement factories with only 4 cement factories with clinkerization and integrated capacities.

Thinking Properties of Mental Health and Brain Mapping

0

The NIH as part of its Brain Research Through Advancing Innovative Neurotechnologies [BRAIN] Initiative, the BRAIN Initiative Cell Atlas Network, or BICAN, recently announced to “map 200 billion cells in the human brain by type and function as well as create an atlas of the primate brain.”

Part of the goal is that “to understand how the brain works mechanically [we] must understand the basic cell types that make up the neural circuitry and how they are wired together to give rise to function and understand the causes of neuropsychiatric diseases.

The project is an invigorating leap forward towards new answers about the brain, a complex organ. However, there is no shortage of studies in cellular and molecular neuroscience in research laboratories around the world. Advances in neuroscience have mostly focused on cells and molecules.

There would be a lot to learn from BICAN, but it may not disclose enough of the brain history needed “to understand the causes of neuropsychiatric diseases.”

In any serious mental illness, there is a problem with thoughts. In any state of good mental health, there are properties of thought that structure the tranquility felt.

The properties of thought define all experiences of neuropsychiatric diseases, going beyond the “function” of neurons, to their construction or construction. There are things that people generally avoid against social, cultural, or economic norms, because thinking goes to places where the consequences are known, to not. But there are people with neuropsychiatric illnesses, without the ability for their thoughts to go out there to find out, so they break.

In general, seeing, hearing or touching something, at different times, can cause anxiety, fear, trauma, depression, joy, laughter, etc. All that is expressed is that the senses become thought versions, these thought versions become priority [full action and attention] and head to destinations to get anyone of them to support.

It is the function of thinking and remembering experiences that are the poles of mental health and disease. People often say dopamine hit, but no one ever experiences dopamine, serotonin or other brain molecules, that’s what they become for the experience – through memory, which makes this determination.

It is possible to desire something badly, or say to have a dopamine secretion, but the fear of the consequences, or the exposure if done at the time, would prevent it from happening. This makes dopamine a subordinate of the overall construction or construction of memory.

Thought can acquire cravings by going to the craving store. Then, depending on what the thought went before or rebounds, subsequently – an element [rep] binds to cravings: it can be food, drink, medicine, travel, etc. There are other cases where the thought does not go to the store of cravings, so when the item is seen, heard, smelled, touched or tasted, it is not wanted.

What is pressing in brain science and related fields are the rules of thought transport in the brain and how they acquire the properties that determine experiences.

This is where virtual reality can step in, displaying or showing what neuroimaging cannot. The functionality could be subsumed with games or other VR apps.

Exploring the brain cell atlas for specific functions can reveal some of their actions. When this part is used to develop drugs, there would be various side effects, because a cell, a group or molecules, are different sets of constructs, so inhibit or induce help, then is not.

Simplified optoretinographic approach makes measuring retinal function easier and faster

0

Researchers have developed a quick and easy way to perform optoretinography, an imaging technique that measures light-induced functional activity in the eye’s retina, the neural network at the back of our eyes. eyes responsible for detecting light and initiating vision. More than 50% of people over the age of 60 in the United States are affected by retinal diseases such as macular degeneration and diabetic retinopathy. These diseases affect the function of the retina in such a way as to reduce sight and can progress to blindness if left untreated. The new approach could help speed the development of new treatments for eye diseases.

“Optoretinography has typically used very expensive equipment that required multiple experts to operate while producing huge volumes of data requiring extensive computational resources,” said research team leader Ravi Jonnal from the University. from California to Davis. “We figured out a way to do it in a more economical and original way.”

Jonnal and colleagues report their new approach, which they call velocity-based optoretinography in Optical, Optica Publishing Group’s journal for high-impact research. They also demonstrate the ability of the method to measure the retinal response in three healthy subjects.

“While velocity-based optoretinography has the potential to provide clinicians with more accurate and earlier insights into retinal functional losses, its first real impact is more likely to be the acceleration of clinical trials for new treatments. retinal disease,” said Jonnal, who performed some of the first optoretinographic measurements as a doctoral student in Don Miller’s lab at Indiana University. “If we can detect whether retinal function is improving or deteriorating faster than with traditional tests such as eye charts, it will dramatically speed up the development of treatments.”

Shape Change Tracking

Optoretinography detects slight changes in the shape of neurons that generate or conduct signals in the retina. So far, Jonnal and other researchers have used adaptive optics and optical coherence tomography (OCT) to visualize and track these neurons in the moving live eye, then applied motion correction algorithms to stabilize the images and extract the functional response. This expensive and time-consuming process requires resolving and tracking the position of individual cell features and using these positions to determine if the cell has changed shape.

“When we use one of our adaptive optics systems to perform optoretinography measurements, the experiment can easily take half a day and result in a terabyte of data to process,” Jonnal said. “Data processing to extract a working signal takes, at a minimum, a day or two longer.”

To avoid having to resolve and track individual neurons, Jonnal and his colleagues wanted to see if they could instead measure the speed, or velocity, at which retinal neurons move relative to each other. “We thought that even though the positions of features vary from cell to cell, the speed at which they move relative to each other would be highly correlated between cells,” Jonnal said. “It turned out to be correct.”

Measuring neurons in motion

To perform velocity-based optoretinography, researchers have developed a new OCT camera that allows a single operator to collect images from more locations in the retina than is possible with other approaches to imaging. optoretinography.

The researchers demonstrated their new technique by using it to collect measurements from three healthy volunteers. They were able to acquire each patient’s data in just ten minutes and have that data processed and get the results in 2-3 minutes. They showed that the functional optoretinographic responses measured with the simple approach changed with the dose of light stimulus used and that the dose-stimulus response was reproducible in and between volunteers.

They are now planning experiments to demonstrate the technique’s sensitivity to disease-related dysfunctions. Jonnal also works with clinicians at the University of California, Davis to use it for patient imaging and to help interpret results from trials of stem cell therapies and gene therapy treatments for inherited retinal diseases. The researchers would also like to apply the new optoretinography approach to animal models of retinal disease.

Source of the story:

Materials provided by Optical. Note: Content may be edited for style and length.

Potted Plants Market 2022 Size, Share, Growth

0

Pune, Sep 22, 2022 (GLOBE NEWSWIRE) — The latest Potted plant market The 2022 research report provides detailed information about the market overview, modern trends, demand and recent developments affecting the growth of the market over the coming year. Potted Plants market report also covers new business development, price, revenue, gross margin, market size, share, potential growth and upcoming market strategy followed by major players. . This report also gives the knowledge of the profiles of the major companies in the market. The report focuses on the Potted Plants market size, segment size (mainly covering product type, application, and geography), competitor landscape, recent status and development trends. Additionally, the Potted Plants market forecast by regions, type and application, with sales and revenue, from 2022 to 2027. The report also covers the market landscape and its growth prospects in the coming years. Finally, the feasibility of new investment projects is assessed and general research conclusions are offered.

Get Sample PDF of Report – https://www.industryresearch.biz/enquiry/request-sample/21231079

Market analysis and overview: Global potted plant market

With industry-standard analytical accuracy and high data integrity, the report brilliantly attempts to unveil major opportunities available in the global Potted Plants Market to help players gain a strong position in the market. Buyers of the report can access verified and reliable market forecasts, including those regarding the overall size of the global potted plants market in terms of revenue.

Potted Plants Market 2022 provides a comprehensive overview of crucial industry elements and elements such as drivers, restraints, past & present current trends, watch scenarios, and technological growth. The report also focuses on global major leading industry players of Global Potted Plants market providing information such as company profiles, product pictures and specification, price, cost, revenue and contact details. This report focuses on Potted Plants Market trends, volume and value at global level, regional level and company level. From a global perspective, this report represents overall Potted Plants Market Size by analyzing historical data and future prospect.

Get Sample Copy of Potted Plants Market Research Report 2022

List of Top Key Players listed in the Potted Plants Market Report are:

  • The threshold
  • bloomscape
  • The potted plant
  • Kirton Farm Nurseries
  • Urban planters
  • House of Plants
  • The Nanjala company
  • The pot company
  • Crocus
  • Patch
  • Gardener’s Supply Company
  • Leon and George
  • Palmer Planter Company
  • The potted garden
  • The Nature Company
  • smart pan
  • Tillery Streetplant Company
  • Plant stand
  • Greenery NYC
  • The Little Garden
  • Urban Flower Company
  • The Company of the Bouqs
  • OLFCO
  • The Green Room Flower Companion
  • Ikea

Overall, the report is proven to be an effective tool that players can utilize to gain a competitive edge over their competitors and ensure sustainable success in the global Potted Plants Market. All conclusions, data and information provided in the report are validated and revalidated using reliable sources. The analysts authoring the report have adopted a unique and industry-best research and analysis approach for an in-depth study of the global Potted Plants market.

Potted Plants Market Segment By Type:

  • Bright plants
  • low light plants

Potted Plants Market Segment By Application:

Inquire more and share questions if any before purchase on this report at – https://www.industryresearch.biz/enquiry/pre-order-enquiry/21231079

Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth rate of Potted Plants in these regions, from 2017 to 2027, covering

  • North America
  • Europe
  • Asia Pacific
  • South America
  • Middle East and Africa

Key Attentions of Potted Plants Market Report:

  • The report provides a comprehensive and broad perspective on the global Potted Plants Market.
  • The market statistics depicted in different potted plant segments offer a comprehensive picture of the industry.
  • Market growth drivers and challenges affecting the development of Potted Plants are analyzed in detail.
  • The report will aid in the analysis of key competitive market scenarios and Potted Plants market dynamics.
  • Major stakeholders, Potted Plants key companies, investment feasibility and new entrants study in the market are offered.
  • The development scope of Potted Plants in each market segment is covered in this report. Macro and micro-economic factors affecting the Potted Plants market
  • The progress is developed in this report. The upstream and downstream components of potted plants and a complete value chain are explained.

Purchase This Report (Price 2680 USD for Single User License) – https://www.industryresearch.biz/purchase/21231079

Detailed TOC of Global Potted Plants Market Report 2022

Global Potted Plants Market Research Report 2022, Forecast to 2027

1 Market Research Overview

1.1 Objectives of the study
1.2 Potted plants introduce
1.3 Combined with the analysis of macroeconomic indicators
1.4 Brief description of research methods
1.5 Market Breakdown and Data Triangulation

2 Summary of global trends

2.1 Potted Plants Segment by Type
2.1.1 Plants with bright light
2.1.2 Low-light plants
2.2 Market Analysis by Application
2.2.1 Household
2.2.2 Commercial
2.3 Global Potted Plants Market Comparison by Regions (2017-2027)
2.3.1 Global Potted Plants Market Size (2017-2027)
2.3.2 North America Potted Plants Status and Prospect (2017-2027)
2.3.3 Europe Potted Plants Status and Prospect (2017-2027)
2.3.4 China Potted Plants Status and Prospect (2017-2027)
2.3.5 Japan Potted Plants Status and Prospect (2017-2027)
2.3.6 Southeast Asia Potted Plants Status and Prospect (2017-2027)
2.4 Basic Product Information
2.4.1 Product Basic Information and Technology Development History
2.4.2 Product manufacturing process
2.4.3 Interview with Key Market Players
2.4.4 High End Market Analysis and Forecast
2.5 Coronavirus Disease 2019 (Covid-19): Impact on Potted Plants Industry
2.5.1 Potted Plant Business Impact Assessment – Covid-19
2.5.2 Potted Plants Market Trends and Potential Opportunities in the COVID-19 Landscape
2.5.3 Measures / Proposal against Covid-19

Continued….

Browse full TOC at – https://www.industryresearch.biz/TOC/21231079

About Us: –

The market is changing rapidly with the continuous expansion of the industry. Technological advancements have provided today’s businesses with multi-faceted benefits driving daily economic changes. Thus, it is very important for a business to understand the patterns of market movements in order to strategize better. An effective strategy gives companies a head start in planning and an advantage over their competitors. Industry research is a credible source for getting the market reports that will give you the head start your business needs.


How sharks could hold the key to our immunity

0

THEY have a scary reputation, but could sharks soon help save many more human lives than the dozen they take each year?

Over 400 million years of evolution, sharks’ immune systems have evolved into finely tuned defenses that are far more precise than those of humans and capable of fending off almost any dangerous virus or life-threatening tumor.

This is thought to be one of the main reasons why some species, like the great white, can live up to 70 years. Sharks also have exceptional wound healing abilities, which means injuries rarely result in death.

Researchers have now solved the riddle of why sharks’ immune systems are so good at warding off disease. And the discoveries could lead to new drugs to fight diseases such as cancer and rheumatoid arthritis.

In humans, when the immune system detects the presence of foreign cells (such as a virus or bacteria), it releases a protein called an antibody. This latches on to a specific molecule on the surface of the virus or bacteria and calls on support from more powerful immune system cells, called T cells, to kill the invader.

Separately, scientists have developed artificial antibodies, “monoclonal” antibodies, which are injected into the body to target certain rogue cells, such as cancer cells.

Once docked to their target, these synthetic antibodies activate the immune system to attack tumor cells (Herceptin, the drug used to treat some forms of breast and stomach cancer, is a monoclonal antibody).

But human and artificial antibodies tend to be bulky Y-shaped molecules that, due to their size, are usually only able to bind to a small number of targets on invading cells. This helps explain why the human immune system and antibody-based drugs aren’t always 100% effective in repelling the enemy.

In sharks, the antibodies are less than a tenth the size of those found in humans, allowing them to penetrate deeper into the tiny cracks found on the surface of bacteria or cancer cells, which increases the chances that they “stick” and that the immune system destroys the invader.

Moreover, tests have shown that shark antibodies are very resistant. Scientists claim they boiled them and dipped them in corrosive acid – but they survived.

“Sharks are among the oldest living creatures on the planet, so scientists wanted to see if their disease-fighting toolkit was the same as humans’,” says Elasmogen CEO Dr. Caroline Barelle. Ltd, a University of Aberdeen spin-off that is developing synthetic versions of shark antibodies for human medicine.

“They quickly discovered that sharks had small and simple antibodies, with potentially huge advantages over large human antibodies that are very complex and can only bind to a single target.”

Elasmogen is testing synthetic shark antibodies against triple-negative breast cancer, an aggressive form of the disease. The idea is that artificial versions of tiny shark antibodies, injected into the bloodstream, will have a better chance of binding to breast cancer cells by squeezing into tiny cracks on the surface and alerting the immune system.

The other option is to load the shark molecules with chemotherapeutic drugs that they can smuggle inside cancer cells.

Trials using shark antibodies to treat cancer could take place in the next five to ten years.

Another target is rheumatoid arthritis, a disease that can cause debilitating pain. Lab tests suggest that man-made shark antibodies could carry drugs that would then lodge on a receptor on the surface of cells in inflamed joints.

© Solo dmg media

Fundamental research improves understanding of new optical materials

0

Research on the synthesis of new materials could lead to more durable and environmentally friendly items such as solar panels and light emitting diodes (LEDs). Scientists from Ames National Laboratory and Iowa State University have developed a colloidal synthesis method for alkaline earth chalcogenides. This method allows them to control the size of the nanocrystals in the material. They were also able to study the surface chemistry of the nanocrystals and assess the purity and optical properties of the materials involved.

Alkaline-earth chalcogenides are a type of semiconductor of growing interest to scientists. They have a variety of possible applications such as bioimaging, LEDs and thermal sensors. These compounds can also be used to make optical materials such as perovskites, which convert light into energy.

According to Javier Vela, Ames Laboratory Scientist and John D. Corbett Professor of Chemistry at Iowa State University, one of the reasons these new materials are exciting is that they “are composed of elements abundant and biocompatible terrestrial species, making them favorable alternatives. compared to the more widely used toxic or expensive semiconductors.

Vela explained that the most widely used semiconductors contain lead or cadmium, two elements harmful to human health and the environment. Additionally, the most popular technique used by scientists to synthesize these materials involves solid-state reactions. “These reactions often occur at extremely high temperatures (above 900°C or 1,652°F) and require reaction times that can last anywhere from days to weeks,” he said.

On the other hand, Vela explained that “solution-phase (colloidal) chemistry can be achieved using much lower temperatures (below 300°C or 572°F) and shorter reaction times.” Thus, the colloidal method used by Vela’s team requires less energy and time to synthesize the materials.

Vela’s team found that the colloidal synthesis method allowed them to control the size of the nanocrystals. The size of nanocrystals is important because it determines the optical properties of certain materials. Vela explained that by changing the size of the particles, scientists can influence the ability of materials to absorb light. “This means that we can potentially synthesize materials more suitable for specific applications simply by changing the size of the nanocrystals,” he said.

According to Vela, the team’s initial goal was to synthesize semiconducting alkaline earth chalcogenide perovskites, due to their potential use in solar devices. However, to achieve this goal, they needed a deeper understanding of the basic chemistry of alkaline earth chalcogenides. So they chose to focus on these binary materials instead.

Vela said their research fills a need to improve scientists’ understanding of photovoltaic, luminescent and thermoelectric materials that are made of earth-abundant, non-toxic elements. He said: “We hope that our developments with this project will ultimately contribute to the synthesis of more complex nanomaterials, such as alkaline earth chalcogenide perovskites.”

– This press release was originally published on the Ames Laboratory website

Discovery sheds light on how Parkinson’s disease spreads in the brain

0

Aggregates of the protein alpha-synuclein spread through the brains of people with Parkinson’s disease through a process of ejection of cellular waste, suggests a new study by researchers at Weill Cornell Medicine.

During the process, called lysosomal exocytosis, neurons eject protein waste that they cannot break down and recycle. The discovery, published August 22 in Nature Communicationcould solve one of the mysteries of Parkinson’s disease and lead to new strategies for treating or preventing the neurological disorder.

“Our results also suggest that lysosomal exocytosis may be a general mechanism for removal of aggregated and degradation-resistant proteins from neurons – in normal, healthy circumstances and in neurodegenerative diseases,” said the lead author. study, Dr. Manu Sharma, assistant professor. of neuroscience at the Feil Family Brain and Mind Research Institute and the Appel Alzheimer’s Disease Research Institute at Weill Cornell Medicine.

Parkinson’s disease is a disorder characterized by the death of neurons in a characteristic pattern of spread in the brain, normally occurring over decades. The condition is best known for causing hand tremors, muscle stiffness, slowed walking, and other normal movement disorders. But it affects a wide range of brain regions, leading to many different symptoms, including late-stage dementia. About 1 million people in the United States have Parkinson’s disease. Available treatments can alleviate some movement abnormalities, but do not halt disease progression, primarily because researchers do not yet have a full understanding of this process.

An important discovery that has emerged from the last decades of research on Parkinson’s disease is that the death of neurons in the disease follows the spread, in the brain, of abnormal aggregates of alpha synuclein, a neuronal protein. This spread is an infection-like chain reaction process in which the aggregates attract normal alpha-synuclein to join them and, as they grow, break up into smaller aggregates that continue to spread. Experiments in mice and non-human primates have shown that injection of these aggregates into the brain can initiate this spread as well as some Parkinson-like neurodegeneration. But the details of how neurons transmit them to other neurons have never been fully understood.

In the study, Dr. Sharma and his team, including co-first author Ying Xue Xie, a doctoral candidate at the Weill Cornell Graduate School of Medical Sciences, showed with detailed studies of mouse models of Parkinson’s that the alpha-synuclein aggregates – capable of spreading and causing neurodegeneration – originate in neurons. These aggregates, they found, then accumulate in capsule-shaped trash cans in cells called lysosomes.

Lysosomes contain enzymes that can break down or “lyse” proteins and other molecular wastes into their building blocks, essentially digesting and recycling them. But the researchers found evidence that alpha-synuclein aggregates, which are tightly woven into a tight-fitting, layered structure called “amyloid,” are not broken down well in lysosomes; instead, they were often found to simply be dumped from their original neurons. In this process, called exocytosis, the lysosome moves towards the cell membrane and fuses with it, so that the contents of the lysosome are discharged – as is, without any encapsulation – into the fluid surrounding the cell. The finding helps resolve a hotly debated question in the field.

The researchers also showed in other experiments that by reducing the rate of lysosomal exocytosis, they could reduce the apparent concentration of propagating aggregates. This, said Dr. Sharma, suggests a future approach for the treatment of Parkinson’s disease.

“We don’t know yet, but neurons might be better off, even in the long run, if they retain these aggregates inside their lysosomes,” he said. “We see similar impairment of lysosomal function in certain genetic disorders, but these do not necessarily lead to a level of Parkinson’s disease.”

Dr. Sharma pointed out that previous studies, including genetic studies, have linked lysosomal abnormalities not only to Parkinson’s disease, but also to many other neurodegenerative disorders. This suggests that lysosomal exocytosis may be a general mechanism for spreading protein aggregates in these diseases – and potentially a general target for treatments and preventive measures.

He and his team are currently pursuing studies on the role of lysosomes in Alzheimer’s disease.

What’s behind the different names of hacker groups

0

No matter how confusing it is to refer to the same group of Russian hackers by a handful of different names – Cozy Bear, Nobelium, APT29 and so on – don’t expect the private companies behind those monikers to drop them. anytime soon.

The big picture: Naming conventions for state-backed hacking groups vary from technical Advanced Persistent Threat (APT) group numbers to fancy animal-based names, making it difficult for people outside of cybersecurity research to understand. which pirates do what.

  • Consider a well-known Russian cyber-espionage group: Mandiant researchers call it APT29, CrowdStrike researchers call it Cozy Bear, and Microsoft calls it Nobelium.

Driving the news: Several cyber threat intelligence firms published research on Iran’s Charming Kitten group earlier this month, but each firm used a different name to identify the group, renewing questions about why researchers don’t standardize conventions of denomination.

Between the lines: Part of that is due to marketing, cyber researchers tell Axios.

  • It’s a reputational win if a cyber threat intelligence firm is able to generalize its naming convention.

Yes, but: Five major threat intelligence firms tell Axios that even if their marketing teams weren’t involved, they would still have these different names because they all have varying visibility into hacker activity.

  • “There won’t always be a one-on-one match between how they see the threat and how I see the threat,” says Jeremy Dallman, senior director of the Microsoft Threat Intelligence Center.

At Mandiant, Cyber ​​espionage researcher Benjamin Read told Axios that they are sticking to APT technical numbers to allow for more precision in their naming conventions.

  • The company has a list of over 4,000 hacking group names.
  • Mandiant also has a core team of three or four employees who review these naming conventions as they learn about the tools and tactics used by these groups.
  • Having ultra-accurate identifications also helps Mandiant in his work with government investigators, Read says.

Other companies choose to create unique products, memorable names for each group.

  • Microsoft picks names from the periodic table.
  • CrowdStrike gives Chinese state groups a name containing “Panda”, Russian state groups are given a “Bear” name, Iranian groups are given “Kitten” names, and North Korean groups are “Chollima”.
  • Broadcom’s Symantec uses bug names.
  • Palo Alto Networks names groups after constellations.

While these naming conventions may seem silly, companies have increasingly started relying on their own naming conventions to differentiate what they are able to confirm for themselves.

  • Palo Alto Networks unveiled its own naming conventions in July to better highlight the infrastructure, techniques and tools they may see hackers using, said Ryan Olson, the company’s vice president of security intelligence. the threats.

The plot: Each company says standardization would be impossible due to the variability in their visibility and the complexity of the threat landscape.

  • Olson relates the issue to the old story of a group of visually impaired people trying to identify an elephant: Everyone thinks the animal is a different thing because they can only touch part of it, like its ear. or its tail.
  • “Because the universe is constantly changing and our views are constantly changing, it would be really difficult to constantly try to scale this across multiple vendors,” Dallman says.

Sign up for the Axios Codebook cybersecurity newsletter here.

In Denmark, Omicron reinfections reveal ineffective post-COVID-19 immunity

0

In a recent study published on medRxiv* preprint server, researchers investigated cases of SARS-CoV-2 variant reinfection in Denmark.

The evolution of SARS-CoV-2 has led to the emergence of multiple variants of concern (VOCs) with increased transmissibility and immune evasion such as Omicron, leading to an upsurge in SARS-CoV-2 reinfections and difficulties mitigation of COVID-19 globally. Studies have investigated frequencies of SARS-CoV-2 reinfection, but have been limited to reverse transcriptase polymer chain reaction (RT-PCR) analysis data, in which SARS-CoV- 2 Pango are not specified. Additionally, a genomic sequencing report is usually categorized as an initial infection or a reinfection, but next-generation sequencing (NGS) data for an initial infection and a reinfection are rarely reported together for an individual.

Study: Rise in cases of SARS-CoV-2 Omicron reinfection reveals ineffective post-COVID-19 immunity in Denmark and points to the need for next-generation sequencing. Image Credit: Noiel/Shutterstock

About the study

In the present study, researchers characterized SARS-CoV-2 reinfections by variant based on the integration of RT-PCR analysis and next genome sequencing (NGS) analysis of the obtained sequences. from Danish SARS-CoV-2 positive individuals and GISAID (Global Initiative on Avian Influenza Data Sharing).

NGS data and clinical metadata of primary SARS-CoV-2 infections and reinfections from a single individual residing in Denmark were analyzed. A total of 21,708 reinfection entries were available between March 1, 2020 and August 28, 2022, with data on sample collection dates on primary infections and SARS-CoV-2 reinfections.

The team documented SARS-CoV-2 clinical metadata as time points of initial and subsequent SARS-CoV-2 infections to measure the duration between initial and subsequent SARS-CoV-2 infections. Additionally, RT-PCR scan results and NGS scan results were available for primary infections and reinfections, respectively.

The team excluded 70 case entries (

Reinfection cases were stratified by variant and subvariant. The GISAID database was searched for two files: one set of files including current metadata for >12 million SARS-CoV-2 sequences and the second set including filtered metadata files from only residents of Denmark with two infections associated with SARS-CoV-2 documented.

Results

Primary infection and re-infection with Omicron (i.e. Omicron-Omicron infections) have been reported within a shorter period (even within three weeks, an average of 22 weeks) than non-Omicron-Omicron infections . Reinfections with Omicron within ten weeks of initial Omicron infection have been widely reported due to BA.1 followed by BA.2.

The frequency of reinfection was significantly higher with Omicron (25%, N=1875) after primary infections with any VOC. No cases of Alpha VOC-induced reinfection were reported, while Delta VOC caused reinfections in 2.3% (n=169) of cases. Pre-Omicron estimates of infection-induced natural immunity were above 90%, which fell to less than 10% within three to four months.

Among those with Delta-induced primary infections, reinfections due to Delta variant

Reinfections with Omicron were reported among 62% (n=211), 20%, (n=68) and 30% (n=102) of cases in which primary SARS-CoV-2 infections were caused by Omicron BA.1, BA.2, and BA.5, respectively, individuals with primary BA.2 infections demonstrated high reinfection frequencies (38%, n=129) with the Omicron BA.5 subvariant (26 %, n = 89). The results indicated that although the SARS-CoV-2 spike (S) protein of the three Omicron subvariants is similar, the differences in the Omicron subvariants were sufficient to prevent the nAbs induced by the infection Omicron BA.1/2 (neutralizing antibodies) to bind with Omicron BA.5 S.

conclusion

Study findings showed that most cases of SARS-CoV-2 reinfection occurred due to Omicron. Reinfections with Omicron among people with primary Omicron infection have occurred in a short time, less than three weeks. The results indicated that primary infections with non-Omicron VOCs were insufficient to provide immune protection to prevent reinfections with Omicron.

Additionally, the results highlight Omicron’s transmissibility and immune evasion and the need for updated SARS-CoV-2 vaccines, continued SARS-CoV-2 surveillance, and evolving SARS assessments. -CoV-2 to guide policymaking for better public health around the world. Additionally, the analysis underscores the need to analyze NGS data at the individual level to provide accurate estimates of the risks of reinfection with SARS-CoV-2.

*Important Notice

medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be considered conclusive, guide clinical practice/health-related behaviors, or treated as established information.

5 Scientific Benefits of Omega-3 Fatty Acids

0

Thanks to their many benefits, omega-3 fatty acids have become a popular topic in nutritional health. These “healthy fats” are found in many food sources, and there are many popular omega-3 supplements on the market.

From reducing your risk of heart disease to alleviating anxiety, it’s easy to see why many people want to increase their omega-3 intake. But are these benefits legitimate? And are there any downsides to omega-3s or their supplements? We’ll look at the science to help you sort it out.

What are omega-3 fatty acids?

Omega-3 fatty acids, a type of polyunsaturated fat, are an essential part of the human diet. Unlike other fats the body is able to synthesize (called non-essential fatty acids), omega-3s cannot be made from scratch. They are vital for various bodily processes, such as making hormones for blood clotting, contraction and relaxation of arteries, and genetic functions. In other words, we need omega-3s, and we can only get them from foods or supplements.

There are three main types of omega-3 fatty acids:

  • Eicosapentaenoic acid (EPA)
  • Docosahexaenoic acid (DHA)
  • Alpha-linolenic acid (ALA)

Add omega-3s to your diet

Foods High in Omega-3 Fatty Acids

Getty Images/fcafotodigital/E+

Different types of foods provide different omega-3 fatty acids. The first two types (EPA and DHA) are abundant in fish, which is why they are commonly referred to as “marine omega-3s”. The third type (ALA) is common in a variety of food sources, including some oils, nuts, leafy vegetables, and some meats.

The best sources of omega-3s include:

  • herring
  • wild salmon
  • Red tuna
  • Mackerel
  • Sardines
  • Anchovy
  • lake trout
  • Striped Bass
  • Nut
  • Linseed oil
  • Meat from grass-fed animals
  • Chia seeds
  • Canola oil

Fish is by far the best source of omega-3s. If you’re vegan or don’t eat seafood, you may need to work especially hard to get enough of these important fats in your diet. In this case, omega-3 supplements can be helpful, especially for EPA and DHA. Although your body naturally converts a small amount of ALA to DHA and EPA, it may be a good idea to make sure you consume fish or supplements that contain it.

Scientifically Backed Benefits of Omega-3s

Capsules and diet rich in omega-3

Getty Images/carlosgaw/E+

Scientists have noted a variety of benefits that may be associated with omega-3 fatty acids. Some of them have more evidence than others, so we’ll review the most notable benefits with some of the most promising scientific backing.

Reduce your risk of heart disease

A wide range of studies have shown a link between heart health and omega-3 fatty acids. These fats seem to have a positive impact on various aspects of cardiovascular health. Most notably, however, omega-3s have been correlated with a more stable heart rate, lower blood pressure and heart rate, better blood vessel function, and lower levels of inflammation.

Replacing saturated fats, such as red meat, butter and whole dairy products, with unsaturated fats such as omega-3s may reduce the risk of developing heart disease.

Fight anxiety and depression

Although more research is needed on the exact correlation between mental health and omega-3 intake, there seems to be strong evidence that these fats can help reduce depression and anxiety in many people. EPA, in particular, has shown promise as a treatment for mild to moderate depression.

Improve eye health

Omega-3s – EPA and DHA in particular – play a major role in building the cellular makeup of our eyes. Not only do they help during our early stages of development, research suggests that a regular and adequate intake of these fats can help prevent vision problems, such as macular degeneration later in life.

Promote prenatal and infant brain development

Scientists are actively studying the general link between omega-3s and brain health, especially in the womb and early in life. Some studies have shown that children of mothers who take omega-3 supplements during pregnancy and breastfeeding may have better mental processing abilities than those who don’t. Additionally, studies have shown that mothers who take DHA supplements can improve breast milk nutrition for infants, leading to better cognitive function and eyesight later in life.

Slow cognitive decline

Because of the link between omega-3s and general brain health, it’s perhaps unsurprising that some research supports that these fats may slow cognitive decline as you age. It may be particularly promising for helping to slow the effects of dementia and Alzheimer’s disease, although more research is still needed in this area.

Scientists are still studying these and other benefits of omega-3 fatty acids, including their effect on ADHD, metabolic syndrome, and certain autoimmune diseases.

Disadvantages of Omega-3 Supplements

Generally, doctors recommend that you get most or all of your omega-3 fatty acids from food sources. Grilled or baked (not fried) fish is the best thing to add to your diet, along with some of the other foods mentioned above.

However, omega-3 supplements, such as fish oil or cod liver oil, provide many of the same benefits as obtaining these fats through food sources. These supplements are generally considered safe when taken in moderation. However, there are a few potential downsides to consider.

Risk of bleeding

There are indications that omega-3 supplements may enhance the effects of blood-thinning medications, herbs, and supplements. When taken together they may increase your risk of bleeding or reduce your ability to stop bleeding.

Other Potential Drug Interactions

More research is needed on how fish oil supplements interact with other medications and dietary supplements. In particular, there may be adverse interactions between omega-3 supplements and medications taken for blood pressure, birth control, and weight loss.

General side effects

Some users of omega-3 supplements have noted general discomfort associated with them. This can include heartburn, nausea, and diarrhea.

Other side effects of omega-3 supplements that some have noted include fishy aftertaste and bad breath, as well as rashes in some cases. People with seafood allergies should also consult their doctor before taking fish oil supplements.

Should you take omega-3 supplements?

Omega 3 capsules in sardine tin

Getty Images/Peter Dazeley/The Image Bank

Omega-3s are essential for cell growth and overall health, and it’s essential to include them in your normal dietary intake. Ideally, this is best done from sources such as fish, nuts, flaxseed oil, and other foods high in omega-3 fatty acids.

However, if you cannot include these foods in your diet, omega-3 supplements are a relatively safe alternative. It’s easy to find supplements that contain a balanced serving of the three main omega-3s, and they’re relatively inexpensive. Keep in mind, however, that these should be taken in moderation and in consultation with your doctor. Some omega-3 supplements may interact with other medications or supplements you take, and you may experience other side effects.

While more research is needed to fully uncover the full benefits of omega-3s, one thing is clear: they are an important part of any balanced diet.

The information in this article is for educational and informational purposes only and is not intended to constitute medical or health advice. Always consult a physician or other qualified health care provider with any questions you may have about a medical condition or health goals.

What jellyfish can tell us about immortality

0

There is a type of jellyfish that is one of the few creatures on the planet that can be considered immortal. To encounter Turritopsis dohrnii, the species of jellyfish that never dies. At least not in the way we might understand death. The cellular mechanism behind its longevity is called transdifferentiation, and it’s a mechanism that science has been trying to learn to use in our own context.

The immortal jellyfish, as T. dohrnii has been dubbed, doesn’t exactly live forever without aging – in fact, in the face of any outside threat, he undergoes a reverse aging process and transforms into an infantile state (the jellyfish version of this). Going back to a jellyfish’s origins can help put this into perspective: Essentially, a fertilized jellyfish egg develops into something called the planula, which settles to the ocean floor. There, it grows into a colony of polyps that eventually release “jellyfish,” or genetically identical adult jellyfish.

A German marine biologist named Christian Sommer discovered this ability in 1988, and science has never rested on the question of immortality since. In a 1996 paper called ‘Reverse the life cycle‘, the scientists made a startling claim: “This discovery appears to debunk the most fundamental law of the natural world – you are born, then you die.”

So when one of these jellyfish suffers an injury, faces starvation, or is otherwise endangered by circumstances, it can turn back into a polyp and reappear as more identical jellyfish. “This is one of the most amazing discoveries of our time,” said Tasmania-based jellyfish researcher Lisa-ann Gershwin.

Related to The Swaddle:

A species of ant has the ability to shrink and regrow its brain: study

The regeneration process means that jellyfish have the ability to “start over” To infinity. Its dying cells reaggregating back to an early stage of life is a mechanism that holds the keys to the realm of immortality – but what kind? Here’s the problem with Theseus’ ship: if the “reborn” jellyfish is made up of cells that have fundamentally changed, is it still the same jellyfish as before? Genetically speaking, yes — but in humans it wouldn’t have the same philosophical meaning. This is why many are specific in noting that jellyfish can be biologically immortal but that’s it. This allows jellyfish to undergo a reset when things go wrong. “This life sucks, let’s try again,” as one Reddit user Put the.

But for its infinite regenerative abilities, we’re hardly doing all we can to understand the exact mechanics at play, or even understanding the creature’s genome to examine what’s responsible for fundamentally altering the natural laws of the world. Science has made progress on this in a recent study, published in PNAS in August, who unpacked more aspects of the mechanism by comparing the immortal jellyfish to its deadly cousin, the Turritopsis rubra. “…we define T. dohrnii as ‘immortal’ because the probability of rejuvenation of sexually mature jellyfish is up to 100%, with no apparent limit in the number of cycles of ontogenetic inversion for a given individual,” the study notes, adding that T.rubra would be rated as “deadly” in comparison.

Our slowness to understand T. dohrnii does not prevent their spread: they are also notoriously invasive. “It is possible to imagine a distant future in which most other species of life are extinct, but the ocean will be overwhelmingly made up of immortal jellyfish, a great eternal gelatin consciousness,” Remarks The New York Times. Of all the complex and majestic creatures that roam the Earth and its seas, the humble and deceptively simple jellyfish may live to outlive us all. Underestimating them indicates an inherent pride in the way we understand the order of living things in the world – one that very few are beginning to question.

“The mystery of life is not hidden in the higher animals… It is hidden in the root. And at the root of the Tree of Life is jellyfish,” said Shin Kubota, one of the few scientists in the world to study jellyfish. Told The temperature.


Related to The Swaddle:

Why Hydras Have The ‘Freaky’ Ability To Grow Their Heads Back


Kubota talks about the marginalization of tiny creatures in the study of animal biology – one we may be noticing lately. The renewed attention to jellyfish is linked to the fact that we have realized how genetically similar they are to ourselves. “There is a shocking amount of genetic similarity between jellyfish and human beings,” said Kevin J. Peterson, a molecular paleobiologist. This means that understanding the genome of the immortal jellyfish could bring us closer to dramatic advances in human medicine. If not immortality, it could extend life by tackling some of the most unbeatable forms of disease that shorten it, like cancer.

There is another creature in the same phylum with the unique ability to live seemingly forever: Hydras. But the mechanics are slightly different: they can regrow lost body parts or regenerate as entirely new creatures from detached tissue. “Cut a hydra into segments, and each segment will become a new hydra. Mix one together and you end up with a soup of cells. new hydra, said UC Davis College of Biological Sciences. Stem cells are essential to this process: in human embryos, they look like virgin cells that eventually differentiate into cells with specialized functions that make up our organ systems. But hydras have powerful stem cells and can be composed entirely of them, earning them the nickname “eternal embryo.”

The genomic similarities between these creatures and humans mean that maybe, just maybe, we have those abilities too. All you have to do is unlock them. One theory is that there is a gene – called the FOXO gene – that is responsible for Hydras not aging at all. And the scientists observed that in humans who lived over 100 years, there was a mutation in their own FOXO gene. others to research found three different stem cells behind this regenerative ability.

In other words, we can expect to learn how to modify our own bodies to improve our quality of life by eliminating some of the deadliest diseases that deteriorate them – by studying some of the creatures we least expected to learn about. But as for not aging at all? We are perhaps a bit too complex for that.

Part of the remarkable abilities of the jellyfish or hydra also lies in their simplicity as organisms. Some, like Kubota, wonder if we even deserve it at all. “We are so smart and civilized, but our hearts are very primitive. If our hearts weren’t primitive, there would be no wars. I fear that we are applying science too soon, as we did with the atomic bomb. In our quest to live forever, documented by many myths and legends, we may first need to know who we are – and find that we have some cleaning to do in our own consciences. Jellyfish may be less complex as organisms, but as holders of the keys to immortality, they might possess wisdom that perhaps eludes our own species. What are we willing to give up to find out?

TikTok’s search engine repeatedly provides misinformation to its mostly young user base, report says

0



CNN

When a TikTok user searches the social media app for information on major news stories, ranging from Covid-19 vaccines to school shootings, nearly 20% of videos shown as search results contain misinformation, according to a research report published on Wednesday.

Researchers from NewsGuard, a journalism and tech tool that tracks online news, searched TikTok and Google this month for information on major news topics such as the 2020 presidential election, the Russian war -Ukrainian and abortion to compare the misinformation provided by their search engines.

TikTok, whose users are mostly teens and young adults, “repeatedly streamed videos containing false claims in the top 20 results, often in the top five,” the report said. “Google, by comparison, delivered higher quality and less polarizing results, with far less misinformation.”

A Google spokesperson declined to comment on the report when contacted by CNN.

The researchers searched for terms like “mRNA vaccine” and “election 2022,” as well as controversial hot topics like “the Uvalde tx conspiracy.” They analyzed 540 TikTok results and found that 105 videos, or 19.4%, contained false or misleading claims, according to the report.

According to the report, a search on TikTok for information about politics, including the 2020 presidential election and the January 6, 2021 U.S. Capitol uprising, often included misinformation as well as references to QAnon conspiracy theories. For example, a search for the question “Was the 2020 election stolen?” produced six videos containing false claims in the top 20 results, NewsGuard found.

NewsGuard researchers also found that TikTok’s search engine “constantly feeds millions of young users with health misinformation, including some claims that could be dangerous to users’ health.” For example, a search for “does mugwort cause abortion” returns more than a dozen results that advocate unproven herbal abortion methods.

TikTok recently began removing abortion-related videos that violate its policy against medical misinformation, including those that share potentially dangerous advice on how to induce an abortion.

In response to NewsGuard’s report, a TikTok spokesperson told CNN that its community guidelines “make it clear that we do not allow harmful misinformation, including medical misinformation, and we will remove it from the platform. We partner with credible voices to elevate authoritative content on topics related to public health, and we partner with independent fact checkers who help us assess the accuracy of content.

TikTok deleted more than 102 million videos in early 2022 for violating its guidelines, according to its Community Rules Enforcement Report. But less than 1% of those videos were taken down for violating the company’s “integrity and authenticity” guidelines, which include misinformation, according to NewsGuard’s review.

The NewsGuard report came amid bipartisan concerns in Washington that US user data could reach the Chinese government and be used to undermine US interests due to a national security law in that country that requires companies located there to cooperate with data requests. .

US officials have expressed concern that China could use Americans’ personal information to identify potential useful agents or intelligence targets, or to inform future misinformation or disinformation campaigns.

Testifying before the Senate Homeland Security Committee on Wednesday, TikTok chief operating officer Vanessa Pappas refused to commit to cutting off US users’ data flows to China, promising instead that the outcome of her negotiations with the U.S. government “will address all national security concerns”. ”

TikTok does not operate in China, Pappas said, although it does have an office in China. TikTok is owned by ByteDance, whose founder is Chinese and has offices in China.

“I was surprised that TikTok was so much worse even than Google and worse, generally as a platform, than Facebook or Twitter when it came to this stuff,” said Steven Brill, founder of NewsGuard, at CNN.

Brill said the report’s findings are of particular concern because of the company’s ties to China and the ease with which children can access app content.

“We should take this as a warning. If I had children the age of TikTok, I would definitely want to know what search engine they use,” Brill said. “I would be quite upset if they relied too much on Google and made reports to school based on what they read on Wikipedia. But that takes so many levels beyond that.

Research Roundup: Hookworms Build Immunity to Common Dewormers

0

Click here to read the full article
194 – September 2022

By Caroline Coile

Researchers at the University of Georgia College of Veterinary Medicine report what some dog breeders already suspected: hookworms are becoming resistant to drugs that previously killed them. In fact, hookworms are evolving to be resistant to all three drugs currently in use. The research team looked at retired racing greyhounds because sandy tracks and paddocks are conducive to the life cycle of hookworms. Four out of five dogs in their study were positive for hookworms, but according to one researcher, the others were probably also positive but had the worms “hidden” in tissues where they don’t reproduce and lay eggs until this worsens the infection and seeps into the dog’s intestines.

Alarmingly, most of these dogs remain positive even after treatment with one of three prescribed hookworm medications. Almost all of the dogs’ fecal samples tested positive for a mutation that allows hookworms to survive treatment with benzimidazoles, one of three commonly used dewormers. There is not yet a molecular test to test resistance to the other two types of dewormers, but other types of tests have shown hookworms to be resistant to these drugs as well.

Greyhound farms are ideal environments for parasites to develop resistant strains due to the large number of dogs present, creating a large population of worms in which mutations can arise and evolve. When these greyhounds are then placed in the pet population, they spread the mutated hookworms into the general environment, and eventually to the general dog population.

Click here to read the full article
194 – September 2022

short url: https://chroniquecanine.com/?p=243716

The Best Weapon and Artifact Build for Cyno

0

In this Cyno guide, we take a look at the best weapons, artifacts, and best team composition for Cyno in Genshin Impact.

Cyno may seem unassuming at first, but his presence strikes fear into many Akademiya seekers. Cyno, known as General Mahamatra of the Sumeru Akademiya, will appear in his own banner in the first phase of 3.1. He is a spear user who has the ability to infuse his attacks with Electro, and also boost his damage with Elemental Mastery. It has somewhat similar gameplay to Razor, but performs much better with the same amount of investment.

Cyno Overview and Abilities

Cyno is a 5-star electro character wielding a polearm, capable of inflicting extreme amounts of electrical damage, in exchange for his very selfish presence in the field. It’s not yet clear how to balance the optimal field time for Cyno and his mounts, but he’s sure to be one of the few hypercarries purpose-built for Electro.

Electro as a primary DPS element hasn’t really existed since, since elemental reactions like Electro-charged and Overcharge usually outperform pure Electro, until now. The introduction of Dendro changed the game for Electro DPS, as the Quicken and Aggravate reactions massively improved the potency of many Electro abilities.

Cyno Elemental Skill – Secret Rite: Chasmic Soulfarer

Performs a rapid thrust, inflicting Electro DMG on opponents along the way.

When Cyno is under the Pactsworn Pathclearer state triggered by Sacred Rite: Wolf’s Swiftness, he will instead trigger a Mortuary Rite which inflicts thunderous AoE Electro DMG and extends the duration of Pactsworn Pathclearer.

This elemental skill is Cyno’s primary source of energy, while also extending the duration of his Electro Burst Infusion. Since this skill receives a massive cooldown reduction when used for the duration of its burst, it also becomes a huge source of damage when paired with the set’s CD reduction effect. of Thundering Fury artifacts.

Cyno Elemental Burst – Sacred Rite: Swiftness of the Wolf

Summons a divine spirit to possess it, transforming into a Pactsworn Pathclearer.

Pactsworn Pathclearer

Cyno’s normal, charged, and dive attacks will be converted to Electro DMG which cannot be negated.

  • Cyno’s Elemental Mastery and Interrupt Resistance will increase, and he gains immunity to Electro-Charged DMGs.

This effect will be canceled when Cyno leaves the field and will last for a maximum of 18s.

Cyno’s Burst works very similarly to Raiden Shogun’s, but it lasts longer and performs better under strong buffs. The energy cost of this burst is 80 energy, but that’s not too much of an issue once he starts spamming his skill.

Cyno Passive Skills

Featherfall Judgment – When Cyno is in the Pactsworn Pathclearer state activated by Sacred Rite: Wolf’s Swiftness, Cyno will enter Endseer position at regular intervals. If he activates Secret Rite: Chasmic Soulfarer while affected by this stance, he will activate the Judication effect, increasing this Secret Rite: Chasmic Soulfarer’s DMG by 35% and firing 3 Duststalker Bolts that deal 50% of Cyno’s ATK as Electro. DMG.

Duststalker Bolt DMG is considered Elemental Skill DMG.

Authority over the Nine Bows – Cyno’s DMG values ​​will be increased based on his Elemental Mastery as follows:

  • The Pactsworn Pathclearer’s normal attack DMG is increased by 125% of his Elemental Mastery.
  • Duststalker Bolt DMG from his Passive Featherfall Judgment is increased by 250% of his Elemental Mastery.

The combination of these two talents already looks like a deadly combo for an elemental mastery stackable Cyno. It’s not yet known if the Duststalker Bolts have shared ICDs, but since Cyno deals a lot of individual hits with his entire kit, the Aggravate and Quicken reactions become much more powerful overall.

Cyno Guide: Best Weapon Build For Cyno

Scarlet Sands StaffThe character who equips it gains 52% of their elemental mastery in bonus ATK. When an elemental skill hits opponents, the Dream of the Scarlet Sands effect will be obtained for 10 seconds: the character who equips it will gain 28% of their elemental mastery as a bonus ATK. Max 3 batteries.

This weapon is arguably his best in the slot, as you can go all-in with Elemental Mastery while gaining a ton of bonus ATK from the weapon’s passive.

The alternatives for the 5-star range of weapons are the Primordial Jade Winged Spear and the Staff of Homa, which deal less damage than the BiS, but are still superior to all 4-star options.

DeathmatchIf there are at least 2 opponents nearby, ATK is increased by 16% and DEF is increased by 16%. If there are less than 2 nearby opponents, ATK is increased by 24%.

It’s amazing how this weapon, which was designed at the start of the game, is still relevant and powerful 2 years later. This weapon provides an incredible crit rate stat, which is rare for a 4 star weapon.

White TasselIncreases normal attack DMG by 48%.

If you’re going for the pure F2P experience, White Tassel is definitely not a bad option. Since Cyno’s playstyle during his burst is mostly normal attacks and E spams, this weapon significantly increases his combo damage. The low ATK provided by the weapon can be circumvented by going with a pure EM build, as its passive talent actually provides flat bonus damage based on its EM.

Best Artifact Sets for Cyno

Searing Fury

2-Coin: Electro DMG Bonus +15%

4 pieces: Increases DMG from Overcharge, Electrocharge, Superconduction, and Hyperbloom by 40%, and bonus DMG from Aggravation is increased by 20%. When Quicken or the aforementioned elemental reactions are triggered, the elemental skill CD is reduced by 1s. Can only occur once every 0.8s.

Cyno relies heavily on Aggravate reactions and his E spam, which Thundering Fury is the best at providing. If you can farm the best stats for it, the Thundering Fury set is your only choice for top damage.

golden dreams

2 pieces: Elemental Mastery +80.

4 pieces: Within 8 seconds of triggering an elemental reaction, the character teaming it will gain buffs based on the elemental type of other party members. ATK is increased by 14% for each party member whose elemental type is the same as the character equipping it, and elemental mastery is increased by 50 for each party member with a different elemental type. Each of the aforementioned buffs will have up to 3 characters. This effect can be triggered once every 8 seconds. The character who equips it can still trigger its effects when not on the field.

In retrospect, many players have been mining the realm of this set since Sumeru was released and likely kept some items with outstanding sub stats. If you happen to have really good parts for this set, and not many for Thundering Fury, it’s still quite viable to use it first until you get a good 4-piece TF set rolled.

Best Team Comps for Cyno

Aggravate/Accelerate Recommended Formation: Cyno, Voyager Dendro, Fischl/Collei, Zhongli (Shield)/Kazuha (Damage)/Bennett (Healer+Buff)

This composition is Cyno’s go-to for all kinds of content and builds on its raw output of electro damage, which is then amped up with Aggravate, Resonance, and out-of-element support. You’ll usually choose to use Dendro Resonance for more EM, but Electro Resonance is a good option if energy is scarce. For the 4th slot, Zhongli is preferred to make Cyno’s combo chain unbroken, but Kazuha and Bennett are also decent options if you’re okay dodging enemy attacks.

Summary

Cyno has been a welcome addition for many Electro fans since the release of Raiden Shogun, and Electro DPS might even see a resurgence after the addition of Dendro reactions. This is only the second patch of 3.0, and we can see even better synergies as more characters are released in future version updates.

Here’s a look at Apple’s new iPhone 14 (and a few other things) | Print edition

0

Views) :

At Apple’s recent iPhone event, the tech giant unveiled not only the new iPhone 14, but a bunch of other devices as well. So what exactly are we looking for in terms of new (and/or improved) hardware? Well, read on and find out.

The iPhone 14 (now in additional flavors of Plus, Pro, and Pro Max)

Being an iPhone event, the spotlight would obviously fall on the latest iteration of Apple’s iPhone. With the iPhone 14 though, there’s nothing to write home about. The iPhone 14 and iPhone 14 Plus are powered by an upgraded version of Apple’s A15 Bionic chip. The iPhone 14 packs the same 6.1-inch Retina XDR OLED display with True Tone, and the iPhone 14 Plus (while dropping the iPhone 13 Mini) increases the screen size to 6.7 inches. Both models have Haptic Touch and up to 1,200 nits of peak brightness. Apple also announced that the iPhone now includes a security service called Emergency SOS via Satellite. As the name suggests, iPhone 14 users can connect to emergency services even if they are outside of cellular or Wi-Fi range, using satellites for communication. You can’t use it to send tweets or Snaps, but you can use it to send your location or a short message to emergency services. The service is free for iPhone 14 users in the United States and will also be available in Canada.

Discover the Apple iPhone 14 and iPhone 14 Plus (Image credits: Apple.com)

The iPhone 14 will start at $799 and the Plus will cost $899. The iPhone 14 is already available for purchase, while the iPhone 14 Plus will be available in October. An interesting note was that all US iPhone 14 models will no longer use a physical SIM card. Instead, they will completely switch to eSims which can support multiple phone numbers and also offer better security.

The iPhone 14 Pro and Pro Max are powered by Apple’s latest A16 Bionic chip, which Apple says is built using a 4nm process. It also packs a 6.1″ and 6.7″ display and, for the first time, features an always-on display. With a variable refresh rate of up to 120Hz, the iPhone 14 Pro and Pro Max are capable of going down to a refresh rate of 1Hz, saving battery with the always-on display and also preventing screen burn-in. ‘screen.

Say hello to the iPhone 14 Pro and iPhone 14 Pro Max (Image credits: Apple)

In terms of design, the iPhone 14 Pro and Pro Max feature a new front design with a small cutout for the front camera. The cutout, called “Dynamic Island”, expands in real time to show important alerts, notifications and activity on maps, music, timers, live activity, battery levels, Face ID, etc Feature. Along with the list of firsts, the iPhone 14 Pro and Pro Max also pack a 48MP camera with a 12MP telephoto lens and a 12MP ultrawide lens. Finally, there is a TOF 3D LiDAR scanner to measure depth. Both devices are priced at $999 and $1099 respectively.

Watch-a-Say? (Apple’s new watches say more than time)

As with the iPhone, Apple has also unveiled its latest Apple Watch Series 8. Again, it’s more or less the same design as the Apple Watch Series 7 but with a larger screen. A key new feature of the Series 8 is the inclusion of a body temperature sensor in addition to the standard heart rate sensor and ECG app. The new temperature sensor is designed for women’s health, especially to track ovulation. The sensor will measure the wearer’s wrist temperature every 5 seconds overnight and notify the user of any temperature changes through the Apple Health app. The sensor also allows retrospective estimates of ovulation and estimates of cycle deviation.

Apple Watch Series 8 now includes a temperature sensor as well as a car
crash detection function (Image credits: XDA Developers)

The Series 8 watch also includes a new car crash detection feature. So if the watch detects that the wearer has been involved in a car accident, it will automatically put you in touch with emergency services and share your location. It will also notify your emergency contacts. To make sure your watch doesn’t do this unnecessarily or on a false positive, the Series 8 incorporates a new three-axis gyroscope and high g-force accelerometer. In terms of battery, the Series 8 also introduces an LPM or Low Power mode, to extend battery life. If Apple’s estimates are reliable, the Series 8 can go from its usual 18 hours to 36 hours on a single charge. The Apple Watch Series 8 starts at $399 for the GPS model and $499 for the cellular model

Intended for sportsmen and explorers. Apple also unveiled the Apple Watch Ultra. By no means a thin device, the Apple Watch Ultra features a 49mm titanium case, a display with up to 2000 nits of brightness, and a larger, more robust crown. It also has a 36 hour battery life which can be extended to 60 hours on LPM. Similar to the Apple Watch Series 8, the Ultra features a body temperature sensor, advanced cycle tracking, international roaming on cellular models, and car crash detection. According to Apple, the Apple Watch Ultra will follow a user participating in a triathlon consisting of a 2.4-mile swim, a 112-mile bike ride, and a 26.2-mile full marathon, all on a single charge.

Apple Watch Ultra is for the athlete and explorer and is built to handle tough situations
(Image credits: Apple.com)

Additionally, the Apple Watch Ultra also features a new Dark Mode (to help with battery life) and also features a Wayfinder watch face with a built-in compass and space for up to eight complications. It also has a built-in depth gauge, as well as new dual-frequency GPS so you can receive GPS signals in hard-to-reach places. The Apple Watch Ultra is priced at $799 (which is the same price as the regular iPhone 14.)

Finally, the Apple Watch SE, considered the entry into the Apple Watch lifestyle, offers users the basic Apple Watch experience, at a more affordable level. It contains the same processor (S8) that is present in both the Apple Watch Series 8 and Ultra, thus enabling crash detection, international roaming and LPM. The watch is priced at $249 for the GPS model and $299 for the cellular model.

Looking to enter the Apple Watch ecosystem on a budget? The Apple Watch SE might be the one for you
(Image credit: The Verge)

AirPods Pro (2 Pro for you?)

While there’s nothing particularly eye-catching about the new generation of AirPods 2 compared to its predecessor, the new AirPods do offer some quality of life improvements. For starters, they’re powered by the new H2 chip, delivering “richer bass and crystal-clear sound across a wider frequency range.” There’s a 2x improvement to ANC (Active Noise Cancellation) and Transparency mode has also been improved to effectively reduce loud background/environmental noise.

The new generation of AirPods Pro offers stronger active noise cancellation, more
battery and a new “Find My” stand with a built-in speaker (Image credits: IGN)

AirPods Pro also offer longer battery life, with up to 6 hours of listening time on a single charge, making them comparable to 3rd generation AirPods and the charging case offers up to 30 hours of total listening time. Curiously, the new AirPods Pro do not support Apple’s lossless Apple Music sound.

The AirPods Pro also now feature Apple’s “Find My” support with a built-in speaker and are IPX4 rated (for water and sweat resistance). The case still charges via the Lightning connector (no Type-C, unfortunately) but can also be charged via an Apple Watch’s magnetic charger in addition to MagSafe charging. The Airpods Pro are priced at $249 in the US, like the original.

And There you go. These are the new devices that Apple unveiled during their “Far Out” event. Do you think it was far? We would love to hear from you.

Looking for your next furry family member but can’t find one in your area? Hitad.lk has the solution with our many lists of dogs for sale in Sri Lanka!

Researchers discover a toxin that kills bacteria in unprecedented ways

0

McMaster researchers have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.

The study, led by John Whitney of the Michael G. DeGroote Institute for Infectious Disease Research, shows that the bacterial pathogen Pseudomonas aeruginosa, known to cause hospital-acquired infections such as pneumonia, secretes a toxin that has evolved to kill other species of bacteria. .

Courtesy of Blake Dillon/McMaster University

John Whitney (right) and Nathan Bullen have studied this toxin for nearly three years.

For Whitney, the key aspect of his discovery is not just that this toxin kills bacteria, but how it does it.

“This research is important because it shows that the toxin targets essential RNA molecules from other bacteria, effectively rendering them non-functional,” says Whitney, an associate professor in the department of biochemistry and biomedical sciences.

“Like humans, bacteria need properly functioning RNA to live.”

The author of the first study, Nathan Bullen, a graduate student in biochemistry and biomedical sciences, describes it as “a total attack on the cell” because of the number of essential pathways that depend on functional RNAs.

Whitney and Bullen, together with colleagues from Imperial College London and the University of Manitoba, studied this toxin for almost three years to understand exactly how it works at the molecular level.

This is the graphic summary of the team’s paper, “An ADP-ribosyltransferase toxin kills bacterial cells by altering structured non-coding RNAs.”

Discovery, published in the journal Molecular Cellwas made by Bullen after rigorous experimentation on common toxin targets, such as proteins and DNA molecules, before finally testing the toxin against RNA.

This finding breaks well-established precedents set by toxins targeting proteins secreted by other bacteria, such as those that cause cholera and diphtheria.

The researchers say this development holds great potential for future research that could eventually lead to new innovations that fight infection-causing bacteria.

Whitney says future antibiotic development can build on the newly discovered vulnerability.

This article has been republished with permission from the Institute for Infectious Disease Research at McMaster University. Read the original.

Beware of Italian ‘mafia entrepreneurs’ – The Washington Post

0

The economic and social crisis supporting Italy’s hard right ahead of the September 25 elections leaves the eurozone’s third-largest economy vulnerable to even deeper infiltration by organized crime.

In a speech in May, one of his last before the collapse of his government, the current interim prime minister, Mario Draghi, warned that organized crime had “taken new but equally frightening forms”. Beyond violence – and the threat of violence – “organized crime has infiltrated corporate boardrooms,” he said. “They pollute the economic fabric from the real estate sector to the wholesale supply chains.” In its quest for profit and power, organized crime – from the Cosa Nostra in Sicily, to the Camorra in Naples and the ‘Ndrangheta in Calabria – has spread its southern tentacles deep into Italy’s wealthy industrial north. Italy. Overall, Italian criminal groups control around 9% of the economy, according to various estimates.

Draghi’s immediate concern was the risk to the 260 billion euros ($261 billion) in European Union recovery funds programmed for Italy by 2026. As the mobsters found new ways to making money during the pandemic – focusing on mask production and funeral services – the EU money offers a fat new target.

As Europe faces the dark winter of a joint economic and energy crisis, law enforcement officials and crime experts are raising fresh alarm about mafia groups acquiring default-risk businesses. It’s a problem in southern Europe, but Italy is particularly at risk because small and medium-sized businesses make up around 80% of the economy. Criminal ownership of a business is a nightmare scenario that would undermine the legitimate economy, distorting competition, the rule of law and the social fabric. Worse, it is already happening.

Milan police commissioner Giuseppe Petronzi recently warned of “a military operation” by the southern mafia to infiltrate the north, one of Europe’s wealthiest regions. Recent data suggests that this is not an exaggeration. Italy saw a 9.7 increase in the number of companies being investigated by financial police for suspected mafia activity between March 2020 and February 2021, the latest data available, according to Vittorio Rizzi , deputy director general of the country’s public security. The Rome-based research group Demoskopika estimated that around 4,500 businesses were at risk of mafia infiltrating after the Covid-19 crisis, particularly those in tourism, restaurants and bars.

The risk Italy now faces is a proliferation of what the United Nations Office on Drugs and Crime calls “the mafia entrepreneur”. Italy was the first country where this role was identified more than ten years ago. Specifically, “mafia entrepreneur” typically involves a member of an organized criminal group – with identities concealed by a front company – taking a minority stake in and effective control of a legitimate business. I recently asked Michele Riccardi, deputy director and senior researcher at Transcrime, a Milan-based research center on transnational crime, how bad he thought mafia infiltration of Italian businesses could be. “I can’t imagine it getting any worse than it is,” he replied sullenly.

The cost falls on everyone as mafia-induced business dysfunction can significantly reduce GDP per capita growth, according to a study published in August by a trio of economists at the Bank of Italy.

How then to deal with the deeper penetration of organized crime into legitimate commerce? Big data can help. Transcrime recently signed a three-year agreement with the financial police of Lombardy, the Milan region, to use big data to track abnormal post-pandemic funding requests and oddities in the structure of business acquirers.

The hope is that better computerized analysis will work faster than criminals can insinuate themselves into the company’s system. And removing human involvement can also overcome other barriers to detection, like fear. A local entrepreneur from the Veneto region I spoke to described a wave of small, family-run businesses coming up for sale since the pandemic. “We know who is selling, but we have no idea who is buying. And sometimes it’s better to mind your own business and not ask,” he said, asking not to be named.

Draghi called for community vigilance to defend the legitimate economy. It is commendable. But the looming energy crisis in Europe could very well widen social divisions, creating the kind of fissures that organized crime can crawl through. Enrico Letta, leader of the Democratic Party, second to Giorgia Meloni’s far-right Brothers of Italy, has warned of a “social and economic crisis” to come this winter. It will only push more businesses to the brink. It doesn’t help that Meloni’s campaign stokes fears of a breakdown in law and order. It also doesn’t help that one of Meloni’s allies, disgraced tycoon Silvio Berlusconi, has spent two decades denying allegations of Mafia ties.

Draghi is widely considered to have brought stability to Italy. A renewed concern over the rule of law will only make foreign companies even more reluctant to invest in a sluggish, debt-ridden economy. Unfortunately, this could further expose Italy to the infiltration of organized crime into the fabric of its industry and society.

More from Bloomberg Opinion:

• In today’s wars, anything can be weaponized: Max Hastings

• Italy’s right clings to the past — and falls flat: Maria Tadeo

• Putin wannabes are a growing threat to Europe: Pankaj Mishra

This column does not necessarily reflect the opinion of the Editorial Board or of Bloomberg LP and its owners.

More stories like this are available at bloomberg.com/opinion

T cells avoid aging with the help of their friends

0

LLike all cells in our body, immune cells age. Over time, they become less and less able to fight infections, cancer, and disease. Previously, researchers believed that the process of aging and weakening of cells, known as cellular senescence, was an inevitable consequence of routine infection and time. But a study published yesterday (September 15) in Cell Biology Nature suggests that an interaction between T cells and antigen-presenting cells (APCs) early in the immune response to viruses may determine the rate at which T cells decline.

Telomeres are long, repeated sequences of DNA that squeeze chromosomes together and protect their ends from unraveling. As cells age, their telomeres get shorter and shorter with each cell division until they can no longer divide. The new study finds that after infection, APCs, the cells that initially trigger the T cell immune response by presenting them with a foreign antigen, cut and deliver their telomeres to T cells, the virus-fighting white blood cells.

The 46 human chromosomes are shown in blue, with telomeres appearing as white dots.

Credit: Hesed Padilla-Nash and Thomas Ried, National Cancer Institute, National Institutes of Health

The researchers found that when APCS deliver their telomeres to T cells, the latter transform into a stem cell-like configuration, which delays their senescence. The researchers also found that this interaction boosts long-term immunity in mice, suggesting that this finding could pave the way for more effective vaccination.

“This article is really fascinating,” says Anthony J. Corravubias, an immunologist at UCLA who was not involved in the study. He says the paper[s] light on a really interesting mechanism that prevents T cells from becoming senescent.

Extension of cell life via telomeres

When a foreign invader such as a virus enters the body, the T cells rapidly divide and their numbers skyrocket. Previously, scientists knew that T cells employed telomerase, an enzyme that stretches telomeres, to combat telomere loss during this rapid division, which over time can lead to shortened telomeres and eventual senescence. But telomerase is not enough to prevent T cell senescence, prompting scientists to search for another key mechanism responsible for protecting T cells from aging.

The researchers, a team from the University of College London led by immunologist Alessio Lanna, first looked at the role telomeres play in aging immune cells and analyzed telomere length during the immune response. when they discovered telomere donation. (Lanna is also CEO of Sentcell, a biotech company that aims to increase human lifespan by rejuvenating T cells.)

To isolate the immune cells, Lanna and his collaborators derived T cells and APC cells from the blood of human research participants and then cultured those cells. Then they exposed the cells to a mixture of antigens made up of pieces of various viruses, to ensure that the APC and T cells come together to replicate a true immune response. Finally, they analyzed the length of the cells’ respective telomeres with a sequencing technique.

See “Can destroying senescent cells treat age-related diseases?”

“We were looking at immune synapses between T cells and antigen-presenting cells when we made an unexpected observation,” says Lanna. When the APC and T cells they observed joined, the T cell telomeres lengthened, while the APC telomeres shrank. This action extended the telomeres of the receptor T cells up to 30 times more than telomerase would.

To determine whether the APCs were indeed donating their telomeres, the researchers labeled the APC telomeres with fluorescent markers. After the cells were presented with an antigen, the team of scientists saw clusters of telomeres leaving the APC nuclei and congregating at the junctions between the APC cells and the T cells. The researchers then isolated these telomere-filled vesicles using fluorescence-activated vesicle sorting. Once the APC-derived vesicles were delivered to T cells, even in the absence of APC, the T cells took up the APC telomeric DNA and stuck it to the ends of their chromosomes.

These vesicles increased T cell proliferation and decreased T cell count with senescence marker proteins, and protected T cell populations with short telomeres from early aging, the team found. There was also an increase in the number of stem-like memory T cells, which are able to perform effector or memory functions if they encounter a pathogen again. Effector cells are involved in increasing inflammation and killing infected cells, while memory cells retain information about threats to the body to trigger future immune responses.

Previous studies by other groups had determined that in the more stem cell-like configuration, T cells live longer than those that have differentiated, Lanna says. The results suggest that the fate of some T cells, whether they become senescent or not, is determined when APCs deliver telomeres to T cells. This means that the fate of some T cells is sealed before the immune response even begins. . “It’s against dogma in the area of ​​immune senescence,” Lanna says.

In vivo immunity enhancement

This telomere donation also appears to boost long-term immunity in mice. In another experiment, the researchers exposed T cells to a flu vaccine, then exposed one group of T cells to vesicles filled with APC-derived telomeres, and another group to vesicles without telomeres. They then injected T cells into separate groups of mice that were also exposed to H1N1, a strain of flu commonly known as swine flu. Mice that received neither type of treatment died almost instantly from the flu, but both types of T-cell treatment seemed to protect the mice after the virus was injected. After 15 days, the researchers again exposed the two groups of mice to H1N1. The mice that received the T cells exposed to telomere-filled vesicles still had a robust immune response to the H1N1 injection, but the other group treated with the T cells died immediately. This suggests that APC-derived vesicles could help T cells maintain their immune function over time, the researchers say.

“We know that we can administer these vesicles to an animal and that will protect the animal in the long term against infection,” says Lanna. The vesicles could even be incorporated into vaccines to prolong the effectiveness of vaccination, he suggests, or eliminate the need for boosters.

The researchers also observed that APCs deliver telomeres to some T cells and not others, although the reason is unclear. Using Flow-FISH, a test that counts cells and analyzes their telomere length one by one, the team found that naïve T cells – cells that have never encountered an antigen – and T cells memory were more likely to absorb telomeres. Meanwhile, various types of effector T cells are less likely to do so.

In addition to their potential application to vaccines, these findings may open up the possibility of treatments that stimulate the release of APC vesicles and make T cells more likely to accept the vesicles, or technologies that extract and deliver vesicles, Lanna says. T-cell senescence has been linked to an increased risk of infections, cancers and dementia, he adds, and such treatments could potentially help delay immune aging and related diseases.

“I think this is a really great study that has a lot of clinical potential, in terms of vaccine efficacy,” Corravubias says. Additionally, “it would be interesting if you could treat patients who are either chronically infected or preventatively to help build their immunity against different infections.”

China approves inhalable Covid-19 vaccine

0

Convidecia Air uses a nebulizer to turn the liquid into an aerosol to be inhaled through the mouth

| THE INDEPENDENT | The China National Medical Products Administration (NMPA) has approved CanSino Biologics’ (CanSinoBIO) recombinant Covid-19 vaccine (adenovirus type 5 vector) for inhalation, Convidecia Air, as a booster.

This vaccine is based on the same adenovirus vector technology platform as Convidecia, the intramuscular version.

Offering a non-invasive option, Convidecia Air uses a nebulizer to convert the liquid into an aerosol to be inhaled through the mouth, the company noted.

The needle-free vaccine can also elicit full immune protection against the SARS-CoV-2 virus after a single inhalation.

In March last year, CanSinoBIO obtained the approval of clinical trial application to analyze Convidecia Air. The vaccine was developed in partnership with the Beijing Institute of Biotechnology (BIB).

According to studies, Convidecia Air could induce robust cellular, humoral and mucosal immunity to achieve triple protection as well as control virus spread and infection.

The company has currently achieved regular manufacturing of several innovative vaccines and established a worldwide supply chain to increase accessibility to quality vaccine products for people around the world.

Inhalable vaccine in trial

An inhalable version of a single-shot, adenovirus-based viral vector vaccine could provide a new option for vaccination against COVID-19.

In October 2021, the World Health Organization set a target for countries to vaccinate 70% of their population against COVID-19 by mid-2022. However, improving access and distribution of vaccines to the more than 90% of people in low-income countries who are still unvaccinated remains a challenge.

Researchers rushing to reduce the logistical and financial barriers of vaccination suggest that the development of inhalable vaccines could be a way forward.

Compared to intramuscular vaccines, which generally require low temperature storage and skilled healthcare personnel to administer them, inhalable vaccines can be administered using disposable devices, with minimal storage requirements for mass vaccination.

Inhalable vaccines can also induce a localized immune response targeting the mucosal surfaces where pathogens enter, instead of a systemic immune response, without specifically targeting the pathogen’s region of infection, as intramuscular vaccines do.

This specificity also means that only a lower dose might be needed compared to intramuscular injections.

New routes of administration

In 2021, Tianjin-based biopharmaceutical company CanSino Biologics (CanSinoBIO) completed a Phase III clinical trial of its intramuscular COVID-19 vaccine, which involved 45,000 volunteers worldwide. The vaccine was later approved for use in China, Hungary, Pakistan, Malaysia, Argentina and Mexico. CanSinoBIO is leading the development of an inhalable version of the vaccine.

CanSinoBIO’s vaccine is a recombinant viral vector vaccine, a class of vaccines that use a modified version of a different virus to deliver instructions to cells that trigger an immune response.

The adenovirus-derived viral vector, which easily infects cells but does not cause disease, serves as a carrier that delivers genetic material that codes for the SARS-CoV-2 spike protein to cells.

Once it enters a cell, the gene is transcribed to express the spike protein, which in turn serves as an antigen that stimulates the immune system to recognize the COVID-19 virus.

Zhu says the inhalable vaccine mimics how COVID-19 enters the human body through the respiratory tract. When CanSinoBIO’s vaccine is aerosolized into tiny particles, it can then be inhaled into the airways and lungs to trigger immunological memory and initiate an immune response in the mucous membranes of the airways.

When producing the inhalable vaccine, CanSinoBIO deletes the genes related to virus replication from the adenovirus type 5 vector, so the vector is defective for replication in the human body. A gene sequence encoding the SARS-CoV-2 spike protein (S protein) is inserted here.

CanSinoBIO has already used an adenovirus vector technology platform to develop a recombinant Ebola vaccine, as well as a tuberculosis booster vaccine and a shingles vaccine.

Acceleration of production potential

After comparing a variety of atomizing inhaler devices on the market, CanSinoBIO chose a vibrating mesh nebulizer from Galway-based company Aerogen for its vaccine which produces droplets two to five micrometers in diameter and has the less impact on the potency and structure of the vaccine.

Zhu’s team says the inhalable vaccine requires only one-fifth the dose of an intramuscular vaccine, which can help the vaccine maker retain more doses and increase production capacity.

CanSinoBIO’s vaccine can also be stored and transported in refrigerators between 2°C and 8°C, which is more favorable in countries with insufficient storage facilities and medical resources.

To establish a large-scale production process for the inhalable vaccine, Zhu says the challenge is to compare the different cell culture methods, with the team ultimately deciding that infusion culture was the best fit. Perfusion culture allows for greater automation with fewer manual operations, while ensuring production quality, stability and flexibility, allowing for increased production without a significant increase in manufacturing space.

“Another challenge we’ve had is getting regulators to accept a vaccination schedule for sequential inhaled vaccines,” Zhu says.

The company is also studying the possibility of using its vaccine as a heterologous booster dose.

CanSinoBIO aims to continue to develop COVID-19 Variants of Concern (COV) vaccines and other inhalation vaccines.

“The aerosolized version of our vaccine provides early evidence for stimulation of humoral, cellular and mucosal immunity,” says Zhu.

****

Australian vine health tech set to scale

0
Advertising

September 15 – An innovative smartphone app developed in Australia that uses artificial intelligence to help winemakers easily diagnose nutritional disorders in vineyards is set to expand following a new marketing deal.

The prototype application that evaluates vine leaf symptom images captured using a standard smartphone camera was developed by a team of grape growers, plant physiologists and machine learning specialists using a research partnership between the NSW Department of Primary Industries (NSW DPI) and Charles Sturt University with funding. of Wine Australia.

Global agtech start-up Deep Planet has licensed the technology exclusively to add to its capabilities and commercialize the technology for the benefit of grape and wine growers.

Deep Planet CEO David Carter is excited to embrace the technology and add it to the suite of viticulture remote sensing, monitoring and prediction capabilities offered by their leading VineSignal platform. Of the industry.

“We’ve worked closely with a number of Australian growers to help them manage the health, irrigation, yield and maturity of their vines using satellite imagery combined with our machine learning and analytics capabilities. ‘IA. Adding and enhancing this technology as a convenient tool for field nutrition monitoring is an obvious next step to improving the impact we can deliver to our customers,” Carter said.

Grapevine nutrition is a significant cost to running a vineyard, and if not managed properly, yield and quality can suffer. The prototype application was developed as a technical solution to help winegrowers deal with the confusion of symptoms of vine nutritional disorders.

Charles Sturt Pro Vice-Chancellor (Research and Innovation), Professor Michael Friend, said image analysis experts at the University, including Associate Professor Lihong Zeng and Professor Manoranjan Paul, have been working with researchers of NSW DPI to develop disease image libraries for AI assessment of vines in the field.

“The app’s detection and diagnostic capability works through image analysis algorithms developed by the team and allows users to quickly identify nutrient deficiencies in the vine and access corrective actions. depending on the diagnosis,” Prof Friend said.

NSW DPI deputy chief executive Dr Adrian Zammit said commercializing research through agreements between government, industry and business can help farmers meet practical challenges.

“It is encouraging to see these research organizations working with a global agricultural technology company and together recognizing the value of this key collaborative research project,” said Dr Zammit.

“NSW DPI is committed to understanding and researching the challenges of our agricultural sector and ultimately delivering practical results that add capability and competitiveness to the farm.”

Advertising
Announcement NeuroTags

Tridek-One pockets €16M to develop autoimmune disease candidates

0

Tridek-One SAS, a French biotech startup specializing in the research and development of CD31 agonists to restore immune balance, has closed a new €16 million ($16.1 million) funding round.

The financing was led by Swiss company Pureos Bioventures with the participation of new investors Bpifrance and Bioqube Ventures, as well as historical investors AdBio partners and Advent Life Sciences.

The funds will be used primarily to identify development candidates against autoimmune diseases, to conduct studies enabling IND and to further strengthen the organization. The company previously raised €3 million ($3 million) in a first round in 2019 involving partners AdBio and Advent Life Sciences.

Founded in 2018 by Giuseppina Caligiuri and Antonino Nicoletti, researchers from INSERM Unit 1148 in Paris, France, with the support of historical investor partners AdBio, Tridek-One is developing a new CD31 agonist approach to modulate immune activation for the treatment autoimmune diseases.

Board Additions

Following the fundraising, Klaus Breiner from Pureos Bioventures and Benoit Barteau from Bpifrance join the company’s board of directors. Erik van den Berg, CEO of AM-Pharma, joins as independent chairman of the board.

“It is a pleasure to join as Chairman as the company builds a great team, with a professional syndicate of international investors engaging in decades of research by the team of Dr Giuseppina Caligiuri and Pr Antonino Nicoletti “said Erik van den Berg, Chairman of the Board of Tridek-One.

“There is still a significant unmet medical need in many autoimmune diseases. Agonizing immune inhibitory receptors like CD31 have the potential to rebalance the immune system without being more broadly immunosuppressive. We are excited to continue translating this concept with Tridek-One through its discovery and preclinical stages,” added Klaus Breiner, Managing Partner at Pureos Bioventures.

“Being supported by investors who believe in our project is a great opportunity. This will allow us to accelerate our work to identify and develop first-in-class immune checkpoint agonists capable of controlling serious inflammatory diseases,” said the founders of Tridek-One.

Natural ways to keep your energy up throughout the day

0

Do you wake up tired most mornings?

Have caffeinated beverages become a necessity to help you get through the day?

If this sounds familiar, it’s time to ditch the quick fixes you rely on and come up with an energy management plan.

Getting started may seem daunting, but you’ll soon have the energy to keep going once you reap the benefits of a happier, healthier, and more productive lifestyle.

So what is energy management?

Think of your energy as a finite resource, like money in an account.

You start the day with a certain amount to spend.

The amount varies from person to person depending on factors such as age, sleep patterns, stress level, medical conditions, and lifestyle.

Activities and interactions take or deposit energy into your account.

Although you don’t always have control over which activities deplete your energy, you can take steps to deposit more energy into your account.

Follow these seven tips to increase your energy and live a happier, healthier and more productive life:

1. Eat nutritious foods

A healthy and balanced diet is at the heart of well-being.

But it’s common to think of healthy eating primarily as a tool for weight loss.

According to the 2020 Dietary Guidelines for Americans, a balanced diet high in fruits and vegetables, lean protein, low-fat dairy, and whole grains is necessary for optimal energy.

You really are what you eat.

Eat a variety of foods from all food groups to get a range of nutrients that will provide energy throughout the day.

Opt for fresh or frozen fruits and vegetables, especially leafy greens and nutrient-dense broccoli, as well as orange vegetables, such as carrots and sweet potatoes.

You can choose from many types of fish and legumes for healthy protein options.

Aim to eat 3 ounces (85 grams) of whole grains, bread, rice, or pasta daily.

2. Sleep seven to eight hours a night

Prioritizing sleep is one of the best things you can do to set yourself up for a successful, energized day.

Sleep deprivation can perpetuate serious health problems, as well as negatively affect your mood, motivation, and energy levels.

Getting quality sleep is a healthy habit that many people need to improve.

Most adults need at least seven to eight hours of sleep every night, so what’s stopping them from getting it?

Observe your sleep patterns if you have trouble sleeping.

Take note of how long you sleep each night, factors that contribute to your sleep or lack thereof, how rested you feel, and how much energy you have during the day.

Then try sleep strategies to improve your sleep, such as creating a relaxing and restful environment, minimizing light and noise, establishing a bedtime routine, managing stress, and turning off electronic devices.

Whatever you decide to start, be consistent.

Using the same sleep routine and sleep strategies will help develop your body’s internal wakefulness and can lead to better quality sleep.

With better quality sleep, people enjoy better health and emotional well-being, reduce their risk of disease, and be more productive.

3. Keep company with the right people

Maximize your time with the people you enjoy being with, as they will help replenish your energy. —AFP

Maximize the time you spend with people you enjoy being with.

Connecting with other people who radiate positivity and have similar interests will excite and energize you.

On the other hand, people you don’t identify with or who have negative outlooks, complain often, or make bad choices will only drain your energy account.

Be selective about the company you keep.

It’s important to set boundaries and boundaries to protect yourself and conserve your energy when you’re around people who don’t fill your energy stores.

4. Avoid news overdoses

Consuming news is an important way to stay connected to what’s happening in the world.

It can be educational, entertaining and even uplifting.

Unfortunately, the news is too often filled with stories of suffering.

These stories can distort your view of the world and cause you to focus on your worst fears, instead of acknowledging the good around you.

You can’t completely avoid these stories, but try to minimize your exposure when you can, especially during tough times.

5. Exercise regularly

Do you feel sluggish in the middle of the day?

Have you ever been out of breath from simple daily tasks, such as grocery shopping or household chores?

The US Department of Health and Human Services recommends adults get at least 150 minutes of moderate-intensity physical activity each week.

Contrary to what you might think, this will add to your energy account, not subtract from it.

Exercise relieves stress and tension, strengthens muscles and boosts endurance, and helps your body work more efficiently during other tasks or physical activities.

6. Do something meaningful every day

stop Stop “doomscrolling” through negative or bad news, as it can seriously damage your mental health. — dpa

What gives you passion ?

Do you have a particular talent that you would like to practice more often or share with others?

Do something you love every day, even if it’s a simple act like cooking a healthy meal or listening to your favorite song.

Putting effort into the things that matter most to you will help you use and reserve your energy in ways that bring out the best in you.

7. Have good thoughts for others

Maintaining a compassionate mindset is another way to conserve energy.

A practical example of this way of thinking is called caring attention.

For example, try making eye contact with a stranger and smiling, while thinking “I wish you luck.”

This positive act can help you not to judge this person.

Judging others can cause us to judge ourselves, and this type of negative internal dialogue can be exhausting.

Take care of yourself

You’ll feel better with every step you take toward this important investment in self-care.

Here are some simple activities that will help you take better care of yourself:

> Watch your energy

Take your energy “temperature” at different times of the day, assigning it a number from 1 to 10, with 10 being the highest energy level.

Pay attention to the details of your day so you can identify the people or events that impact you the most.

> Make incremental changes

Once you are aware of some of the people or events sabotaging your energy, consider your next steps.

Rather than tackling everything at once, choose an area that is important to you and be realistic with the goals you set for yourself.

For example, if disorganization in your home is a big source of daily stress, pick one wardrobe, closet, or drawer to empty every week, instead of overwhelming yourself with doing it all at once.

Then move on to your next goal when you feel ready.

> Plan and prioritize

Take note of the times of day when your energy levels tend to be highest.

Decide how you can take advantage of these times by prioritizing important tasks when you feel fresh and productive. – By Jolene Hanson/Mayo Clinic News Network/Tribune News Service

Jolene Hanson is a clinical social worker in psychiatry and psychology in Minnesota, USA.

BeautyHealth’s Hydrafacial Announces Partnership to Develop Revolutionary Exosome Booster

0

LONG BEACH, Calif.–(BUSINESS WIRE)–The Beauty Health Company (NASDAQ:SKIN), home to flagship brand Hydrafacial, today announced a collaboration with biotech company Organicell to co-create a first-to-market exosome booster that will treat signs aging and inflammation of the skin. The booster will leverage new exosome technology based on regenerative medical therapies and, when developed, will be available as a custom treatment supplement for Hydrafacial.

“We are excited to begin development with Organicell to co-create a potentially game-changing Hydrafacial booster based on their breakthrough exosome technology,” said Andrew Stanleick, President and CEO of BeautyHealth. “This partnership builds on our range of boosters and is the perfect example of the power of co-creation in our R&D model, which gives us access to the most innovative technologies and formulas and translates them to market according to a accelerated schedule.”

Exosomes are small membrane vesicles, which are among the most productive and conducive to healing wounds and fighting inflammation. These benefits will help treat the skin and fight the signs of aging when delivered as a booster thanks to Hydrafacial’s exceptional delivery system.

Organicell’s technology exosomes contain more than 300 cytokines, chemokines and growth factors harvested under cGMP conditions that will allow Hydrafacial to put billions of exosomes into each booster vial. In the booster, they will promote cell communication, repair and regeneration to treat the signs of aging and inflammation like never before.

Organicell CEO Matt Sinnreich said, “Organicell is honored to pair our scientific team with the formulators of Hydrafacial to help create a booster that not only pioneers new technology, but has the potential to change the facial industry forever.”

This collaboration marks a major step forward in Hydrafacial’s booster strategy, centered on partnerships and co-creation. Today, Hydrafacial offers a range of 20 boosters, the majority co-created with other skincare brands such as Murad, ZO and JLo Beauty.

Hydrafacial’s co-creation model can deliver a boost in less than six months, a fraction of the time typically needed to develop a full skincare line. This allows Hydrafacial to react quickly to consumer trends, ensuring a steady stream of groundbreaking offerings that directly address consumer needs.

Hydrafacial’s new exosome booster will be available early next year.

About Beauty Health Company

The Beauty Health Company is a global category building company focused on delivering health and beauty experiences by reinventing our consumers’ relationship with their skin, body and self-confidence. Our flagship brand, Hydrafacial™, created the hydradermabrasion category using a patented Vortex-Fusion delivery system to cleanse, peel, exfoliate, extract, infuse and hydrate skin with proprietary solutions and serums. Hydrafacial™ provides a non-invasive and accessible experience with a powerful community of estheticians, consumers and partners, connecting aesthetics with beauty to democratize and personalize skincare solutions across ages, genders, tones of skin and skin types. Hydrafacial™ is available in over 90 countries with an installed base of nearly 23,000 delivery systems delivering millions of consumer experiences each year. For more information, please visit www.beautyhealth.com.

About Organicell Regenerative Medicines, Inc.

Organicell Regenerative Medicine, Inc. (OTCQB: OCEL) is a clinical-stage biopharmaceutical company primarily focused on the development of innovative biological therapies for the treatment of degenerative diseases and the provision of other related services. The Company’s proprietary products are derived from perinatal sources and manufactured to retain naturally occurring exosomes, hyaluronic acid and proteins without the addition or combination of any other substance or diluent. To learn more, please visit https://organicell.com.

Forward-looking statements

Certain statements made in this press release are “forward-looking statements” within the meaning of the “safe harbor” provisions of the United States Private Securities Litigation Reform Act of 1995. When used in this press release, the words ” estimates”, “forecasts”, “expects”, “anticipates”, “plans”, “projects”, “intends”, “believes”, “seeks”, “may”, “will”, “should”, “future”, “propose” and variations of these similar words or expressions (or negative versions of these words or expressions) are intended to identify forward-looking statements.

These forward-looking statements are not guarantees of future performance, conditions or results, and involve a number of known and unknown risks, uncertainties, assumptions and other important factors, many of which are beyond the control of The Beauty Health Company and could cause actual results to differ materially from those discussed in the forward-looking statements.

Important factors, among others, that may affect actual results or results include The Beauty Health Company’s ability to manage growth; the possibility that The Beauty Health Company will be adversely affected by other economic, business and/or competitive factors; the ongoing business relationship with Murad; recall effectiveness; and the impact of the continued COVID-19 pandemic on the Company’s business. The Beauty Health Company undertakes no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.

Apple Watch Series 8 and Watch ultra have vs Samsung Galaxy Watch 5 and Watch 5 Pro one of which has bigger batteries

0
While the Apple Watch Ultra was the highlight of the “Far out” launch event, it’s the mainstream Apple Watch Series 8 lineup that will most likely be on people’s festive shopping lists. Apple’s arch-rival Samsung also recently launched its new Galaxy Watch 5 range and in this review, we’ll be comparing the biggest issue with the two brands’ smartwatches: battery life.

Related News

Garmin Fenix ​​7X Solar - Not just another smartwatch, this thing is hardcore

Garmin Fenix ​​7X Solar – Not just another smartwatch, this thing is hardcore

Battery life has always been the Achilles heel of smartwatches, aside from Garmin’s Fenix ​​7X, most smartwatches struggle to get through a full day of use. Apple Watch Series 7 users had similar issues, as did Samsung Galaxy Watch 4 users. Let’s see what both manufacturers did to fix this problem.
battery size comparison
Battery Size Comparison Chart
apple watch Cut Battery Samsung Galaxy Watch Cut Battery
Apple WatchSE 245mAh Galaxy Watch 4 247mAh
Apple WatchSE 44mm 296mAh Galaxy Watch 4 44mm 361mAh
Apple Watch Series 8 282mAh Galaxy Watch 5 284mAh
Apple Watch Series 8 45mm 308mAh Galaxy Watch 5 44mm 410mAh
Apple Watch Ultra 49mm 542mAh Galaxy Watch 5 Pro 45mm 590mAh

Apple introduced a “Low Power” mode with the Series 8 and Ultra watches, this mode essentially disables the “Always On Display” (AoD), background heart rate monitoring, blood oxygen readings and automatic workout tracking. Low Power Mode is disabled if you enable Workouts, however, it can be manually enabled during a workout where GPS and heart rate readings are required in limited amounts, such as your morning run. Cellular and Wi-Fi connectivity is also limited, making it essentially an ordinary smartwatch.

Related News

Apple Launches New Apple Watch Ultra India Price Availability and Features

Apple launches new Apple Watch Ultra; Price, availability and features in India

Samsung, on the other hand, has gone ahead and increased the battery size, allowing users to fully utilize the features of the Galaxy Watch 5 line with extended battery life. The Galaxy Watch 5 Pro has an even higher battery capacity than Apple’s Watch Ultra which is actually aimed at Garmin users.

US signs deal with Google to develop chips for researchers

0

The logo of Google LLC is seen at the Google Store Chelsea in Manhattan, New York, U.S., November 17, 2021. REUTERS/Andrew Kelly

Join now for FREE unlimited access to Reuters.com

WASHINGTON, Sept 13 (Reuters) – The U.S. Commerce Department said it has entered into a cooperative research and development agreement with Alphabet Inc (GOOGL.O) Google to produce chips that researchers can use to develop new nanotechnology and devices to semiconductors.

The agreement was signed between the Department of Commerce’s National Institute of Standards and Technology (NIST) and Google. The chips will be made by semiconductor company SkyWater Technology (SKYT.O) at its semiconductor foundry in Bloomington, Minnesota, the department said Tuesday.

Google will pay the initial cost of setting up production and subsidize the first round of production, according to the agreement. NIST, along with university research partners, will design the circuitry for the chips.

Join now for FREE unlimited access to Reuters.com

The Biden administration’s Chips and Science Act was recently passed by Congress and signed into law. It authorizes funding aimed at reviving domestic semiconductor production in response to supply chain disruptions.

A series of companies announced new semiconductor factories resulting from the passage of the legislation, which authorized about $52 billion in government subsidies for the production and research of semiconductors in the United States, and a investment tax credit for chip factories estimated at $24 billion.

“NIST plans to design up to 40 different chips optimized for different applications. Because the chip designs will be open source, researchers will be able to pursue new ideas without restriction and freely share data and device designs,” the Commerce Department said in a statement. .

Research partners contributing to the design of the chips include the University of Michigan, University of Maryland, George Washington University, Brown University and Carnegie Mellon University, the statement added.

Financial details of the deal were not disclosed.

Join now for FREE unlimited access to Reuters.com

Reporting by Kanishka Singh in Washington Editing by Matthew Lewis

Our standards: The Thomson Reuters Trust Principles.

Nanoparticles stimulate mouse immune system to attack cancer

0

Exosomes are tiny, fluid-filled sacs that are naturally released from cells into the blood and other bodily fluids. These nanoparticles facilitate communication between cells by carrying genetic information and proteins, and have long been considered a promising tool for delivering targeted drugs to specific organs. Now, in a scientific first, cancer researchers have developed multifunctional exosomes for cancer treatment and tested them in mice.

On their surface, exosomes display four different types of proteins involved in triggering an antitumor immune response in humans. The modified exosomes, called GEMINI-Exos, are described in an article published in the September 7 issue of Molecular therapy and open up the possibility of reprogramming native nanocarriers, which are safer and less likely to cause long-term adverse effects than synthetic nanoparticles, in different ways for personalized immunotherapy.

Sonia Melo, a biochemist at the Institute for Health Research and Innovation in Portugal, explains that the novelty of this research lies in the combination of different molecules on the surface of the exosome, each acting on a different mechanism within antitumor immune response. This offers the possibility of “attacking simultaneously on more than one front to defeat the enemy”: cancer.

To design the therapeutic exosomes, Yong Zhang, a biochemist at the University of Southern California (USC), and his colleagues began by identifying exosomes from human cell cultures by looking for a naturally occurring marker on their surface, known as of CD-9. They isolated the exosomes and then fused the marker on each exosome with four molecules, called PD-1, OX40L, CD3 and EGFR, which regulate immune response and cancer progression.

To test whether these modified exosomes help the immune system, Zhang and his team developed humanized mice by introducing human immune cells into immunocompromised animals. These animals were also injected subcutaneously with human breast cancer cells that turned into tumors. The mice were then injected every other day (six times in total) with the modified exosomes, while the control group received native exosomes.

When the researchers mapped tumor growth in mice treated with GEMINI-Exos for 50 days after tumor inoculation, they found that the treated mice had smaller tumors compared to the control group and a stronger antitumor immune response. stronger than mice with native exosomes. “This demonstrated to us that modified exosomes can lead to [a] a long-lasting immune response not only for breast cancer, but for many other types of cancers that can be treated with immunotherapy,” says Zhang.

See “The Next Frontier of CAR T-Cell Therapy: Solid Tumors”

While Melo says she thinks this work could potentially lead to breakthroughs in cancer immunotherapy, there are safety issues with engineered exosomes that need to be considered. These particles contain RNA, she says, and scientists have little control over how engineering will alter the genetic information inside the exosomes. “I don’t know if I would inject myself with these artificial exosomes if I had cancer, because I know how poorly controlled the system is,” Melo says. “That’s a major downside not just to this work, but to the field itself.”

Zhang agrees that this is a barrier and stresses the need for further research to assess the therapeutic benefits, as well as the risks posed by fusing other proteins to the CD-9 marker. For now, his group is putting these questions on hold, instead testing the effectiveness of modified exosomes in other types of cancers.

Bouygues Travaux acquires OO-STAR floating offshore wind foundation technology

0

Bouygues Travaux Publics is expanding its range of infrastructure solutions for offshore wind farms with the exclusive acquisition of OO-STAR floating foundation technology, owned by Floating Wind Solutions.

Bouygues Travaux Publics, which already owns the gravity foundation technology with the Fécamp offshore wind farm project, is acquiring this floating foundation technology on an exclusive basis.

OO-STAR is a patented concept of semi-submersible wind turbine foundation, originally developed by Dr.techn. Olav Olsen then transferred to Floating Wind Solutions (FWS), which Bouygues Travaux Publics has just acquired.

The hydrodynamic and structural behavior of the foundation is supposed to guarantee optimal performance of the turbine and high durability of the structure, allowing greater efficiency.

Bouygues Travaux Publics and Dr.techn. Olav Olsen now intends to combine their engineering and construction expertise to optimize the process of designing and implementing this technology, with the aim of providing an integrated, innovative and competitive solution for the wind market. floating offshore. The semi-submersible concrete foundations will be mass-produced quickly and cost-effectively, the company said.

“This acquisition reflects Bouygues Travaux Publics’ ambition in the wind power sector and confirms its desire to reduce the carbon footprint of its activities. This technological investment is an important step, as it gives us a significant technological advance to support the market more quickly in the necessary environmental transformation process”, said Philippe AmequinCEO of Bouygues Travaux Publics.

This technology can be adapted to a wide range of marine environments, reducing the carbon footprint of wind farm infrastructure and lowering operation and maintenance costs, the company said.

“Dr.techn. Olav Olsen has more than 50 years of expertise in developing infrastructure solutions in the oil and gas sectors and has been working on the development of OO-STAR technology for 10 years. We are delighted to establish this close partnership with Bouygues Travaux Publics and support them in the construction of competitive infrastructure solutions for the floating offshore wind market”, said Olav Weider, CEO, Dr.techn. Olav Olsen.

Follow offshoreWIND.biz on:

Want to stay healthy in space? So you want artificial gravity

0

Space travel presents many challenges, not the least of which is related to the health and safety of astronauts. And the farther these missions get from Earth, the more important they become. Beyond Earth’s protective atmosphere and magnetosphere, there is the threat of long-term exposure to solar and cosmic radiation. But while radiation exposure can be mitigated with proper shielding, there are few strategies available to deal with the other major hazard: long-term exposure to microgravity.

Aboard the International Space Station (ISS), astronauts rely on a strict regimen of exercise and resistance training to mitigate the physiological effects. These include muscle wasting, loss of bone density, organ function, eyesight, and effects on cardiovascular health, gene expression, and the central nervous system. But as a recent NASA study revealed, long-duration missions to Mars and other places in deep space will need to be equipped with artificial gravity. This study examined the effects of microgravity on fruit flies aboard the ISS and demonstrated that artificial gravity provides partial protection against these changes.

The study was conducted by researchers from the Space Biosciences Division of NASA Ames Research Center, the University of New Mexico COSMIAC Research Center, the Universities Space Research Association (USRA), the Nevada Bioinformatics Center of the University of Nevada, Blue Marble Space Institute of Science (BMSIS), the Biological and Physical Sciences Division at NASA Headquarters, and several universities. The article detailing their findings was published on September 6e in the review Cell reports.

Delete all announcements on the universe today

Join our Patreon for as low as $3!

Get the ad-free experience for life

Universe today

Video captured of fly activity in microgravity inside the Multi-Use Variable Gravity Platform (MVP). Credits: cell reports

In this study, the team conducted a month-long investigation using the Multi-Purpose Variable Gravity Platform (MVP), a centrifuge-based commercial test bed that arrived on the ISS in 2019. This experiment has separate compartments and provides flies with fresh food. as they live and reproduce. This allowed the team to house different generations of flies separately and under different levels of gravity, with one exposed to microgravity (like their astronaut counterparts aboard the ISS) and another exposed to Earth’s gravity. (9.8m/s2or 1 g).

The research team then monitored their behavior using cameras built into the hardware. At different times, some of the flies were frozen and sent back to Earth for analysis to see how the different levels of severity affected their gene expression and its impact on their nervous systems. As Dr. Janani Iyer, USRA Project Scientist at NASA Ames Research Center, explained in a recent NASA press release:

“Microgravity poses risks to the central nervous system, suggesting that countermeasures may be needed for long-duration space travel. As we return to the Moon and Mars, reducing the harmful effects of microgravity will be essential to ensure the safety of future explorers.This study is a step in the right direction to explore the protective effects of artificial gravity in space and to understand adaptation to Earth conditions after return from space.

Fruit flies are the ideal organism for this type of research due to their similarities to humans in terms of cellular and molecular processes and their short lifespan and reproductive cycles (two months and two weeks respectively). ). Almost 75% of the genes that cause disease in humans are shared by fruit flies, meaning that changes in their gene expression will resemble possible changes in humans. Moreover, the three weeks they spend in space is equivalent to about thirty years of a human’s life, allowing scientists to observe decades of biological information in a short time.

Techshot’s MVP allows researchers to control and vary the severity level of their experiments using centrifuge technology. Credits: NASA

When the experiment was complete, the flies were returned to Earth aboard a SpaceX Dragon capsule and transported to NASA Ames for further analysis. For two days, scientists conducted behavioral and biochemical tests on these “flyonauts”, which consisted of monitoring their movements inside their habitat, cellular changes in their brains, how changes in the expression of genes affected their nervous system, etc. They then combined their observations with images from the MVP cameras and compared the results to a control group that remained on Earth.

Among the behaviors studied, the scientists looked at how the flies climb the walls of their container – a natural response that fruit flies have when tapped. They found that the flies in microgravity were more active than those exposed to artificial gravity but struggled in the climbing test when they returned to Earth. Post-flight analysis also revealed that flies exposed to microgravity experienced neurological changes while those exposed to artificial gravity aged differently and faced less severe challenges to acclimatize upon return.

These results suggest that spaceflight causes stress that leads to negative behavioral and neurological effects, as well as changes in gene expression in the fly’s brain. They also suggest that artificial gravity can mitigate these effects during spaceflight, although there are still long-term challenges when it comes to reacclimating to Earth. Although these results do not accurately predict human health effects, they provide an approximation and a good starting point for future research. As summarized by Dr. Siddhita Mhatre, KBR Wyle Senior Scientist at Ames and author of the paper:

“With upcoming long-duration deep space missions, where astronauts will be exposed to varying levels of gravity, it is imperative that we understand the impacts of altered gravity on neurological function. If we can use artificial gravity to delaying space-related deficits, we may be able to extend the timelines of future missions, and spaceflight alongside astronauts will help continue our efforts to keep astronauts healthy.

NASA is currently studying centrifuges and artificial gravity for space stations and deep space missions. Examples include NASA’s concept study titled “Non-Atmospheric Universal Transport for Extended Exploration of the United States” (NAUTILUS-X), a rotating torus-shaped module that would provide artificial gravity. NASA further proposed that a demonstration module (the ISS Centrifuge Demo) could become a sleep module for the ISS crew. This module would be 9.1 m (30 ft) in diameter, have an inside diameter of 0.76 m (2.5 ft) and provide between 0.08 and 0.51 g of partial gravity.

It also aimed to provide a proof of concept for a larger torus that could be integrated into an eventual spacecraft known as a Multi-Mission Space Exploration Vehicle (MMSEV). This concept and similar research studies highlight the importance of astronaut health and safety measures for long-duration spaceflight. As NASA and other space agencies send astronauts to the Moon (to stay this time) and pursue crewed missions to Mars and beyond, artificial gravity may become a regular feature of spacecraft, space stations and even surface habitats.

Further reading: Nasa, Cell reports

The IISc team uncovers the mechanism of cellular processes

0

Researchers from the Indian Institute of Science (IISc) and their collaborators have discovered the real-time mechanism involved in biological processes such as cell division, cell motility, transport of nutrients into cells and viral infections.

Although the seamless transition of cell membranes between distinct 3D configurations is known to be responsible for these processes, the experiment conducted by the IISc team sheds light on the actual mechanism involved in the process.

The researchers studied colloidal membranes, which are micrometer layers of aligned rod-shaped particles, because they exhibit many of the same properties as cell membranes.

Unlike a sheet of plastic, where all molecules are immobile, cell membranes are fluidic sheets in which each component is free to diffuse.

“This is a key property of cell membranes that is available in our [colloidal membrane] so,” said Prerna Sharma, associate professor in the Department of Physics, IISc, and corresponding author of the study published in the journal Proceedings of the National Academy of Sciences.

Colloidal membranes were composed by preparing a rod-shaped virus solution of two different lengths: 1.2 micrometers and 0.88 micrometers.

Researchers studied how the shape of colloidal membranes changes as the fraction of short rods in solution increases.

“I made several samples by mixing different volumes of the two viruses and then observed them under a microscope,” said avoirika Khanra, a doctoral student in the Department of Physics and first author of the paper.

The researchers observed that when the saddles fused laterally, they formed a larger saddle of the same or higher order.

However, when they merged at nearly right angles away from their edges, the final configuration was a catenoid-like shape. The catenoids then fused with other saddles, giving rise to increasingly complex structures, such as trinoids and four-noids.

A key idea of ​​the study was to show that the Gaussian curvature modulus of membranes increases as the fraction of short rods increases. This explains why the addition of shorter rods drove the membranes towards saddle-like shapes, which are less energetic. This also explains another observation from their experiment where the lower order membranes were small in size, while the high order membranes were large.

20220912-213805

Ex-government scientist named first head of ARPA-H

0

PResident Joe Biden plans to appoint longtime biologist and former government scientist Renee Wegrzyn as the first director of the fledgling Advanced Research Projects Agency for Health.

Biden’s announcement comes as ARPA-H champions the debate over the multibillion-dollar agency headquarters and which elusive disease areas should be prioritized. The president officially launched the agency in March with initial funding of $1 billion from Congress, but the search for its first director took months.

Wegrzyn, 45, currently works at Boston-based Gingko Bioworks, a bioengineering company, but has previous experience at two government agencies. Activity Advanced Research Projects.

advertising

“I am deeply honored to have the opportunity to shape ARPA-H’s ambitious mission and foster a vision and approach that will improve health outcomes for the American people, including President Biden’s Cancer Moonshot. “Wegrzyn said in a statement nodding to the president’s goal. to end cancer deaths and reduce new cases. The scientist will join Biden at an event in Boston on Monday to promote Project Moonshot.

Wegrzyn is one of four former DARPA officials whom STAT reported in July had been interviewed for the ARPA-H position by White House science adviser Francis Collins. She won’t need Senate confirmation for her role, but is sure to face intense scrutiny from lawmakers who have questioned the need for a new health agency, arguing that ‘it could replicate the efforts of the National Institutes of Health.

advertising

Proponents of Biden’s vision say ARPA-H will work on broad solutions — such as preparing products for market — rather than early research and will break with the NIH culture criticized by congressional skeptics as too risk averse.

“ARPA-H will create the space for transformation and collaboration needed to support the next generation of moonshots for health, not only for complex diseases like cancer, but also systemic barriers like gaps in the supply chain. supply and equitable access to advanced technologies and remedies for all. “said Wegrzyn.

At Gingko, the scientist led the business development and innovation of a subsidiary, Concentric, which implemented a Covid-19 monitoring and testing system for schools. Gingko itself uses synthetic biology for a variety of purposes, ranging from studying infectious diseases to developing biosafety.

Wegrzyn did similar work for DARPA, where she served as a program manager for the Office of Biological Technologies. His work there included the PREPARE the projectwhich targeted genetic responses to pathogens such as infectious diseases, and other gene editing programs.

The pandemic has underscored the need for biosafety research, she said Inside precision medicine last month. “We can’t be reactive to things like that,” she said. “We want to be proactive and recognize and detect these threats. Whether natural or man-made, many of the same systems will be used to respond to them.

Wegrzyn earned his Ph.D. in Applied Biology from Georgia Tech. She has served on the Scientific Advisory Boards of the National Academies of Science Board on Army Research and Development, Revive & Restore, Air Force Research Labs, Nuclear Threat Initiative, and Innovative Genomics Institute.

Stay ahead of the flu with advice from a local dietitian

0
Jessica Corner provided this Citrus and Beet Salad Recipe.
  • Jessica Corner is a registered dietitian at Loblaws in Bowmanville.

The dreaded flu season is coming, and now is a good time to start preparing your defense systems. Immunity is your body’s ability to prevent the invasion of pathogens, including bacteria, viruses, and other foreign disease-causing substances.

There are several easy ways to strengthen your body’s defense system and be healthier this fall. If you’re not sure where to start, here are some tips recommended by your local Loblaws dietitian.

Eat a variety of foods – It is important to ensure that your body receives an adequate supply of vitamins and minerals. The best way to do this is to eat a diet rich in fruits, vegetables and whole grains. A high-fiber, plant-based diet with lots of immune-supporting nutrients can also help build and maintain a strong immune system. Immune support nutrients can be found in plant foods, such as sweet potatoes, spinach, carrots, mango, and broccoli, to name a few. If you are concerned about achieving adequate amounts of nutrients in your diet, talk to your dietitian about practical strategies that will work for your lifestyle.

Include probiotic foods in your diet – Foods like kefir and probiotic yogurt contain bacteria, which can help aid your immune response. I like to recommend a diet-focused approach when it comes to including probiotics in your day. By consuming foods rich in probiotics, you will reap the benefits of other food nutrients, such as protein and calcium, found in kefir and probiotic yogurt.

Stay hydrated – Keeping your body hydrated is an important step in maintaining a strong immune system. Water, in particular, plays a major role in keeping our defense systems functioning. Every cell in our body needs water to do its job, so if we’re dehydrated, our immune system might start to slow down. One way to determine if your hydration status is adequate is to pay attention to the color of your urine. Pale yellow or a light straw color usually indicates good hydration (please note that certain vitamins, minerals and medications can affect the color of your urine).

Get your flu shot – In addition to leading a well-balanced life that includes physical activity and a variety of nutrients from food, the best way to protect yourself and your loved ones is to get your flu shot every year. You can get your flu shot at your local Loblaws pharmacy when they become available to reduce your risk of catching the flu this season.

CITRUS AND BEET SALAD

Ingredients

• Small ruby ​​red grapefruit, peeled

• 1 organic navel orange

• 16 sliced ​​no-name beets, drained

• 4 cups (1 L) PC Organics baby spinach

• 1/4 cup (50 mL) PC Blue Menu Salad Dressing lemon poppy seed

Instructions

1. Holding the grapefruit on its side on a cutting board, cut it into eight slices. Repeat with orange, cutting into eight thin slices. Using 2 orange slices, 2 grapefruit slices and 4 beet slices for each of 4 salad plates, arrange the slices on plates in a large circle, overlapping them slightly and alternating beets and citrus.

2. Gently toss the spinach with 2 tbsp. (25 ml) vinaigrette. Place a quarter in the center of each plate over the beets and citrus fruits. Sprinkle the 2 tbsp. (25 mL) remaining dressing over fruit. Serve immediately, garnished with red onion if desired.

Jessica Corner is a registered dietitian at Loblaws in Bowmanville. She assists clients by encouraging balanced eating habits with gentle nutritional practices. She is a non-dietary dietitian who advocates for freedom from dietary restriction. Contact her at [email protected] or 905-442-8727.

Weather: Rain at the start of the week, beautiful in the back half

0

ITHACA, NY – It’s going to be a rainy start to the week, but don’t pack up the sun hats and hiking boots. The second half of the week promises to be quite pleasant, with seasonal heat and sunny skies. Fall may be approaching, but let’s enjoy the last gasps of summer while they’re in town.

Your weekly weather forecast

The first half of the week will be largely under the influence of a large, slow-moving low-pressure storm system currently forming over the Western Great Lakes. With weak steering flow aloft and high pressure over the western Atlantic Ocean, the system will essentially oscillate in place for the next day or so before eventually finding an exit via the eastern Great Lakes and river valley. Saint Laurent.

What this means in terms of sensitive weather is that it is going to be quite stormy and choppy over the next two days, although temperatures are expected to remain seasonally mild as Tompkins County will reside in the warm sector of the depression turning anti-clockwise.

Today is just the beginning as the warm front of the low shifts over the southern portion and the Finger Lakes. Expect periods of light to moderate rain, usually between 0.10 and 0.25″, with highs in the 70s. The lack of atmospheric energy this morning will keep thunderstorm activity to a minimum. As the rain shield moves northeast and Ithaca is firmly in the warm sector, there will be a break in the rain tonight, although it will remain cloudy. Overnight lows will be in the 60s.

Monday will see those warmer temperatures build up as highs approach 80 across most of the county with near overcast skies. As the low and its cold front begin to move eastward, there will be enough instability and thermal energy to trigger a few isolated showers in the morning, followed by much more persistent showers and a few weak thunderstorms during the afternoon hours. New precipitation amounts on Monday will be 0.10 to 0.25″. Periods of rain will continue overnight Monday through Tuesday as the cold front moves toward sunrise. Quantified Precipitation Forecast (QPF) models show another 0.10″-0.25″ likely overnight, with lows around 60.

Tuesday will be a little cooler with highs in the mid 70s, but with the front past and the low slowly rising northeast into Canada, the rain will lessen as the day progresses and cloud cover will start to dissolve. Another 0.10-0.25″ is likely, although mostly in the morning; by early evening the weather will be drying out and partly cloudy. On Tuesday evening, drying and clearing will continue as the high builds up from the northwest. Skies will be mostly clear and it will be a kind of “windows open” night to sleep with lows in the mid 50s.

With the high pressure continuing to build on Wednesday, it will be a pleasant September day, although there will be a rather strong northwesterly breeze. Skies will be mostly sunny with highs in the mid to high 70s. On Wednesday evening the winds will subside as daytime heating is lost and the core of the anticyclone approaches. This with largely clear skies will result in an optimal radiant cooling setup, and if you’re out late Wednesday night you’ll need a jacket, as lows will be around 50 at the lake and in the town of ‘Ithaca, and the upper 40 on the summits and in the outlying towns.

On Thursday, direct northerly winds will bring cooler Canadian air. This will result in a pleasant but cooler day than we have seen in a while, with mostly sunny skies and highs in the upper 60s. Thursday evening will be another optimal cooling environment, so with mostly clear skies and calm air, temperatures will drop into the mid 40s across the county for lows. Friends, we are approaching autumn, get used to it.

As the heart of the high skirts eastward on Friday, the southerly flow on the trailing flank of its clockwise circulation will raise temperatures a few degrees, up to the low 70s for the highs with a sunny sky. Friday night will welcome partly cloudy skies with lows around 50.

Medium-range patterns show a west-east frontal trough over northern New York on Saturday, and this will likely pass near or through Tompkins County later on Saturday or early next Sunday. At this time, daylight hours on Saturday look pleasant, with partly cloudy skies and highs in the upper 70s. Sunday looks a bit riskier with some showers depending on the timing of the trough, although temperatures are again in the mid to high 70s for the highs. Lows will be between the mid-50s and around 60s.

Graphics courtesy of NOAA Climate Prediction Center.

Extended Outlook

For the second half of September, the large-scale pattern favors a pronounced jet ridge and above-normal temperatures over the central and eastern United States, moving farther east more near October, with a jet trough further upstream over the continental western United States. Over the northeast, precipitation is expected to be near normal for the period. I will note that the only real concern with a setup like this is that it tends to be favorable to hurricanes that make landfall. However, in the tropics things are fairly calm at the moment so any hurricane activity seems to be out of the picture for the next few days.

“Zombie cells” at the heart of the quest for an active and vital old age

0

In an unfinished section of his basement, Richard Soller, 95, spins down an improvised track circling boxes filled with medals he won in track and field and long-distance running.

A few steps away is an expensive leather recliner he bought when he retired with visions of relaxation in old age. He proudly proclaims that he never used it; he’s been too busy training for competitions like the Senior National Games.

Soller has achieved an enviable goal pursued by humans since ancient times: to stay healthy and active at the end of life. It’s a goal that eludes so many people that aging is often associated with frailty and illness. But scientists are trying to change that — and tackle one of humanity’s greatest challenges — with a little-known but burgeoning area of ​​aging research called cellular senescence.

It is based on the idea that cells eventually stop dividing and enter a state of “senescence” in response to various forms of damage. The body eliminates most of them. But others linger like zombies. They are not dead. But as Nathan LeBrasseur of the Mayo Clinic says, they can damage nearby cells like moldy fruit spoiling a bowl of fruit. They accumulate in older bodies, which growing evidence links to age-related conditions such as dementia, cardiovascular disease and osteoporosis.

But scientists are wondering: can we stop the accumulation of zombie cells?

“The ability to understand aging — and the potential to intervene in the fundamental biology of aging — is truly the greatest opportunity we’ve had, perhaps in history, to transform human health,” says LeBrasseur.

With the number of people age 65 or older expected to double worldwide by 2050, cellular senescence is “a very hot topic,” says Viviana Perez Montes of the National Institutes of Health.

A hundred companies, as well as university teams, are exploring drugs to target senescent cells. And the research offers tantalizing clues that people could help tame senescence themselves by using Soller’s favored strategy: exercise.

Although no one believes senescence holds the key to a very long life, Tufts University researcher Christopher Wiley hopes for a day when fewer people suffer from age-related diseases.

“I’m not looking for the fountain of youth,” Wiley says. “I’m looking for the fountain not to be sick when I’m older.”

Leonard Hayflick, the scientist who discovered cellular senescence in 1960, is himself vital at 94. He is a professor of anatomy at the University of California, San Francisco and continues to write, present, and speak on the subject.

His scientific fame did not come easily. He discovered cellular senescence by accident, growing human fetal cells for a cancer biology project and noticing that they stopped dividing after about 50 population doublings. It wasn’t a big surprise; cell cultures have often failed due to things like contamination. What was surprising was that others stopped dividing at the same point. The phenomenon was later called “the Hayflick limit”.

The finding, Hayflick says, challenged the “60-year-old dogma” that normal human cells could replicate indefinitely. A paper he co-authored with colleague Paul Moorhead was rejected by a leading scientific journal, and Hayflick faced a decade of ridicule after it was published in Experimental Cell Research in 1961.

“It followed the usual pattern of major scientific discoveries, where first the discoverer is ridiculed, then someone says, ‘Well, maybe it works’…then it becomes accepted to some extent, then becomes more widely accepted,” says Hayflick.

Scientists say cellular senescence can be helpful. It likely evolved at least in part to suppress the development of cancer by limiting the ability of cells to continue dividing. It happens throughout our lives, triggered by things like DNA damage and the shortening of telomeres, the structures that cap and protect the ends of chromosomes. Senescent cells play a role in wound healing, embryonic development and childbirth.

Problems can arise when they accumulate.

“When you’re young, your immune system is able to recognize these senescent cells and eliminate them,” says Perez. “But when we start to age…our immune system activity also decreases, so we lose the ability to eliminate them.”

Experimental drugs designed to selectively kill senescent cells have been dubbed “senolytics,” and Mayo holds patents on some. In mice, they have been shown to be effective in delaying, preventing or alleviating several age-related disorders.

The possible benefits for people are just beginning to appear, and at least a dozen clinical trials with senolytics are now testing things like whether they can help control the progression of Alzheimer’s disease and improve the health of the skeleton.

Amid the buzz, some companies are marketing dietary supplements as senolytics. But the researchers warn that they have not been shown to work or be safe.

Today, LeBrasseur, who runs a center on aging in Mayo, says exercise is “the most promising tool we have” for healthy end-of-life functioning.

Research suggests that it counteracts the buildup of senescent cells. For example, a study conducted by LeBrasseur last year provided the first evidence in humans that exercise can significantly reduce indicators, found in the bloodstream, of senescent cell burden in the body.

Many older adults, like Soller, intuitively equate exercise with youth.

After a hamstring tear kept him from running in high school, Soller fell into an unhealthy lifestyle in early adulthood, smoking two packs of cigarettes a day. But he and his wife Jean quit when their daughter Mary arrived.

He started racing again just before he turned 50, and since then has raced in races across the United States and competed in decades of Senior Games competition. In May, Soller joined 12,000 like-minded athletes in Florida for the final national games in the Fort Lauderdale area – winning five medals to add to his collection of 1,500 awards.

Soller says exercise keeps him fit enough to deal with whatever comes his way.

“Do as much as you can,” he says. “That should be the goal for anyone to stay healthy.”

Brain-eating amoeba helps scientists better understand the building blocks of life

0

AMHERST, Mass. — To understand how life became what it is today, there is perhaps no better answer than a brain-eating amoeba. Researchers at the University of Massachusetts Amherst are studying an organism called Naegleria and I think it may offer new insight into the evolution of life on Earth.

Scientists have studied how Naegleria evolved to develop microtubules that help the cell perform internal tasks ranging from transporting food and waste to providing structural support. The findings may also help design treatment strategies against brain-eating amoebas.

Life relies on microtubules made up of sets of tubulins. In addition to maintaining the daily functions of the cell, microtubules help divide and replicate the cell. Specifically, there is a stage in mitosis where microtubules pull chromosomes to opposite sides of the cell, splitting them into two identical sets.

Previously, biologists assumed that the brain-eating amoeba used a specific type of tubulin during cell division. But in the new study, the team showed that Naegleria evolved to have three different sets of tubulins. One pair of tubulins helps only during mitosis while the other, called flagellated tubulinis responsible for cell movement.

In the study, the team compared tubulins in Naegleria and the structures they build with those seen in other species. “If we can understand the basic biology of Naegleria“says Katrina Velle, postdoctoral researcher in biology at UMass Amherst and lead author of the study, in a statement. “We can learn how to kill it by designing drugs that target the amoeba’s unique tubulins.”

Naegleria gruberi cells use one set of tubulins to build a mitotic spindle (cyan, left) and another set of tubulins (orange, right) to transform into a type of flagellated cell. (Credit: Katrina Velle, Fritz-Laylin Lab, UMass Amherst)

Naegleria can also give researchers insight into the ground rules that have guided the evolutionary progress of life. “All organisms must replicate,” says Lillian Fritz-Laylin, a UMass Amherst biology professor and lead author of the paper. “We know how replication processes work for certain cells, but there’s a huge whole that we don’t understand. Naegleria let’s test the rules made by the scientists to see if they hold up here.

The team used microscopes to study the Naegleria cells they have grown in the lab. These cells were stained with different chemicals to identify tubulins, emitting a vibrant color. The microscopes helped them take very high resolution 3D photographs that allowed them to measure, count and analyze the different microtubule structures.

“People often think that technology drives science,” adds Fritz-Laylin. “But in this case, the questions we are trying to answer are so fundamental to the functioning of life on earth, and of such interest to so many scientific specialties, that we had to assemble an international team of experts In this case, collaboration, teamwork and effective communication drove the science.

The study is published in the journal Current biology.

British software provider Sage Group’s appetite for mergers and acquisitions is growing

0

UK-based software provider The Sage Group PLC has ramped up its M&A activity over the past 20 months, outpacing its peers in the number of completed deals.

Sage, which sells payroll, accounting and enterprise resource planning, or ERP, solutions to small and medium-sized businesses, completed its acquisition of Lockstep Network Inc. in late August. In total, the company has announced five transactions since the start of 2021, including the acquisition of Brightpearl Ltd., a retail ERP software company, for $299 million in January.

Sage peers have been less active in mergers and acquisitions recently. Intuit Inc., which has closed 30 deals over the past decade, has closed no deals so far this year. Advanced Computer Software Group Ltd., which is owned by private equity firm Vista Equity Partners Management LLC, announced two acquisitions in 2022, but none in 2021.

The number of deals announced in 2022 by ERP software vendors globally is on track to reach or surpass recent highs, although the size of announced deals is shrinking.

In the first eight months of 2022, industry acquirers announced 440 deals, compared to 471 in all of 2021, according to data from 451 Research. The average deal in 2021 was valued at $771 million, nearly three times more than the average deal announced this year to date.

SNL Picture

Historically, Sage has taken a conservative approach to spending, prioritizing profitability over growth. By comparison, Sage’s competitors have invested heavily in research and development and acquisitions.

Sage’s share price has remained fairly stable over the past five years, while competitors Intuit and Xero Ltd. gained more than 200%.

SNL Picture

Xero, which has seen the strongest share price growth among its peers, has also been the biggest R&D spender, allocating between 23% and 32% of revenue to R&D in the five years to 2021. .

Sage seems to be changing its strategy to follow a similar playbook. The company gradually increased its R&D spending from $244 million in 2017 to $407 million in 2021 as it transitioned to a cloud subscription model. Still, Sage’s ratio of R&D expenditure to revenue remains low compared to its peers, at 16.1% versus 31.4% for Xero.

SNL picture

451 Research is part of S&P Global Market Intelligence.

How to Charge a Hyundai Ioniq 5

0
The 2022 Hyundai Ioniq 5 is an innovative all-new electric car with a distinct design and a starting price of $39,950. Built on the Electrical Global Modular Platform (e-GMP), this compact SUV is one of the fastest charging electric vehicles available today.

Keep reading to find out how to charge an Ioniq 5.

Contents

Hyundai Ioniq 5 battery options

The base model of the standard Hyundai Ioniq 5 SE range has a 58 kilowatt-hour (kWh) battery. It is a rear-wheel-drive (RWD) compact SUV with a total range of up to 220 miles at full load. It charges from 10% to 100% in about five hours using a Level 2 charger connected to a 240-volt outlet.

SE, SEL and Limited trim levels have a longer-range battery of 72.6 kWh. These are available in both RWD and All-Wheel Drive (AWD) models. The RWD option has an estimated total range of 303 miles, while the estimated range for the AWD model is 256 miles.

Dependent vehicle function

You can tap into the power of your Ioniq 5’s battery with vehicle-to-charge (V2L) capability. The V2L function allows you to power other electrical devices from inside the car. This innovative technology is ideal when you’re on the go and need to power things like camping gear, scooters, projectors, phones, laptops, or even another electric vehicle.

A power converter connects to the exterior charging port or the socket under the rear seats. It uses stored battery power to deliver up to 3.6 kilowatts (kW) of electricity. This feature works even when the vehicle is turned off.

The V2L connector is not included when you purchase a new Ioniq 5, but you can purchase the accessory separately.

RELATED: Electric Car Rebates and Incentives: What to Know by State

How to Charge a Hyundai Ioniq

Put the vehicle in the “P” position, apply the parking brake and turn off the car. There are several ways to open the loading door. You can touch and push the surface of the door, press the button on your key fob or use voice recognition if you have already set it up on the MyHyundai Bluelink mobile app. From there, connect the charging cable and start charging.

The estimated charging time will be displayed on the dashboard. When your charging session is over or you need to get back on the road, remove the cable from the connection point and put the plug back in the charging station case. The charging door should close automatically when you remove the cable.

Home charging

Level 1: A 120-volt portable charging cord is included with the purchase of a new Hyundai Ioniq 5. This charger connects to a standard household outlet and provides between 6 and 12 amps of power. Level 1 charging is significantly slower than other charging options.

This method will only increase your battery level by minimal amounts, even when plugged in overnight. Hyundai estimates that the portable charger will take around 58 hours to charge from 10% to 100% for the standard range battery and 68 hours for the long range battery.

Level 2: A Level 2 charging station is recommended for routine home charging. This setup requires a 240 volt outlet on a dedicated circuit. It powers your battery with alternating current (AC), providing a faster, more consistent charge than a standard 120-volt household connection. It will take almost six hours from a low battery to charge the standard range battery to 100%. The long-range battery takes just over seven hours to reach 100% with a Level 2 charger.

Level 2 home charging stations require professional installation by a licensed electrician. hyundai recommends home chargers greater than 10kW for the Ioniq 5. The electrician will need to install a 60 amp circuit breaker in your electrical panel to accommodate the power output.

If you live in an apartment building or other multi-unit dwelling, check with your property manager for available options. Many complexes are installing charging stations for residents as electric vehicles become more common in these residential spaces.

RELATED ARTICLE: Electric Vehicle Charging Label Guide

Public charging

Level 2: When you’re on the go, level 2 public chargers are usually easy to find. Look for them in busy areas like grocery store parking lots, malls, office parks, and outside major hotel chains. Check the blue link app to help you locate a public charging station in your area.

These chargers are usually equipped with different types of connectors to adapt to various models of electric vehicles, including the Ioniq 5, which uses a CCS input port.

Level 3: DC fast chargers are widely available and also stationed in populated areas of the country and interstate exits. These charging stations supply your battery with direct current (DC) for a more immediate boost. Fast chargers are great for road trips and long trips. However, Hyundai advises that battery performance and durability may deteriorate if DC chargers are used continuously. For good battery health, plan to use a Level 2 AC connection as your primary charging method. This betting practice will help keep your high voltage battery in “optimal condition”.

Quick Charge

The Hyundai Ioniq 5 is one of the fastest electric vehicles on the market, with a charging capacity of 800 volts. It can go from 10% to 80% state of charge in as little as 18 minutes when connected to a 350 volt DC fast charger. If you’re short on time, you can always boost the battery to 62 miles in about five minutes using a high-voltage rapid charger.

Charging speed and time estimates vary based on several factors, including outside temperature, current battery levels, vehicle settings, and more.

Where to charge the Ioniq 5

You can charge the Ioniq 5 at home through your home charging station setup or at public charging stations. Simply locate the CCS connector cable, plug in the charger following the instructions above, and power on.

Hyundai has partnered with Electrifying America provide two years of free recharge for their network owners. It’s one of the largest fast-charging networks in the country, with over 700 locations across the United States.

Each free DC fast charging session is capped at 30 minutes, and level 2 free charging sessions are capped at 60 minutes. You can register for the program via the Electrify America app.

Read related articles:

Role of key neurons, which alter function in response to seasonal changes in light exposure

0

Seasonal changes in light – longer days in summer, shorter days in winter – have long been associated with human behaviors, affecting everything from sleep and eating habits to brain and hormonal activity. Seasonal affective disorder (SAD) is a prime example: a type of depression linked to reduced exposure to natural sunlight, usually occurring during winter months and more often at higher latitudes when daylight hours are the shortest.

Light therapy has been shown to be an effective remedy for treating SAD, as well as conditions such as non-seasonal major depression, postpartum depression and bipolar disorder, but how seasonal changes in day length and light exposure to light affects and alters the brain at the cellular and circuitry level. kept scientists largely in the dark.

In a new study, published on September 2, 2022 in Scientists progressresearchers at the University of California, San Diego School of Medicine used a mouse model to illuminate a process in which affected neurons alter the expression of neurotransmitters in response to day-length stimuli, triggering associated behavioral changes.

The work was led by the study’s lead author, Davide Dulcis, PhD, an associate professor in the Department of Psychiatry at UC San Diego School of Medicine and a member of the Center for Circadian Biology at UC San Diego.

Nestled in the hypothalamus of the human brain is a small structure called the suprachiasmatic nucleus (SCN), each made up of approximately 20,000 neurons. (The average human brain contains about 86 billion neurons and 85 billion non-neuronal cells.)

The SCN is the body’s timekeeper, regulating most circadian rhythms – physical, mental and behavioral changes that follow a 24-hour cycle and affect everything from metabolism and body temperature to when hormones are released. The SCN works based on the supply of specialized light-sensitive cells in the retina, which communicate changes in light and day length to our body.

In the new study, Dulcis and colleagues describe how SCN neurons coordinate to adapt to different lengths of daylight, changing at the cellular and network levels. Specifically, they found that in mice, whose brains function similarly to humans, neurons change their mix and expression of key neurotransmitters which, in turn, alter brain activity and day-to-day behaviors. later.

Seasonal changes in light exposure have also been shown to alter the number of neurons expressing neurotransmitters in the paraventricular nucleus (PVN), a region of the brain that plays a critical role in controlling stress, metabolism, growth, reproduction, immunity and other autonomic functions. .

“The most impressive new finding from this study is that we discovered how to artificially manipulate the activity of specific SCN neurons and successfully induce dopamine expression in the hypothalamic PVN network,” Dulcis said.

“We revealed novel molecular adaptations of the SCN-PVN network in response to daylength in adjusting hypothalamic function and daily behavior,” added first author Alexandra Porcu, PhD, a member of Dulcis’ lab. “The multi-synaptic neurotransmitter switching we have shown in this study may provide the anatomical/functional link mediating seasonal changes in mood and the effects of light therapy.”

The authors suggest their findings provide a new mechanism for how the brain adapts to seasonal changes in light exposure. And because adaptation occurs within neurons exclusively located in the SCN, the latter represents a promising target for new treatments for disorders associated with seasonal changes in light exposure.

Co-authors include: Anna Nilsson, Sathwik Booreddy, Samuel A. Barnes, and David K. Welsh, all at UC San Diego.

Source of the story:

Materials provided by University of California – San Diego. Original written by Scott LaFee. Note: Content may be edited for style and length.

Linear Motion Display Market Pricing Strategy, Latest Industry News, Top Company Analysis, Research Report Analysis and Share by Forecast 2028

0




Global Linear Motion Screens Market report spotlights major statistics of the current industry state and is a beneficial source of developments and opportunities for individuals and firms interested in the Linear Motion Screens industry. The report primarily concentrates on the Linear Motion Screens market growth in productivity, demand, trade and investment with company profiles, specification and product picture. Worldwide Linear Motion Screens market study predicts revenues for applications across key regions with scope of Linear Motion Screens market, manufacturing cost structure analysis, and product overview.

The Linear Motion Screens market report contains a deep analysis of this industry vertical, laying emphasis on the key trends and lucrative opportunities that promise great returns. It also comprises of practices that can be adopted by businesses to effectively face the challenges coming their way. Furthermore, it expounds the impact of COVID-19 on the business sphere, highlighting its long-term consequences and subsequently mentioning the growth prospects for the upcoming years.

Crucial points from COVID-19 case studies:

  • Footprint of COVID-19 globally, as well as its socio-economic impact.
  • Changes in supply chain and demand share.
  • Business scenario before and after the pandemic.

Request a sample copy of this report @ https://www.newsorigins.com/request-sample/59037

Regional Analysis Overview:

  • The linear motion display market is segmented into various regional markets, namely North America, Europe, Asia-Pacific, South America, Middle East and Africa.
  • The contribution of each region to overall growth is explained in detail.
  • The revenue, sales and growth rate of each geographical area are discussed at length.

Other Highlights of the Linear Motion Screens Market Report:

  • The Linear Motion Display Market product landscape is segmented into Single bridge and double bridge.
  • The volume share and revenue of each product segment are explained in the report.
  • The document includes significant data regarding production models, market share, as well as the annual growth rate of each product category over the estimated period.
  • The report segments the application spectrum of the Linear Motion Displays market into Fertilizer, Plastic Products, Sand, Gravel, Coal and Other.
  • The market share and estimated growth rate of each application segment is also provided.
  • The major competitors in the linear motion display market are Sandvik, Derrick, FLSmidth, IFE, Binder+Co, CYRUS, Enestee, RHEWUM, SIEBTECHNIK, FFA Fiebig, Bevcon Wayors, Bezner, National Oilwell Varco, Weir, IME, McNally Sayaji, Electro Magnetic, Don Valley Engineering, Schenck Process, Siethom and NM Heilig.
  • The study examines the companies mentioned on the basis of essential parameters such as their gross margins, product and service portfolio, market compensation, production capacity, market share and pricing model.
  • A careful study of the prevailing trends and their subsequent impact on companies operating in this sector duly presented.
  • An in-depth analysis of the supply chain, as well as details of manufacturers, suppliers and consumers are housed in the study.

Moreover, the research paper infers the viability of a new project through various methodologies such as Porter’s five forces analysis and SWOT assessment.

Points covered in the report

  • The points discussed in the report are the major market players involved in the market such as market players, raw material suppliers, equipment suppliers, end users, traders, distributors etc.
  • The complete profile of the companies is mentioned. And capacity, production, price, revenue, cost, gross, gross margin, sales volume, turnover, consumption, growth rate, import, export, sourcing, future strategies, and technological developments they are making are also included in the report. This report analyzed historical and forecast data over 12 years.
  • The growth factors of the market are discussed in detail in which the various end users of the market are explained in detail.
  • Data and information by market player, by region, by type, by application, etc., and custom research can be added based on specific needs.
  • The report contains the SWOT analysis of the market. Finally, the report contains the conclusion part where the opinions of industry experts are included.

Customization request for this report @ https://www.newsorigins.com/request-for-customization/59037

Human immune system primes itself for action just by seeing sick people, expert says

0

A great lack of knowledge still prevents people from understanding how this phenomenon works.

iStock

By: Kimberly Rodrigues

A new study has found that humans begin to experience physiological changes before they get sick. According to an expert, when people are around other sick people, they may be better prepared for illness as their immune system begins to prepare for potential infection.

“In other words, our brain can get information from sick people and then cause changes in our physiology. For example, looking at images of sick people can already trigger an activation of the immune system,” says Patricia Lopes, assistant professor of biological sciences at Chapman University’s Schmid College of Science and Technology.

She reportedly said this means that parasites like viruses impact a person’s physiology more than she realizes, because every time another person is seen sick, the body expends energy. for preparing.

“Our physiology, particularly the immune system – the system that protects the body from invaders – is tightly regulated,” Patricia explains in a university statement.

“Once we get sick, our physiology can change dramatically to support recovery from the disease.”

She is of the opinion that there is evidence that the physiology of human beings changes when they see another sick person.

In her study published in Functional Ecology, Patricia writes that uninfected animals, including humans, have built-in mechanisms to avoid becoming infected with a parasite.

She adds: “Uninfected animals can attempt to prevent parasitism in several ways.”

A “less well-studied, and therefore less understood” method of avoidance is physiological avoidance, she says.

However, a key question is whether this type of “preparation” for disease is actually able to reduce infection in any way.

Patricia cites a large knowledge gap that still prevents people from understanding how this phenomenon works and how it can affect a person and spread the disease as a whole.

So, in the context of a large outbreak like COVID-19 or monkeypox, does individuals’ overall heightened awareness of the parasites around them somehow help them avoid the virus? ‘infection ?

According to previous studies, humans naturally view disease as something revolting and repulsive, says the Daily Mail.

Therefore, as a result, they tend to avoid people they perceive to be sick, as a form of self-preservation.

A 2010 study published by the University of British Columbia found that people who were shown pictures of sick people had elevated levels of interleukin-6 (IL-6), which is secreted by white blood cells as a defense mechanism.

Commenting on this, Mark Schaller, co-author of the study, reportedly said in a statement at the time: “It makes evolutionary sense that the immune system only responds aggressively when really needed. “.

He adds: “If I see a bunch of sick people, maybe a big infection is there, and I better kick my immune system into high gear.”

The Energy Chamber strongly supports the Central African Business Energy Forum

0

African Energy Chamber

In 2022, it is imperative that Africa prioritizes regional cooperation and collaboration if the continent is to achieve its goal of eradicating energy poverty by 2030. For producing and non-producing countries, tackling together in the energy crisis will not only ensure that all of the continent has access to electricity, but that a new era of socio-economic growth is ushered in, an era that brings new levels of job creation, industrialization and energy security.

In pursuit of regional cooperation, the African Energy Chamber (AEC) is proud to officially endorse the upcoming Central Africa Energy Business Forum (CABEF), to be held September 8-9, 2022 in Doula, Cameroon. Under the theme “Building oil and gas infrastructure to end energy poverty in Central Africa by 2030”, this year’s edition of CABEF will bring together energy stakeholders and policy makers from the sub-region from Central Africa to discuss the challenges and opportunities in the region’s booming hydrocarbon sector. .

With huge oil and gas resources, the countries of the Central African Economic and Monetary Community (CEMAC) have exceptional energy production potential. However, due to aging infrastructure and low levels of investment across oil and gas value chains, energy access rates in the region have remained low and economic growth limited. In 2022, as the CEMAC countries aim to reverse this trend, forums such as CEBAF 2022 will be essential, as it represents the best platform where discussions will be held on how to stimulate investments for an exploration and optimal oil and gas production and eliminate energy poverty. once for all.

While boosting regional cooperation is essential, the lack of adequate investment across the oil and gas value chain, as well as the unproductive and investment-disincentive foreign exchange rules introduced by the Bank of States of Central Africa continue to restrict energy trade and monetization, as well as the flow of energy investment in the region. If left unaddressed, these policies will prevent meaningful progress in eliminating energy poverty. With CEBAF 2022 being the official meeting place where regional energy leaders can discuss challenges such as those these policies bring, the AEC strongly advocates for the review of these policies to ensure sustainable development and trade. cross-border energy resources.

“With CEMAC countries aiming to achieve universal electricity access and energy independence and security, the region’s vast yet untapped oil and gas resources not only provide an opportunity to achieve these goals, but will be key to improving regional energy security and socio-economic growth,” says NJ Ayuk, Executive Chairman of the AEC, adding that “CABEF presents an ideal platform where CEMAC leaders can discuss energy agreements. investment with continental and international parties, paving the way for industry growth and optimal use of local resources for GDP growth. We hope to see discussions on improving cooperation between countries. of the CEMAC to overcome the main obstacles to the energy sector, in particular the lack of financing and the gaps in terms of infrastructure in the sect upstream, intermediate and downstream ers.

With Gabriel Mbaga Obiang Lima, Minister of Mines and Hydrocarbons of Equatorial Guinea, who launched the historic Central African Pipeline System (CAPS) during MSGBC Oil, Gas&Power 2022 last week, a new era of regional market growth looms on the horizon. For mature producers such as the Republic of Congo and Equatorial Guinea, CAPS will connect these countries to regional markets, while for emerging producers such as Gabon, Cameroon, Central African Republic and Chad, the opportunity to exploit new reserves while strengthening their own hydrocarbon exports. With the introduction of CAPS – which is expected to be presented to CABEF by the relevant energy ministers – new opportunities for job creation, increased youth participation and the involvement of local service companies await.

“It is imperative, now more than ever, to have a region with a pipeline. CAPS aims to do just that, connecting the resource-rich region while providing new opportunities for young people in the energy field. For CEMAC and the African continent as a whole, improving youth participation will be key to addressing energy poverty and boosting socio-economic growth,” Ayuk continued.

The opportunities introduced by CAPS will only be stimulated by all the oil companies active in the region.

Regional and international players such as TotalEnergies, ExxonMobil, Perenco, bp, Vaalco, Eni, BW Offshore, Kosmos Energy, Tower Resources and Chevron, already well established in the region, represent key partners for regional producers. Conducting exploration campaigns, bringing new production platforms online while improving infrastructure development and exports, these companies have and continue to strengthen the Central African energy sector. Today, as the region consolidates its position as a leading oil and gas market, the continued engagement of these companies will be key to unlocking the future of Africa’s energy sector.

Distributed by APO Group for the African Energy Chamber.

Exercise best tool against aging

0

More and more scientists are exploring cellular senescence – a state in which cells no longer divide.

Senescent cells, which accumulate in older bodies, have been linked to age-related conditions such as dementia and cardiovascular disease.

Scientists are exploring drugs that target senescent cells. But the most promising tool against the negative effects of senescent cells, experts say, is exercise.

“A very hot topic”

Viviana Perez Montes of the National Institutes of Health described cellular senescence as “a topic.” The Associated Press reports that about 11,500 projects involving cellular senescence have begun since 1985. The AP’s report was based on its study of an NIH research database. A large number of projects have started in recent years, according to the report.

This research is based on the idea that cells stop dividing and enter a state of “senescence” in response to damage. The body expels most of these cells.

But others remain in the body. They can damage nearby cells, says Nathan LeBrasseur of the Mayo Clinic. He compared it to how one bad fruit can ruin a container full of fruit.

But scientists are wondering: can we stop the unhealthy buildup of senescent cells?

“The ability to understand aging…is truly the greatest opportunity we had, perhaps in history, to transform human health,” says LeBrasseur. Extending healthy years affects “quality of life” and “public health”, he said.

The number of people aged 65 or over is expected to double worldwide by 2050.

Although no one believes senescence holds the key to an extremely long life, Tufts University researcher Christopher Wiley hopes for a day when fewer people suffer like his grandfather did before he died. He had Alzheimer’s disease.

“I’m not looking for the fountain of Youth“, says Wiley. “I’m looking for the fountain to not be sick when I get older.

FILE – Richard Soller holds up the medal he won in the 200-meter final at the Senior National Games, Monday, May 16, 2022, in Miramar, Fla. (AP Photo/Marta Lavandier)

Drugs

About 100 companies, as well as academic groups, are exploring drugs to target senescent cells.

Scientists are careful to note that cellular senescence can be helpful. The process probably developed at least in part to suppress the development of cancer. Cellular senescence occurs throughout our lives, caused by things like DNA damage and the shortening of telomeres, structures that protect the ends of chromosomes. Senescent cells play a role in wound healing, embryonic development and childbirth.

But problems can arise when senescent cells accumulate.

“When you’re young, your immune system is able to recognize these senescent cells and eliminate them,” says Perez, who studies cell biology and aging. But, as we begin to age, in Perez’s words, “our immune system activity also becomes decreasesso we lose the ability to eliminate them. »

Experimental drugs designed to eliminate senescent cells have been called “senolytics”. In mice, they have been shown to be effective in delaying, preventing or alleviating several age-related disorders.

At least 12 clinical trials with senolytics are now testing whether the drugs can help control Alzheimer’s disease, improve skeletal health and more.

There is still a lot to learn.

FILE – Leurene Hildenbrand, 85, competes in mixed doubles pickleball action during the Florida Senior Games presented by Humana on Saturday, Dec. 9, 2017, in Clearwater, Fla.  (Brian Blanco/AP Images for Humana)

FILE – Leurene Hildenbrand, 85, competes in mixed doubles pickleball action during the Florida Senior Games presented by Humana on Saturday, Dec. 9, 2017, in Clearwater, Fla. (Brian Blanco/AP Images for Humana)

Exercise

Today, LeBrasseur, who runs a center on aging in Mayo, says exercise is “the most promising tool we have” for good health in later life, and its power extends to our cells.

Research suggests that exercise thwarts the buildup of senescent cells, helping the immune system clear them and fight molecular damage that can affect the senescence process.

Last year, LeBrasseur conducted a study that provided the first evidence in humans that exercise significantly affected the process. It reduced the signs in the bloodstream of the effects of senescent cells in the body.

After a 12-week exercise program, researchers found that older adults showed decreased signs of senescence and improved muscle strength, physical ability, and self-reported health. A recently published research review is gathering even more evidence — in animals and humans — for exercise as a therapy targeting senescence.

Although such studies are not well known outside of scientific circles, many older people associate exercise with youth.

Breeder Mike Gale, 81, has set up an athletic throwing circle on his large property in California. He and some of his friends throw the disc and use other exercise equipment.

“I would love to compete in my 90s,” Gale says. “Why not?”

Richard Soller, 95, says exercise keeps him fit enough to deal with what comes his way, including the discovery that his 62-year-old wife had developed Alzheimer’s disease. The two sometimes walk the streets of their neighborhood together, hand in hand.

“Do as much as you can,” he says. “That should be the goal for anyone to stay healthy.”

I am John Russell.

And I’m Ashley Thompson.

Laura Ungar reported this story for The Associated Press. John Russell adapted it for VOA Learning English.

Quiz – Researchers: exercise is the best tool against aging

Quiz - Researchers: exercise is the best tool against aging

Start the Quiz to find out

________________________________________________________________________

words in this story

topic – nm someone or something people talk about or write about

opportunity – nm a time frame or situation in which something can be done

transform – v. to change (something) completely and generally in a good way

fountain of Youth – expression a legendary fountain that is believed to give eternal youth to anyone who drinks from it

heel – v. to become or cause (something) to become less big, important, etc.

ability – nm the ability to do something: a mental, emotional or physical ability

clinical – adj. relating to or based on work done with real patients: of or relating to the medical treatment that is given to patients in hospitals, clinics, etc.

Use of ergonomic pipettes in a teaching laboratory

0

Find out how a research team supports student training at all stages and uses ergonomic pipettes to protect their health

Dr. Paul Rowley uses the Ovation® pipettes to reduce shoulder and neck fatigue [image: rowleylab.com]


Principal investigators have a lot of work to do to establish research agendas within their lab, train their group, and create a supportive work environment and culture. This includes setting up equipment and working methods that protect the health of laboratory members.

In this article, new Principal Investigator and Associate Professor at the University of Idaho, Dr. Paul Rowley, speaks to SelectScience® about his research on yeast-produced toxins, the education and training philosophy of his research group, and how he supports member health with Ergonomic Ovation® Pipettes from VistaLab™ Technologies.

Foster learning and teaching

“We work a lot with yeasts and viruses, both mammalian and microbial,” Rowley says of his team’s work. “I focus on examining yeast viruses and toxins – on Saccharomyces cerevisiaebaker’s and brewer’s yeast, and study the viruses that infect this organism, as well as the ability of viruses to stimulate the production of toxins in yeasts.

“Often the toxins produced are due to the viral infection,” says Rowley. “We don’t know much about viruses or toxins, so it’s a very open field. I’m starting to understand a little more about the types of toxins and how we can potentially use them to fight agricultural and human diseases. We also have a lot of fun working with undergraduates to ask questions about the fundamentals of these molecules and viruses.

Rowley’s group takes the responsibility of training the next generation of scientists seriously with a number of undergraduate and graduate students learning and working in the lab. “Over the past six years, I’ve had about 47 undergraduate students in my lab,” Rowley attests.

Rowley’s educational support goes beyond that at the university level. As he explains, “I just received a career award from the National Science Foundation, which is a prestigious award for early-career teachers. This grant is all about public awareness. To get high school and undergraduate students out and about isolating yeast from the environment, from a range of sources such as tree bark, fruits and insects which also harbor lots of yeast . So we’re going to have this kind of citizen science project where they collect all these things.

“Once we have the yeast, we will investigate whether or not these different yeasts produce different toxins,” Rowley continues. “Then we can use these toxins to understand how certain cellular processes work in yeast. If we can understand how these toxins cause changes in yeast cell physiology, we can hopefully apply this knowledge to higher organisms and how these toxins affect many different animals and cell types. There is a mixture of discovering new toxins, new viruses and new yeasts, as well as fundamentals.

“It ranges from graduate and postdoctoral students all the way to high school students. So a really good diverse mix of people to do this job,” says Rowley. “I love citizen science projects where people can actually participate and make a meaningful contribution. It’s not just an engagement project.

Work comfortably with Ovation® pipettes

Training the next generation of scientists also means providing them with laboratory equipment that could better suit them or protect their health. When performing repetitive motions – in the case of Rowley’s lab, regular pipetting – problems can arise.

Honestly, it felt like night and day… The neck pain, the shoulder pain, it pretty much went away.

Dr Paul Rowley

University of Idaho

Early in his career, Rowley experienced discomfort when using pipettes: “When I was a postdoc, I worked a lot on the bench. And I started noticing this shoulder tension and neck pain. In Aberdeen when I was a student, we also had a student who had carpal tunnel, and I remember these pipettes sitting on the bench that had this weird design.

When it came to starting her own lab, Rowley decided to find out more. He discovers the Ovation® pipettes from VistaLab™ Technologies. He was able to test them before purchase to see if they made a difference, and, as Rowley says, “Honestly, it felt like night and day. It was really a game-changer for me in terms of how I felt when I was on the bench. The neck pain, the shoulder pain, it’s pretty much gone. I really appreciated the opportunity to try and see if it was good for me.

The upright position and angle when holding pipettes is a key factor for Rowley, as he elaborates, “It’s not lying on the bench, it’s sitting on the bench. So you don’t have to dig underneath to grab it, and it’s less likely to be knocked over. The overall design and the ability to pipet with your arms at a right angle rather than straight up with your hand over your shoulder – for me this is by far the best feature.

“My main reason for researching a new type of pipette was my own health,” Rowley continues. “And then I thought, ‘Well, if it affects me that much, then when I start my new lab, I’m going to make sure I have that brand of pipettes. Because they just made such a difference for me, I know it makes a difference for my students. I’ve had students who left my lab and had to use regular pipettes to complain. They say, ‘Wow, we really appreciate the Ovations now that we’ve left them behind.’ They now go to another lab and have to use regular pipettes and they notice the difference.

You can read more about Dr. Rowley’s lab work and citizen science projects here>>

Undergraduate awards given to seven students for their academic achievement

0

Princeton University celebrated the academic achievements of its students by awarding four undergraduate awards to seven students during commencement exercises on Sunday, September 4.

“We are especially proud of these exemplary university students and happy to celebrate their academic achievement,” said College Dean Jill Dolan. “They have worked diligently on their studies, while demonstrating how to make the most of the many opportunities Princeton offers its undergraduate students. They offer rich and varied study programs and exemplify how you can be a successful student and a productive, well-rounded citizen of the University. My colleagues and I are satisfied with their accomplishments and proud of their commitments.

Princeton undergraduates honored for their academic achievements during commencement exercises gather with President Christopher L. Eisgruber (back row, center) and College Dean Jill Dolan (far right). The students are (front row, from left) Lucy Ann Sirrs, Arya Maheshwari, Yuri Yu and Aleksa Milojević, and (back row, from left) Beatrix Bondor, Casey Beidel and Brendan Kehoe.

Freshman First Honor Award

This year’s top freshman honor award is shared by Arya Maheshwari and Zhihan (Yuri) Yu. The award is given to members of the sophomore class in recognition of outstanding achievement during the first year.

Maheshwari, from Los Altos, California, attended Harker School in San Jose, California. He plans to major in mathematics and obtain certificates in Computer Applications and Applied and Computational Mathematics. He is a Fellow of Whitman College.

This summer, he was a software engineering intern at Two Sigma, a financial sciences company in Houston, along with nine other rising sophomores from around the country.

Yu, of CantonChina, participated the Affiliated High School of South China Normal University in Guangzhou. She plans to major in Comparative Literature and earn certificates in Gender and Sexuality Studies, East Asian Studies, and German. She is a Fellow of Rockefeller College.

This summer, Yu remained on campus and conducted an independent research project on early 20th-century Chinese poetry and the third-person Chinese feminine pronoun, with funding from the Office of Undergraduate Research. She was mentored by Alexis Ferguson, a Princeton graduate student in the English Department and Gender and Sexuality Studies program. Yu also studied German language and culture with German lecturer Adam Oberlin through the Princeton-in-Munich virtual program.

The George B. Wood Legacy Sophomore Award

This year, the George B. Wood Legacy Sophomore Award is shared by Casey Beidel and Brendan Kehoe. The award is given annually to members of the junior class in recognition of their outstanding academic achievements during the second year.

Beidel, of Rutherford, New Jersey, attended Bergen County Academies in Hackensack, New Jersey. He is studying sociology and is also working on certificates in American Studies, Gender and Sexuality Studies, and Musical Theatre.

This summer he completed a PICS internship in fundraising and development at New Door Ventures, a San Francisco nonprofit organization that strives to provide young people currently disconnected from education and employment with internships, jobs , workshops and paid courses. He is a Fellow of Mathey College.

Kehoe is of South Glastonbury, Connecticut, where he attended Glastonbury High School. He majors in electrical and computer engineering and plans to pursue certificates in linguistics, robotics and intelligent systems.

He has been an outdoor action leader during freshman orientation in 2021 and 2022 and has helped lead the Princeton Model Congress since his freshman year in college and will be program director this year. A member of the Princeton Racing Electric team, he is also involved with Princeton University Players and will serve as stage manager for some of the student-run ensemble’s shows this year. He is a member of Forbes College.

This summer, Kehoe completed an internship at the High Meadows Environmental Institute with the Sustainable Cements Group, led by Claire White, associate professor of civil and environmental engineering and at the Andlinger Center for Energy and the Environment.

The George B. Wood Legacy Junior Award

This year, the George B. Wood Legacy Junior Prize is shared by Beatrice Bondor and Lucy Sirrs. The award is given to members of the senior class in recognition of their outstanding academic achievements during the junior year.

Bondor, from New York, attended the Horace Mann School there. A member of New College West, she majors in English and is pursuing certificates in French language and culture, creative writing (poetry), and European cultural studies.

For her graduation thesis, she is the writing of a collection of poems, advised by Michael Dickman, lecturer in creative writing and at the Lewis Center for the Arts. The collection will tell the story of Virginia’s founding period and cultural collisions.

Outside of the classroom, Bondor is co-chair of the Orange Key Student Tour Guides, campus tours ambassador with the Office of Admissions, editor of the Nassau Literary Review, member of the Behrman Undergraduate Society of Fellows, and Fellow of the Pre- Law Society.

This summer, she studied at Lincoln College, University of Oxford as a Bread Loaf Fellow in the English Department at Princeton, including taking a pro-thesis research seminar directed by Autumn Womack, assistant professor of African-American studies and English.

Sirrs, from Missoula, Montana, attended Hellgate High School in Missoula. A member of Mathey College, she majors in neuroscience and is pursuing certificates in gender and sexuality studies and dance.

She spent her summer on campus working on her graduation thesis, which examines how hormones, specifically testosterone, affect social and antisocial behavior in mice in a variety of different contexts. Sirrs conducts her research in the lab of Annegret Falkner, Assistant Professor of Neuroscience, under the mentorship of Eartha Mae Guthman, Postdoctoral Research Associate.

Outside of the classroom, she previously served as president of the student-run Princeton University Ballet and is a member of the student-run eXpressions Dance Company. She is a mentor with the Princeton Chapter of Ballet and Books, a non-profit organization that teaches young children to read through the combination of dance and storytelling.

Class of 1939 Scholar Award

Alexa Milojevic received the Princeton Scholar Award for the Class of 1939, which is awarded annually to the undergraduate who, at the end of the junior year, has achieved the highest academic standing for all previous college work at the university.

Milojevic, from Belgrade, Serbia, attended the Mathematical Grammar School there. Co-winner of the Freshman First Honor Prize in 2020 and recipient of the Shapiro Award for Academic Excellence for the 2019-2020 academic year, he is a major in mathematics.

His graduation thesis is on number theory. His adviser is Peter Sarnak, Eugene Higgins professor of mathematics.

Outside the classroom, Milojevic is involved in directing and organizing the Princeton University Math Contest, a math contest written by Princeton undergraduates and hosted by high school students across the United States and abroad. He is a member of Mathey College.

Disease expert says COVID testing isn’t as important as immunity

0

A program to order free COVID-19 tests from the federal government was suspended on Friday as funding for the program ended. But an infectious disease expert says mass testing isn’t as necessary as immunity.

A program to order free COVID-19 tests from the federal government was suspended on Friday as funding for the program ended. But an infectious disease expert says mass testing isn’t as necessary as immunity.

“Most experts have, at this point, said mass testing is unlikely to make a difference,” said Dr. Monica Gandhi, an infectious disease physician and professor at the University of California, San Francisco School of Medicine. Francis. “It’s not as important to collect data on mass testing, as it was in the beginning.”



She said he should stay home if he had symptoms of COVID, but public health’s focus, at this point, is on immunity.

“Before that, we had to do mass testing because we had no immunity. We had no vaccine, our elderly populations were at high risk of getting sick,” Gandhi told OMCP.

“After vaccines, the whole point is to try to give us, not an external way to protect ourselves – like a mask or a test – but an internal way, which is immunity,” she said. declared.

“And that’s what we get. We get it from a natural infection. We get it through safer vaccination.

She says, especially for older people, the best next step is to get the new boosters that target omicron BA. 5 and BA. 4 variants to maintain immunity.

On Thursday, the CDC approved the updated boosters which they say will provide immunity against the omicron strain, which is the dominant strain circulating in the world.

“Our old boosters are directed against what we called the ancestral or original strain, sometimes called the Wuhan-Hu-1 strain. That strain is gone,” Dr. Gandhi said.

The CDC said that because they are obsolete, old vaccines will no longer be given as a booster. They will always be used for the initial dose.

“We don’t have any clinical data on these boosters because the FDA said, ‘You don’t need to give me clinical data. Just tell me if the antibodies are increased, if you give a booster BA 5 “, she said. “So they did studies in mice and the BA 5 antibodies are very high.

Gandhi said people over the age of 60 are most at risk of serious illnesses and still benefit the most from these boosters.

“Older people always, in infectious diseases, need reminders, need more protection,” she said. “So I would focus on that population over 60.”

She pointed to a recent study that shows 80% of American children have been infected with COVID at least once.

“They don’t need boosters over and over again because they have a young immune system,” Dr. Ghandi said.

The Washington, DC Department of Health said omicron boosters and the seasonal flu vaccine will be available Sept. 7 at COVID centers across the city.

In Maryland, the new omicron-focused boosters are already positioned statewide for deployment after Labor Day.

Virginia has ordered 141,700 doses of the new vaccines that will be shipped to local health districts. Residents can enroll at Vaccinate.Virginia.gov, contact their call center at 877-829-4682, or ask their health care provider.

“I Took Spirulina Every Morning and Here’s What Happened”

0

I’m not one for supplements. I hate pills, am suspicious of drugs and pharmaceutical companies and believe in getting my nutrients the old fashioned way, by eating plant-based foods such as fruits, vegetables, beans, nuts , seeds and whole grains. But when the folks at Fresh Farm sent me a large box of spirulina cubes (essentially frozen iced cubes of dense spirulina algae), I decided it wasn’t about popping a similar powdery substance to a vitamin, but a natural way to figure out if spirulina is worth all the hype.

What is Spirulina?

Spirulina is a blue-green algae (also known as cyanobacterium), Spirulina is a potent source of the powerful antioxidant phycocyanobilin which helps fight aging and inflammation in the body.

Spirulina is also nutrient dense, containing 10% more protein than another popular algae, chlorella, and contains all 9 essential amino acids your body needs for optimal functioning.

Spirulina is a good source of heart-healthy omega-3 and omega-6 fatty acids, which most people who don’t eat fish need to get from other plant sources such as seaweed, nuts, and beans. seeds. One tablespoon (or 7 grams) of spirulina provides about 1 gram of omega-3 and omega-6 fatty acids.
Read more: The health benefits of spirulina and chlorella

Is spirulina good for you?

Spirulina is known to have multiple health benefits. It can reduce inflammation in the body, which helps reduce everything from joint pain to all sorts of side symptoms, from bloating to clearing up your skin.

By reducing inflammation, spirulina makes everything work better while providing your body with the nutrients and powerful antioxidants it needs to function optimally. Spirulina has virtually no calories, helps boost immune function, sharpens your brain power, and promotes clear skin.

Spirulina has also been shown to help lower cholesterol, so if your “bad” cholesterol is a bit higher than your doctor would like, tell them about a study that showed people who took 1 gram of spirulina per day reduced their LDL cholesterol (the type at risk) and their triglycerides by more than 16%.

Other benefits of spirulina: It has been shown in scientific studies to help control blood sugar, lower blood pressure, fight sinusitis and increase endurance strength.

In a potentially exciting human study, tobacco chewers with precancerous oral lesions who took 1 gram of spirulina daily performed better than those who took a placebo. Among those who took spirulina, 20 out of 44 saw their lesions disappear, while in the placebo group, only 3 out of 43 had similar results. The effects mean that spirulina could be considered a natural chemopreventive therapy, the authors wrote, although more of these studies are needed.

Read more: The health benefits of spirulina and chlorella

Spirulina nutrients

One tablespoon (about 7 grams) of spirulina powder contains:

  • 4 grams of protein
  • 11 percent of your RDA for vitamin B1
  • 15 percent of your RDA for vitamin B2
  • 4 percent of your RDA for vitamin B3
  • 21% of your RDA for copper
  • 11% of your RDA for iron
  • Magnesium, potassium and manganese

Spirulina is full of antioxidants, including phycocyanin which gives it its blue-green color, which is difficult to dilute, even in a smoothie. These antioxidants are anti-inflammatory and have been proven to also help fight oxidation or aging that puts stress on cells. It has even been shown to be neuroprotective and to improve brain function in laboratory animals. What does this mean for humans? By helping to reduce inflammation, reduce cell damage, and keep your brain sharp, you can consider spirulina in your morning smoothie to be the fountain of youth.

I found that when I took spirulina in the morning, even if I ate chips or sweet or salty snacks later in the day, my body retained the energy levels and anti-inflammatory qualities when I wasn’t eating. no junk food (which makes me tired and puffy). So you can think of spirulina as “nutritional insurance” to make sure you’re getting the nutrients your body needs, and it can help mitigate any bad choices you might or might not make later in the day (j fully admit that this applies to me!).

I took spirulina every day. Here is what happened

I made a big blender full of spirulina and fruit, which was big enough to last me for days, then made it again. One day I just drank pure spirulina, which I don’t recommend because it’s such a dark green-blue color and tasteless that it was hard to drink. Here is my Spirulina Smoothie, which I named anti-inflammatory smoothie. Add any fruits and seeds or nuts you have sitting down and try different additions (like spinach or kale). Here’s mine:

Spirulina anti-inflammatory smoothie

  • 1 spirulina cube (about a teaspoon or 5 grams)
  • 1 half cup of blueberries
  • 1/4 cup raspberries
  • 1/4 cup strawberries
  • 1 ripe banana
  • 1 cup oat milk (I chose Malk)
  • 1 big handful of ice cream
  • 1 tablespoon flax seeds
  • 1 ounce of almonds
  • 1 ounce shelled pistachios
  • Optional: 1 scoop vanilla plant protein powder. (I used Venus Williams’ Happy Viking)

Pulse in your blender until completely blended. That was enough for four days. I refrigerated the rest, then made a new batch on day five. The particularity of spirulina is that it is an antioxidant, so it keeps longer than most foods that could spoil in less time.

Day 1. Clearer skin

After weeks of battling a cheek and chin rash (blame my phone or the sun or my bad habit of finding these blemishes with my fingers while reading but they wouldn’t go away) my pimples subsided and started to disappear. It also has a way of making me leave them alone. If they don’t hurt me, I don’t touch them. I credit the anti-inflammatory aspect of my spirulina smoothie.

Day 2. No more joint pain

My races have been a miserable drudgery of hot, humid and knee-aching endurance competitions. The hardest part was not walking and keeping running due to pain in my left knee, which has been a problem since knee surgery from a skiing accident half a lifetime ago. When I eat well and avoid all sweets and dairy products, my knee stays well unswollen. But the spirulina seemed to target the problem area outside the joint where the pain often occurs in the form of a sharp, stabbing thunderbolt in the knee with every step. Nothing. No excuse not to keep running. My race was fun, and the only difficult part was my lack of fitness!

Day 3. More energy even after a snack

I call it “nutritional insurance”, but you can call it a bargain: I know that if I eat potato chips or oatmeal, even sugary non-dairy treats, it often leaves me with fatigue, bloating and, of course, regretting my momentary decision to turn myself in. Okay, I still felt some of that regret, but none of the other usual symptoms. Was it the spirulina? You can’t be sure, but my energy stayed high and my body had no apparent ill effects from the snack attack. Okay so maybe it wasn’t the healthiest choice but we all have to live a little! Crisps and ice cream can be plant-based and aren’t your healthiest choice either! I decided that spirulina had saved me and I got back on track!

On day 4 I decided I’m “all-in” when it comes to spirulina

When I tried these little mini experiments in the past I couldn’t wait for them to be over and stop having to eat or drink the nutritious foods or drinks I was trying to put my body first. nutrition journalism. Not this time. I’m “all in” when it comes to taking spirulina daily. I want to try the powder and put it in my smoothie and other drinks because the one thing I don’t always like is eating or drinking a heavy meal in the morning or even a smoothie. So I will try new ways daily to introduce spirulina into my body. Why not? If it works this fast and efficiently, I know I need all the nutrients it gives me.

What to Look for in Spirulina

Instead of just buying pills or powders, which can contain fillers, gels, and other unwanted ingredients, look for spirulina that only has one ingredient, like the frozen cubes I tried. , made by the New Farmers, a Brooklyn-based company that specializes in frozen spirulina cubes. They ship them to your door and you keep them frozen until you want to use them. The powdered type of spirulina has been dried and ground, so if you want something closer to how it occurs in nature, give these a try. You can order them from New-Farmers.com.

Bottom Line: Spirulina in the Morning Reduces Inflammation Throughout the Day

If you have painful joints or persistent pimples, try taking spirulina in the morning and see if these symptoms go away. It could be a sign of chronic inflammation from eating or drinking foods that cause cell inflammation like dairy, meat, sugar, or packaged foods. Spirulina contains nutrients your body needs and antioxidants to fight inflammation and it works.

For more reviews, visit Beet Herbal Products articles.

Indian-born professor named ‘Emerging Leader in Health and Medicine Scholar’

0

Houston, Sept. 4 (PTI): Indian-born Swathi Arur, professor and vice president of genetics at the University of Texas MD Anderson Cancer Center, has been selected as one of the emerging leaders in health and medicine 2022 by the National Academy of Medicine (NAM).

Arur is the first MD Anderson faculty member to be named to this prestigious group since its inception in 2016.

Her passion for improving health was evident from her undergraduate studies at the University of Delhi in 1991-1994, where she started a non-governmental organization focused on providing better health care to children living with HIV. HIV.

She received her PhD in microbiology from the Indian Institute of Medical Sciences in 2001 and continued her postgraduate studies at the University of Connecticut, where she led efforts to integrate quantitative mass spectrometry into cell cultures in apoptosis research, one of the first examples of this advanced technology in proteomics.

“We are delighted to have Dr. Arur recognized by the National Academy of Medicine for his extraordinary contributions and leadership in the life sciences,” said Peter Pisters, President of MD Anderson. “His passion, expertise and fundamental work in advancing cancer metastasis research are invaluable to our institution, and we applaud his selection to this exemplary group of researchers.” The NAM Emerging Leaders Forum, to be held in Washington, D.C. on April 18-19, 2023, will allow these scholars to engage in interdisciplinary discussions among the nation’s emerging leaders in health and medicine. ELHM Fellows will also help shape NAM’s priorities by focusing on pressing medical challenges, improving health policy, and increasing equity for all.

“We don’t inherit a perfect world. Instead, the world is more often the product of our actions and what we pay for and leave behind,” Arur said. “Being named an Emerging Leader is not only an honor, but it also gives me the opportunity to work with and learn from global leaders in health and medical policy who are constantly striving to make the world a better place. ” Arur has received numerous accolades to date, including 2016 MD Anderson Presidential Fellow, 2017 Andrew Sabin Family Fellow, 2018 Distinguished Faculty Mentor, and 2022 Honored President for Education and Advancement. mentoring.

In 2020 Arur was elected a Fellow of the American Association for the Advancement of Science. She currently serves on the board of directors and is chair of the awards committee of the Genetics Society of America.

She is a permanent study member of the Cellular, Molecular, and Integrative Reproduction Study Section of the National Institutes of Health (NIH) and editor of Development. She is also co-chair and chair of the Gordon Research Conference in Developmental Biology in 2023 and 2025, respectively.

NAM, founded in 1970, is an independent organization of professionals advising the entire scientific community on critical health issues.

The Emerging Leaders in Health and Medicine (ELHM) program was launched to increase the academy’s engagement with outstanding early and mid-career interdisciplinary professionals in biomedical sciences, population health, healthcare , health policy and other related fields. PTI SHK IJT

(This story is published in the auto-generated syndicate feed. No edits have been made to the title or body by ABP Live.)

This Brain Supplement Provides Daily Nourishment and Lifetime Support

0

Citicoline, a neuronutrient hero, supports healthy levels of important neurotransmitters, namely dopamine, norepinephrine and acetylcholine.* These neurotransmitters are known to support mental processes such as clarity and focus.

Citicoline has also been shown by research to support Warning, processing speedand mental energy by increasing ATP in the brain (i.e. supporting the brain’s energy stores).*

In addition to citicoline, resveratrol, an antioxidant phytonutrient, has vasoactive properties and has been clinically shown to support blood flow to the brain and cerebrovascular health.* Improved cerebral blood flow means optimized delivery of oxygen and nutrients to my brain, supporting a clear head and overall cognitive function. (Yes please.)

The clarity and mental energy that head guard + helps me fight pesky mind fog which arises on occasion and stay on top of my productivity and performance.*

In addition to the impressive multi-dimensional cognitive performance support, I have noticed that my mood balance has never been better.

These positive mood-supporting benefits are due to kanna, a fascinating nootropic plant native to South Africa. Kanna book synergistic double action on the central nervous system, supporting cognitive function (including cognitive flexibility and executive function) and emotional processes in the brain.*

I find myself noticeably more relaxed and balanced throughout the day, but still feel mentally sharp. I will take a little zen with my mental clarity every day.

The victim of an offense faced with “imminent” harm may sue, 3rd Circ. Said

0
By Dorothy Atkins (September 2, 2022, 9:27 p.m. EDT) — The Third Circuit on Friday revived the class action lawsuit proposed by a former employee of ExecuPharm Inc. alleging that the research-based pharmaceutical company’s negligence led to a data breach that had leaked his private information on the dark web, believing that the “imminent” risk of impersonation of the employee gives him standing to file a lawsuit.

In a previous opinion, a unanimous three-judge panel found that Jennifer Clemens’ emotional distress and the money she spent on credit monitoring services to prevent identity theft following the data breach of ExecuPharm in which hackers published its information on the dark web are sufficient to establish concrete harm for permanent Article III…

Stay one step ahead

In the legal profession, information is the key to success. You need to know what’s going on with customers, competitors, practice areas and industries. Law360 provides the intelligence you need to stay an expert and beat the competition.

  • Access to case data in articles (numbers, filings, courts, nature of lawsuits, etc.)
  • Access to attached documents such as briefs, motions, complaints, decisions, motions, etc.
  • Create custom alerts for specific article and case topics and more!

TRY LAW360 FREE FOR SEVEN DAYS

General Atomics wins contract for continued EMALS and AAG evaluation of French next-generation aircraft carrier

0

SAN DIEGO – September 02, 2022 – General Atomics Electromagnetic Systems (GA-EMS) today announced that it has been awarded a contract from the U.S. Naval Air Systems Command (NAVAIR) to continue the development and evaluation of bespoke configurations of the Electromagnetic Aircraft Launch System ( EMALS) and Advanced Arresting System (AAG) as a potential foreign military sale to the French Navy for their next-generation aircraft carrier, Porte-Avions Nouvelle Génération (PA NG).

“We are proud to support the ongoing efforts between our nations to realize the potential of integrating EMALS and AAG on board the future flagship of the French Navy,” said Scott Forney, President of GA-EMS. . “For decades, French and American Charles de Gaulle Nimitz-class the carriers provided interoperable capabilities to conduct joint operations and launch and recover aircraft from each other’s ships. EMALS and AAG aboard French and American next-generation aircraft carriers will provide increased interoperability between our navies and greater flexibility to launch a wider range of current and future aircraft for decades to come.

GA-EMS will continue to evaluate optimal EMALS and AAG configurations for performance and document ship interfaces and impacts on PA NG. The contract will end in 2023 with a review of system requirements and an assessment of French suppliers for the potential manufacture of components in France.

In previous contract awards over the past two years, GA-EMS has participated in carrier studies to investigate the feasibility of implementing EMALS and AAG for future French carrier design. In December 2021, the US State Department announced that it had approved a possible Foreign Military Sale for a two-EMALS, three-AAG configuration to France.

The first of the class USS Gerald R. Ford (CVN 78) recently completed its 10,000th successful launch and arrested landing using EMALS and AAG. The systems continue to operate successfully as CVN 78 prepares for its next deployment. GA-EMS is currently under contract with the Navy to support CVN 78 sustainment requirements and is providing EMALS and AAG for the next two Ford-class carriers currently under construction, John F Kennedy (CVN 79) and Company (CVN 80). GA-EMS is also working with the Navy to determine EMALS and AAG contract and schedule requirements for the fourth Ford-class aircraft carrier, Doris Miller (CVN 81).

About Atomic General Electromagnetic Systems
The General Atomics Electromagnetic Systems Group (GA-EMS) is a world leader in the research, design and manufacture of unique electromagnetic and electrical power generation systems. GA-EMS’ history of research, development and technology innovation has led to an expanding portfolio of specialty products and integrated system solutions supporting aviation, space systems and satellites, missile defense, energy and power, as well as processing and monitoring applications for critical defense, industrial and commercial customers worldwide. For more information, visit www.ga.com/ems

Media Contact
[email protected]

American Society for Cell Biology Announces 2022 Honorary Awards and Recognition

0

Newswise — The American Society for Cell Biology (ASCB) recognizes 18 outstanding individuals for their diverse achievements in the life sciences.

“The ASCB Honors Awards recognize individuals who make significant contributions to our community,” said ASCB CEO Rebecca Alvania. “The Society honors those whose research significantly advances our understanding of the cell, whose dedication to education and mentorship in cell biology prepares the next generation, whose commitment to public policy helps make advancing biomedical research and whose achievements in creating inclusive scientific cultures ensure continued progress. in developing a more equitable and diverse community of cell biologists.

The following individuals have been recognized either by receiving an honorary award or by being invited to present a keynote or lecture.

ASCB will feature the profiles of some of these winners on its website in the coming months. The ASCB will mention the winners throughout the Cell Bio 2022 meeting, December 3-7, at the Walter E. Washington Convention Center in Washington, DC.

E. B. Wilson Medal: Presented to distinguished researchers for their considerable contributions to cell biology over a lifetime of science.

Don W. Cleveland: Head, Cell Biology Laboratory, Ludwig Institute for Cancer Research, Emeritus Professor and Chair of the Department of Cellular and Molecular Medicine, University of California, San Diego

Bruce Alberts Award for Excellence in Science Education: Awarded to an individual who has demonstrated innovative and sustained contributions to science education, prioritizing the national impact of the nominee’s activities.

David J. AsaiSenior Director, Science Education, Howard Hughes Medical Institute

EE Just Conference: Tribute to early 20th century biologist Ernest Everett Just, who made seminal contributions to cell and developmental biology, to recognize outstanding scientific achievement by an American researcher from a historically excluded racial or ethnic group. Recipient selected by the Minority Affairs Committee.

Renato J. Aguilera, Deputy Research Director of the Border Biomedical Research Center (BBRC); Director of the Cellular Characterization and Bioreserve Unit of the Research Infrastructures of the BBRC; director of the graduate program in biological sciences; Director of the U-RISE and G-RISE NIH training programs at the University of Texas, El Paso

Keith R. Porter Lecture: Named in memory of Keith R. Porter and presented to an outstanding and innovative leader at the forefront of cell biology, actively contributing new knowledge fundamental to our understanding of cell biology.

Juan S. Bonifacino, Associate Scientific Director, Neurosciences and Cellular and Structural Biology Division; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health

Sandra K. Masur Senior Leadership Award: Awarded by the Women in Cell Biology Committee (WICB) to any late-career scientist with outstanding scientific achievement and active leadership in mentoring women and people from underrepresented groups.

Rebecca HealdProfessor, Co-Chair, Department of Molecular and Cellular Biology, University of California, Berkeley

WICB Junior Award for Research Excellence: Presented to an early-career female or non-binary individual making outstanding scientific contributions to cell biology, developing a strong independent research program, and exhibiting the potential to pursue a high level of scientific endeavor and leadership.

Shirin BahmanyarAssociate Professor, Department of Molecular, Cellular and Developmental Biology, Yale University

Excellence in Inclusion Award: Recognize a scientist who has a strong research background or plays a critical role in advancing cell biology research and who has demonstrated the importance of inclusion and diversity in science through mentorship, change cultural, outreach or community service. A grant from the Howard Hughes Medical Institute funded this award.

Needhi BhallaProfessor of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz

Public Service Award: Honor national leadership and outstanding public service in support of biomedical research or the promotion of sound research policy. Recipient selected by the Public Policy Committee.

George LangfordProfessor Emeritus of Biology, Syracuse University

Mentoring talk: A guest speaker who exemplifies mentorship through its impact on the training of scientists and scholars from underrepresented groups, especially racial and ethnic minorities. Recipient selected by the Minority Affairs Committee.

John T. MatsuiDirector, Biology Scholars Program and Associate Dean, Biological Sciences, University of California, Berkeley

Diversity Scholarship: A guest speaker selected by the Co-Principal Investigators of the Innovative Programs to Enhance Research Training grant and approved by the Minority Affairs Committee.

Gina GarciaAssociate Professor, Department of Educational Foundations, Organizations, and Policy, University of Pittsburgh

LGBTQ+ Keynote: A guest presenter chosen by the members of the LGBTQ+ Committee.

Erin GoleyAssociate Professor of Biological Chemistry, Director of Admissions, BCMB Graduate Program

Associate Professor of Biological Chemistry, Johns Hopkins University School of Medicine

Günter Blobel Early Career Award: Awarded to an outstanding early career life scientist who has served as an independent investigator for no more than seven years at the time of nomination.

Dorothy A. LeritAssociate Professor, Department of Cell Biology, Emory University School of Medicine

Innovation in research: Recognizes early and mid-career scientists for their new and innovative research in cell biology. For this purpose, innovation is defined as an achievement that has a significant impact on progress in advancing the field of cell biology and is based on work performed in the three years prior to nomination.

Manuel (Manu) LeonettiGroup Leader II, Quantitative Cell Science, Chan Zuckerberg Biohub

Innovation in Education Award: Awarded to an individual who demonstrates innovation in education, defined as a new educational achievement that has a significant impact on the achievement of the ASCB mission. Innovation must be aligned with the core principles of the ASCB Statement on Effective and Inclusive Undergraduate Biology Education.

Jayme DyerAssistant Instructor in the Department of Biology, Durham Technical Community College

Merton Bernfield Memorial Award: Created to honor outstanding postdocs or graduate students with membership donations in memory of pediatrician and cell biologist Merton Bernfield.

Jaye GardinerPostdoctoral Research Associate, Fox Chase Cancer Center

Porter Prize for Excellence in Research: Two prizes, one awarded to a graduate student and one to a postdoctoral researcher selected on the basis of scientific excellence. In the spirit of Keith Porter, the focus will be on their contributions to the advancement of science and on the novelty and creativity of their discoveries.

Ben T Larsonpostdoctoral researcher, University of California, San Francisco

Saket Rahul BagdePhD Student, Institution or Organization Affiliation: Department of Molecular Biology and Genetics, Weill Institute of Cellular and Molecular Biology, Cornell University

Molecular Biology of the Cell Paper of the Year Award: Awarded to the first author of a paper (graduate student or postdoctoral fellow) chosen by the editorial board of the ASCB Journal of Basic Science Research, Molecular biology of the cellas the best article published from June of the previous year to May.

Vilma Jiménez SabininaCell Biology and Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany

“Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex.” https://doi.org/10.1091/mbc.E20-11-0728

Walmart’s trademark filings show the company’s interest in clinical trials

0
  • Walmart has trademarked “Walmart Healthcare Research Institute” and “My Health Journey”.
  • According to the filings, Walmart wants to conduct clinical trials, compile research and consult for others.
  • The filings come as Walmart tries to meet its ambitious health goals.

Walmart appears to have new ambitions as part of its healthcare expansion.

The Bentonville, Arkansas-based retail giant filed two trademark applications on August 11 – “Walmart Healthcare Research Institute” and “My health journey— which indicate that Walmart hopes to conduct clinical trials to evaluate experimental treatments and therapies at some point in the future.

Both trademark filings contain identical language and include Walmart’s purposes:

  • Provide information on medical and scientific research “in the field of pharmaceuticals and clinical trials”.
  • Conduct clinical trials “for others”.
  • Compile data and provide consulting services to others in research and clinical trials.

It’s unclear how Walmart may use these branded apps and when Walmart might begin conducting clinical trials. A Walmart spokesperson did not immediately respond to a request for comment.

Walmart isn’t the first retailer to enter the clinical trial space. CVS Health announced in May 2021 that it was launching a clinical trial services business to recruit patients, provide decentralized options – including in CVS sites, at home or virtually – and generate retrospective and prospective studies based on the results.

And in June of this year, Walgreens also announced that it would launch a clinical trial company to reach a more diverse set of communities.

Sari Kaganoff, managing director of consulting at Rock Health Advisory, told Insider that the majority of patients who enter clinical trials are usually highly educated, affluent and white. She said retailers entering the space that have many locations across the United States — Walmart has more than 4,700 stores nationwide — will help reach more patients.

Making clinical trials “accessible to a wider range of the population will help get better data and allow people who need this treatment that may not yet be available in the mainstream to do so,” he said. said Kaganoff.

Clinical trials could be part of Walmart’s growing healthcare ambitions

These trademark filings come as Walmart continues to try to meet its aggressive health goals and outperform other retailers in the space.

Walmart has worked for years to grow its healthcare network, making several acquisitions to bolster its telehealth and pharmacy services and place clinics in four different states to provide affordable care to Americans.

And in 2018, Walmart’s board announced an ambitious plan to open 4,000 clinics across the United States by 2029.

But this plan is progressing slowly so far – the company has open only 24 clinics across Georgia, Arkansas, Florida and Illinois.

Kaganoff said it makes sense for Walmart to get into clinical trials because it’s a money-making business. But to surpass existing players like CVS and Walgreens as well as potential new entrants like Amazonthe retailer will need to continue to strengthen its primary care offering and educate the public that Walmart can be a top destination for health care, she said.

“I imagine Walmart will have to really prove itself to a trusted medical provider rather than a fairly cheap place to get checked out,” Kaganoff said.

Do you work at Walmart or do you have ideas to share? Contact reporter Ben Tobin through the Signal +1 (703) 498-9171 encrypted messaging app or by email at [email protected] Check Insider’s Guide to Sources for more tips on sharing information securely.

NeoImmuneTech to Present NT-I7+ Immune Checkpoint Inhibitor Results at SITC

0

NeoImmuneTech said it will report interim results from a trial of NT-I7 (efineptakine alfa), a T-cell enhancer, in combination with an immune checkpoint inhibitor at the annual meeting of the Society for Immunotherapy of Cancer (SITC) in the United States. in November.


NeoImmuneTech’s study has been selected for an oral presentation at the “Next-Generation Cytokine Therapy” session of the SITC event.


NeoImmuneTech is to present interim results from a study of NT-I7 (efineptakine alfa) in combination with an immune checkpoint inhibitor to the Society for Immunotherapy of Cancer (SITC) in the United States in November.


Researchers will share their knowledge of notable cytokines as cancer treatments during the session.


Topic and explicit content will be revealed after October 5, when SITC 2022 opens abstract topics.


The SITC annual meeting will be held November 8-12 in Boston, US NeoImmuneTech will provide the oral presentation for 15 minutes starting at 4:20 p.m. on November 11.


NT-I7 has demonstrated therapeutic potential in refractory diseases such as pancreatic cancer and stable microsatellite colon cancer, where immune checkpoint inhibitors alone have not produced good results.


NeoImmuneTech’s NT-I7 was selected for a poster discussion session at the American Society of Clinical Oncology meeting in June.


The company said NT-I7 showed a disease control rate (CDR) of 40.7% and 34.6% in MSS pancreatic and colon cancer, respectively. Additionally, the company stated that tumor size decreased by 100% and 72% in two patients with pancreatic cancer, suggesting that NT-I7 will prolong the survival of patients with pancreatic cancer. cancer, the company said.

A 10 GW/ha solar power plant was inaugurated in Ain Sokhna

0

Mohamed Shaker, Minister of Electricity and Renewable Energy, on Tuesday inaugurated a solar power plant, with a production capacity of 10 GW/h per year, at the Chinese fiberglass factory Jushi in the northwest from the Gulf of Suez Economic Zone, to Ain Sokhna.

The project was implemented through a partnership agreement between Jushi and Inara Capital, a leading company in the field of renewable energy, which is one of the economic zone’s partners in green hydrogen projects.

Minister Shaker said that great efforts are being made by the ministry and in coordination with various authorities in this regard to implement the strategy of the Egyptian state in the electricity sector and achieve the target of 42% electricity. energy produced from renewable sources, including solar and wind, in 2035.

The Minister added that the State pays great attention to these projects and cooperates with neighboring countries in the electricity interconnection, in particular what is currently happening between Egypt, Greece and Italy, which confirms that Egypt is a promising market in this area.

He pointed out that the signing of a memorandum of understanding for green fuel projects between the Suez Canal Economic Zone, companies affiliated to the Ministry of Electricity and the Sovereign Wealth Fund of Egypt will help accelerate the pace of construction of energy projects, in conjunction with Egypt’s hosting of the climate change summit (COP27).

Walid Gamal El-Din, head of the Suez Canal Economic Zone, said the project is in line with the implementation of political leaders’ directives towards the use of clean energy and within the framework of the the Suez Canal Economic Zone to locate renewable energy industries, in addition to motivating development partners and investors to invest and harness new and renewable energy in their project extensions to realize our vision of the whole transformation of this type of energy.

Sherif El-Gabaly, Chairman of Inara Capital, said that the project is the start of the optimal exploitation of the potential of the economic zone in the production of clean and renewable energy, and he thanked all the institutions concerned who have facilitated this project with our Chinese partners. find this optimal way.

Wu Ping, general manager of Jushi Egypt, said the plant is the largest among Chinese investments in Egypt, as it includes 3 production lines with a production capacity of 200,000 tons per year and provides 2,500 jobs. . It is also one of the largest fiberglass production projects, as it earns revenues of more than $220 million per year with an export value of around $200 million per year.



New labeling approach lets look at the packages cells send out for insight into health

0

Dr. Sang-Ho Kwon (center) and his research team. Credit: Michael Holahan, University of Augusta

Our cells are constantly communicating, and scientists have developed an efficient way to discover the messages they send in biological suitcases filled with proteins called exosomes.

These spherical exosomes, which reside in the inner membrane of a cell but will eventually make their way to another cell, carry large molecules like proteins, a building block of the body and engines of biological activity, and the RNA, which produces proteins.

“It’s an ongoing process,” says Dr. Sang-Ho Kwon, a cell biologist in the Department of Cell Biology and Anatomy at Augusta University’s Medical College of Georgia, and he’s increasingly more evident that it occurs both in states of health and disease.

“We’re trying to figure out this puzzle of what exosomes are doing in different scenarios,” Kwon says. He is the corresponding author of a study in the Extracellular Vesicles Journal detailing a tagging technique he and his research team have developed to analyze the contents of exosomes from any specific cell type to better understand their role in wellness and disease.

“Their contents can help us tell what our cells are telling themselves,” Kwon says, and likely provide early clues that we’re getting sick and help us better understand how we get sick.

Cargo is thought to be loaded early in the formation of exosomes by their precursor endosomes, near the cell membrane, which function much like filling the mail truck at the post office before it sets off. The exosomes will stay there until they are released by the cell to travel to other cells.

Kwon and his team wanted to catch the cargo early in the process.

Currently, the main way to study the contents of exosomes is to first take the exosomes out of their context, to isolate them, a rather laborious process that can lead to inconsistent results. In fact, it can isolate a different type of vesicles, basically from biological compartments in our body of which exosomes are just one type.

The MCG team has developed a more efficient method that allows studying only the contents of exosomes, and studying where they are.

Their tagging system includes a variant of APEX, or ascorbate peroxidase, which is fused to another protein known to search for exosomes. “APEX is kind of the missile that gets me inside,” Kwon says. APEX has a strong affinity for biotin, a B vitamin, which binds to neighboring proteins, such as those carried by the developing exosome, marking them and thus helping to identify them. Biotin can also cross the cell membrane behind which the exosomes are located. Another protein, streptavidin, which naturally binds to biotin, allows them to purify and clearly identify the protein cargo as well as the RNA that will produce the future proteins, using analyzes provided by spectrometry of mass.

Kwon focuses on kidney damage, and they used their system to show that oxidative stress, a byproduct of oxygen utilization, which is excessive and destructive in disease states, alters the cargo content of exosomes made by kidney cells and found in urine. . For example, the expression levels of some proteins changed, and some proteins even disappeared.

Their technique should facilitate the development of databases of the usual contents of a variety of different cell types that will allow comparative studies of what happens to their contents in different disease states such as studies of Kwon’s kidney damage or the cancer.

“It turns out that by looking at exosomes in urine or blood, and looking at what’s inside, we can tell if the cell is injured or healthy,” he says.

Their first use of the labeling system was in live kidney cells in culture. They now want to use it in an animal model of kidney disease.

The science team says the labeling system can further help track changes in exosome content over time and potentially how cells respond to treatment when diseased.

Exosomes are known to play a key role in cell communication, both between cells of the same type and with other types. Again, there is growing evidence of the role exosomes play in disease, including sharing with other cells the news that they are sick and potentially helping to spread disease. “It’s not just about conveying good news. It’s also conveying bad news,” Kwon said.

He notes that their cargo undoubtedly varies in these various scenarios, an important reason for being able to detect what the exosomes are carrying. The changes may ultimately serve as a good way to monitor response to treatment, another aspect of exosome research that is “exploding,” Kwon says. Scientists are also exploring the potential of using exosomes to actually deliver treatment, filling these biological packages with drugs that can be delivered directly to where you want them.

In fact, immune cells, which are essential for health and disease, also release exosomes. These biological compartments also seem to play an important role in the elimination of cellular debris and other waste products from the cells.

“It’s an emerging area right now,” Kwon says. Proteins are the main occupant because they can send signals, but they can also bind to other proteins and change their function, he says. RNA can do the same, and tiny microRNAs can alter gene expression and, therefore, cellular function.

Kwon’s interest in exosomes was sealed when, as a postdoc at the University of California, San Francisco, he cultured kidney tubules, which return vital nutrients to the blood and eliminate unwanted ones in the urine, in a dish and found evidence that exosomes played a key role. role in the evolution of gene dynamics there.

He calls the focus on exosomes “reverse science”, with most people looking at how the cell changes while he and a growing number of colleagues look at the packets the cell sends to understand what the cell is doing. While that might not seem like it to most people, he says it’s actually a less complex way to look at cellular activity because you’re looking at a smaller package with a lot less protein.


Cell ‘exosomes’ could improve cancer drug delivery to tumors


More information:
Byung Rho Lee et al, Ascorbate peroxidase-mediated in situ labeling of proteins in secreted exosomes, Extracellular Vesicles Journal (2022). DOI: 10.1002/jev2.12239

Provided by Medical College of Georgia at Augusta University


Quote: New labeling approach allows packets sent by cells to be examined for insight into health (2022, August 30) Retrieved August 30, 2022, from https://phys.org/news/2022-08- approach-enables-packages-cells-gain .html

This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

Human Health and Boron – EIN Presswire

0

boron human health

Boron is an essential mineral for optimal health and fitness. This nutrient has pleiotropic effects, which can have multiple beneficial effects on the body.

NEW YORK, NEW YORK, USA, Aug. 29, 2022 /EINPresswire.com/ — Boron may also aid in the modulation of various bodily systems. Recently, scientists have discovered boron polymorphisms linked to disease in various species, highlighting the growing importance of this mineral for human health.

Occurrence and Sources of Boron
Boron is a metalloid element that exists in small amounts in the environment. It is an essential micronutrient for plants but can be toxic to animals at high concentrations.

Boron occurs naturally in rocks, soil, water and air – weathering of rocks and volcanic activity release boron into the environment. Plants absorb boron from the soil and concentrate it in their tissues. Animals absorb boron from plants or other animals that have eaten plants.

Most people are exposed to low levels of boron in food, air, and water. Higher exposure levels may occur near certain industrial facilities that release boron to air or use it in manufacturing processes.

How Boron Affects Human Health
Boron is a mineral necessary for human health because it participates in hydroxylation reactions, which are vital for the synthesis and metabolism of various substances. Boron is an effective arthritis treatment that improves bone development in 95% of cases by improving calcium absorption in bones, joints and cartilage. It also impacts many hormones, including testosterone and estrogen. Boron neutron capture agents may help in the treatment of cancer. Boron formulations can also be used to attack breast cancer cells in vitro.

Boron is thought to affect blood clotting. It alleviates the symptoms of congestive heart failure. Boron reduces the accumulation of lipids and allows the elimination of cholesterol in various ways, reducing the risk of developing conditions such as blood clots and atherosclerosis and protecting the body against heart attacks and strokes.

Borates like boron have various inhibitory actions on enzymes, making them useful for cancer, wound healing, and disease control. They also reduce genotoxicity. Additionally, boric acid enhanced the function of acetylcholinesterase, which is suppressed by pesticides and protects the human body from oxidative stress caused by CCL 4 and other agents.

Boron stimulates bone growth
Boron is important for bone development as it contributes to metabolism, bone regeneration, bone formation and mineralization. It is also known to influence various metabolic activities in bone, such as its interaction with magnesium, vitamin D and calcium, which are essential for bone metabolism. This synergistic relationship with Ca and Mg homeostasis contributes to its role in bone strength for human health and well-being.

Aging can lead to bone weakness in porous bones, and boron can help overcome this aggravation by ensuring that calcium and magnesium levels are working properly. Boron stimulates osteoblastic cell activity via the influx of calcium, i.e. calcium fructoborate, which significantly decreases serum C-reactive protein levels, indicating that this unique plant mineral borate preparation improves bone energy and strength by reducing inflammation associated with loss of bone mineral density.

Additionally, boron has been shown to facilitate bone metabolism with proliferation, cell survival, osteoblast protein mRNA expression, and mineralization.

Boron for embryonic development
Pregnant women should pay special attention to their diet, since the fetus is completely dependent on maternal nutrition. This includes trace elements, which are essential for the normal development of the fetus. If these nutrients are not properly passed to the fetus, it can lead to mineral deficiencies that can lead to fetal dysplasia and other irregularities.

Also, newborns who do not receive adequate maternal nutrition during gestation or pregnancy are more likely to be deficient in minerals and other nutrients during childhood.

Many researchers have studied the role of boron nutrition in animal and human health. Nielsen’s “stress model” is a widely used hypothesis that suggests that the lack of one or more nutrients in the diet can lead to negative health outcomes and the effects of boron supplementation on low-fat diets. copper or magnesium levels in the body. In these situations, boron altered the biochemistry of various nutritional indicators, including hemoglobin, blood sugar, platelets, and hormone levels.

Boron is good for brain activity
Boron is an essential element for brain function, and its deficiency causes adverse effects on the central nervous system. Studies of human brain activity have revealed that a lack of boron in the diet leads to reduced electrical activity in the brain.

Boron supplementation (3 mg/day) in participants following a diet containing approximately 0.25 mg boron/2000 kcal for approximately 63 days alters the electroencephalogram, with a tendency to action at lower frequencies and greater interaction at higher frequencies of the dominant frequency spectrum.

Meanwhile, supplemental boron has been associated with better psychomotor skills, less drowsiness, mental clarity, improved short-term memory, and increased attention in older men and women.

Boron and its role in wound healing
Boron is known for its healing properties, as a 3% solution of boric acid has been reported to heal deep wounds. Boric water (pharmacopoeia) was previously known for its antimicrobial properties. Today, borates are used in very low concentrations to treat various wounds and improve human health.

The mode of action of boron in wound healing is associated with the synthesis of proteins, collagen and proteoglycans. Boron also controls the growth of the extracellular matrix, which aids in wound healing by stimulating the expression of proteins, collagen and proteoglycans. It also promotes the release and synthesis of tumor necrosis factor.

Boron for hormone metabolism
Boron is a nutrient that improves steroid hormone metabolism, particularly sex hormone metabolism, by increasing testosterone levels in men and estrogen levels in postmenopausal women. It has also been found that intensive training for two months could reduce testosterone production in non-professional bodybuilders.

Nevertheless, boron supplementation effectively regulates this hormonal level for optimal human health. It can also increase estrogen levels in postmenopausal women, allowing them to regain their sexual energy a few days after starting treatment. Boron can reduce the need for pharmaceutical solutions or hormone replacement therapy by increasing the natural level of sex hormones in the body.

Boron may also ease menopausal symptoms such as night sweats and hot flashes, confirming adequate mineral levels. Postmenopausal women frequently suffer from hormonal imbalances affecting the most important processes in the body.

Boron is key to a healthy immune response
Boron influences immune cell populations in response to other dietary factors, such as fatty acids. A 12-week study in healthy young men found that n-3 polyunsaturated fatty acid (PUFA-3) supplementation at a dose of 6 g/day decreased the number of white blood cells, primarily decreasing the number of granulocytes. As a result, the proportion of lymphocytes in white blood cells increased.

However, the mechanisms underlying boron’s anti-inflammatory or immune response capabilities have been attributed to several factors, including suppression of serine proteases, leukotriene synthesis, decreased oxidative stress, modulation of activity T lymphocytes and the regulation of antibody concentrations.

Boron may help fight cancer
Boric acid positively influences prostate cancer cells to maintain good human health. These anti-carcinogenic properties could be linked to their effects on NAD and calcium channels.

NAD is required for cellular cholesterol and fat production. The movement of Ca++ into and out of cells is also important for cell survival. When NAD/NADP development is interrupted, cell function suffers. Boric acid concentration has been found to affect NAD production and Ca++ secretion in cancer cells.

Borates are beneficial for cancer treatment by inhibiting cell growth and flattening prostate cancer cells. They reduce cytochemicals, MAPKs, and AE cyclins, resulting in cells with weaker adhesion, F-actin changes, invasive activity, and migration. Boric acid inhibits tumor cell proliferation in LNCaP and DU-145 cell lines and strongly inhibits tumor growth.

A note on toxicity
The primary human health concern associated with exposure to boron is its potential toxicity. Boron causes skin and eye irritation and respiratory effects if inhaled. Ingestion of large amounts of boron can lead to gastrointestinal disturbances, diarrhea and vomiting. Severe conditions can lead to coma or death. Long-term exposure to low levels of boron can lead to kidney damage.

Despite these potential human health effects, there is currently no evidence that exposure to boron levels commonly found in the environment poses a significant health risk.

Brendan McMahon
BORATES TODAY
[email protected]
Visit us on social media:
Facebook
Twitter
LinkedIn

Diet can influence mood, behavior and more – says neuroscientist

0

MonicaDus, University of Michigan

During the long sea voyages of the 15th and 16th centuries, a period known as the Age of Discovery, sailors reported seeing visions of sublime food and verdant fields. The discovery that they were only hallucinations after months at sea was agonizing. Some sailors wept with nostalgia; others threw themselves overboard.

The cure for these harrowing mirages turned out to be not a concoction of complex chemicals, as once suspected, but rather the simple antidote of lemon juice. These sailors suffered from scurvy, a disease caused by a deficiency in vitamin C, an essential micronutrient that people acquire by eating fruits and vegetables.

Vitamin C is important for the production and release of neurotransmitters, the brain’s chemical messengers. Without it, brain cells do not communicate effectively with each other, which can lead to hallucinations.

As this famous example from early explorers illustrates, there is an intimate connection between food and the brain, one that researchers like me are striving to unravel. As a scientist studying nutritional neuroscience at the University of Michigan, my primary interest is in how components of foods and their breakdown products can alter the genetic instructions that control our physiology.

Beyond that, my research also aims to understand how food can influence our thoughts, moods, and behaviors. Although we can’t yet prevent or treat brain conditions with diet, researchers like me are learning a lot about the role nutrition plays in the daily brain processes that make us who we are.

It is perhaps unsurprising that a delicate balance of nutrients is essential for brain health: deficiencies or excesses of vitamins, sugars, fats and amino acids can influence the brain and the behavior of negative or positive way.

Vitamin and mineral deficiencies

As with vitamin C, deficiencies of other vitamins and minerals can also precipitate nutritional diseases that negatively impact the brain in humans. For example, low dietary levels of vitamin B3/niacin – commonly found in meat and fish – cause pellagra, a disease in which people develop dementia.

Niacin is essential for converting food into energy and building blocks, protecting the genetic imprint from environmental damage, and controlling the amount of certain genetic products produced. Without these critical processes, brain cells, also called neurons, malfunction and die prematurely, leading to dementia.

In animal models, decreasing or blocking niacin production in the brain promotes neuronal damage and cell death. Conversely, increased niacin levels have been shown to lessen the effects of neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease and Parkinson’s disease. Observational studies in humans suggest that sufficient levels of niacin may protect against these diseases, but the results are still inconclusive.

Interestingly, niacin deficiency caused by excessive alcohol consumption can lead to effects similar to those seen with pellagra.

Another example of how nutrient deficiency affects brain function can be found in the element iodine, which, like niacin, must be acquired from one’s diet. Iodine, found in seafood and seaweed, is an essential building block of thyroid hormones – signaling molecules important for many aspects of human biology, including development, metabolism, appetite and sleep. . Low levels of iodine prevent the production of adequate amounts of thyroid hormones, impairing these essential physiological processes.

Iodine is particularly important for the development of the human brain; before table salt was supplemented with this mineral in the 1920s, iodine deficiency was a leading cause of cognitive impairment worldwide. The introduction of iodized salt is thought to have contributed to the gradual increase in IQ scores over the past century.

Ketogenic diet for epilepsy

Not all nutritional deficiencies harm the brain. In fact, studies show that people with drug-resistant epilepsy — a condition in which brain cells fire uncontrollably — can reduce the number of seizures by eating a very low-carb diet, known as the name of ketogenic diet, in which 80% to 90% of calories are obtained from fat.

Carbohydrates are the body’s preferred source of energy. When it’s not available — either because of fasting or a ketogenic diet — cells get fuel by breaking down fat into compounds called ketones. Using ketones for energy leads to profound changes in metabolism and physiology, including the levels of hormones circulating in the body, the amount of neurotransmitters produced by the brain, and the types of bacteria living in the gut. .

Researchers believe that these diet-dependent changes, specifically the higher production of brain chemicals that can calm neurons and reduce levels of inflammatory molecules, may play a role in the ability of the ketogenic diet to reduce the number of seizures. . These changes may also explain the benefits of a ketogenic state — either through diet or fasting — on cognitive function and mood.

Certain foods can negatively affect your memory and mood.

Sugar, saturated fats and ultra-processed foods

Excessive levels of certain nutrients can also have adverse effects on the brain. In humans and animal models, a high intake of refined sugars and saturated fat — a combination commonly found in ultra-processed foods — promotes eating by desensitizing the brain to hormonal signals known to regulate satiety. .

Interestingly, a diet high in these foods also desensitizes the taste system, causing animals and humans to perceive foods as less sweet. These sensory alterations can affect food choice as well as the reward we get from food. For example, research shows that people’s responses to ice cream in brain areas important for taste and reward are dampened when they eat it every day for two weeks. Some researchers believe that this decrease in food reward cues may increase cravings for even more fatty and sugary foods, similar to how smokers crave cigarettes.

Diets high in fat and processed foods are also associated with reduced cognitive function and memory in humans and animal models, as well as a higher incidence of neurodegenerative diseases. However, researchers still don’t know whether these effects are due to these foods or to the weight gain and insulin resistance that develop with long-term consumption of these diets.

Time scales

This brings us to a critical aspect of the effect of food on the brain: time. Some foods can have an acute influence on brain function and behavior – for example over hours or days – while others take weeks, months or even years to have an effect. For example, eating a slice of cake rapidly changes the fat-burning ketogenic metabolism of an individual with drug-resistant epilepsy to a carbohydrate-burning metabolism, thereby increasing the risk of seizures. In contrast, it takes weeks of sugar consumption for taste and brain reward pathways to change, and months of vitamin C deficiency to develop scurvy. Finally, when it comes to diseases like Alzheimer’s disease and Parkinson’s disease, the risk is influenced by years of dietary exposure in combination with other genetic or lifestyle factors, such as smoking.

Ultimately, the relationship between food and the brain is a bit like the delicate Goldilocks: we don’t need too little or too much, but just enough of each nutrient.

Monica Dus, Associate Professor of Molecular, Cellular and Developmental Biology, University of Michigan

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Walk again or stop blindness. How gene therapy is revolutionizing medicine

0

“It’s something impressive, an absolute revolution for medicine,” he says. Osvaldo Podhajesarmolecular biologist who integrates Leloir Institutewho with their team are almost the only ones to investigate gene therapy in Argentina. These treatments are based on the concept of being able to modify a cell at the genetic level so that a disease can be reversed. A few examples that show how disruptive these treatments are are patients. Spinal muscular atrophy (SMA) those who sit or walk, those who progress to blindness due to Alzheimer’s disease Work and regained vision or those who were somehow healed leukemiaIn this league, where science sheds light on some fictional stories, it’s this type of in-game therapy that represents a unique window to a new opportunity for thousands of people.

One of the possible techniques to perform this type of therapy is described Hernan Martinochief Research scientists from the University Hospital of Australia’s Pediatric Neurology and the Argentine Federation of Rare Diseases (Fedepof)Genetically modified consists in administering genetic material to the patient by means of a viral vector. This modified virus, which also removed the possibility of being pathogenic, is the one that enters the cells and corrects the error.

For its part, Suzanne Baldinimedical director of Argentine Chamber of Medicinal Specialties (Caeme)who, among other topics, spoke about gene therapies at the first meeting of media and pharmaceuticalwhich took place in Mendoza, in which they participated Country, show that the cell nucleus contains chromosomes, which are formed by genes. Since each chromosome has two pairs, it is possible for one or both to be mutated. Dominant diseases require only one copy to be abnormal to develop in the individual, while recessive diseases require both copies to be mutated. And these errors or mutations are what this type of therapy tries to correct.

Speakers at the Medios and Pharma meeting hosted by the Argentine Chamber of Medicinal Specialties (Came) in Mendoza were Juan Manuel Santa María, IQVIA General Manager for South Latin America; Daniel Luna, head of the IT department of the Italian hospital; Lukas Lehtinen, Executive Director of the Masters in Intellectual Property at Universidad Australia; Ruben Torres, Health Practitioners: Susanna Baldini, Keme Medical Director, and Natalia Gandolfi, Keme Access Manager

a little history

Podhajaser Explains that the first clinical trials of gene therapy took place in 1990 and involved genetically modifying the T cells of a young girl with an immune deficiency linked to the ADA (adenosine deaminase) gene. In boys who suffer from this disease, their immune system does not work properly and they must remain isolated. Since then, thousands of clinical studies have been carried out in this discipline, used in congenital metabolic diseases (where the mutated gene is known to be unable to produce normal proteins) and in more complex diseases such as cancer or neurodegenerative diseases . . ,

,Gene therapy has made remarkable progress And those children with ADA gene mutations can benefit from gene therapy and can now lead normal lives with their reorganized immune systems. But advances in gene therapy have occurred not only in this particular disease, but also extend to retinopathy, where people with blindness have regained their vision as if Leber’s congenital amaurosis. In this case, the RP65 gene is directly delivered to the retina. or with friends spinal muscular atrophy Anyone who cannot sit can do so again after receiving specific gene therapy for the mutated gene which is also administered using viral vectors,” he explains. Podhajaser,

amartino Recalls the case of a patient in the late 1990s who was treated for an illness OTC, who had a very severe immune reaction against the vector and died. This has delayed many other research related to gene therapy. However, later studies continued and today the results are generally very successful. Of course he says amartinoThere is not enough time yet to know if these treatments will have an effect for long-term use.

two types of gene therapy

On the one hand, this description amartino, there is in-vivo therapyIn this type of therapy, the viral vector that transfers the gene can be applied directly to the organ or tissue where the disease is most affected.

“Instead, in ex-vivo Stem cells are taken from the patient, we modify them and insert a new gene. Then we reinfect the previously modified cells. It’s like an autograftTo do this, you must first give him chemo and remove all his white blood cells. The use of one type of therapy or the other will depend on the disease of the patient, although there are diseases for which both methods are studied, ”explains the expert.

An example of ex vivo therapy is CAR-T. is used“This is cell gene therapy where cells are taken from the patient and they are genetically engineered so that they can attack the malignant cells. Thus, the patient kills their own cancer. For now, this type of treatment is mainly used for certain types of leukemia.“, he pleads baldin,

Podhajaser warns that the use of Cart It is a treatment that, although it is already used, is very complex. An appropriate laboratory is required to modify these cells with the gene of interest. After modification, the cells are kept in the laboratory for a certain time and reintroduced to the patient. The patient must be close to this laboratory and the cells cannot be shipped from Argentina to the United States because they will not arrive correctly.

another problem of Cartto add Podhajaser Like conventional cancer therapy, the tumor has resistance over time. CAR-Ts are usually directed against a specific protein which they recognize and use to attack the malignant cell. Unfortunately, tumors can reappear from cells that do not express this protein and thus survive treatment.

“The third disadvantage is that Cart They do not work as a sole treatment in solid tumors, which are the most common tumors. And the reasons are simple: they work so well in hematopoietic tumors because they are cells that do not form compact tumor tissue, unlike most cancers. And CAR-T just can’t get into the tumor,” he explains. Podhajaser,

Innovative, but overpriced

“One of the issues with these treatments is the cost. Millions of dollars are invested in research and development for hundreds of rare diseases, but this high level of investment will inevitably make treatments very expensive,” he laments. Express. amartino,

In Argentina, there was a case demonstrating the complexity of obtaining sufficient funding for this type of treatment. Emma, the child who suffered from SMA type 2 and needed US$2,100,000 of drugs from the Novartis laboratory. In order to increase this amount, the influential person Santiago Maratía launched the “All with Emmita” campaign.

,Too expensive gene therapy, in the order of hundreds of thousands of dollars. Many of the accepted gene therapies either cure a person with a previously incurable disease or significantly improve their quality of life. To settle the payment of these treatments, what is done are negotiations between the developing companies and the States, because being rare diseases, there are not so many patients who need these treatments, ”says -he. . Podhajaser,

with your colleague, baldin Gives the example of Spain, where there is a “shared risk” regime between companies and the state. If they give a treatment to the patient and he does not succeed, they do not pay for said treatment.

Business Leaders Wanted in New Era Sectors; survey shows 40% of 220 cos CEOs jumped ship in past three years

0
India Inc is witnessing CEO turnover as lucrative deals from new-era companies and high-growth sectors attract professionals amid talent shortages.

Since 2019, the chief executives of 90 companies – about 40% of 220 surveyed – have jumped ship, according to a study commissioned by ET. The banking and financial services sector (59%), followed by retail (51%) and industrials (49%), saw such peak attrition, according to a study of listed and unlisted frontliners by the company. Global Executive Search EMA Partners.

Separately, independent data compiled by ET showed that of the roughly 200 departures of professional CEOs from the NSE 500 companies over the past 10 years, 27 (13%) lasted less than a year, while 119 (59% ) are gone in less than five years. . Only 17 CEOs (8%) have worked more than 10 years in a company. Turnover prompts boards to proactively pursue succession planning and re-examine compensation, with an increasing emphasis on longer terms, as frequent departures of CEOs can disrupt a business, in addition to having a negative impact on the share price.

“The unprecedented attrition of corner rooms can be attributed to the market reach for the top position, which has widened significantly in recent years, particularly in certain fast-growing sectors such as technology , digital and new era businesses that also offer strong opportunities for wealth creation and growth,” said K Sudarshan, Managing Director, India, and Regional President, Asia, EMA Partners.

The exodus is also due to leaders reassessing their professional and personal priorities.

“Executives are looking to revamp and re-examine their work-life balance,” said Shailesh Haribhakti, chairman of auditing and accounting firm Haribhakti & Co, and independent director of several Indian companies.

Modified perspective

“They are now starting to look for purpose in a more focused and accentuated way and the boards are aware of that,” Haribhakti said.

According to leadership consultants, one of the pet peeves of professional CEOs is interference from the owner/developer’s family or board of directors.

Suresh Raina, a partner at global leadership consultancy Heidrick & Struggles, cited the example of a chief executive of a large infrastructure and energy company who is considering quitting less than a year after joining. — and without another job offer — due to too much interference.

“The CEO feels it’s not worth it to him,” Raina said, without revealing the name of the person or the company, adding that the plethora of opportunities at the top of the pyramid allows people to take such risks, as a leader. knows that he will soon be able to find another job.

Company concerns

With the quality of management becoming an important consideration in evaluating companies, CEO turnover has become a concern at the board level.

“The abrupt departure of a CEO is the strongest signal a company gives to the market that something is wrong with the business,” said Arun Duggal, chairman of

and an independent director on several boards. “It’s also an important signal to other stakeholders, including employees and customers, and raises many questions about the company’s strategy, stability and future.”

Conversations in boardrooms increasingly focus on having leaders more involved in the game and a longer-term association with the company. Family businesses are expanding the scope of decision-making so professionals feel more empowered, board members and chief executive consultants said.

“The unstable external environment as well as high attrition – at CEO level and among senior executives – makes it imperative for companies to enter into contracts that can bind senior professionals to a longer association,” said Naina Lal Kidwai. , senior adviser, Rothschild & Co, and non-executive director of several boards of directors.

What is the impact of the SARS-CoV-2 omicron wave in South Africa?

0

A study published in the journal Science Translational Medicine described severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissibility, population-level immunity and the impact of the omicron wave in South Africa.

Study: SARS-CoV-2 transmission, persistence of immunity and estimates of the impact of Omicron in South African population cohorts. Image Credit: PHOTOCREO Michal Bednarek/Shutterstock

Background

The omicron variant of SARS-CoV-2 was first detected in South Africa in November 2021. Prior to its emergence, South Africa experienced three distinct waves dominated by wild-type SARS-CoV-2 with D614G mutation, beta variant and delta variant, respectively.

Compared to previously circulating viral variants, omicron exhibits a highly mutated genome, which makes the variant immunologically superior at evading pre-existing population-level immunity (herd immunity) induced by previous infections and vaccinations.

In the present study, scientists determined the long-term dynamics of SARS-CoV-2 in two groups of households from a rural and urban area in South Africa. Both groups were followed for 13 months.

Specifically, the scientists estimated the robustness of cross-reactive immunity induced by consecutive waves of SARS-CoV-2 variants. They recreated the landscape of herd immunity in South Africa before the emergence of the omicron variant, as well as determined the impact of the omicron wave in the same population.

SARS-CoV-2 epidemiology in South Africa

The study was conducted in a rural area and an urban area located in two South African provinces. The study population included 1200 people living in 222 households. Only 10% of the study population were fully vaccinated during the study period.

At baseline, the seroprevalence of nucleocapsid anti-SARS-CoV-2 antibodies was 1.1% in the rural area, which increased to 7%, 25% and 39% after the first (D614G), the second (beta), and third (delta) waves, respectively. The infection rate was almost 60% in this region.

In the urban area, seroprevalence was 14% at enrollment, which increased to 27%, 40% and 55% after the first, second and third waves, respectively. The infection rate was almost 70% in this region.

Dynamics of viral RNA shedding

Household exposure to the virus depends primarily on levels of viral RNA excreting among family members.

Analysis of viral RNA dynamics revealed that the three variants have similar characteristics, represented by a short proliferation phase and a longer clearance phase.

The prevalence of symptomatic infection among household members was 13%, 16, and 18% for SARS-CoV-2 D614G, beta, and delta variants, respectively. The time of peak viral shedding coincided with the time of symptom onset, indicating that significant viral shedding occurs before symptom onset.

Further analysis revealed that symptomatic infections are characterized by a high viral load. The highest viral load was seen in delta infections, followed by beta and SARS-CoV-2 D614G infections. Notably, household members with prior infections had significantly reduced viral shedding levels and duration upon re-infection.

Risk of primary infection and reinfection with SARS-CoV-2

A positive correlation was observed between the intensity of household exposure and the risk of SARS-CoV-2 infection. This association was stronger at the proliferation stage than at the clearance stage. The delta variant showed the highest infectivity, followed by the beta and D614G variants.

Regarding the protective efficacy of pre-existing immunity, the results revealed that prior infection provides 92% protection against reinfection during the first three months, which decreases to 87% after nine months.

The lowest risk of infection was observed in people over the age of 65 during the D614G wave. During the delta wave, the risk was highest in children and adolescents 6 to 18 years old. In addition, an increased risk of infection has been observed in obese people and those residing in urban areas.

Impact of the omicron wave in the urban region

Scientists developed mathematical models to assess the trajectory of omicron waves as well as viral dynamics in the urban region.

Model projections revealed that omicron has a growth advantage of 0.338 per day over delta. The basic reproduction number was also higher for omicron. As expected, a higher infection rate was observed during the omicron wave than during previous waves. Over 40% of omicron infections were expected to be reinfections and breakthrough infections.

Using a baseline scenario for the immune evasion characteristics of Omicron, the impact of the omicron wave was estimated. The results revealed that the ratio of the basic omicron to delta reproduction number is 2.4, the infection rate is 69%, the duration of the wave is 32 days, and the proportion of reinfections and breakthroughs vaccination is 68%.

To understand the robustness of omicron-induced immunity against existing and future variants, mathematical models were developed to project the degree of protection under different exposure conditions (contact rate).

Given the contact rate of the delta wave, models predicted that the degree of herd immunity would not be sufficient to prevent a recurrent omicron outbreak unless previous omicron infections induce protection. robust and durable.

Considering a 100% higher contact rate, models predicted that if it reappeared, omicron could cause outbreaks, regardless of the protection induced by previous omicron infections. Taken together, these predictions indicate that an induction of contact rates can lead to the emergence of new waves caused by pre-existing or new viral variants.

Elon Musk announces Starlink will provide dead zone coverage for T-Mobile

0

T-Mobile says it’s getting rid of mobile dead zones with a new partnership with SpaceX’s Starlink satellite internet, to an event hosted by T-Mobile CEO Mike Sievert and Elon Musk. With their “Coverage Above and Beyond” configuration, mobile phones could connect to satellites and use a connection slice providing approximately 2 to 4 megabits per second of connection (total) over a given coverage area.

This connection should be enough to let you text, send MMS, and even use “select messaging apps” whenever you have a clear view of the sky, even if there isn’t. is no traditional service available. According to a press release from T-Mobile, “satellite-to-cellular service” will be available “across the continental United States, Hawaii, parts of Alaska, Puerto Rico and territorial waters.” The service is expected to launch in beta by the end of next year in “select areas”, and Sievert says he hopes it will include data one day.

According to Musk, second generation Starlink satellites next year’s launch will be able to stream a service using some of T-Mobile’s mid-band PCS spectrum, which was boosted when it was allowed to buy Sprint a few years ago. Musk said the new satellites have “big, big antennas” 5 to 6 meters in diameter to accommodate the new connections and the plan is to launch the equipment using his next Starship rocket.

“If there aren’t too many people in the cellular zone, you might even get some video,” Musk said. As Sievert described it, operators of messaging apps like WhatsApp or iMessage will need to work with T-Mobile and Starlink to get their services to recognize the satellite connection and work with it once it launches.

Musk provided a bit more detail saying that, unlike regular internet service, it could work without access to Starlink’s full constellation of satellites. By limiting it to certain messages and services, as well as only places that don’t currently have cellular connectivity, it could use a more intermittent connection for “basic” coverage, although you might have to wait 30 minutes for a message to go through.

The two executives said they are looking for partnerships with mobile carriers around the world who would be interested in reciprocal spectrum-sharing agreements so their customers can connect to SpaceX. T-Mobile customers could also use these connections when traveling to other countries.

musk too said on Twitter that one of his other companies, Tesla, will use the technology for the premium connectivity functionality in its electric vehicles. Currently, Tesla uses AT&T’s network for things like live traffic viewing, satellite maps, and music streaming.

Musk said the service can even work when your phone is in your pocket or in a car.
Picture: SpaceX

Sievert said that when it launches, T-Mobile’s “vision” is for it to be included free in the carrier’s “most popular plans,” though he said today’s event isn’t not an official announcement. He said T-Mobile wants to make it available to people with “low-cost” plans for a lower “monthly service fee” than current satellite connectivity services. (That potentially encompasses a wide price range, though – Garmin InReach Satellite Messaging Subscription Packagesfor example, start at $14.95 per month, but go up to $64.95 per month.)

T-Mobile says subscribers’ current phones will be able to use the network – no special equipment is required. As Elon Musk said in the ad, “the phone you currently have will work.”

Mike Sievert, CEO of T-Mobile, and Elon Musk, chief engineer of SpaceX

Mike Sievert, CEO of T-Mobile, and Elon Musk, chief engineer of SpaceX
Picture: SpaceX

The fact that it uses the traditional cellular spectrum is a bit of a double edged sword. Not requiring special equipment is an obvious advantage, but T-Mobile does not own the rights to this spectrum worldwide. So while SpaceX’s satellites can technically communicate with phones internationally, T-Mobile may not have the rights to the same bands its system uses when you take your phone to another country or to the waters. international.

This is not the case for traditional satellite communication networks, such as the Iridium system used by Garmin. If phone makers want to introduce their own version of this feature, which Apple is rumored to be working on, partnering with other satellite providers could give them more coverage than T-Mobile plans to offer.

As Walter Piecykanalyst at LightShed Partners, says The edge“Apple and Samsung may have an easier time integrating existing satellite connectivity into their upcoming phones than Starlink will have to deal with trying to reconcile spectrum rights with wireless carriers around the world.”

Fights over spectrum rights could get messy and have. T-Mobile and Verizon have lobbied the Federal Communications Commission to stop a company called AST & Science from launching satellites that could provide cell phone service from space, saying its system could interfere with its terrestrial networks. SpaceX is embroiled in a battle with Dish Networks over 12Ghz spectrum, which the latter wants to use for terrestrial 5G. Musk’s company has warned its home internet users that Dish using 12Ghz could totally destroy its satellite internet service. Analysts even wondered if the service announced today would require additional FCC approvals.

Sievert also said T-Mobile is “open” to using SpaceX for its network backhaul in the future, especially in rural areas. While that’s a few steps up from what the two companies currently offer (again, Musk says each cell will support around 2-4 megabits), it could help make it less expensive for the carrier to use. expand your network. Such a plan would be similar to what Verizon has announced in conjunction with Amazon’s Kuiper Satellite Internet Project, although that plan seems much further away from fruition as Amazon does not appear to have launched any of its satellites yet. .

Earlier this year, SpaceX lost a bid for rural internet grants due to the cost of its equipment. But if he can build on existing T-Mobile equipment, which rural residents may already have, that could help his case with the Federal Communications Commission. Thursday’s presentation certainly hit rural coverage, with videos of people in remote parksmountains or animal husbandry.

Update at 10:15 p.m. ET: added information on where the service will be able to cover, as well as Tesla using it for premium connectivity in its cars.

Dosage Determines Percentage of Omicron, Other Variants in Covid Wastewater | MIT News

0

Sewage monitoring emerged amid the Covid-19 pandemic as an effective, non-invasive way to track a viral outbreak, and advances in technology have allowed researchers to not only identify but also quantify the presence of particular variants of concern (VOCs) in wastewater samples.

Last year, researchers from Singapore-MIT Alliance for Research and Technology (SMART) made headlines for develop a quantitative test for the Alpha variant of SARS-CoV-2 in sewage, while also working on a similar test for the Delta variant. Previously, conventional wastewater detection methods could only detect the presence of SARS-CoV-2 viral material in a sample, without identifying the virus variant.

Now, a team from SMART has developed a quantitative RT-qPCR test that can detect the Omicron variant of SARS-CoV-2. This type of analysis allows wastewater surveillance to accurately trace the dynamics of variants in a given community or population, and to support and inform the implementation of appropriate public health measures tailored to the specific characteristics of a particular viral pathogen.

The ability to count and rate particular VOCs is unique to SMART’s open source test and allows researchers to accurately determine movement patterns in a community. Therefore, the new test can reveal what proportion of SARS-CoV-2 virus circulating in a community belongs to a particular variant. This is particularly important because different SARS-CoV-2 VOCs – Alpha, Delta, Omicron and their offshoots – emerged at various times during the pandemic, each causing a new wave of infections to which the population was more susceptible.

The team’s new allele-specific RT-qPCR test is described in an article, “Rapid displacement of SARS-CoV-2 Delta variant by Omicron revealed by allele-specific PCR in wastewaterpublished this month in Water Research. The main author of the work is Eric Alm, professor of biological engineering at MIT and principal investigator in the Antimicrobial resistance (AMR) interdisciplinary research group within SMART, the research enterprise of MIT in Singapore. Co-authors include researchers from Nanyang Technological University (NTU), National University of Singapore (NUS), MIT, Singapore Center for Environmental Life Science Engineering (SCELSE), and of the Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IZSLER) in Italy.

Omicron exceeds delta in three weeks in Italian study

In their study, the SMART researchers found that the increase in population coverage of the booster vaccine in Italy was consistent with the complete replacement of the Delta variant by the Omicron variant in wastewater samples from the Torbole Casaglia wastewater treatment plant, with a catchment area of ​​62,722 people. Taking less than three weeks, the rapid rate of this displacement can be attributed to Omicron’s infection advantage over the previously dominant Delta in vaccinated individuals, which may come from Omicron’s more efficient evasion of the vaccination-induced immunity.

“In a world where Covid-19 is endemic, VOC monitoring through sewage monitoring will be an effective tool for tracking variants circulating in the community and will play an increasingly important role in guiding the response. public health,” says paper co-author Federica Armas, senior post-doctoral fellow at SMART AMR. “This work has demonstrated that wastewater monitoring can be used to quickly and quantitatively trace VOCs present in a community.”

Wastewater monitoring is vital for future pandemic responses

As the global population becomes increasingly vaccinated and exposed to previous infections, nations have begun the transition to classifying SARS-CoV-2 as an endemic disease, shifting active clinical surveillance back to rapid antigen testing decentralized and therefore reducing the sequencing of patient samples. However, SARS-CoV-2 has been shown to produce new COVs that can quickly emerge and spread rapidly in populations, displacing previously dominant virus variants. This was seen when Delta moved Alpha around the world after the first emerged in India in December 2020, and again when Omicron moved Delta at an even faster rate after its discovery in South Africa in November 2021 The continued emergence of new COVs therefore requires continued vigilance on the surveillance of circulating SARS-CoV-2 variants in communities.

In a separate summary document on wastewater monitoring titled “Making waves: SARS-CoV-2 wastewater monitoring in an endemic future,» published in the journal Water Research, SMART researchers and collaborators found that the utility of wastewater monitoring in the near future could include 1) monitoring the trend of viral loads in wastewater for quantified viral estimates circulating in a community; 2) source sampling of wastewater—for example, taking samples from particular neighborhoods or buildings—to identify neighborhood and building-level infections; 3) integrate wastewater monitoring and clinical monitoring for cost-effective population monitoring; and 4) genome sequencing of wastewater samples to track circulating and emerging variants in the population.

“Our experience with SARS-CoV-2 has shown that clinical testing can often only paint a limited picture of the true extent of an outbreak or pandemic. With the prevalence of Covid-19 and the anticipated emergence of new variants of concern, qualitative and quantitative data from wastewater monitoring will be an integral part of a cost-effective and resource-efficient public health surveillance program, allowing authorities to make more informed policy decisions. adds corresponding author Janelle Thompson, associate professor at SCELSE and NTU. “Our review provides a roadmap for the wider deployment of wastewater monitoring, with opportunities and challenges that, if addressed, will not only enable us to better manage Covid-19, but also societies. future-proof for other viral pathogens and future pandemics.”

Furthermore, the review suggests that future wastewater research should adhere to a set of standardized wastewater treatment methods to reduce inconsistencies in wastewater data for improved epidemiological inference. . The methods developed in the context of SARS-CoV-2 and its analyzes could be of invaluable interest for future wastewater monitoring work on the discovery of emerging zoonotic pathogens – pathogens that can be transmitted from animals to humans. humans – and for the early detection of future pandemics.

Moreover, far from being limited to SARS-CoV-2, wastewater monitoring has already been adapted for use in the fight against other viral pathogens. Another article from September 2021 described a progress in the development of effective wastewater monitoring for dengue, Zika and yellow fever viruses, with SMART researchers successfully measuring the decay rates of these medically important arboviruses in wastewater. This was followed by another review paper by SMART published in July 2022 which explored current progress and future challenges and opportunities in wastewater monitoring for arboviruses. These developments represent an important first step towards establishing arbovirus sewage surveillance, which would help policymakers in Singapore and beyond take better-informed and more targeted public health action to control outbreaks of arboviruses. arboviruses such as dengue, which is a major public health problem in Singapore.

“Our lessons learned from using wastewater monitoring as a key tool during Covid-19 will be crucial in helping researchers develop similar methods to monitor and control other viral pathogens and future pandemics” , says Lee Wei Lin, first author of the latest SMART paper and researcher at SMART AMR. “Sewage monitoring has already shown promising utility in helping to combat other viral pathogens, including some of the world’s most prevalent mosquito-borne diseases, and there is significant potential for the technology to be suitable for use against other infectious viral diseases.”

The research is led by SMART and collaborators at SCELSE, NTU and NUS, co-led by Professor Eric Alm (SMART and MIT) and Associate Professor Janelle Thompson (SCELSE and NTU), and is supported by the Singapore National Research Foundation (NRF) under its Campus of Excellence in Research and Technological Enterprise (CREATE) program. The research is part of an NRF-funded initiative to develop sewage-based surveillance for rapid outbreak detection and response in Singapore.

SMART was established by MIT in partnership with NRF in 2007. SMART is the first CREATE entity developed by NRF and serves as the intellectual and innovation hub for research interactions between MIT and Singapore, undertaking research projects cutting-edge research in areas of interest to Singapore and MIT. SMART currently includes an Innovation Center and five interdisciplinary research groups: AMR, Critical Analytics for Personalized Medicine Manufacturing, Disruptive and Sustainable Technologies for Precision Agriculture, Future Urban Mobility, and Low-Energy Electronic Systems.

The GRI AMR is a translational research and entrepreneurial program tackling the growing threat of antimicrobial resistance. Leveraging talent and converging technologies in Singapore and MIT, they are tackling AMR head-on by developing multiple innovative and disruptive approaches to identify, respond to, and treat drug-resistant microbial infections. Through strong scientific and clinical collaborations, our goal is to provide transformative holistic solutions for Singapore and the world.

Study examines factors that influence immune responses more than 15 months after SARS-CoV-2 infection

0

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed more than 6.4 million lives worldwide. Research on COVID-19 has highlighted various clinical manifestations, from asymptomatic symptoms to severe symptoms.

Several studies have reported the development and persistence of antibodies following SARS-CoV-2 infection.

Study: Factors influencing immune response more than 15 months after SARS-CoV-2 infection: A population-wide longitudinal study in the Faroe Islands. Image Credit: Corona Borealis Studio/Shutterstock

However, as antibodies wane over time, it is important to assess their durability to determine the period of protection against COVID-19.

Background

Data on the long-term durability of anti-SARS-CoV-2 antibodies after symptomatic infection are scarce. It is also important to understand the extent of the protective capacity of these antibodies against COVID-19 reinfection. Although several studies indicated the development of neutralizing antibodies post-COVID-19, the limited duration of the follow-up period posed a challenge in determining the period of protection against subsequent infection. Nevertheless, this information is essential for effective management of the pandemic in the future.

Several studies have indicated that anti-SARS-CoV-2 antibodies persist for at least 12 months. An Italian study observed the persistence of anti-Spike (S) receptor-binding domain (RBD) IgG in most participants for 14 months after COVID-19. A varied level of immune responses has been reported from individual to individual.

In the Faroe Islands, until the emergence of the SARS-CoV-2 Omicron variant, the reinfection rate was relatively rare. To determine the durability of immune responses against SARS-CoV-2, a longitudinal analysis, considering two waves of COVID-19 that occurred in the Faroe Islands, was conducted. The first wave started in March 2020 and ended in April 2020, while the second wave occurred between August 2020 and December 2020.

About the study

Long-term humoral immunity against SARS-CoV-2 was investigated in this study. The antibody response was determined by analyzing 1063 blood samples, from 411 patients (aged 0-93 years), from two waves of infections. Blood samples were taken multiple times from each patient for fifteen months after the onset of COVID-19.

Total anti-SARS-CoV-2 RBD IgM, IgA and IgG antibodies were determined using a qualitative RBD sandwich ELISA. Additionally, neutralizing antibodies (NAb) were assessed using an ELISA-based pseudo-neutralizing assay. The ELISA-based test was used to determine IgG subclasses in a subset of samples. The durability of SARS-CoV-2 antibody responses was analyzed via nonlinear models.

Results

The study cohort exhibited a wide range of COVID-19 symptoms, such as asymptomatic, mild, moderate, and severe illness. In this national longitudinal study, antibodies specific for SARS-CoV-2, up to fifteen months after infection with SARS-CoV-2, were evaluated.

In 94% of participants, a detectable level of SARS-CoV-2 antibodies, particularly IgG, was found. Antibody levels varied differently over time in COVID-19 patients. A characteristic decrease in IgG levels has been observed from the onset of COVID-19. In both waves, the researchers observed that after the initial drop in the IgG level, it stabilized and remained stable for almost seven months. This pattern is known as the biphasic pattern.

The biphasic pattern is consistent with the hypothesis that part of the plasma cells in an acute immune reaction are transformed into memory plasma cells. This result suggests a shift from antibody production by short-lived plasma cells to antibody production by memory plasma cells.

Although a reduction in IgG levels occurred, the neutralizing capacity of circulating antibodies remained significantly elevated. This finding suggests the high efficiency of neutralizing antibodies induced by natural infection. A strong relationship between IgG levels and neutralizing antibodies has been established, suggesting the existence of immunity acquired by infection for about fifteen months.

Interestingly, only one Faroese resident experienced reinfection with COVID-19 among 4477 people diagnosed with COVID-19 as of December 17, 2021. The finding of this study is consistent with previous studies that reported that IgG1 and IgG3 were the most common subclasses, where IgG1 was primarily responsible for the IgG response. After the first sampling, among the total antibody composition, 83% were found to be neutralizing antibodies, which increased to 94% in the second sampling.

Only 19% of participants had persistent IgA and 3% had IgM 15 months after infection. Positive IgA responses varied significantly over time. A characteristic decrease in IgA has been observed since the onset of the infection. As with IgG, higher IgA levels have been observed in men and the elderly.

Importantly, the current study indicated that BMI, hospitalization and smoking affected IgG antibody synthesis. A low level of IgG was found in smokers, high levels in hospitalized people, and a faster decline in antibodies was seen in people with a high BMI. These factors may influence the risk of reinfection and the duration of protection against the SARS-CoV-2 virus. In younger participants, the magnitude and durability of immune responses post-COVID-19 were lower than in older participants who required hospitalization.

conclusion

Taken together, the majority of participants revealed a robust and durable immune response after SARS-CoV-2 infection, which lasted fifteen months after an initial decline for the first seven months. This study found that gender, smoking status, age, and hospitalization influence initial levels of SARS-CoV-2 antibodies. The rate of antibody decay was found to be primarily related to age, gender, and BMI.

An industrial gas company seeks to store carbon dioxide under Maurepas Lake

0

LIVINGSTON PARISH – Beginning in October, surveyors will examine what lies beneath Maurepas Lake using sonar-like sound waves.

“You trigger little, tiny seismic charges that send vibrations down to the earth, and you read what comes back to see what kind of layers you have,” said Patrick Courrèges of the Louisiana Department of Natural Resources.

The plan is to create a 3D map as deep as two miles below the lake to find the safest places to store carbon dioxide, rather than letting it escape into the atmosphere.

“You’re looking for layers that shield the upward movement of that area,” Courrèges said.

This is an effort by Air Products and Chemicals Incorporated to reduce greenhouse gas emissions.

“Projects like this make it all possible,” Gov. John Bel Edwards said at a previous press conference.

Last year, Governor Edwards announced that the company was building a blue hydrogen clean energy complex in Ascension Parish.

“The carbon dioxide generated in the manufacturing process will be captured, removed and permanently sequestered, instead of being released into the atmosphere,” Edwards said.

“In 2026, this clean energy complex will produce 750 million cubic feet of clean hydrogen per day. To put it into perspective, that’s enough energy to drive 3 million cars,” Air Products Chairman and CEO Seifi Ghasemi said.

Officials say this process is the future of energy and there is nothing to worry about storing carbon dioxide under the lake. The investigation will be completed in the spring.

In the meantime, there are some concerns. Livingston Parish Council will introduce an order on Thursday to at least suspend the issuance of new permits so members can learn more about the process.

“We think it’s safer in the ground than in the air, but what does it do to our drinking water? Is there a risk of leaks? What is the plan in case of disaster? We just haven’t been able to get that information for our people asking for it,” said Livingston Parish District 8 Councilman Randy Delatte.

Exoduas officials, who will lead the investigation, say it will not disrupt recreational use of the lake.

Air Products has released this statement; “A subsurface survey provides a visual inspection of the subsurface geology. It is conducted as part of the permitting process. Understanding the geology of the area helps ensure the selection of optimal locations to permanently sequester carbon dioxide (CO2) about one mile below the lake.Maurepas Lake has been the subject of several similar safe surveys in the past.These surveys follow proven processes to ensure the safe collection of data regarding the geology below the lake. lake and surrounding area Air Products’ Louisiana Clean Energy Complex to be built in Ascension Parish is scheduled to be commissioned in 2026. The facility will provide approximately 2,000 construction jobs on three years and 170 new permanent jobs with an average salary over $93,000.”

Find more information here.

A meeting was held Wednesday in the parish of Saint-Jean-Baptiste. Anyone who missed the meeting can contact Exoduas or LDNR with their concerns and questions.

Modified nucleotides used in Covid vaccines work as expected

0

The remarkable efficacy of mRNA vaccines against SARS-CoV-2 has generated much interest in synthetic mRNA therapeutics for disease treatment and prevention. But some fundamental scientific questions remain about whether the modified nucleotides used in vaccines faithfully produce the protein products for which they are designed.

Synthetic mRNAs used in COVID-19 vaccines incorporate the modified nucleotide N1-methylpseudouridine to improve stability and reduce unwanted immune responses. These two characteristics are necessary for the proper functioning of the vaccine. Yet the incorporation of this non-standard nucleotide introduces the possibility that the cellular machinery may misinterpret the genomic information encoded by the mRNA, leading to errors in protein translation that could have unexpected effects down the line. .

Zahir

Don’t worry, as it turns out. A new study from Washington University in St. Louis finds that N1-methylpseudouridine used in COVID-19 mRNA vaccines is translated faithfully. The research, published in Cell Reports, was conducted by scientists in the lab of Hani Zaher, associate professor of biology in Arts & Sciences.

“Cellular mRNAs typically lack N1-methylpseudouridine,” said Kyusik Kim, a graduate student in the Molecular Cell Biology program, first author of the study. “We found that the presence of N1-methylpseudouridine in mRNAs does not seem to lead to an increase in the number of errors during translation.

Kyusik Kim
Kim

“If that’s the case,” Kim said, “then we can continue to use them therapeutically and we won’t have to worry as much about them making the wrong protein.”

The translation of the genetic code into functional protein is a feat accomplished in all areas of life by the ribosome. The Zaher lab conducts research that expands our understanding of the mechanisms that govern translational fidelity on the ribosome and the impact of these mechanisms on cell shape.

In this particular study, researchers at the Zaher lab used several experimental systems to study the effects of N1-methylpseudouridine on translation. They discovered that N1-methylpseudouridine is accurately read by the ribosome. They also found that mRNAs containing N1-methylpseudouridine did not appear to produce miscoded proteins more frequently than mRNAs containing unmodified nucleotides.

“There has been a huge explosion of interest in using mRNA therapeutics for many different diseases,” Kim said. “This paper adds more confidence that mRNA therapeutics aren’t going to make proteins they weren’t meant to make.”


Kim et al., N1-methylpseudouridine found in COVID-19 mRNA vaccines produces faithful protein products, Cell Reports (2022), https://doi.org/10.1016/j.celrep.2022.111300

Funding: This work was supported by a grant from the National Institutes of Health (NIH) (R01GM141474).

The authors thank the Alvin J. Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital and the Institute of Clinical and Translational Sciences (ICTS) at Washington University in St. Louis for the use of the Genome Technology Access Center, who provided sequencing services for this study.

Women & Hi Tech Announces Leading Light Award and Scholarship Nominees

0

Over 80 women and male allies in STEM will be celebrated on October 6e.

INDIANAPOLIS, August 24, 2022 /PRNewswire/ — Women & Hi Tech is pleased to announce over 80 nominees and nominees for its Leading Light Awards & Scholarship Gala. This flagship biannual event focuses on celebrating Indiana women in STEM – women risk takers, leaders, educators, mentors and those changing our local STEM landscape. At the Indiana Roof Ballroom on October 6ethe organization will announce the recipients of the awards and scholarships at a gala. As an annual corporate sponsor of Women & Hi Tech and scholarship sponsor, Bell Techlogix is ​​proud to help share this exciting announcement.

The theme for this year’s event will be “In This Together”. Indiana The STEM community continues to grow and thrive as we all come together and innovate through diverse perspectives. Women & Hi Tech envisions STEM industries transformed by collaboration, and promotes, supports and encourages female and male allies who make this possible. The Leading Light Awards & Scholarship Gala is a biannual signature event to celebrate outstanding allies of women and men working to advance STEM fields while cultivating a diverse pipeline of talented future STEM leaders. When we work together to level the playing field, the results are more valuable for everyone.

The program facilitator is Jennie LopezHead of Global Recruitment and Talent Acquisition for Eli Lilly and Company. Jennie embodies “Bring Yourself to Work” in everything she does. It reinforces diversity and engages employees and organizations to reach new heights. Women & Hi Tech would also like to acknowledge and thank Eli Lilly and Company for their exclusive sponsorship of the 2022 Leading Light Awards & Scholarship Gala.

For more information on the Leading Light Awards, visit https://womenandhitech.org/2022-Leading-Light-Awards/.

Category Award Nominees

Equity and Inclusion Champion Award

  • Angel HenrySenior Director of Transformation Value Management Office and VP DEI, Genesys
  • candy geediversity and inclusion partner, Roche
  • Holly HarringtonSenior Director of Supplier Diversity and Chief Diversity Officer, Indianapolis Airport Authority
  • KristenCooperCEO and Founder, The Startup Ladies
  • Sonal Sheth ZawahriFounder, true you
  • Stacey McCreeryFounder and CEO, ROI Search Group

OperationALL Male Allies Award

  • Glenn KellerIT Director, Countrymark
  • Luke Zhang, Data scientist, resulting
  • Michel HinelineCEO, Make Ripples LLC
  • Michael LogginsGlobal Vice President, Information Technology, SMC
  • Ron FrankenfieldCEO, Bell Technologix
  • Scott Besexecutive director, Purdue Polytechnic High Schools

Mentor me! Award nominees

  • oh Jaylan FisherCoach, Speaker, HR Generalist, GoalFit LLC/120Water
  • oh Teresa Conroy Rothsenior technology and business executive, AXIA Consulting
  • oh Wendy SteinSVP, Site Head Indianapolis, General Manager Roche Diagnostics Operations, Roche

Leadership Award Nominees

  • Akilah DardenPresident, The Darden Group LLC
  • Christine SkaggsAnalytical Pharmaceutical Design Consultant, Eli Lilly & Co.
  • Danielle ShockeyExecutive Director, Girl Scouts of Central Indiana
  • Catherine KiangPrincipal Scientist, Eli Lilly & Co.
  • Linda CalvinTechnical Manager, Transcend Consulting
  • Mariah OlivierFounder and CEO, Boss Babe Network
  • Melissa Lavallatechnical support supervisor, Roche
  • Robyn MillerAssociate Director – Digital Health Applications and Operations, Eli Lilly & Co.

Risk Taker Award Nominees

  • Brei Cecil-SatchwellDirector of Foundation Operations, TechPoint Foundation for Youth
  • Faith RaineyManager, Customer Support Center, Roche Diagnostics

Rising Star Award Nominees

  • Jakki KieltyArea Manager, Endress + Hauser
  • Jamie InskeepDirector of Programs, TechPoint Foundation for Youth
  • Katie ObbagySenior Specialist – Technical Functional Excellence, Cummins Turbo Technologies
  • Maria HultHead of Sub-Chapter – Complaint Investigation Resolution, Roche Diagnostics
  • Mariah Olivierdigital marketing professional and founder of Boss Babe Network, TeeSnap, BBN, Behind the Screen
  • Mary HendricksonSenior Software Engineer II, Sallie Mae Bank
  • Michelle SharonManager, Roche Support Network Customer Support Center – Systems & Compliance, Roche Diagnostics
  • Pallavi satsangiGlobal Customer Quality Engineer and North America Warehouse Quality Operations Management, Cummins Inc
  • Sonal Sheth ZawahriFounder, true you
  • Stephanie Sponseldirector of operations, netlogx

You inspire us! Award nominees

  • Akilah DardenPresident, The Darden Group LLC
  • Jessica BakerConsulting Scientist, Eli Lilly & Co
  • Catherine KiangPrincipal Scientist, Eli Lilly & Co
  • Katie ObbagySenior Specialist – Technical Functional Excellence, Cummins Turbo Technologies
  • Sonal Sheth ZawahriFounder, true you
  • Terri TrabueGross to Net Contract Analyst, Roche Diabetes Care

Outstanding Educator in STEM Award Nominations

  • Genevieve McLeish PettyComputer Science Teacher, Cold Spring School
  • Megha JunejaHead of Academic Support and Coaching, Purdue Polytechnic High Schools
  • Sarah Mundyscience teacher, Purdue Polytechnic High Schools
  • Sharita ItemsEngineering and Technology Educator, East Tipp Middle School
  • Susan ElliotSTEM teacher, Lowell Elementary

Outstanding Achievement Among STEM Award Nominees

  • E. ZeNai Brooks, Controller, Corporate Responsibility and Foundation, Cummins; Chief Strategy Officer, Mind Your Business Accounting and Consulting; First Lady, New Liberty Missionary Baptist Church
  • KristenCooperCEO and Founder, The Startup Ladies
  • Rabia KhanPresident, Managed Systems Solutions
  • Sonal Sheth ZawahriFounder, true you

Changing landscape award nominees

  • Akilah DardenPresident, The Darden Group LLC
  • Christine Krullprogram director, Roche
  • Dawn Rosemonde, Practice Diversity Partner, Barnes & Thornburg LLP; Published Author (Boss Presence), Speaker and Founder, Reign Today
  • Deborah Pollack MilgatePartner, Barnes & Thornburg
  • Sarah BurnsSenior Director, Global Science Communications, Eli Lilly & Co.
  • Stacey McCreeryFounder and CEO, ROI Search Group

Scholarship and grant applicants by category

Undergraduate scholarship applicants

  • Alivia Fieldscellular, molecular and developmental biology, Purdue University
  • Courtney MummertInterior Design Science, Ball State University
  • Jaden Sollercyber security, Anderson University
  • Jazlyn Collyearcyber security, Indiana Technology
  • Jordan ClarkEngineering, Taylor University
  • OdessaLyonBiology, Indiana University
  • Rebecca BoydChemistry, Purdue University
  • Zoe BarnspereIntegrative Biology and Organism, Indiana University
  • Allie McClureMechanical Engineering, Indianapolis University
  • Amerti GutaCellular and Molecular Biology and Biochemistry, DePauw University
  • audrey harrisonNeurobiology and Physiology, Purdue University
  • Corissa McClammerBiotechnology, Ivy Tech Community College
  • Danielle CookInformation system, Indiana Institute of Technology
  • Ella Virtcyber security, Purdue University
  • Evie IslandsNew Media and Computing, IUPUI
  • Gracie HicksBiomedical Engineering and Chemistry, Marian University
  • Hannah RupertEngineering, Indiana Wesleyan University
  • Jadelynn LoganBiology & Computer Science, Ball State University & Ivy Tech Community College
  • Jessica JessaEngineering, Hannover College
  • Kimeesha GrahamElectrical Engineering and Chemistry, Marian University & IUPUI
  • Lauren DavisChemistry & Spanish, St. Mary’s College
  • Lily WoesteBiomedical Engineering and Biology, Marian University
  • McKenna StahlKinesiology, Purdue University
  • Rashi TyagiComputer Science, IUPUI
  • Samantha SchickBiology with a specialization in pre-veterinary medicine, Franklin College
  • Sara LakeNursing, University of Manchester
  • summer sextonComputer Science, Media Arts and Sciences, IUPUI
  • Stephanie LawrenceComputer Science and Mechanical Engineering, Marian University & Purdue University

Graduate Scholarship Applicants

  • Anusuya Das, Right. IU McKinney School of Law
  • Jalynn Gormanoccupational therapy, Huntington University
  • Kelly OrzePhysician Assistant Studies, Franklin College
  • Kimberley WheatenEpidemiology – Concentration in Diabetes and Cancer, IUPUI
  • Lovette CostonInformation system, Indiana Wesleyan University
  • Mariah Judyphysical therapy, Indianapolis University
  • Michiko Jacksoninformation and communication sciences, Ball State University

Professional Development Scholarship Applicants

  • LaJoi RobinsonStartup Ladies Membership
  • Dinah AllenUX/UI design certificate

About Women and High Tech

Women & Hi Tech is a 501(c)3 nonprofit organization founded in Indianapolis in 1999. Women & Hi Tech is a pillar of Indiana’s STEM community and provides valuable resources for STEM professionals and students. With a membership of nearly 2,000 professionals and students governed by an all-volunteer Board of Directors and emeritus members, Women & Hi Tech is the only Indiana-based nonprofit organization dedicated to changing the landscape of women represented in STEM must be equally inclusive for all.

www.womenandhitech.org

https://www.facebook.com/WomenAndHiTech/

https://www.linkedin.com/company/womenandhitech

https://twitter.com/WomenandHiTech

https://www.instagram.com/womenandhitech

About Bell Techlogix:

Bell Techlogix provides transformational next-generation digital workplace and infrastructure management solutions to large and midsize businesses, as well as the public sector. With services that create, integrate and support the next wave of business transformation, Bell Techlogix delivers true customer partnership and an enhanced digital experience. Bell Techlogix offers a flexible approach that is globally capable yet locally focused that will consistently enable you to achieve growth, cost savings and acceleration of your business.
For more information about Bell Techlogix, please visit us on the web at https://belltechlogix.com/industry-solutions/education/follow us on Twitter, like us on LinkedIn or Facebook.

SOURCE Bell Techlogix and Women & Hi Tech

Amazon Packable seller lays off employees and begins liquidating

0

About a year ago, online retailer Packable was preparing to go public through a special-purpose acquisition company. As the SPAC market has evaporated and the economy is collapsing, Packable is laying off staff and preparing to liquidate, according to internal documents reviewed by CNBC.

Packable is the parent company of Pharmapacks, an online retailer of health, personal care and beauty products. Pharmapacks was founded in 2010 as a one-stop brick-and-mortar pharmacy in the Bronx, New York, before turning to the internet and establishing a big home on Amazon.

Last September, Pharmapacks was Amazon’s top seller in the United States, although it now ranks fifth among the site’s top sellers nationwide, according to the research firm. Market impulse.

Packable said in an employee notice Monday that it was laying off 138 people, or about 20% of its workforce, with the remaining 372 employees to be terminated when “individual wind-up responsibilities are completed.” The memo was signed by Leanna Bautista, the company’s director of human resources.

Packable failed to secure new funding that would have allowed it to remain in business, the notice states.

“We diligently researched internal and external financing options, but were ultimately unsuccessful,” the company said. “As the business has no viable financing alternative, we are now forced to cease operations, liquidate any remaining collateral and close the business, including the establishment on which you are dependent.”

Packable has already secured funding from leading investors including Carlyle Group, Fidelity and Lugard Road Capital. In addition to Amazon, the company sells products on marketplaces operated by Walmart, eBay and Target.

In 2020, Amazon was Packable’s largest channel by far, accounting for 80% of sales, according to an investor presentation. Amazon’s third-party marketplace has become the centerpiece of its dominant e-commerce business, as it now accounts for more than half of online retail sales. Due to Amazon’s global reach and massive customer base, many retailers rely on the company for the majority, and in some cases all, of their business.

Packable’s last year was fraught with challenges. After announcing in September its intention to merge with a SPAC – Highland Transcend Partners I Corp. — in a deal valuing the company at $1.55 billion, the market began to turn and investors lost their appetite for SPACs.

In March, compressible canceled the case to take the company public, citing “adverse market conditions”, just days before Highland Transcend’s scheduled shareholder meeting. Packable CEO Andrew Vagenas quietly resigned in April and was replaced by Daniel Myers, according to the company’s website. Myers, a former supply chain manager at Mondelez, was appointed on the Packable board last year. Vagenas still sits on the company’s board of directors, according to his LinkedIn.

Not a single SPAC was issued in July as what was left of the market completely dried up, according to CNBC’s calculations of data from SPAC Research. A boom in 2020 and 2021 created over 600 SPACs looking for targets.

For Packable, the capital’s demise represented a dramatic turning point for a business that exploded after the onset of the Covid-19 pandemic. With consumers stuck at home, online spending has surged and investors have flocked to the space.

Revenue slowed last year from double-digit growth in 2020 as the company struggled to overcome supply chain constraints, which “resulted in significant stock-outs, order delays and delays in onboarding new customers,” according to an investor presentation.

However, the business was still able to expand in early 2022. In February, Packable said his average daily income in January rose to around $1.6 million from $1.5 million in the fourth quarter of 2021.

Representatives for Packable did not immediately respond to a request for comment.

LOOK: What’s Behind the Hype in the Amazon Aggregator Space

New players in the immune response — ScienceDaily

0

The human body contains 600 to 800 lymph nodes, which are specialized organs that trigger immune responses. To be informed of infections in the body, lymph nodes are connected to individual organs via lymphatic vessels. From the organs, the lymphatic vessels carry fluids and special immune cells to the lymph nodes. These immune cells are called dendritic cells; they carry information from the organs to the lymph nodes and pass it on to other immune cells.

Now it is clear: dendritic cells are not solely responsible for this important flow of information. A research team led by immunologist Professor Wolfgang Kastenmüller from Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, has found that so-called unconventional T cells also migrate continuously from tissues to the lymph nodes and influence immune responses.

This discovery has implications for both vaccination strategies and cancer immunotherapies.

Different subtypes of unconventional T cells

“Each tissue in our body contains different subtypes of unconventional T lymphocytes,” explains Wolfgang Kastenmüller. “Because these cells each migrate to the nearest lymph node, individual lymph nodes also differ in T cell composition. And this has a direct effect on the immune responses of individual lymph nodes.”

For example, a lymph node that has been informed of an infection in the lungs triggers a different immune response than a lymph node that receives its information from the intestine or the skin.

Take advantage of the differences between the lymph nodes

A vaccine given into the skin or muscle, for example, always targets the lymph nodes that are connected to the skin. However, the vaccine may be much more effective if given near other lymph nodes. This consideration also applies to cancer immunotherapies.

“That’s why we want to study next whether we can use the difference in lymph nodes to make vaccinations more effective or to improve immunotherapies against cancer,” explains Professor JMU. Another interesting question is whether differences in lymph nodes can be actively influenced. And it is worth clarifying the importance of new findings with regard to the development of autoimmune diseases and cancer.

Participating research groups / funding

The researchers’ findings were published in the journal “ImmunityMarco Ataide, Paulina Cruz de Casas and Konrad Knöpper, all from Kastenmüller’s team at the JMU Chair of Systems Immunology I, were significantly involved in the work.

Researchers from the Würzburg Helmholtz Institute for RNA-based Infection Research (HIRI), the JMU Institute for Molecular Infection Biology (IMIB), the Marseille-Luminy Immunology Center (CIML) and the Medical Clinic II of the University Hospital from Würzburg also participated.

The work was financially supported by the Max Planck Society and by the European Research Council as part of an ERC Consolidator Grant for Wolfgang Kastenmüller.

Source of the story:

Material provided by University of Würzburg. Original written by Robert Emmerich. Note: Content may be edited for style and length.

Kyowa Hakko USA Announces Inclusion of its Cognizin® Citicoline in Solaray SharpMind Focus

0

Solaray SharpMind Focus

Our mission has always been to source the highest quality ingredients to help people everywhere live brighter and enjoy the moments that matter most. Cognizin® Citicoline is a highly researched brain health nutrient that embodies our core values ​​by bringing the most effective supplements to the market.

Kyowa Hakko USA, an international manufacturer of health ingredients and a world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food and beverage products, announced the inclusion of its Cognizin® Citicoline in Solaray SharpMind Focus, a brain and memory supplement to support brain health.

Solaray’s Director of Innovation and Science, Max Willis, said, “Since 1973, our mission has always been to find the highest quality ingredients to help people everywhere live brighter and brighter lives. to enjoy the moments that matter most, and Kyowa Hakko’s Cognizin® Citicoline is a researched brain health nutrient that embodies our core values ​​of bringing the most effective supplements to the market.

Kyowa Hakko USA is “delighted to have Cognizin® Citicoline featured as a key ingredient in Solaray SharpMind Focus,” says Karen Todd, MBA, RD, Vice President, Global Brand Marketing, Kyowa Hakko USA, Inc. “We are always striving to progress and innovation in the field of brain health.

SharpMind Focus, Solaray’s newest nootropic supplement, contains 250mg of Cognizin® Citicoline, an exclusive form of citicoline – a brain health nutrient found naturally in the body.* Citicoline is a cellular building block that is synthesized phospholipids, which make up about 30% of brain tissue and provide essential support for neurons. Cognizin® has been clinically studied to support brain health, focus and attention.

In addition to Cognizin® Citicoline, SharpMind Focus contains 100mg of powerful brain food Bacopa monnieri and 125mg of fermented organic Lion’s Mane Mushroom for memory support. VegCaps (vegetarian capsules or pills) are also vegan and gluten-free. The product is packaged in 100% post-consumer recycled plastic bottles.

*The Food and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure or prevent any disease.

About Cognizin® Citicoline:

Cognizin® Citicoline, manufactured by Kyowa Hakko Bio Co., Ltd., is a clinically studied and marketed form of Citicoline, a natural substance made endogenously in the body and especially vital for brain health. Citicoline is a powerful nutrient for brain health. A proprietary form of citicoline, Cognizin® has been clinically studied to support mental energy, focus, attention and recall. Cognizin® Citicoline was recognized as a finalist for NutraIngredients “Ingredient of the Year” in the Cognitive Function category and winner of the Europe 2022 award. Cognizin® is made through a fermentation process to give high quality and purity. Cognizin® is also very stable, GRAS, ultra-pure and allergen-free. For more information about Cognizin®, visit Cognizin.com.

About Kyowa Hakko USA:

Kyowa Hakko USA is the North and South American office of Kyowa Hakko Bio Co. Ltd., an international manufacturer of health ingredients and a global leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals, food and drinks. Kyowa is the manufacturer of branded ingredients including IMMUSE® LC-Plasma, Eyemuse® Lacticaseibacillus paracasei KW3110, Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, as well as L-Alanyl-L-Glutamine. For more information, visit http://www.kyowa-usa.com.

About Solaray:

Founded in 1973, Solaray, Inc. is one of the pioneer brands of vitamins, minerals and herbal supplements in the natural products industry, helping to establish the category. Part of The Better Being Co. (formerly Nutraceutical), Solaray aims to help people live brighter and healthier themselves through its commitment to award-winning product innovation, rigorous testing protocols, extensive supplement health and wellness education and sustainability programs that give back to the environment and the communities therein. Solaray offers a full line of vitamins, minerals, herbs and herbal extracts that help consumers around the world lead a healthy lifestyle, with over 900 product solutions to meet a wide range of needs. For more information and to purchase products, please visit Solaray online at Solaray.com, or on Facebook and Instagram.

Media interested in arranging an interview with Karen Todd, please contact Giselle Chollett: [email protected] or 917.386.7116.

Share the article on social networks or by e-mail:

Tumbling-Box Washing Machine Market Pricing Strategy, Latest Industry News, Top Company Analysis, Research Report Analysis and Share by Forecast 2028

0




The research analysis on Tumbling-Box Washing Machine market offers a thorough assessment of the major growth opportunities, roadblocks, and other channels for expansion that will affect the industry's growth between 2022 and 2028.

Additionally, the research report predicts that during the projection period, this marketplace would display a healthy CAGR and produce commendable returns.

The document provides a comprehensive analysis of the economic condition to assist stakeholders in developing effective growth strategies for their future investments. The report also provides information on well-known companies that are operating in this industry sector, including information on their business portfolios and development trends as well as key information on the market segmentations.

Request Sample Copy of this Report @ https://www.newsorigins.com/request-sample/50427

Key Information from the Tumbling-Box Washing Machine market report:

  • Statistical information on overall market size, revenue potential, and total sales capabilities.
  • Additionally, market segments with high CAGR have been noted.
  • An in-depth review of recent market trends.
  • Additional avenues for business development.
  • Important information about distributors, retailers and seller of Tumbling-Box Washing Machine Market.

Product category:

  • Fully automatic and semi-automatic

  • Market valuations for each of the products mentioned
  • Detailed pricing plans for different product types.
  • The Tumbling-Box Washing Machines market study provides an in-depth analysis of forecasted total revenue and sales for several product categories.

App overview:

  • The revenue and sales volume for each application model, including their respective consumption habits and market share, are documented in the report.

Competitive Landscape:

  • Alliance Laundry Systems LLC
  • Haier
  • LG Electronics Inc.
  • Panasonic Company
  • Robert Bosch GmbH
  • Siemens AG
  • Toshiba Corp and Whirlpool Corporation

  • The competitive study offers crucial information about each company and its unique characteristics.
  • The study examines the revenue, sales tactics, gross margins, and revenue of each market competitor.
  • In addition, essential advice regarding the progression of the company is provided to newcomers.
  • The pricing policies, product portfolios, distribution networks and financial advances of major companies are also assessed.

Drum Washing Machine Market Segments Covered in the Report:

Regional land:

  • North America (United States, Canada and Mexico)
  • Europe (Germany, France, UK, Russia, Italy and rest of Europe)
  • Asia Pacific (China, Japan, Korea, India, Southeast Asia and Australia)
  • South America (Brazil, Argentina, Colombia and rest of South America)
  • Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, South Africa and Rest of Middle East and Africa)
  • The report examines the growth rate of each regional market over the period 2022-2028.
  • Revenue generated and sales for each region along with their respective expansion potential are shown.

This The Tumbling-Box Washing Machine Market Analysis Report contains answers to your following questions:

  • What CAGR will the Tumbling-Box Washing Machine market register from 2022-2028?
  • How is Tumbling-Box Washing Machine Market Product Type split?
  • Which regions are listed in the Tumbling-Box Washing Machine market report?
  • Which companies are defining the competitive landscape of the Tumbling-Box Washing Machine market?

Customization request for this report @ https://www.newsorigins.com/request-for-customization/50427

Sure Signs Your Immune System Isn’t As Strong As It Should Be – Eat This, Not That

0

Your immune system works hard to fight off foreign invaders like infections and germs to keep you healthy and it never takes a break. It works around the clock every day to protect you, so helping your immune system stay strong is vital to your overall well-being. So how can you help boost your immunity? Eat this, not that! Health spoke with Dr. Michael Hirt, board certified in nutrition from Harvard University and board certified in internal medicine and is with the Center for Integrative Medicine in Tarzana, California who shares what to know about your immune system, the signs that it is too weak and how to help strengthen it. As always, please consult your doctor for medical advice. Read on and to ensure your health and the health of others, don’t miss these Sure signs you’ve already had COVID.

iStock

Dr. Hirt tells us, “You know exercise can make your heart stronger. You know puzzles can make your brain smarter. However, even after two years of pandemic health courses, people still don’t know how to reliably boost their immune systems. Like your cardiovascular and nervous systems, the immune system is subject to the same lifestyle choices that affect the rest of your body. Eat too much sugar, drink too much alcohol, shorten your sleep hours, and you shouldn’t be surprised that you’re going to wake up with a racing heart, a foggy brain, and the onset of a sore throat. You are the sum of your choices, and a robust immune system is no exception to your cumulative health investments (or lack thereof).

Upset stressed young woman suffering from abdominal and stomach pain during menstruation, PMS in bedroom at home.  Inflammation and infection.  Food poisoning
Shutterstock

“Your immune system’s innate programming is all about attacking microbial threats and coordinating repairs ranging from skin scrapes to broken bones,” says Dr. Hirt. “Under the influence of environmental toxins, gut imbalances (due to diet and bacteria) and genetic tendencies, parts of your immune system can go ‘rogue’ and attack the body it’s sworn to defend only It’s called an autoimmune disease because the immune system attacks parts of itself like the joints, skin, or internal organs It’s never meant to happen, serves no evolutionary benefit, and requires major lifestyle changes, detox, and medical interventions to stop the attack and eliminate triggers. Without a coordinated healing effort, the immune system will likely continue to attack itself and require strong immunosuppressive measures.

Smiling young woman looking at her vitamins
Shutterstock

Dr. Hirt shares, “If you are considering trying to boost your immune system, think about how you would increase the effectiveness of your country’s defense forces. To have a stronger and more efficient army, you would feed them healthy food, ensure you are well rested, avoid unnecessary stress, house them on clean bases, provide them with advanced equipment and have plenty of ammo so that never run out of bullets and missiles. Same thing with your immune system. Eat the healthiest food possible, in the cleanest possible environment, with the least stress possible, having had the most restful sleep possible and taking the best possible vitamins, including zinc, vitamin C and vitamin D. Just like our military, your immune system never takes a collective break in defending you against all threats, both foreign and domestic. »

Portrait of confident doctor in private clinic
iStock

Dr Hirt says: “Most adults catch a cold or the flu 2-3 times a year. If you get sick every month, you may have a more severe immune deficiency that requires testing and treatment.”

Shutterstock

“When you cut yourself, superficial wounds usually take seven days to heal,” Dr. Hirt tells us. “If you’re watching your skin take weeks to heal, your immune system may be compromised.”

Man lying on the bed at home, high fever and cough.
Shutterstock

According to Dr. Hirt, “When you get an upper respiratory infection, most people with a healthy immune system can fully recover within ten days. If your symptoms persist for most of the month, there may be problems with the strength of your immune system’s responsiveness.”

woman lying on the bed with a phone in her hand.
iStock

“There are many reasons to be tired,” says Dr. Hirt. “Many people are surprised to learn that one of them is a weakened immune system or a low white blood cell count. screening for your immune system.”

Heather Newgen

Heather Newgen has two decades of experience reporting and writing about health, fitness, entertainment and travel. Heather is currently a freelancer for several publications. Read more

ETF RAAX: soft performance before inflation took off (NYSEARCA: RAAX)

0

Bet_Black

In my recent note on the Fidelity Stocks for Inflation (FCPI) ETF, I laid out a few reasons why exposure to inflation-friendly stocks, when the market appears to be adjusting risk discounts downwards, might be worth it. prove be a painful disappointment.

There is no denying that the revival of the hawks has put a damper on the turmoil in the markets at the start of this year, and the inflation that implies higher interest rates, a higher cost of capital and weaker future growth. was the main reason. But after July’s CPI and PPI reports as well as somewhat soft economic data out of China that could cool the commodity market, betting on prices across the economy to climb even higher, especially since the Fed is clearly not hesitating to undertake significant hikes if necessary, is a precarious move.

VanEck Inflation Allocation ETF (NYSEARCA:RAAX) is yet another inflation-focused investing vehicle I’d like to discuss. The reasons I don’t like it are mostly based on the premise that inflation is about to or has probably already plateaued. And since the performance of the RAAX strategy during periods of moderate inflation was simply lackluster, gaining exposure to the fund at this stage is extremely risky. Additionally, cost-averse investors here would note that an expense ratio of 74 basis points is a painful detractor of returns, especially over the long term. It is therefore difficult to build a bullish thesis for this ETF.

How does RAAX calibrate the portfolio to outsmart inflation?

As the fact sheet tells us, RAAX focuses on increasing real (inflation-adjusted) returns while trying to minimize “downside risk during sustained market declines.” That is, there is a market timing ingredient in this strategy.

Please note that the fund was renamed in June 2021; prior to that, it was known as VanEck Vectors Real Asset Allocation ETF.

RAAX’s investment philosophy is based on the active multi-asset approach. Concretely, it is the fund of funds which groups together various ETFs supposed to outperform when inflation becomes a concern for the economy. The selection process is exclusive, with few details available.

These ETFs are selected primarily from the universe of real assets with particular attention paid to commodities, including oil and agriculture, but there are also other classes traditionally considered capable of benefiting from inflation, such as real estate, infrastructure and MLPs, among others. Gold is also on the shortlist. Additionally, in the past, RAAX has invested in bitcoin and clean energy ETFs like VanEck Vectors Low Carbon Energy (SMOG), which is a somewhat unconventional way to defy inflationary pressures assuming these assets have a fairly short story. Anyway, I don’t see any BTC-focused funds or clean energy coins in the portfolio as of this writing.

An important note is that the fund attempts to time the market, and when the managers see sentiment as clearly bearish, it may switch to a 100% cash and cash equivalents position.

In the current iteration, RAAX holds 20 stakes, including a meager cash position of just 16 basis points. The fund is heavily concentrated in the Invesco DB Optimum Yield Diversified Commodity Strategy ETF No K-1 (PDBC), with over 22.6% allocated. VanEck Merk Gold (OUNZ) shares are another large position representing 16.5%. There are also smaller allocations to iShares Gold Trust (IAU) and SPDR Gold MiniShares Trust (GLDM), as well as iShares Gold Strategy ETF (IAUF), together accounting for around 44 basis points. It should be noted that RAAX also has indirect exposure to the price of gold as it also favors the ETF VanEck Vectors Gold Miners (GDX) which invests in companies that benefit from cash flow and increased profits when demand for the yellow metal is boiling.

It is mainly exposed to oil through the fund Energy Select Sector SPDR (XLE) and the SPDR S&P Oil & Gas Exploration & Production ETF (XOP); The VanEck Vectors Oil Services ETF (OIH) is an indirect bet on the price of crude to stay higher for longer.

Overall, natural resources dominate in its composition, with category weightings as follows:

RAAX Categories

Created by the author using data from the RAAX site

Lackluster performance before inflation took off is a warning sign

First, let’s look at the performance of RAAX against the iShares Core S&P 500 (IVV) ETF. The table below highlights periods when the VanEck ETF has outperformed the market.

ETF comparison

Created by author using data from Portfolio Visualizer

Launched on April 9, 2018, RAAX has underperformed IVV every year, including the eight months of 2018, resulting in a CAGR of 1.5% (excluding August 2022). It wouldn’t be an exaggeration to say that risk-adjusted returns are also poor. Specifically, with IVV offering a Sortino ratio slightly above 1 (2 is the target), the fund only achieved 0.15.

Dear readers would probably answer here that for most of this period inflation was something of secondary importance, and the market narrative was first controlled by the trade war, then the coronavirus recession came and took rendered all previous economic forecasts irrelevant.

Chart
US Consumer Price Index Annual Data by YCharts

CPI changes were hovering around the 2% target, and it was in 2021 that the fear of inflation began to capture investors’ attention before becoming the overarching theme across the globe, as even markets as frozen as Switzerland or Sweden had to recognize that price growth could no longer be tolerated. It is certainly true. Not coincidentally, we see that RAAX outperformed IVV massively five times in 2022, only finishing behind the market in June and July when the technology and growth cohorts started to recover.

Let’s also compare its one-year performance to IVV as well as the SPDR SSGA Multi-Asset Real Return ETF (RLY) for better context.

Comparison of ETFs

Created by author using data from Portfolio Visualizer

Clearly, RAAX eclipsed the market, with the lowest correlation of the bunch, but pure equity inflation ETFs still fared much better. RLY, which is more like the VanEck fund with a multi-asset approach, also beat it, with a higher CAGR and lower standard deviation.

In closing, I would say that the fund is relatively new, and extrapolating from its abysmal performance during the era of low inflation to build a multi-year bearish thesis would be a mistake. However, this data is a clear warning, and I see no reason to defend the bullish side either.

Final Thoughts

RAAX has seen astronomical growth in its AUMs, growing approximately 1,247% in the past year and over 413% in the past six months. Does that mean it’s worth pursuing now? The explosive growth of the Ark Innovation ETF (ARKK) AUM during the tech pandemic hype is a succinct illustration of how risky it can be to launch bets on the themes that are in the spotlight.

Chart
ARKK data by YCharts

The inflation theme has also become overhyped, making recipients most susceptible to underperformance when it falls out of favor.

In sum, I am of the opinion that investing in RAAX does not make sense at this stage.

If past performance is any guide, investors will see above-market returns when the economy hits an overheated phase marked by high inflation, and then those gains will gradually evaporate amid normalization as the RAAX strategy was unable to provide significant returns during periods of moderate inflation. , as in 2018 and 2019. Meanwhile, spending will also eat away at returns. Thus, signs of slowing price growth are a strong reason not to consider increasing allocations to inflation-friendly ETFs, whether pure equity funds or multi-asset funds. . Also, I see no good reason to sell the fund at these levels as well, so a Hold rating would be an optimal choice.

ASK THE NUTRITIONIST: How does fresh produce benefit my health?

0

In this week’s column, Nonie De Long explains why fresh produce can positively transform the health of the majority of people.

Dear readers, today’s question comes from May in Port Hope. She wrote to tell me that she had added fresh produce to her daily diet this year with huge benefits for her skin, energy and digestion. She notices that it doesn’t matter which ones she eats, as long as they are fresh. She measures and eats two cups of vegetables with her lunch and dinner and eats two fruits a day. Sometimes she cooks the vegetables and sometimes not. But she feels they have changed her health. She wants to know what is in the product that has made such a difference. How is it so transformative?

that’s a great question. Before I start bragging about the greatness of fresh produce, however, I want to mention that not everyone enjoys it like that. There are a few intestinal and autoimmune diseases that cause fresh produce to worsen health rather than improve it. If you’ve heard of Mikhaila Peterson, you’ve heard of her. Her severe RH arthritis did not improve until she went on a complete carnivore diet. My feeling is that this type of reaction to produce usually occurs after many disturbances in the digestive system. But for the vast majority of people, fresh produce can help transform health for the better.

What do fresh produce contain?

Fiber:

As you’ve probably heard, many vegetables are high in fiber. The various fibers in vegetables help cleanse the walls of the colon, stimulate peristalsis (which moves food), and feed the beneficial bacteria we need for good health. The downside of fiber is that when you’re not used to eating a lot, the results on your digestive system can be dramatic for a while. It’s best to make gradual changes or stay home when making more drastic changes to your diet until you know what to expect. Give yourself three to six weeks to adjust to any new eating routine to really test the impact on your digestive health.

Probiotics and prebiotics:

You might be surprised to learn that fresh produce is very high in bacteria, both on and in it. Studies are pouring in to show us just how essential they are for optimal health. How many bacteria does the product contain? “In a study from July in Frontiers in microbiology, researchers found that an average apple contains about 100 million bacteria. Most are inside, not on the skin. They came from many different taxa, unlike probiotic supplement pills, which tend to be just one type of bacteria. Of the millions of bacteria present in a given apple, there are very rarely any that cause disease; most are harmless or even beneficial. Source. I can’t find clear information on the role of pesticide and fungicide sprays and ripening on the development of these organisms. If you know the answer to this question, write to us to share it with us.

Soil organisms:

Soil organisms are bacteria that live in the soil and act as probiotics for plants. They do for plants what probiotics do for us: break down matter for nutrients, synthesize vitamins, develop and strengthen the immune system, fight harmful bacteria, and more. They make the soil welcoming for plants. Healthy soil is full of these organisms, and the fresh produce from that fertile soil is also full of them. When we consume fresh produce grown in healthy soils, we also consume these SBOs.

The role of SBOs in healthcare is only now being unpacked. Some scientists believe they can play a huge role in disease prevention. “This huge reservoir of extra antibodies is always on hand for the immune system to use, as long as the individual regularly ingests SBOs. Without SBOs, this reservoir of additional antibodies is completely unavailable. Thus, by regularly ingesting SBOs, the efficiency of the human immune system is greatly enhanced. This extra contingent of antibodies is always there to attack the infection; therefore, the immune system doesn’t have to work as hard as it normally would to fight infection.” Source And that’s just one of the complex roles of SBOs in human health! Read More more, click here.

Live enzymes:

Fresh produce is full of live enzymes. Until we cook it, that is! Enzymes are proteins that are responsible for chemical reactions and decomposition actions in the body. They are essential for liver health, breaking down food to release nutrients, building muscle tissue, and removing toxins from the body, to name a few important roles. Consuming a diet that contains fresh enzymes helps supply external enzymes to the body so that internal enzymes can be used in other ways. Think of it as resource conservation. You may not have realized it, but lactose intolerance is actually a deficiency of a specific enzyme needed to break down lactose in dairy products. Food enzymes help us get the most out of our food and function at optimal levels. This is why a portion of each meal should consist of fresh, uncooked produce.

Macronutrients:

The macronutrients in vegetables are usually carbohydrates and some proteins. Carbohydrates are used for energy and proteins are the building blocks of the body. The produce is generally not oily, with avocado being an exception. Because produce is mostly carbs, it digests quickly, which is why when you eat a meal that is mostly produce, you feel hungry soon after. Fast digestion leaves us less bloated and full than what we’re used to with our heavy, processed diets today.

Micronutrients:

Fresh produce contains many micronutrients. These include:

  • vitamins
  • Minerals and trace elements
  • Phytonutrients (special plant nutrients responsible for their color, flavor and smell)

These nutrients are extremely important for many functions in our body, and some are even essential, which means we cannot make them but must get them from our diet. Deficiencies and imbalances of some of these nutrients can predispose us to disease. Fresh produce is a good source of many of these nutrients and the only source of phytonutrients.

If you don’t recognize the term phytonutrients, you’ve probably heard of carotenoids, flavonoids, lycopene, resveratrol and others. Broken down, phytonutrients simply mean plant-specific nutrients. These nutrients are known to be powerful in supporting immune function and cell regeneration. They can help fight cancer in the organs.

“Phytonutrients are actually the basis of more than 40% of today’s medicines, including those used to treat lung and heart disease, diabetes, obesity and certain types of cancer. They are also found in herbs and spices, as well as medicinal plants that have played an important role in ancient history in promoting well-being. Source These are nutrients you want in your diet. And the solution is simple: eat more fresh produce!

Thanks, May, for writing. As always, if readers have their own health questions, I welcome them! Just send me an e-mail. If you are looking for more specific health information, check out my website.

Namaste!
Nonie Nutritionist

Mirae Asset Global Investments Co. Ltd. acquires 1,596 shares of FactSet Research Systems Inc. (NYSE: FDS)

0

Mirae Asset Global Investments Co. Ltd. increased its stake in the shares of FactSet Research Systems Inc. (NYSE: MSDSGet a rating) by 5.9% in the 1st quarter, according to the company in its most recent Form 13F filed with the Securities and Exchange Commission. The fund held 28,632 shares of the business services provider after buying an additional 1,596 shares during the quarter. Mirae Asset Global Investments Co. Ltd. owned 0.08% of FactSet Research Systems worth $12,431,000 at the end of the most recent reporting period.

Several other institutional investors and hedge funds also changed their positions in the company. The North Carolina State Treasurer increased its stake in shares of FactSet Research Systems by 12.3% in the first quarter. The North Carolina State Treasurer now owns 16,000 shares of the business services provider worth $6,946,000 after purchasing an additional 1,750 shares during the period. Campbell & CO Investment Adviser LLC bought a new position in shares of FactSet Research Systems during the first quarter at a value of $642,000. The Bank of Nova Scotia increased its stake in shares of FactSet Research Systems by 27.3% in the first quarter. The Bank of Nova Scotia now owns 38,427 shares of the business services provider valued at $16,683,000 after purchasing an additional 8,230 shares during the period. Commerce Bank increased its stake in shares of FactSet Research Systems by 2.7% in the first quarter. Commerce Bank now owns 13,085 shares of the business services provider valued at $5,681,000 after buying 347 additional shares during the period. Finally, River Wealth Advisors LLC increased its stake in shares of FactSet Research Systems by 21.1% during the first quarter. River Wealth Advisors LLC now owns 568 shares of the business services provider valued at $247,000 after buying 99 additional shares during the period. 89.99% of the shares are currently held by institutional investors.

Insider buying and selling

In related news, CEO Frederick Philippe Snow sold 2,500 shares of FactSet Research Systems in a trade dated Monday, August 1. The stock was sold at an average price of $424.92, for a total transaction of $1,062,300.00. Following the completion of the sale, the CEO now owns 3,988 shares of the company, valued at $1,694,580.96. The transaction was disclosed in a filing with the Securities & Exchange Commission, available at the SEC website. In other news from FactSet Research Systems, CEO Frederick Philippe Snow sold 2,500 shares of the company in a transaction that took place on Monday, August 1. The stock was sold at an average price of $424.92, for a total value of $1,062,300.00. Following completion of the transaction, the CEO now directly owns 3,988 shares of the company, valued at $1,694,580.96. The sale was disclosed in a filing with the Securities & Exchange Commission, available at this hyperlink. Also, VPE Jonathan Reeve sold 335 shares of the company in a transaction that took place on Friday, July 8. The shares were sold at an average price of $401.55, for a total value of $134,519.25. Following the completion of the transaction, the executive vice president now directly owns 111 shares of the company, valued at $44,572.05. Disclosure of this sale can be found here. Insiders sold 11,407 shares of the company valued at $4,482,202 during the last quarter. 0.83% of the shares are currently held by insiders of the company.

A Wall Street analyst gives his opinion

Several brokerages have recently commented on FDS. Deutsche Bank Aktiengesellschaft raised its price target on FactSet Research Systems from $418.00 to $463.00 in a Wednesday, August 10 research note. Barclays cut its target price on FactSet Research Systems from $550.00 to $440.00 and set an “overweight” rating on the stock in a Friday June 24 research note. Credit Suisse Group cut its price target on FactSet Research Systems from $475.00 to $390.00 and set a “neutral” rating on the stock in a Friday, June 24 research note. Redburn Partners began covering FactSet Research Systems in a research note on Tuesday, May 17. They issued a “sell” rating on the stock. Finally, Morgan Stanley cut its price target on FactSet Research Systems from $362.00 to $338.00 and set an “underweight” rating on the stock in a Tuesday, June 21 research note. Three analysts rated the stock with a sell rating, seven gave the company a hold rating and two gave the company a buy rating. According to MarketBeat.com, FactSet Research Systems currently has an average rating of “Hold” and an average target price of $416.25.

FactSet Research Systems Price Performance

Shares of NYSE MSDS opened at $446.37 on Friday. The company has a debt ratio of 1.66, a quick ratio of 2.12 and a current ratio of 2.12. The company has a market capitalization of $16.95 billion, a PE ratio of 43.80, a P/E/G ratio of 3.36 and a beta of 0.80. The company has a 50-day simple moving average of $402.36 and a two-hundred-day simple moving average of $404.90. FactSet Research Systems Inc. has a fifty-two week low of $345.92 and a fifty-two week high of $495.39.

FactSet Research Systems (NYSE: MSDSGet a rating) last reported results on Thursday, June 23. The business services provider reported EPS of $3.76 for the quarter, beating analyst consensus estimates of $3.18 by $0.58. FactSet Research Systems achieved a return on equity of 44.24% and a net margin of 22.41%. The company posted revenue of $488.75 million in the quarter, compared to a consensus estimate of $476.06 million. In the same quarter a year earlier, the company posted earnings per share of $2.72. As a group, stock analysts expect FactSet Research Systems Inc. to post EPS of 13.48 for the current fiscal year.

FactSet Research Systems Dividend Announcement

The company also recently announced a quarterly dividend, which will be paid on Thursday, September 15. Investors of record on Wednesday, August 31 will receive a dividend of $0.89 per share. This represents a dividend of $3.56 on an annualized basis and a dividend yield of 0.80%. The ex-dividend date is Tuesday, August 30. FactSet Research Systems’ dividend payout ratio (DPR) is 34.94%.

FactSet Research Systems Company Profile

(Get a rating)

FactSet Research Systems Inc, a financial data and analytics company, provides integrated financial information and analytical applications to the investment community in the Americas, Europe, Middle East, Africa and Asia-Pacific. The Company provides insights and insights through the Research, Analytics & Trading, Content & Technology and Wealth Solutions Workflow Solutions.

Further reading

Institutional ownership by quarter for FactSet Research Systems (NYSE:FDS)



Receive daily news and reviews for FactSet Research Systems – Enter your email address below to receive a concise daily summary of breaking news and analyst ratings for FactSet Research Systems and related companies with MarketBeat.com’s free daily email newsletter.

identify the target of immune attacks on liver cells in metabolic disorders | Writing

0

When fat builds up in the liver, the immune system can attack the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that triggers these defenses, a finding that helps explain the underlying dynamics of liver damage that can accompany type 2 diabetes and obesity.

In a study published Aug. 19 in Science Immunology, researchers mimicked these human metabolic diseases by genetically modifying mice or feeding them a diet high in fat and sugar. They then looked at changes in the arm of the rodent’s immune system that mounts defenses tailored to specific threats. When misdirected at the body, this immune response, which involves B and T cells, damages the organs and tissues it is meant to protect.

“For a very long time, people have wondered how T and B cells learn to attack liver cells, which are under increased metabolic stress due to a high-fat, high-sugar diet,” said lead researcher Dr. Dr. Laura Santambrogio, who is Professor of Radiation Oncology and Physiology and Biophysics, and Associate Director of Precision Immunology at Weill Cornell Medicine’s England Institute for Precision Medicine. “We have identified a protein – probably the first of a long series – that is produced by stressed liver cells and then recognized by B and T cells as a target.”

Back row left to right: Madhur Shetty; Marcus DaSilva Goncalves; Laura Santambrogio; Lorenzo Galluzzi; Aitziber Buque. Front row left to right: Jaspreet Osan; Shakti Ramsamooj; Cristina Clement; Takahiro Yamazaki

Activating the immune system further compounds the damage that already occurs in this organ in people with these metabolic conditions, she said.

In type 2 diabetes or obesity, the liver stores excess fat, which can stress the cells, leading to a condition known as non-alcoholic steatohepatitis, commonly known as fatty liver disease. Stress leads to inflammation, a nonspecific immune response that, although intended to protect, can damage tissue over time. Researchers now also have evidence that B and T cell activity also contributes.

B cells produce proteins called antibodies that neutralize an invader by latching onto a specific part of it. Similarly, T cells destroy infected cells after recognizing partial sequences of a target protein. Sometimes, as in autoimmune diseases, these cells activate the body by recognizing “self” proteins.

Dr. Santambrogio and his colleagues, including Dr. Lorenzo Galluzzi, assistant professor of cell biology in radiation oncology at Weill Cornell Medicine and Dr. Marcus Goncalves, assistant professor of medicine at Weill Cornell Medicine and endocrinologist at NewYork-Presbyterian/Weill Cornell Medical Center, along with researchers from Dr. Lawrence Stern’s group at the University of Massachusetts Medical School, wanted to know which molecule in liver cells became their target.

Examining the activity of another type of immune cell, called dendritic cells, led them to a protein, called PDIA3, which they believe activates both B and T cells. , cells make more PDIA3, which travels to their surfaces, where it becomes easier for the immune system to attack.

While these experiments were performed on mice, a similar dynamic appears to be at play in humans. Researchers have found elevated antibody levels for PDIA3 antibodies in blood samples from people with type 2 diabetes, as well as autoimmune conditions affecting the liver and its bile ducts.

Unlike autoimmune diseases, however, improving your diet and losing weight can reverse this liver disease. The link to diet and a decrease in fatty liver was already well established, Dr. Santambrogio said.

“We’ve added a new piece to the puzzle,” she said, “by showing how the immune system begins to attack the liver.”

Many physicians and scientists at Weill Cornell Medicine maintain relationships and collaborate with outside organizations to foster scientific innovation and provide expert advice. The institution makes this information public for the sake of transparency. For this information, see the profiles for Dr. Lorenzo Galluzzi and Dr Marcus Goncalves.

Serbia’s NECP in public review until September 5

0

Serbia is considering the possibility of adding small nuclear power plants from 2032, and the government plans to reduce emissions by 34.2% to 44.4% by 2030. In the work scenarios of the National Integrated Plan for the energy and climate, the Ministry of Mines and Energy is planning new wind and solar power plants by the end of the decade with a total capacity of 4.7 GW or 6.4 GW. The share of renewable sources in electricity production is estimated between 49% and 59%.

As part of the process of developing the Integrated National Energy-Climate Plan – INEKP, the Ministry of Mines and Energy has called on all interested parties to submit comments by September 5 on four scenarios. They include options to start connecting small modular reactors – SMRs to the grid in 2032.

The production of National Energy and Climate Plans or NECPs is an obligation under the rules of the European Union and the Energy Community to achieve the objectives of both sectors on the way to achieving carbon neutrality. mid-century here.

There is another scenario, which is not the subject of the first consultations. Namely, it was analyzed exclusively to see what would happen if Serbia adopted the EU’s general goals, including reducing greenhouse gas emissions by 55% by 2030. In the EU , each country has its own objectives. Three other scenarios are in development, according to the announcement.

Five scenarios have been published and three more are in development

The INEKP or NECP was to be produced for the period 2021 to 2030 with a vision up to 2050, but the projections now start with 2023. The purpose of the overview is to show the current status and measures needed in the areas of decarbonisation, energy efficiency, energy security, the internal energy market and research, innovation and competitiveness.

The plan must define an optimal energy mix and allow the improvement of security of supply and the reduction of energy poverty.

Up to 2.2 GW of coal-fired power generation capacity remains in 2050 only as reserve

The four scenarios cover the period up to 2030 with options for a later introduction of nuclear energy. The capacity of these sources is 400 MW in 2032, 800 MW in 2035 and 1.6 GW in 2042. Green hydrogen reaches 1% of final energy consumption by 2030.

In all scenarios, Serbia adds 680 MW of capacity from pumped storage hydropower plants in 2028 and another 600 MW two years later. As for the 2050 vision, no active coal plants are seen at that time, but 1.8 GW to 2.2 GW would be kept in reserve and used if needed.

In the version with small modular reactors, their overall capacity reaches 1.6 GW in 2042

In the four scenarios of Serbia’s NECP, the share of renewable sources in the gross final energy consumption reaches 41% to 43% and 190 MW or 200 MW of solar power plant capacity is added every year. The total is slightly over 1.5 GW.

The share in electricity production in scenarios 1, 2 and 3 is 52% to 59% in 2030. They envisage new wind capacity which will gradually increase from 340 MW per year to 1 GW in the last year, i.e. 4, 9GW in total.

The fourth scenario involves less wind power

The so-called S scenario presents a different dynamic for wind power and less added capacity: a total of 3.2 GW from 2023 to 2030, of which 86% is connected to the grid in the last three years of the period. This results in a share of renewable energy production of 49%.

Thus, the country’s NECP plans to install a total of 4.7 GW or 6.4 GW of wind and solar power over the next eight years.

As for the reduction in annual emissions compared to the level measured for 1990, it is between 34.2% and 44.4%, compared to 29% from 2020.

North Macedonia is the only Western Balkan country and Contracting Party of the Energy Community to have adopted its NECP two months ago, while Albania submitted its draft in December.



Post views:
2

Group launches internet speed survey – Cleveland County Herald

0

Data will be key to securing grants and funding county broadband

RISON — The Accelerate Cleveland County Broadband Committee is launching a countywide online survey this week to get a true reading of broadband speeds in the county. The data collected will be used to seek grants and other investments to improve service throughout the county.

This is the current Federal Communication Commissions (FCC) broadband map for Cleveland County. Areas shaded green, which represent more than half of the county, are said to have broadband download speeds of over 100 Mbps. A voluntary speed test survey conducted by the Arkansas Broadband Office in 2020 found that about two-thirds of the 81 people who responded to the survey in Cleveland County had download speeds below 10 Mbps. The current survey by Accelerate Cleveland County aims to get a more accurate record of actual internet speeds in the county.

The survey is coordinated by the University of Arkansas at Fayetteville and the Accelerate Arkansas program. Surveys will continue to be accepted until September. Organizers hope to get several hundred surveys, if possible, to provide a true sample of internet speeds in the county.

While high-speed fiber optic cable is currently installed in Rison and Kingsland, the Accelerate Cleveland County committee is looking to expand fiber optic service beyond these city limits and throughout the county.

Accelerate Cleveland County is part of the Accelerate Arkansas Project, which is an initiative launched by the Arkansas Connectivity Coalition, a group of more than 15 state organizations committed to expanding Internet access. The group was created to help support state and local communities plan and secure the federal funds needed to expand access and ensure high-speed Internet is more accessible and affordable.

Respondents are asked to use the device they usually use to access the internet (laptop or desktop, tablet, smartphone, etc.) and also use the connection they usually use to access to the Internet (telephone company, satellite, hot spot, cellular signal, etc.). The survey aims to accurately document how people access the Internet in Cleveland County and what kind of speeds they get.

To take the survey, go online to https://uark.qualtrics.com/jfe/form/SV_2fvt7RZACFlW4WG

Accelerate Cleveland County also launched a Facebook page where residents can access the survey.
There is also a QR code found on an ad in this issue of the Herald that will allow people to access the survey via a smart phone or other device capable of reading QR codes.

One of the issues the Cleveland County committee noticed early on was that the Federal Communications Commission (FCC) map used by the government and granting agencies to determine where high-speed internet is available did not provide a picture. specifies actual speeds within the county. Talent said the map shows most of the county has internet download speeds of 100 megabits per second (Mbps), which he says isn’t accurate based on speed tests in those areas.

Currently, the FCC’s fixed broadband speed benchmark is 25 Mbps download and 3 Mbps upload. However, FCC Chairman Jessica Rosenworcel suggested in July that the new minimum be increased to 100 Mbps download and 25 Mbps upload to increase Internet usage in the future.

Nicolas Aguelakakis, senior economic adviser for the Arkansas Department of Commerce’s Broadband Office, said the FCC maps are disputed for their accuracy and an effort is underway to make the maps more accurate.

He explained that the map is based on information provided to the FCC by the internet service provider. If a single location within a “census block” (a geographic region within the county or city) receives 100 Mbps service, then the entire census block is labeled as having 100 Mbps service.

During the 2020 COVID pandemic, the Arkansas Broadband Service Office conducted a voluntary survey to test statewide internet speeds. According to a map posted on the agency’s website, 81 locations in Cleveland County responded to the survey. Of these respondents, 55 (68%) had speeds below 10 Mbps; 21 (26%) had 10 to 20 Mbps; four (4%) had 20-25 Mbps; and two (2 percent) had 50-85 Mbps

The two locations reporting the highest speeds (50-85 Mbps) appeared to be from businesses based on their location on the map.

The Accelerate Cleveland County Broadband Committee has met weekly for the past five weeks to develop a strategy to improve broadband service throughout Cleveland County.

Pleasant Ridge Community Justice of the Peace Donnie Herring and Rison Area Herald Britt Talent Editor/Publisher are co-chairs of the committee. Other committee members include Judge Bruce Brown of the Pansy area, County Judge Melody Spears of New Edinburg, County Clerk Jimmy Cummings of the Mt. Carmel community, John Appleget and Stephen McClellan of the Rison area. and subdivision developer Bracy Young of Rye.

Bruce Grubb of Cleveland County Telephone, a local Internet service provider, is also on the Accelerate Cleveland County committee.

Talent said the mission of the Accelerate Arkansas program is to provide fast, reliable Internet service at an affordable cost to areas of the state that currently have high-speed broadband access. Cleveland County was one of five communities in the state selected for the initiative.

One of the Accelerate Arkansas training sessions focused on developing a vision for each of the communities participating in the program. The Cleveland County Committee has proposed the following vision statement: “To establish fiber optic broadband service providing a minimum of 100 Mbps download and 100 Mbps upload to every home and business in Cleveland County at a price affordable to improve commerce, entrepreneurship, education, healthcare, communication, recreation and other opportunities.
After learning that the new standards could be increased to 100 Mbps download, Talent said the committee decided to include those speeds in the vision statement to match the possible new federal standard. He said the committee also consulted with the local internet service provider to verify that these speeds would be possible if fiber optic cable was installed throughout the county.

Convened by Heartland Forward, the Arkansas Connectivity Coalition behind the Accelerate Arkansas program is made up of nonprofits, advocacy organizations, thought leaders, and philanthropic organizations, including the Arkansas Black Mayors Association, Arkansas Community Foundation, Arkansas Electric Cooperatives Inc., Arkansas Farm Bureau, Arkansas Impact Philanthropy, Communities Unlimited, Diamond State Networks, Forward Arkansas, Holman Strategies, Runway Group, University of Arkansas-Department of Communication, Arkansas System Division of Agriculture, Winrock International and Winthrop Rockefeller Foundation.

Sign up for the eHerald today!