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Bruker showcases life science and materials research solutions

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The high-value instrumentation was on display in Munich, Germany at this year’s analytics

Bruker Corporation is showcasing its high-value scientific instruments, software and integrated solutions for applications in materials and energy research, biopharma, applied markets, as well as life sciences and translational research this week. at Analytica 2022.

Frank H. Laukien, Ph.D., President and CEO of Bruker Corporation, said, “Our differentiated, high-value scientific instruments and solutions showcased at analytica 2022 demonstrate the diversity, flexibility, and high performance that Bruker brings. to the world of laboratory science. Bruker is committed to providing technology, software, chemical and biological solutions optimized to enable the success of our customers. We are very excited to introduce new solutions that now also enable single-cell spatial metabolomics, a key new capability for in situ multi-omics single-cell biology and cancer research.

Applied and industrial markets

Bruker launches the HYPERION II FT-IR/IR Laser Imaging Microscope as a flexible research platform, combining FTIR microscopy with QCL IR laser imaging. The HYPERION II is the first IR laser microscope that offers the three modes of transmission, reflection and ATR. The intuitive software allows seamless switching between FT-IR and QCL technology. With an unprecedented imaging speed of 6mm² per second, it sets the new benchmark in vibrational microscopy.

The new TGA II FT-IR module enables advanced gas analysis by hyphenation of thermogravimetry (TG) and FT-IR spectroscopy. Its new cell design allows high temperature analysis up to 370°C. Most applications can now be covered by a DTGS detector without the need for liquid nitrogen. The TGA II is prepared for adaptation to TG balances from partner Netzsch and other manufacturers.

Bruker introduces PoN mass spectrometry for accelerated measurements without chromatography to bring the power of mass spectrometry (MS) to new food, beverage, forensic, industrial, safety, environmental and pharmaceutical applications. The new DART-EVOQ Point of Need (PoN) triple quadrupole MS system was developed with the IonSense DART source to enable PoN workflows that reduce analysis time to seconds or minutes, with little or no preparation for rapid analyzes of solids, liquids or gas samples.

Food Analysis Solutions

Bruker launches the MPA II Dairy Analyzer for a new standard in quality control and analysis of liquid and solid samples in the dairy industry, as well as plant-based alternatives. It allows automated sampling and homogenization for liquid product analysis, or with an integrating sphere can also measure heterogeneous materials without sample preparation in diffuse reflection. Near-infrared (NIR) spectroscopy is a recognized method for liquid and solid sample types, described in ISO 21543 | IDF 201 guidelines published in 2020.

A new Olive Oil-Profiling 1.0™ NMR solution provides analysis of the authenticity and quality of olive oil, one of the most adulterated food products in the world. Olive Oil-Profiling 1.0 is available on the Fourier™ 80 benchtop system for olive oil bottlers, as well as the FoodScreener™ 400 MHz NMR platform for advanced testing laboratories.

New laboratory solutions for BioPharma

Bruker introduces the new Fourier 80 FT-NMR capabilities for pharmaceutical and chemical analysis. The Fourier 80 benchtop spectrometer requires no special lab infrastructure or cryogens and offers excellent 1H sensitivity of 200:1 for gradient spectroscopy proton probes, bringing FT-NMR to more research labs and analysis. The new Fourier 80 Adjustable Temperature (AT) option allows analysis up to 60°C, and the AT option is compatible with the Fourier 80 PAL autosampler option.

A new benchtop FT-NMR Reaction Monitoring Solution and GxP Prep Kit for RxnLab™ 80 Fourier Reaction Monitoring Solution has been introduced for chemical and pharmaceutical laboratories, and features temperature-controlled reaction lanes for optimize process control and reaction product monitoring of the MPA II dairy analyzer with the new Fourier 80 flow accessory. Running InsightMR software, the RxnLab brings benchtop FT-NMR to bio and chemical production for non-NMR experts. The new Fourier 80 GxP Prep Kit enables full GxP compliance for development and manufacturing labs with 21 CFR Part 11 compliance.

Integration of the timsTOF flex platform with 5-micrometer single-cell resolution and new MALDI Hiplex-IHC assays ushers in the era of unbiased single-cell spatial metabolomics (SSCM) and enables in situ multi-omics tissue research and single-cell biology to accelerate drug development. Bruker’s strategic partnership with AmberGen brings breakthrough capabilities to single-cell biology with spatial multi-omics capabilities that allow researchers to simultaneously observe how drugs affect both protein and metabolic states by combining targeted spatial protein profiling MALDI HiPLEXIHC with an unbiased bias, Cell-Resolved Small Molecule MALDI Imaging for co-localization of proteins and small molecules such as glycans, lipids, metabolites or xenobiotics

Microscopy and Nanoanalysis

The new NeuraLight 3D Ultra™ module expands neuroscience research capabilities and optogenetic applications on Bruker’s Ultima multiphoton microscopes. NeuraLight 3D Ultra provides breakthrough 3D holographic photostimulation optimized for large-scale functional and Fourier 80 Benchtop FT-NMR studies of neural networks and brain computation. Based on proprietary Spatial Light Modulator (SLM) technology, NeuraLight 3D Ultra uses a new, larger LCD chip for a wider field of view, improved targeting accuracy, and a top speed of 600 frames per second. holograms per second.

Bruker introduces XFlash® 7, the next generation of EDS detectors for elemental analysis with QUANTAX™ energy dispersive X-ray spectrometer (EDS) accessories that enable chemical analysis on electron microscopes with speed, ultimate sensitivity and reliability. Unique new features in XFlash 7 further increase performance and productivity and reduce cost of ownership. XFlash 7 detectors offer a range of detector window sizes, shapes and materials, and are designed to provide maximum collection angles for X-rays, with an optimized ratio of detector active area and sample distance -detector.

Translational and clinical research in proteomics

The new timsTOF® HT features a 4th generation TIMS-XR (Trapped Ion Mobility Separation) cell and 14-bit digitizer for even greater dynamic range in proteomics, improved peptide coverage and more accurate quantification, especially in plasma and 4D tissue unbiased proteomics and epiproteomics. Dia-PASEF acquisition on the timsTOF HT quantifies proteins over a wide dynamic range, even in challenging samples, such as heart tissue, without sacrificing throughput or sensitivity.

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