Home Cellular science covid: Sinopharm’s Covid Booster Reverses Antibody Decline and Improves Cellular Responses: Study

covid: Sinopharm’s Covid Booster Reverses Antibody Decline and Improves Cellular Responses: Study

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BEIJING: A third injection of Sinopharm’s Covid-19 vaccine results in a rebound in antibody levels that drop months after a second dose, a small-scale Chinese study has shown.
It has also been shown that the booster improves cellular responses to the coronavirus.
The results, which are yet to be peer reviewed, come as China begins giving a third injection of Covid-19 to higher-risk members of the population, as concerns grow about the fact that declining antibody levels over time could weaken protection against the virus.
The Sinopharm vaccine is one of China’s main inoculation tools and is also used in countries such as the United Arab Emirates and Cambodia.
About five months after a second dose of Sinopharm, the average concentration of neutralizing antibodies against the virus fell 70% from the level seen four weeks after this injection, according to analysis of samples taken from vaccinated health workers. .
But a week after a third injection, the antibody concentration had increased 7.2-fold from the level seen five months after the second injection, researchers from a hospital affiliated with Sun Yat-sen University said in the newspaper.
The BBIBP-CorV shot study did not discuss how changes in antibody concentration might impact vaccine efficacy, or how the enhanced antibody works against variants of the virus.
Several other vaccines have also shown declining antibody levels over time and their developers have used this data to advocate for the boosters.
But some scientists say more data is needed to decide if boosters are needed.
Cellular responses, another important part of the human immune system, also improved after the third shot of Sinopharm, according to the journal.
“The humoral and cellular responses were induced by the third dose in a robust and rapid manner,” the researchers said, adding that the cellular responses could be the key to lasting protection.
But two experts outside the study said the involvement of cell readings may be limited, in part because it remains unclear how T cell-mediated responses correlate with protection from Covid injections. .


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