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Innate immunity in the lung studied by imaging | Events

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Biography

Professor Paul Kubes is Professor in the Department of Physiology and Pharmacology at the University of Calgary, Canada. Paul leads the University’s research strategy on infections, inflammation and chronic disease in a changing environment and holds the Canada Research Chair in Leukocyte Migration. He interrogated the immune system using cutting-edge imaging technology, including spinning disc confocal, resonant scanning confocal and multiphoton microscopy. approaches to imaging immune cells in transgenic and knockout mouse models. His research has helped delineate the molecular mechanisms that contribute to leukocyte recruitment to sites of inflammation and his work has helped to understand the cascade at several stages of leukocyte recruitment, including the proteins responsible for leukocyte engagement and their attachment to the endothelium, as well as the examination of proteins that contribute to the migration of leukocytes out of the vascular system. By imaging complex cellular behaviors in real time, Professor Kubes has helped us develop a visual understanding of how immune cells function, such as neutrophils, monocytes, macrophages, eosinophils, and iNKT cells in physiological and disease states. pathological.


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