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Live Longer and Disease Free: Teen Book Examines Research on Increasing Longevity | Health

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The fear of losing your parents and seeing them suffer from age-related illnesses is unbearable for all of us. But very few would go so far as to try to change the course of nature. All 17, Lakshya Sharma, a class 12 student of DPS, Sector 45, Gurgaon, shows a deep interest in research on the lengthening of average human life and the treatment of age-related diseases and proposed a book titled “Cellular Senescence & Secretory Phenotypes through the lens of Aging, In Vivo Reprogramming Technology”, published by Notion Press which looks at cellular senescence, a biological factor that causes aging. The book presents the research done so far in the field by international experts.

“There are many biological factors that affect the aging of an organism. Cellular senescence is the most medicinal biological factor that causes aging. What I mean by drug is that it can be controlled or altered through the use of appropriate medications. When we disrupt this biology, animals continue to age, but they age with a longer lifespan and health expectancy, ”says DPS, Sector 45 student Gurgaon, who plans to pursue graduate studies in the States. -United.

Love for his parents and curiosity for things going on around him prompted Lakshya to take an interest in the subject.

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“I had lost my grandmother to cancer and was in agony from her loss. I didn’t want to lose my parents anytime soon because of illnesses or because of their old age. I wanted my mom and dad to be there until I was alive. To live without them would seem foolish to me. I decided to read how can I increase the number of years that they can live and make sure that they do not suffer from any disease in their old age because I could not absorb to see them weakened ”, a declared the teenage prodigy to HT. Digital

Lakshya envisions a world where the elderly can live illness-free lives. “Imagine being old without actually being old,” he says. According to the young author, researchers in the United States experimented with mice by suppressing their senescent cells, after which they found that the animals survived longer and did not suffer from any chronic age-related illnesses such as loss of vision, hearing loss, osteoarthritis, among others.

Little Lakshya poses with his father.

Lakshya’s deep interest in research from an early age led him to work with various senior researchers at top IITs where he came across this term senescence and its impact on aging and he did not look into it. back after that.

“I had a general interest in research from a young age and was particularly curious about things going on around me, so I wanted to dig deeper, I wanted to know more about it. over the past two years and I had also worked in few labs of top IITs like IIT Bombay, IIT Delhi. At IIT Bombay, I was motivated to write my book because while I was working there, under the guidance of a lab professor, he explained to me how protein analysis in cancer works. So from there I read this particular term called senescence, ”Lakshya said in a phone conversation.

“Senescence is a cellular condition caused by internal or external stressors that causes cell cycle arrest, morphological alterations, mitochondrial and lysosomal dysfunction, and the secretory phenotype associated with senescence. End-stage somatic cells can can now be reprogrammed into pluripotent stem cells or another differentiated state using reprogramming technologies During cell reprogramming, epigenetic regulation undergoes dynamic rearrangement. Reprogramming can be used to actively adjust epigenetic regulation as it does not ‘does not need any changes to the underlying DNA. Although reprogramming has been studied primarily at the cellular level in vitro, studies have shown that somatic cells in multicellular animals can be reprogrammed in vivo, “read the article. synopsis of the book.

Lakshya is a normal teenager when he isn’t doing research and says speeches, debates, and theatrical performances are his other areas of interest.


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