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Key Trends, Industry Dynamics, Development Strategies and Competitive Landscape 2027 – Business Ethics

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According to a report published by MarketsandResearch.bizreport Global Solar Ingot Wafer Market is expected to grow at a rapid rate from 2021 to 2027. This research would guide the optimal approach for the forecast years and help make sense of the performance of individual companies and the market as a whole with respect to previous years. The report thoroughly analyzes related downstream and upstream industries, including raw material suppliers, equipment manufacturers, industry analysts, traders, distributors and consumers.

The research provides buyers with a comprehensive overview of the industry using particular methodologies, allowing them to plan their business plans accordingly. The report also provides a comprehensive picture of the market by summing, synthesizing and studying data from multiple sources by analyzing key parameters such as profit, price, promotions and competition. In the study, current market players are analyzed in their business trends, costs and sales, applications and various approaches taken to support the solar ingot wafer market.

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Analysis of various socio-economic factors of different regions is required to perform PESTEL analysis. The report also offers informative and up to date data on the Global Solar Ingot Wafer Market which will be helpful for taking informed decisions in the businesses. Business analysts also collect data and study trends based on information from demand and supply intermediaries in the value chain.

The end-user industry involved in the market includes:

Mono Solar Cell, Multi Solar Cell,

Type Industry engaged in the market includes:

Monocrystalline, Polycrystalline,

Manufacturers involved in the market include

GCL(CN), LDK(CN), China Jinglong(CN), Yingli Solar(CN), ReneSola(CN), Green Energy Technology(TW), Sornid Hi-Tech(CN), Jinko Solar(CN), Nexolon( KR), Solargiga Energy Holdings, Trinasolar (CN), Targray, Dahai New Energy (CN), SAS (TW), Comtec Solar, Pillar, Huantai GROUP, Crystalox, Eversol, Topoint (CN), Maharishi Solar, Photowatt, Shaanxi Hermaion Solar, CNPV,

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Regions analyzed for the mentioned market include

Americas (USA, Canada, Mexico, Brazil), APAC (China, Japan, Korea, Southeast Asia, India, Australia), Europe (Germany, France, UK, Italy, Russia), Middle East and Africa (Egypt, South Africa, Israel, Turkey, GCC countries)

Report customization:

This report can be customized to meet customer requirements. Please contact our sales team ([email protected]), who will ensure that you get a report tailored to your needs. You can also get in touch with our executives at 1-201-465-4211 to share your research needs.

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Call: 1-201-465-4211
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Sutherland LSC cancels contracts with mobile phone companies | Community News

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The local school board (LSC) at Sutherland Elementary School voted unanimously against renewing two contracts for cellular equipment installed on a chimney at the school.

Cell tower equipment will begin shutting down this summer, after the LSC voted 10-0 on Feb. 15 following the school community leading a petition to remove the equipment.

More than 260 people have signed the petition and several people have expressed health concerns about the equipment in recent meetings.

“Any local school board’s process has to listen to the community – and the voice of the community was very clear,” said Sutherland principal Meg Burns, who was among the contract voters. “We are mandated by our neighborhood to serve families in our neighborhood. As such, the vote was obvious.

According to CPS, Sutherland has two cell tower contracts – one with Cingular, which expires June 30, and another with Verizon, which expires in June 2023.

The online petition was about the Cingular contract, but LSC president Jimmie Ambrose said the vote would end the deals for both contracts when they expire.

Ambrose has previously said he believes the cell tower equipment is safe.

He said he voted not “not to say the technology is harmful”, but “because we haven’t been given a contract to vote”.

He also noted that the LSC had requested that a CPS lawyer attend the private executive session of the February 15 meeting, but that did not happen after the lawyer accepted the offer during a meeting. previous meeting.

“So I had no choice,” Ambrose said, “but to vote no because of those factors.”

He said CPS attorneys informed him that Cingular would not be able to remove its equipment and find an alternate location to maintain service in the area by June 30, so it is likely that the equipment will remain for an indefinite period after this date.

According to CPS officials, Cingular and Verizon have been informed that their contracts will not be renewed; Typically, it takes 18 months for a cell tower location to be fully downgraded from a CPS site, and cell towers will remain active during this time.

There are 91 CPS schools that have cellular antennas on their premises, officials said.

“CPS aims to provide a safe and healthy environment – ​​inside and outside district buildings – for our students, staff and families,” a spokesperson said. “The district is working with school communities and our vendors to reach amicable agreements to safely and smoothly implement any changes to services, products and the school campus environment.”

An LSC member abstained from voting due to a parent working at the school.

Both deals cost $30,000 a year, and Sutherland receives one-third of the revenue, $20,000, from the contracts.

According to CPS, Sutherland has an enrollment of approximately 600 students, so as the petition states, the contracts provide the school with approximately $33 per child per year.

Becca Blue, a parent at the school, pleaded during the public comment portion of the Feb. 15 meeting to remove the equipment, just as she has done in previous meetings.

“We are a neighborhood school,” Blue said. “Our neighborhood has spoken. He spoke loudly, passionately.

Blue has previously said there are no prizes for the potential health problems a cell tower could cause. The petition raised concerns about students who attend classes near cellphone towers and who may experience cognitive dysfunction, dizziness, headaches, nausea and memory loss.

According to cancer.org, cell towers emit radio frequency (RF) waves. Currently, the website says, the towers show no signs of trouble.

“Cell towers are still relatively new, and many people are rightly concerned about whether the RF waves they emit could have health effects,” the site says. “Currently, there is no strong evidence that exposure to RF waves from cell phone towers causes any noticeable health effects. However, this does not mean that RF waves from cell towers have proven to be absolutely safe. Most expert organizations agree that more research is needed to help clarify this, especially for any possible long-term effects.

In meetings leading up to the vote, members of the school community said they would help with fundraising to replace lost revenue resulting from a non-renewal of a contract.

Burns expressed confidence in that pledge.

“They all said they had a stake in the school and if that meant they had to work harder to raise funds to ensure we would be able to pay staff and pay for things. our families need, they would be there for us,” Burns said, “and I believe that.

Burn, who has been a director since 2017, said that while she is in Sutherland – and while she is in Sutherland – the LSC will serve the interests of the community first. This was demonstrated by the overwhelming vote.

“Our local school board is unified,” she said, “in making decisions that affect our community.”

COVID 19: The architecture of respiratory pandemics

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by G. Ashish Kalra
Bachelor’s (University of Texas, Austin), Master’s (Cornell University), MBA (Chicago Booth School of Business, University of Chicago)
The current pandemic has been devastating, killing over 6 million humans worldwide. Variants have baffled the best of science, neutralizing many invented vaccines. First of all, we spent a lot of time on the source of this virus, whether it came from a laboratory or an animal host. The virus comes from a host animal (infected by a bat). The most important is biologist number 1, Kristian Andersen, who concludes: “The virus must have arisen by natural selection, not by manipulation”. In “Nature”, 2020, Anderson summarizes that the SARS2 Spike protein is not of the best calculated design, and therefore it cannot be “manipulated”. It has a “natural origin”. If it came from a lab, the spike protein would have fitted “optimally” to the human ACE2 receptor. It therefore does not come from a Laboratory. In recent articles in the prestigious journal “Science”, renowned virologist Mike Worobey again showed the “animal host” origin of the virus. Post the Science article, in the words of Dr. Thea Fischer, epidemiologist at the University of Copenhagen “The question of whether the virus spread from animals has now been settled with a high degree of evidence, and therefore of trust.” Additionally, the COVID19 symptoms of respiratory problems and “acute respiratory syndrome” in humans are exactly the same as those of Nipah, SARS, and MERS. SARS was caused by human consumption of civets (a 4-legged mammal) in Guangdong, China in 2002. (Source: CIDRAP, Minnesota & Robert Roos in “Science 2003) and MERS was caused by human consumption of camels (Middle East, 2012: Source: World Health Organization, CDC)
After careful study of animal viruses over the past 100 years, I have reconfirmed, supported by scientific evidence, that bat coronaviruses (as shown below) have caused Hendra virus (horses), the virus Nipah (pigs), Ebola (bats), MERS (Camels), SARS (civet cats) and now COVID19 (pangolin/badgers/raccoon dogs).

My first book, “The Killer Bat”, Kalra, 2021 (on Amazon, Flipkart) describes this mechanism in more detail. Animals were the “intermediate host”.
These viruses are then transmitted to humans, when humans consume these bat-infected animals. Examples are the Asian flu pandemic (1957-58), caused by the human consumption of ducks (Source: CDC) when over 1.1 million people were killed. Hendra virus appeared in horses in 1994. Nipah virus followed in 1997 in Malaysia due to human consumption of pigs (infected by bats). The deadly SARS virus (bat-infected civets) followed in 2002/03 and spread to 27 countries in less than 6 weeks. Same with the MERS virus (human consumption of camels infected with bats) in 2012. MERS was located early, so it did not spread like SARS
Why do these “respiratory pandemics” occur?
The Furin Cleavage Site
At the heart of these bat coronaviruses is a “furin cleavage site” that is present in all coronaviruses. When a human eats a bat-infected animal, this “furin cleavage site” activates a protease enzyme called “Furine”. The role of furin is KEY in understanding the evolution and metamorphosis of respiratory pandemics.
“The cellular protein ‘Furin’ cleaves the protein at the S1/S2 cleavage site, and this cleavage is essential for protein S-mediated cell-cell fusion and entry into human lung cells.”
– Hoffman, Weber, Pohlmann, Molecular Cell, May 2020

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“Kalra Furin’s Rule”
These respiratory pandemics happen for a structured reason. It’s because of humans eating animals, which are infected with bat coronaviruses. Let’s say in the case of SARS, a civet was being eaten and it is infected with a bat coronavirus. There is a Furin Cleavage site in every Bat Coronavirus. On the civet eaten, there is a protease enzyme called “Furine” which is activated. According to virologists Hoffman and Weber, this cellular protein Furin cleaves protein S at the S1/S2 site and this cleavage is essential for protein S cell-cell fusion and entry into human lung cells“. Following the work of Hoffman and Weber, basically according to Kalra Furin’s rule, this furin drives the cell-cell fusion of protein S and entry into human lung cells, and this “furin” hijacks the protein in human cells, amplifies the virus, then spreads the virus, amplifies the virus, and this virus finally causes the death of human beings. Please see diagram above.
1. This Furine action of ENTRY INTO HUMAN LUNG CELLS is the cause of respiration and “acute respiratory syndrome” in human beings. There is a “following hyperviral effect” which is transmission (human to human) at N, i.e. when the virus begins to spread exponentially, as seen in the pandemic of Asian Flu (Ducks, 1957), SARS (Civets, 2002), MERS (Camels, 2012) and now COVID 19 (Pangolin/Blaireaux, 2020)
2. [(Animal-Human)+(Human-Human)raise to N Transmission] : It is spread from Human Mouth to Mouth by “breath”, not by touch or by consuming the same dish. It is “Virus Optimality” that causes “Optimal Virus Distribution” from the Virus point of view. It will inflict maximum damage to human beings. It follows a formula of [(Animal-Human) + (Human-Human) raise to N]where N is the number of humans. “Virus optimality” is when it travels “short distances up to 3 meters through the air”, mouth to human mouth (aerosol transmission). This leads to a “viral effect or network effect of the virus”. This method of transmission is far superior to touching or eating the same dish.
3. This Furin action, which is a direct function of the Furin cleavage site, is nearly identical across SARS-COV2, SARS, MERS, Nipah, Hendra, Ebola, and Marburg viruses. Furin cleaves the spike protein at the S1/S2 site. This cleavage is required for protein S-mediated cell-cell fusion and entry into human lung cells and the resulting acute respiratory syndrome (as seen in SARS, SARS-CoV-2, MERS and others. SARS-COV2 (COVID19) has a polybasic insertion (PRRAR) at the S1/S2 cleavage site that can be “cleaved by furin”. Similar “furin action” in SARS. An analogous cleavage pattern was present at S1/S2 of the Spike protein in MERS (Camels). Same in the case of Nipah virus (pigs infected by bats). different, depending on the animal. More details can be found in my 3rd book to be published on March 3, “La Solution Zéro Covid”, Chp4
4. In addition, these bat coronaviruses have also spread to pets like Cattle, pigs and chickens (Stanley Perlman & Fehr, PMID 25720466)causing “fatal” diseases: Entiritis in cattle and pigs, Respiratory diseases (chicken).
5. “The Wuhan Strain” and “The Delta Variant” : There is the original “Wuhan Strain”, originating from Wuhan, China. The virus spread due to regular 8-9 flights from Wuhan to the United States, Europe and Iran after the Chinese New Year, spreading by mouth to mouth. The “delta variant” is d/dx (H5N8) = first derivative of the H5N8 virus in chickens. Originally from India. Caused the second deadly wave in India. Similar transmission mechanism. The New York Times’ Gorman alludes to it in “A New Bird Flu jumps to Humans” (April 26, 2021). Bat coronaviruses cause “respiratory problems in chickens” which led to respiratory problems in humans when consuming these chickens, which led to the “Oxygen Crisis” (In India, the wild animals are not eaten, the consumption of cattle is prohibited and the consumption of pigs is very low).
To conclude, bat coronaviruses through the action of “Furin” through Furin cleavage sites play an extremely important role in “protecting the animal kingdom” from human encroachment. Similarly, when cannibals eat human beings, they contract brain disease. Different ecosystems. Deadly viruses and pandemics occur when humans eat animals (wild animals and pets). Moreover, animals are able to absorb these bat coronaviruses. Humans cannot, because humans and animals are different ecosystems. A structured 2-year shift to a “plant-based diet” and one serving of lab meat (Beyond Meat, Impossible Foods) is the solution needed. Period.

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Email: [email protected]
Twitter: @AshishKalra44
LinkedIn: Ashish Kalra

Disclaimer: Content produced by Ashish Kalra

Global Prostate Biopsy Devices Market 2021 Industry research covers top company like BD, Argon Medical Devices, Invivo, Cook Medical

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MarketQuest.biz studies provide complete project solutions for strategic decision-making, including Global Prostate Biopsy Devices Market analysis with accurate estimates and forecasts, aiming to provide maximum industry clarity. The research is based on a comprehensive assessment of a number of elements, including market dynamics, market size, issues, stakes, competitive analysis, and companies involved. The research examines a number of critical factors driving the growth of the global prostate biopsy devices market.

The future development trends of the industry are based on a rapid quantitative and qualitative assessment of data received from various sources. The segmentation study includes a descriptive evaluation of the segments, a presentation of the market stocks constituted by each section, the rate of increase of each section, and the attractiveness of the element in terms of income.

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The regional integration of the product is determined by financial variables, therefore the growth trends are influenced by these. The market opportunity for each geographic region is also examined in terms of growth rate, macroeconomic considerations, consumer buying patterns, and market supply and demand situations. Further, extensive primary and secondary research, the study was created. Interviews with notable individuals in the Prostate Biopsy Device industry were conducted for primary research, and rating and ranking studies have been developed accordingly.

Market segmentation based on type:

  • Reusable devices
  • Disposable devices

Market segmentation based on application:

  • Hospitals
  • Ambulatory Surgery Center (ASC)
  • Diagnostic centers

The following companies are covered in the global market:

  • comics
  • Argon medical devices
  • invivo
  • Medical cook
  • TSK
  • UROMED
  • Amecath
  • Sterylab
  • Geotech

Geographical territories covered by the market:

  • North America (United States, Canada and Mexico)
  • Europe (Germany, France, UK, Russia, Italy and Rest of Europe)
  • Asia-Pacific (China, Japan, Korea, India, Southeast Asia and Australia)
  • South America (Brazil, Argentina, Colombia and rest of South America)
  • Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, South Africa and Rest of Middle East and Africa)

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The report gives the answer to some of the frequently asked questions such as, Who was the market leader in 2020, according to manufacturer/vendor/players?,What is the market growth rate? and What is the most capable market phase?

Report customization:

This report can be customized to meet customer requirements. Please contact our sales team ([email protected]), who will ensure that you get a report tailored to your needs. You can also get in touch with our executives at +1-201-465-4211 to share your research needs.

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mark the stone
Business Development Manager
Call: +1-201-465-4211
E-mail: [email protected]

Immunity before and after SARS-CoV-2 Omicron variant in South Africa

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In a recent study published in the New England Journal of Medicine researchers conducted a national epidemiological survey to determine seropositivity against severe acute respiratory syndrome (SARS-CoV-2) prior to the emergence of the concerning new variant of Omicron (VOC).

They also analyzed the change in the epidemiological scenario of the fourth wave of the coronavirus disease 2019 (COVID-19) pandemic in Gauteng Province in South Africa.

Study: Population immunity and severity of Covid-19 with the Omicron variant in South Africa. Image Credit: G.Tbov/Shutterstock



Since its appearance on November 25, 2021 in South Africa, Omicron’s highly mutated COV has caused considerable mortality across the world. The presence of more than 32 mutations in the spike protein (S), three mutations in the membrane protein (M) and six mutations in the nucleocapsid protein (N) of Omicron conferred an increased ability to evade the neutralizing effects of host immunoglobulin. -G (IgG).

Previous studies have reported the epidemiological trends associated with earlier VOCs such as Beta and Delta variants in South Africa. The present study is a follow-up study to add to the results of the epidemiological evaluation of the Omicron-dominant COVID-19 fourth wave.

About the study

This survey was conducted between October 22, 2021 and December 9, 2021 to assess the fourth wave epidemiology and determine seropositivity against Omicron COV S and N proteins among Gauteng residents.

Data on positive cases, hospital admissions and deaths from the onset of COVID-19 to 12 January 2022 were obtained from the Daily Hospital Surveillance Database (DATCOV), South African Council of Medical Research and the South African National Institute of Communicable Diseases using an electronic system. questionnaire method. Considering sample size attrition due to death or people migrating to other countries, household contacts who participated in a similar survey conducted between November 2020 and January 2021 were included in the survey. ‘study.

For determination of seropositivity, blood was collected from participants after ethical and informed consent was obtained. Blood samples were examined for the presence of anti-spike and anti-nucleocapsid IgG antibodies using serological tests.

Results and discussion

A total of 7,948 people completed the questionnaire. However, only 7010 samples were analyzed after exclusion of duplicate and inadequate samples. Only 18.8% of these 7,010 participants were vaccinated.

Overall, 73.1% seropositivity was observed, with seroprevalence rates being higher in the vaccinated (93.1%) than in the unvaccinated (68.4%). Adults aged 50 or over were more seropositive (79.7%) than children under 12 (56.2%). Seroprevalence was heterogeneous between districts, with the highest values ​​in Johannesburg (76.2%). Men, smokers, and unvaccinated people over the age of 50 with no history of SARS-CoV-2 infection residing in informal communities were most susceptible to COVID-19.

Prior to the Omicron wave, 36% and 20% of Gauteng residents were single and double vaccinated, respectively, as of November 25, 2021. Unlike previous COVID-19 waves, a significantly high incidence (2.26,932 cases) was noted with the Omicron wave, while the degree of severity, in terms of hospitalizations (11.2%) and deaths (7.2%), was lower. There was a rapid increase in Omicron-induced cases that peaked within a month, compared to the two-month peak during the third wave. The Omicron-dominant wave was coming to an end around January 12, 2022.

The high seropositivity rates observed prior to the emergence of the Omicron COV may be due to the cumulative effect of the development of robust natural active humoral responses and long-term T cell-mediated immunity developed in response to infection. prior to COVID-19, and natural passive immunity. vaccine-acquired immunity.

Higher incidence of SARS-CoV-2 but lower severity seen in the pandemic’s fourth wave of COVID-19 could be due to higher viral transmissibility and immune evasion properties, but higher potency. low VOC Omicron genetically mutated against SARS-CoV-2 neutralizing antibodies, specifically anti-S IgG.

Conclusion

In summary, a high seroprevalence was noted in females 18-50 years old, vaccinated, Gauteng population residing in self-contained, non-smoking homes, likely due to hybrid immunity developed in response to previous COVID-19 infections. 19 and administration of the vaccine. .

Although the presence of anti-N IgG antibodies in serum positively indicates current infection, anti-S IgG antibodies should be used in serological testing to determine if an individual has previously been diagnosed with COVID-19.

While the new Omicron variant was more transmissible than other COVs such as beta and delta, it caused less severe disease reflected in a drastic decrease in morbidity and mortality associated with SARS-CoV-2 in the fourth wave of Omicron-dominant COVID-19.

Nanobubbles lead to significant oxygen savings in salmon farms

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Moleaer has tested its nanobubble technology with Grieg Seafood BC and CPI Equipment. The project, known as the CO²L Flow (pronounced cold flow) system, was led by Grieg using Moleaer’s patented nanobubble technology and CPI’s ODiN system, for the development of a salmon farming system in semi-closed confinement. Using Moleaer’s nanobubble generators resulted in a 75% reduction in oxygen consumption compared to existing technologies, according to a press release from the California-based company.

The generators work by injecting trillions of oxygen-rich nanobubbles into water supplies, increasing dissolved oxygen (DO) levels at the highest transfer efficiency and lowest cost, thereby reducing the operational expenses of salmon farms.

“We are committed to implementing long-term sustainable solutions to address some of the challenges we face as aquaculturists. Using Moleaer’s technology, we can safely deploy sea lice barriers up to 15 meters without compromising the mixing and dissolved oxygen levels inside the mesh enclosure. This is important to us, as maintaining optimal conditions within the new CO²L Flow System when the barriers are lowered is critical to the health and well-being of our fish,” said Dean Trethewey, production manager at seawater from Grieg Seafood, in a press release.

“Technology and innovation are the backbone of the aquaculture industry. We work closely with our customers, especially Grieg Seafood BC, to always listen to farmers’ problems and recommendations to improve our technology and create innovative solutions. Our latest collaboration with Moleaer’s nanobubble technology has been a huge success and, if deployed, will be a game-changer for other fish farming companies in all regions of the world,” said Kris McNichol, President of CPI Equipment.

“The aquaculture industry needs sustainable solutions that increase production without jeopardizing our environment. Our technology is unique because we provide nanobubbles with proven benefits in terms of reducing oxygen and energy costs, while cleaning up the environment and producing better water quality and higher fish production. said Nicholas Dyner, CEO of Moleaer.

A near real-time view of the drains inside the human brain

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A new non-invasive technique provides a near real-time view of waste disposal vessels in the human brain.

A joint research team from the Medical University of South Carolina (MUSC) and the[{” attribute=””>University of Florida describes the first non-invasive and near real-time visualization of the human brain’s waste-clearance system in Nature Communications. The brain is densely organized, and visualizing the structures dedicated to waste removal, also known as lymphatic structures, had been a limitation in the field.

“This is the first report to show the complete human brain lymphatic system architecture in living humans,” said Onder Albayram, Ph.D., an assistant professor in the Department of Pathology and Laboratory Medicine and Department of Neuroscience at MUSC, who led the research team and is senior author of the article.

Albayram was intrigued by the possibility of lymphatic structures in the brain. “The lymphatic clearance system is all over the body for different organs,” he said. “I asked myself simply, ‘Why not the brain?’”

Brain's Drains

MRI showing the dorsal flow of the brain’s waste-clearance system. Credit: Dr. Onder Albayram, Medical University of South Carolina

Improved visualization of the brain’s waste-clearance system could enhance our understanding of how the healthy brain functions. It could also provide insight into what goes wrong in neurogenerative diseases such as Alzheimer’s and how the brain recovers from traumatic brain injuries (TBIs).

Pound for pound, the brain is the most metabolically demanding mass in the body – weighing around 3 pounds but requiring 20% of total oxygen consumption. That metabolic demand comes with the need to dispose of waste regularly.

As blood carrying oxygen permeates tissues to deliver vital nutrients, it collects pathogens, damaged cells, and waste. This fluid then drains into lymphatic vessels to be filtered through lymph nodes, which dispose of any unwanted waste products.


MRI showing the dorsal flow of the brain’s waste disposal system (in green). Credit: Dr Onder Albayram, Medical University of South Carolina

“It has long been believed that the brain lacks lymphatic vessels,” said Sait Albayram, MD, a professor in the Department of Neuroradiology at the University of Florida, who is the lead author of the paper.

“That thinking began to change about a decade ago, when early reports of rodent experiments hinted at lymphatic vessels surrounding the brain, side-by-side with blood vessels. But evidence of lymphatic vessels in the human brain remained rare before this study.

Onder Albayram compares the brain in the skull to an apple suspended inside a jar. The inside of the “jar”, or skull, is lined with a layer of delicate membranes called meninges. A fluid known as cerebrospinal fluid (CSF) surrounds the brain. The conventional thought was that waste-laden fluid from the brain drained into the CSF along the blood vessels, was carried out of the skull and then drained into the veins. Research over the past decade has instead hinted that the process is more complex and has suggested the existence of dedicated lymph vessels in the brain for waste disposal.

“The lymphatic clearance system is present throughout the body for different organs. I just thought, ‘Why not the brain?’ — Onder Albayram, Ph.D.

However, seeing these vessels in action in a living human brain posed technical limitations. Chief among them is the required use of the toxic rare earth metal gadolinium, a toxic rare earth metal used as a contrast agent during MRI, a technique used to visualize and differentiate brain structures.

In this study, the researchers were able to overcome this limitation and use MRI to visualize the lymphatic vessels in the meninges without the need for a contrast agent. Instead, the team used differences in brain protein content to create a contrast gradient. Low-protein structures appear dark and high-protein structures appear bright, with high enough resolution to see intricate detail.

“The discovery of meningeal lymphatic networks in mammals over the past decade has opened a new chapter in our understanding of cellular waste management in the brain,” said Adviye Ergul, MD, Ph.D., professor in the Department pathology and laboratory. Medicine at MUSC, who was not one of the study authors.

“This new study goes one step further by eliminating the need to inject contrast agents to visualize lymphatic vessels,” she said. “This is a major achievement that will reinvigorate the field to go deeper into the brain and expand our knowledge of the brain’s lymphatic system.”

This simple yet innovative approach allowed the researchers to capture clear images of the lymphatic vessels, with their high protein content – around 50 times that of CSF – as they connected areas of the brain to lymph nodes in the neck.

The research team then compared the differences between older and younger brains, and found a reduction in waste disposal in older brains.

Using this noninvasive MRI technique, researchers and doctors can now see what the lymphatic vessels of a healthy brain look like, Onder Albayram said, and study how they change with age. They may also determine their role in the progression of neurodegenerative diseases, such as Alzheimer’s disease and related dementias. The technique could also be used to investigate ways to increase lymphatic production in the brain as we age and perhaps offer insight into recovery after TBI.

“Imagine the brain in the jar again, surrounded by delicate lymphatic vessels,” Onder Albayram said. “What happens during a TBI? Are the lymphatic vessels damaged and how do they recover? This technique will allow us to begin to answer these questions.

Reference: “Noninvasive MRI Imaging of Human Brain Lymphatic Networks with Cervical Lymph Node Connections” by Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile and Onder Albayram, January 11, 2022, Nature Communication .
DOI: 10.1038/s41467-021-27887-0

About MUSC

Founded in 1824 in Charleston, MUSC is home to the oldest medical school in the South as well as the state’s only integrated academic health sciences center, with a unique charge of serving the state through education, research and patient care. Each year, MUSC educates and trains more than 3,000 students and nearly 800 residents in six colleges: dentistry, graduate studies, health professions, medicine, nursing and pharmacy. MUSC contributed more than $327.6 million in biomedical research funding in fiscal year 2021, continuing to lead the state in securing federal and state institutes of health funding with more than $220 million of dollars.

Industrial Redirection Labels Market Report Covers Future Trends with Research from 2022 to 2027 – Cenveo Inc., Fuji Seal International, Inc., Flexcon Company

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Industrial Rerouting Tags Market Study 2022-2027:

The Global Industrial Redirection Labels Market report provides insight into the global industry including valuable facts and figures. This research study explores the global market in detail like industry chain structures, raw material suppliers, along with manufacturing. The industrial rerouting tag sales market examines the major segments of the market scale. This smart study provides historical data from 2015 as well as a forecast from 2022 to 2027.

The complete value chain and essential downstream and upstream elements are scrutinized in this report. Key trends like globalization, progress in growth reinforce fragmentation regulation and ecological concerns. This Market report covers technical data, manufacturing plants analysis, and raw material source analysis of Industrial Rerouting Tags industry along with which products have highest penetration, their profit margins and R&D status. The report makes future projections based on the market subdivision analysis which includes global market size by product category, end-user application, and various regions.

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This Industrial Rerouting Labels Market report covers manufacturer data including shipment, price, revenue, gross profit, interview record, trade distribution etc., this data helps the consumer get to know the competitors better.

First leading manufacturer covered in this report:
Cenveo Inc., Fuji Seal International, Inc., Flexcon Company, Inc., Brady Corporation, 3M, Avery Dennison Corporation, HB Fuller Co., Henkel Ag & Company, Ccl Industries Inc.

Analysis of product segments:
Pressure Sensitive, Glue Applied, Heat Shrink & Stretch Sleeve, In Mold, Others

Based on the app:
Transport and logistics, durable consumer goods, construction, other (aerospace, marine)

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Regional Analysis For Industrial Redirection Labels Market

North America (United States, Canada and Mexico)
Europe (Germany, France, United Kingdom, Russia and Italy)
Asia Pacific (China, Japan, Korea, India and Southeast Asia)
South America (Brazil, Argentina, Colombia, etc.)
The Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, Nigeria and South Africa)

The objectives of the report are:

– Analyze and forecast the market size of the Industrial Redirection Tag industry in the global market.
– To study the global key players, SWOT analysis, value and global market share of key players.
– Determine, explain and forecast the market by type, end use and region.
– To analyze the market potential and benefits, opportunities and challenges, restraints and risks of key regions of the world.
– To discover significant trends and factors driving or restraining market growth.
– Analyze market opportunities for stakeholders by identify high growth segments.
– Critically analyze each sub-market terms individual growth trend and their contribution to the market.
– Understand competitive developments such as agreements, expansions, new product launches and market possessions.
– Strategically outline the key players and thoroughly analyze their growth strategies.

View full report @ https://www.marketresearchupdate.com/industry-growth/industrial-reroute-labels-report-2022-2027-358213

At last, the study provides details on the main challenges which will impact the growth of the market. They also provide comprehensive details of business opportunities to key stakeholders to grow their business and increase revenue in specific verticals. The report will help the company existing or intending to join in this market to analyze different aspects of this field before investing or expanding their business in the industrial redirection label markets.

Contact us:
[email protected]

qatar: Qatar sets the “validity period of immunity”: 9 months for Covishield & 6 months for Covaxin last shot | India News

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NEW DELHI: Following European nations, neighboring Qatar has also decided to consider travellers’ vaccination certificate valid if the last vaccine was taken within a certain period of the proposed visit date. From India’s perspective, this “duration of immunity” is nine months for Covishield and six months for Covaxin.
Since Covid booster shots in India are now allowed to a few people based on criteria such as age, international travelers should be included in this list so that their plans are not affected. This is all the more so as regular international flights could resume from next month.
The Qatar Ministry of Health website states that those who have received an approved/recognized Covid-19 vaccine (by it) will be considered fully vaccinated for a period of immunity validity. “Valid for nine months from 14 days after the second vaccination or the booster dose of the Pfizer, Moderna, Astra Zenica Covid vaccines,” it says.
“Valid for six months from 14 days after the second dose or booster dose of conditionally approved COVID-19 vaccines (which includes Covaxin). A positive serology on the antibody test lab result is required and should be valid for 30 days from the test,” a Qatar tourism official said.
“Those who received a booster dose using (Qatar) approved vaccines (including Covishield) the immune status is extended to nine months from seven days after the booster dose and serological antibody test n ‘is no longer necessary,’ the website lists among other terms. Those intending to travel should go through the full list of requirements.
India is still on Qatar’s list of “red sanitary measure countries”. Therefore, fully vaccinated visitors must submit a negative report of a pre-travel RT-PCR test performed within 48 hours of departure. A one-day hotel quarantine is required and a rapid antigen test on the first day of hotel quarantine in Qatar is carried out.
The fixing of immunity validity period by EU, Qatar and soon many other countries has left Indian travelers in dilemma as recalls are not allowed for all here from now on. “I’m over 60 and got the booster. My wife is 57 and not entitled to the same, which she needs for a valid vaccination certificate to travel to Qatar. We had booked tickets to Doha last month and now this rule is coming in. We don’t know what to do,” said a Delhi-based couple who did not want to be named.

How to complete the Vox Obscura quest in Destiny 2

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The Vox Obscura Exotic quest is the final narrative beat to explore Empress Caiatl and her cabal in Destiny 2‘s Season of the Risen. It also comes with a new Exotic Grenade Launcher, Dead Messenger, as a reward upon completion. As players receive the quest at the start of the risen season – after Operation Elbrius at the HELM war table – the recommended level to deal with it is at the soft power cap of 1550. This may take a while up to players to reach this milestone, but Guardians 10 levels below can still beat Vox Obscura, especially if they bring a teammate or two to help them. Although Vox Obscura’s Psion Defectors can be defeated solo, a full squad will have a much easier time on this quest.

From destroying broadcast transmitters with a Drake to hunting down Psions in the dark underbelly of a Rebel Cabal base, here’s how to complete Vox Obscura and acquire the Dead Messenger Exotic Grenade Launcher.

Recommended Loadouts

Screenshot via Bungie

Much of your choice of weapons and subclasses in Vox Obscura will come down to personal preference, but using ranged weapons such as Linear Fusion Rifles and Sniper Rifles will make the mission much easier . You’ll encounter enemies such as Goliath Tanks and large Psions that are highly susceptible to critical hit damage dealt best by weapons like Threaded Needle, Eriana’s Vow, and Arbalest. Gjallarhorn and other rocket launchers are also very effective throughout each encounter.

The only required part of your arsenal is a weapon capable of stunning unstoppable champions. In Season of the Risen, Hand Cannons, Pulse Rifles, and Glaives all have seasonal mods capable of doing this, though your choices will vary depending on the seasonal meta.

While Devil’s Ruin, Bastion, and Leviathan’s Breath have the inbuilt ability to stun unstoppable champions, these weapons either lack good long-range abilities or just aren’t worth the Exotic spot.

If you’re below the recommended light level of 1550, bringing at least one Well of Radiance Warlock or Ward of Dawn Titan will make many of the tougher fights more manageable.

Penetration of the Psion base on Mars

Image via Bungie

The start of Vox Obscura will see you deployed to the recently returned Mars, and only a small Cabal patrol stands between you and your first objective marker. Go down the hill and hack the door to access the back wing of the base hangar. Resistance in these halls will be limited to a handful of Psions and Scorpius turrets, which shouldn’t be too much of a problem on your way to parking three interceptors. Grab one of the available interceptors and use its cannons to destroy the marked wall, creating a makeshift exit into the Barrens.

First meeting

Image via Bungie

Once you enter an interceptor, a 4:30 countdown to an orbital barrage will begin. If this timer reaches zero, your squad will fade and you will have to start over from the beginning of the mission.

Your first objective will be to clear an airstrip for Caiatl to deliver reinforcements to you, which involves taking out a nearby Goliath tank. Although the Interceptor is required to access the Barrens, it is recommended to tackle this objective on foot as the Interceptor is easily destroyed by the tank, Scorpius turrets and enemy controlled Interceptor at the outside. Using ranged weapons to eliminate enemies and destroy Goliath tank thrusters is safer and often faster. Players also need to take out an unstoppable champion that spawns in a small building next to the Goliath tank to proceed. Once the area is clear, Amanda Holliday will arrive to give you a Drake tank for the next stage of the encounter.

Your next waypoint will require a decent travel time, taking you from The Barrens to destroy broadcast transmitters in another area called Scablands. A Cabal troop will be deployed through Thresher once you receive the Drake, but killing them is not necessary. Players can pass them to save time, with the large sandbars around the path to the Scablands providing cover that helps keep the Drake healthy.

Screenshot via Bungie

The Scablands is a large arena with two Goliath tanks, three armored transmission towers and a large defense including Scorpius turrets, Psions and War Beasts. Eliminating the two Goliath tanks is your priority. The Drake tank is optimal for this task, but constant movement is required to avoid being hit by guided artillery strikes in the area.

Optionally, during this encounter, Psion Spotters can be killed to stop these artillery strikes, but only go there if it doesn’t reduce your remaining time too much. Once both Goliath tanks are dead, a platform at the back of the arena will allow you to transmate into new Drake tanks if yours is low on health.

Your attention will then turn to the three armored towers. To destroy the initial shield around them, you’ll need to detonate several generators under the three towers. Once the generators are destroyed, aim for a small weak spot in each tower marked by a secondary shield that glows bright blue. This shield can only be destroyed by the Drake Tank’s primary fire, and once it’s down, you can fire a second shot into the weak spot it was protecting to destroy the tower. Stopping all three broadcast transmitter towers will end the encounter and end the timer, regardless of how many enemies are left in the area.

Screenshot via Bungie

With the broadcast off, turn your gaze to the rebel Psion perpetrating the propaganda, located within the base itself. Destroy the waypoint-marked wall with an Interceptor or Drake cannon to make an entrance inside, where you’ll find a rally banner and your first Vox Obscura checkpoint.

Second meeting

Image via Bungie

A second countdown begins the moment you approach the rally flag, marking a 10-minute run to the control room deep within the fortified base. The first room of enemies has two main targets to fear: an unstoppable champion and a powerful arsonist called Ba’Aruk. Once these two enemies and the Minor Cabal next to them have fallen, you can advance deeper into the base where you will find open escape ports that provide access to the lower floors. Here, you’ll also be introduced to the central danger of this encounter, the floor vents that occasionally shoot blue flames upwards that deal heavy damage to anyone caught.

Screenshot via Bungie

On the lower floor, you must kill three Psion Codewardens to access the control room. These Codewardens are protected by nearby Psion Commanders, who you’ll find dangling in their own psionic shields. Psionic shields only protect them from outside fire, meaning you can use a melee attack to break Codewarden’s shields. Once each Codewarden has been dispatched, nearby Cabal terminals in their respective rooms will become available for hacking. Hack all three terminals and the door to the control room will open.

The door to the control room is protected by a line of Scorpius turrets, so be careful when exiting so your journey to the final boss isn’t short-lived.

Qabix, insurgent

Screenshot via Bungie

Vox Obscura’s final boss is a large Psion called Qabix, who uses a number of unique attacks during combat. One borrows a mechanic from the Deep Stone Crypt raid, suspending a player in a bubble of void energy. To free yourself, shoot the glowing light dots outside the bubble with any weapon that won’t blow you up in the process. Qabix will also be bolstered by squads of Psions and Scorpius turrets throughout the fight, and removing them from the equation is key to making the encounter less overwhelming and providing more windows to damage the boss.

Qabix has two immunity phases throughout the fight, each broken by the same method as the Psion Codewardens’ shields. Three hanging Psion Commanders will be located around the control room, and once each has been killed, Qabix can be damaged once more. Repeat this process twice and keep Qabix’s waves of reinforcements in check so the fight against the rebel Psion goes fast – after all, time is always running out. When Qabix falls, the 10 minute timer ends and you can head to the top of the control room to intercept the broadcast for Caiatl.

Screenshot via Bungie

Tucked away in a side room to the right of the control panel, an Emperor Calus opulence-themed chest awaits. Opening the chest inside will grant you Dead Messenger, as well as the ability to drop the Ivory Empress Exotic Sparrow and Season of the Risen weapons during Vox Obscura replays.

With broadcast equipment stopped and Dead Messenger acquired, you have completed the normal difficulty of the Vox Obscura Exotic quest.

Olympus Discovery Center brings advanced microscopy to brain research

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Olympus continues to demonstrate its commitment to advancing bioscience research with the opening of the new Olympus Discovery Center at the Center for Interdisciplinary Research on the Brain and Learning (CIRCA) at the University of Montreal. The new facility provides researchers with access to the advanced microscopy tools they need to advance their research.

Image Credit: Olympus Solutions for Life Sciences

Improving learning by studying processes at the neural level

Comprised of more than 60 researchers from seven faculties, CIRCA strives to accelerate interdisciplinary research in brain science and its applications through disciplines that operate in practice settings. CIRCA scientists use state-of-the-art equipment at the Olympus Discovery Center to study the neural basis of brain development, function, neuroplasticity, learning processes, and factors that disrupt and promote learning at different ages. They are also developing new intervention approaches to improve learning by creating links between brain science and data science.

Support bioscience research with advanced imaging systems

To study the function, development and regeneration of the central nervous system at the cellular and subcellular level, the Olympus Discovery Center at CIRCA is fully equipped with innovative and high-performance optical microscopes. The microscopy lab includes some of Olympus’ most advanced systems for life science imaging, including a FLUOVIEW™ FV3000 Upright Confocal Laser Scanning Microscope, a PhaseView® Alpha3 light sheet microscope, as well as several conventional inverted and electrophysiology microscopes.

By combining the imaging expertise of local Olympus staff with the tissue clearing capability and research ingenuity of CIRCA, the Olympus Discovery Center at CIRCA is positioning itself as a focal point of education and demonstration for the research community in Quebec and Eastern Canada.

The inauguration of an Olympus Discovery Center at the University of Montreal is part of our desire to encourage and promote innovation and discovery in biosciences. We are proud that Olympus microscopy technologies will help CIRCA scientists make advances in neuroscience research that will help shape and improve the way people learn.


Lee Wagstaff, Vice President of Sales, Marketing for Olympus Scientific Solutions Americas

“CIRCA is a unique research center that promotes interdisciplinary and cross-sectoral approaches to study brain function and lifelong learning. The Olympus Discovery Center will be instrumental in exploring the neural bases of learning and developing new therapeutic strategies to restore brain function. Olympus and CIRCA provide the best environment to train the next generation of health researchers and practitioners,” says Jean-François Bouchard, Associate Director of Research, Graduate Studies and Faculty Affairs, School of Optometry, University of Montreal.

Olympus Discovery Centers provide researchers with the ability to acquire and analyze vital imaging data using advanced microscopy tools. They also serve as a nexus for histology training, information and technique development, and a learning center for sample preparation, imaging, and image processing. Olympus works closely with its academic partners to develop new products to meet the changing needs of researchers.

Source:

Olympus Solutions for Life Sciences

How to entertain a gene circuit without exhausting its host

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February 25, 2022

Since launching the first online degree in 2017, the number of undergraduate chemistry and biochemistry majors at Arizona State University’s School of Molecular Sciences has more than doubled. Additionally, the new group of online students is significantly more diverse than the field student population, with 65% female and four times as many black students and six times as many military and veteran students as on-site students. field.

One such military student is Cory Smith, a line biochemist currently serving in the Air Force as a U-28A mission pilot, who recently completed his seventh deployment to the Middle East. Smith aims to get into medical school and then return to active duty as a medical officer.

Cory Smith, an online biochemist, has his sights set on getting into medical school and then returning to active duty as a military medic.
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Despite multiple deployments and a variety of temporary assignments, Smith has managed to maintain a 4.0 GPA.

“I’ve taken classes in several different states, as well as several countries in Europe, the Middle East and Asia,” Smith said. “I even had to ship several weeks of chemistry lab equipment to myself so that I could complete the labs on the road. Without programs like this at ASU, it would have been much more difficult to continue serving while progressing on my path to becoming a physician.

In the summer of 2021, Smith traveled to Arizona and the Tempe campus, where he met students and professors he otherwise only knew through online interactions, complete his organic chemistry lab classes and feel like a real solar devil.

“Cory is an enthusiastic and dedicated student, and despite his busy flight schedule, he regularly attends office hours and stays active in class. I’m glad SMS can support military students like Cory, who serves our country, thanks to the online program,” said Ara Austin, faculty member in the School of Molecular Sciences and director of online engagement and strategic initiatives at the College of Liberal Arts and Sciences.

Last year, Smith was the recipient of the SMS Veterans Scholarship. This scholarship supports undergraduate students, whether military veterans or children of veterans, who are pursuing studies and careers in molecular sciences.

“Winning this scholarship means a lot to me,” Smith said. “Having my hard work recognized by my teachers and the (school) community gives me significant validation and motivation to continue performing well.”

Many ASU students are able to achieve their goals through the generosity of alumni, members of the school community, and ASU employees, among others. Smith is grateful to those who have contributed to ASU to make this and other scholarships available to him and other students.

“I am sincerely grateful to have been chosen as the recipient of the SMS Veterans Scholarship,” he said. “Scholarships are especially important for online students, as the recognition helps strengthen their bond with school.”

“One of the unexpected benefits of delivering programs online is the extent to which they have opened up access to college education for students from more diverse backgrounds,” said Ian Gould, Associate Dean of Innovation. online at college. this respect than any other program we’ve tried in the past few years. Cory is a perfect example. I am always amazed that students like Cory can take on heavy responsibilities in life while maintaining a perfect GPA in challenging science classes. We are very proud of Cory.

In-depth research of the global cryostats market, industry statistics 2022

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the Cryostat market The report covers the entire global market scenario including key players, their future campaigns, preferred vendors, market shares along with historical data and price analysis. It continues to offer key details on changing dynamics to generate market improving factors. Its objective is to rationalize the company’s costs. You can also find interest and expense points on current income here. The best thing about the Cryostats market report is the provision of guidelines and strategies followed by major market players. The investment opportunities in the market that are highlighted here will go a long way in moving the business forward. Knowing the current market situation is the most important thing discussed here to help major players survive in the deadly market.

This cryostats market study describes the economic catastrophe caused by the covid-19 epidemic, which has affected all sectors of the company. A major global economic loss has occurred due to various industrial closures and loss of income. A high degree of information is offered here to assess the market situation.

Get Sample Full PDF Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://reportsglobe.com/download-sample/?rid=174047

The authors of the report draw up an encyclopedic assessment of the most important regional markets and their evolution in recent years. Readers are provided with accurate facts and figures about the Cryostats market and its important factors such as consumption, production, revenue growth, and CAGR. The report also shares gross margin, market share, attractiveness index, and value and volume growth for all segments studied by analysts. It highlights key developments, product portfolio, markets served and other areas depicting business growth of major companies profiled in the report.

The report has been prepared using the latest primary and secondary research methods and tools. Our analysts rely on government documents, white papers, press releases, reliable investor information, financial and quarterly reports, and public and private interviews to gather data and information about the market in which they operate.

Key Players Covered in the Cryostats Market:

  • Janis Research Company, LLC
  • Leica Biosystems Nussloch GmbH
  • Advanced medical and optical systems
  • Jinhua Yidi medical device
  • Thermo Fisher Scientific Inc.
  • Slee Medical GmbH
  • Cryotech, Inc.
  • Advanced Search Systems, Inc.
  • AMOS Scientific Pty. ltd
  • Luminous instruments

    Cryostats Market Split By Type:

  • Bath cryostats
  • Closed cycle cryostats
  • Multistage cryostats
  • Continuous flow cryostats

    Cryostats Market Split By Application:

  • Biotechnology
  • Forensic Sciences
  • Energy and power
  • Aerospace
  • Health care
  • Marine biology
  • Metallurgy

    The Cryostats market report has been segregated into distinct categories such as product type, application, end-user, and region. Each segment is rated based on CAGR, participation, and growth potential. In the regional analysis, the report highlights the potential region, which is expected to generate opportunities in the global Keyword Market in the coming years. This segment analysis is sure to prove to be a useful tool for readers, stakeholders, and market players to get a complete picture of the global Keyword Market and its growth potential in the coming years.

    Get | Discount on the purchase of this report @ https://reportsglobe.com/ask-for-discount/?rid=174047

    Scope of the Cryostats Market Report

    ATTRIBUTES

    The description

    ESTIMATED YEAR

    2022

    YEAR OF REFERENCE

    2021

    FORECAST YEAR

    2022 to 2028

    HISTORICAL YEAR

    2020

    SECTORS COVERED

    Types, applications, end users, and more.

    REPORT COVER

    Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends

    BY REGION

    North America, Europe, Asia-Pacific, Latin America, Middle East and Africa

    Geographic segment covered in the report:

    The Cryostats report provides information on the market area, which is divided into sub-regions and countries/regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and growth rate for each region, country and sub-region over the estimated period.

    • North America includes the United States, Canada and Mexico
    • Europe includes Germany, France, UK, Italy, Spain
    • South America includes Colombia, Argentina, Nigeria and Chile
    • Asia Pacific includes Japan, China, Korea, India, Saudi Arabia and Southeast Asia

    Goals and Objectives of the Cryostats Market Research

    • To understand the Cryostat opportunities and advancements determines the market highlights, along with the key regions and countries involved in the market growth.
    • Study the various segments of the Cryostats market and the dynamics of Cryostats in the market.
    • Categorize the Cryostats segments with increasing growth potential and assess the futuristic segment market.
    • To analyze the most important trends related to the different segments which help decrypt and convince the Cryostats market.
    • Check region-specific growth and development in the Cryostats Market.
    • To understand the major Cryostats market players and the competitive image value of the Cryostats market leaders.
    • To study the key plans, initiatives, and strategies for the development of the Cryostats Market.

    The study thoroughly examines the profiles of major market players and their key financial aspects. This comprehensive business analysis report is useful for all new and existing participants when designing their business strategies. This report covers KEYWORD production, revenue, market share and growth rate for each key company and covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. Historical cryostat ventilation data from 2016 to 2021 and forecast for 2022-2028.

    Ask questions about personalization at @ https://reportsglobe.com/need-customization/?rid=174047

    Some highlights from the table of contents:

    1 Presentation of the report

    2 Market Trends and Competitive Landscape

    3 Cryostats Market Segmentation by Types

    4 Cryostats Market Segmentation by End Users

    5 Market Analysis by Major Regions

    6 Product Commodity Cryostats Market by Major Countries

    7 North America Cryostats Landscape Analysis

    8 Europe Cryostats Landscape Analysis

    9 Asia-Pacific Cryostats Landscape Analysis

    10 Latin America, Middle East and Africa Landscape Analysis of Cryostats

    11 Profile of Key Players

    How Reports Globe is different from other market research providers:

    The creation of Reports Globe has been underpinned by providing clients with a holistic view of market conditions and future possibilities/opportunities to derive maximum benefit from their business and assist in decision making. Our team of in-house analysts and consultants work tirelessly to understand your needs and provide the best possible solutions to meet your research needs.

    Our team at Reports Globe follows a rigorous data validation process, which allows us to publish publisher reports with minimal or no deviation. Reports Globe collects, separates and publishes over 500 reports each year covering products and services in many areas.

    Contact us:

    Mr. Mark Williams

    Account Manager

    WE: +1-970-672-0390

    E-mail: [email protected]

    Website: Reportsglobe.com

  • ISU Experts Explain How to Boost Your Immunity to Ukraine Invasion Misinformation

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    Following the news of Russia’s invasion of Ukraine can be difficult, but not because there is a lack of information. Social media, be it TikTok, Twitter or Facebook are flooded with updates whether in the form of words, pictures or videos. But for those unfamiliar with the geopolitical context of the situation, or even this region of the globe itself, it can be difficult to contextualize information, or know whether a source of information is trustworthy, by making its best to be exact. .

    WGLT spoke with two experts from Illinois State University’s School of Communication to get their thoughts on how to navigate news, social media, and misinformation or misinformation campaigns aimed at targeting passive consumers .

    Nathan Carpenter is director of convergent media for the School of Communication and leads its social media analytics command center. In late 2019, Carpenter traveled to Georgia to give presentations on various social media topics as part of a media literacy program set up by the United States Embassy. Georgia was the first republic to break away from the Soviet Union in the early 1990s; its history of conflict means that democracy and freedom of expression are under threat.

    Illinois State University

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    Nathan Carpenter is director of convergent media for the School of Communication and leads its social media analytics command center.

    Joseph Zompetti is a communications professor who recently received a fellowship from the Center for Civic Engagement at ISU. Zompetti has a background in political science and communications and has studied fake news phenomena and Russian disinformation tactics. He has conducted research on these issues alongside colleagues from the Republic of Georgia and Kyrgyzstan.

    Here’s what they had to say:

    More than a wallet problem

    Zompetti: I think people should pay attention to what’s going on. Even if we feel disconnected – we are on the other side of the planet and may not have Ukrainian friends or family or from there – that does not mean that it does not affect us directly. There are going to be economic repercussions; gas prices will increase and we will see an increase in other prices for goods and services because of the sanctions imposed on Russia.

    But it also affects us on a more principled level: I’m not sure the Biden administration has said this explicitly, or as clearly as they should, but it’s really a battle between democracy and authoritarianism. This, really, I think is a fight for the soul of democracy and what that means. I hope people put that into perspective when they feel the pinch in their wallets.

    Carpenter: I think one thing that we all need to recognize and understand is that it is almost beyond our ability to comprehend the amount of information being produced on social media sites right now. We have an innate desire to be truly above that and consume as much of it as possible; we want to keep consuming that until we find an answer to what’s going on, or find some sort of solution.

    I think one of the biggest (tips I have) is to really take it slow and not necessarily follow the trends. Trends will tell you what everyone is looking at right now and they can be deceiving. Pay less attention to what these trends say and instead think about what they mean. Be careful and slow down – you don’t need to know first. Being able to accept this can help – and it can even help you rely on experts who can be much more nuanced. It’s okay if it takes you a few more minutes to get information, process it, and review it.

    Find sources that challenge you

    Zompetti: We’ve seen the (misinformation) happen before – there’s already a conspiracy theory sprouting where people are speculating that maybe Russia and China have some sort of military alliance and that as a result of that , China could take over Taiwan, or something of that nature. There is no evidence to suggest that Russia and China have any alliance; in fact, it’s probably more the opposite.

    Here’s the problem with a lot of disinformation campaigns or conspiracy theories: they’re often based on a single fact, or a few facts, that might be true. Then people interpret them in weird ways without checking any further proof facts and speculations run wild. I think people should be critical consumers of information in that they should try to get their information from the most reliable sources they can find and then diversify those sources. In other words, don’t just take the word from one source. Listen to a variety of different sources, or read a variety of different sources, so you can find the best possible perspective.

    JZ.jpg

    Illinois State University

    /

    Illinois State University

    Joseph Zompetti is a communications professor who recently received a fellowship from the Center for Civic Engagement at ISU.

    Carpenter: I think you have to find reliable sources. When I say trustworthy, I don’t mean people you like, or people who are popular just because they’re popular and you go with their first “hot catch”. You need to find professional, knowledgeable people to assess – and that can take time. It’s really important that you’re also willing to accept things that are going to be uncomfortable, that you’re willing to listen to things that may not affirm your view of the world or the trajectory you think the situation should take. Events don’t really care how you feel, so it’s important that you’re prepared to find sources that challenge you.

    Zompetti: Many people will hear, especially when browsing their social media feeds, about the role of propaganda, disinformation and cyber warfare attacks. I want people to understand that it’s no small feat, that in the 21st century, the use of information and knowledge as a tool, as a weapon for political and military purposes, is now a reality. Of course, the propaganda has been around for centuries, but it has never been used to the extent that it is now, or that we might see. So when people entertain things like conspiracy theories or disinformation and misinformation and don’t critically question what’s going on, they’re really doing themselves a disservice. It’s really part of this much bigger problem that we all have a part to play in: making sure that this information is as accurate and verifiable as possible – and protecting and preserving it. Because that’s ultimately one of the ways we can fight the bully.

    The STOP method

    Carpenter: There’s a researcher and specialist in civic engagement and disinformation by the name of Mike Caulfield and he actually came up with a great assessment method called SIFT.

    The first thing he says is Stop — slow down, don’t share right away.

    The next thing in the acronym is Investigate The source. It’s one of the hardest things we can do in this process because we know there’s a lot of bias. By investigating the source, we can say, “Where did this information come from? Especially right now, because we have plenty of players on the wider social web who are intentionally trying to sow the seeds of mistrust.

    The third is To find better coverage. This one is interesting because it doesn’t assume that you have wrong or bad information, but what it says is that there could be corrections. Especially when hearing early reports or breaking news, there may be information that is not yet fully understood, or inaccurate but accurate at this time based on the information provided. We need to be able to slow down and ask if there are other people on the ground saying the same thing.

    Finally, the last part of this SIFT assessment method is what is called Trace, which means tracing claims, quotes and media to their original context. And that goes to the classic idea of, say, images potentially distorting things. We see a lot on social media where someone will share, say, in the event of a war, pictures of destroyed buildings or vehicles. What we’ve seen in a lot of cases is that people share things, want attention, and just share a photo they find on Google and say, “That’s something I see right now. moment”. It’s really important that when you see an image like this, that you research the caption, look at the date it was posted and created, and use tools like Google’s reverse image search to find the original source in many cases that you can.

    We see this method used with great success in many spaces – not just college classrooms. I think it’s something that anyone can do a really good job with.

    Zompetti: So much is happening and everything is changing so quickly, but I just want to point out that this idea of ​​misinformation is no longer something we can brush off. It’s a completely different world and while on the one hand it’s great, I’m also worried that so much information is making us lose sight of some of the most important things.

    Carpenter: Another thing I can recommend is taking breaks. It’s a very, very depressing thing. It’s very heavy. What is happening right now is beyond many of our abilities to comprehend. It feels like there’s not a lot of action we can take and it can be difficult, it can take us to very dark places. Take this knowledge, at this point, and find ways to help others, especially as you consume a lot of bad and dark news.

    Versameb appoints global urology experts to its advisory board

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    Appointment of experts to support the development of the lead applicant VMB-100, an RNA-based therapy for stress urinary incontinence

    BASEL, Switzerland, February 24, 2022 /PRNewswire/ — Versameb AG (“Versameb”), specializing in the discovery and development of innovative RNA-based drugs, today announces the formation of an advisory board comprised of industry leaders from urology. These include the teacher Roger Dmochowski of Vanderbilt UniversityProfessor Margot Damaser from Cleveland Clinic Lerner College of Medicine and Assistant Professor Frédéric Birkhäuser from St. Anna and Hirslanden Clinic Lucerne.

    Versameb is building a pipeline of promising first-class RNA therapies based on its next-generation RNA platform technology, VERSagile. The newly formed Board of Directors will advise on the clinical development of its lead candidate, VMB-100, for the treatment of stress urinary incontinence (SUI) which is currently undergoing development activities preclinical advances and is expected to enter clinical development in the second half of 2022.

    Up to 50% of adult women experience SUI at some point in their lives without currently approved restorative drug treatment. Physical changes resulting from pregnancy, childbirth, and menopause are risk factors for the development of SUI. VMB-100 has first class potential and has generated promising preclinical data showing regeneration of muscle tissue and restoration of urinary sphincter function.

    Klaas Zuideveld, CEO of Versameb, said: “The formation of an advisory board marks an important milestone for Versameb as we advance our lead candidate in stress urinary incontinence towards clinical development. We are delighted and honored to work with three global experts in the field whose individual expertise and in-depth knowledge will be particularly important as we move into clinical development.”

    Roger Dmochowski is Professor of Urology, Chief Associate Surgeon for Vanderbilt University Medical Center, and world leader in the fields of urology and incontinence. He is a member of the Bone, Reproductive, and Urology Drugs Advisory Committee (BRUDAC) of the FDA and a co-author of the FDA guidelines for regenerative medicine in urology. He has led and participated in numerous clinical trials in incontinence and has received numerous awards, including the Lifetime Achievement Award from the Urodynamics Society for his achievements in the clinical treatment of incontinence. He is a director and past president of the American Board of Urology, a member of the American College of Surgeons, the American Urological Association and the International Continence Society. Dr. Dmochowski has published over 320 articles, 100 book chapters and 460 abstracts and over 260 presentations at various national and international meetings. He is editor-in-chief of Neurourology and Urodynamics and sits on the editorial board of several scientific journals.

    Margot Damaser is a professor of biomedical engineering at the Cleveland Clinic Lerner College of Medicine in Case Western Reserve University and the staff of the Glickman Urological & Kidney Institute. During her distinguished career spanning over 25 years, she has studied urinary incontinence and pelvic floor disorders. His research focuses on the development and testing of new devices and regenerative approaches to improve the diagnosis and treatment of urinary incontinence, voiding disorders and pelvic floor disorders. She has expertise in animal models of stress urinary incontinence and pelvic floor disorders. She earned her doctorate in bioengineering from the University University of California, Berkeley and the San Francisco Bioengineering Program. She has published over 150 peer-reviewed scientific papers, served as a member of the National Institutes of Health (NIH) and other grant review study sections, and has served on several national advisory committees, including the Council Advisory of the National Institute of Diabetes and Digestive Diseases and Kidney Disorders (NIDDK) to the NIH. Dr. Damaser is a member of the College of Fellows of the American Institute for Medical and Biological Engineering (AIMBE), an honor reserved for the top 2% of biomedical engineers in the United States.

    Frederic Birkhauser is co-lead urologist at the St. Anna and Hirslanden Clinic in Lucerne and consultant urologist at the Universities of Basel and Bern, Switzerland. He has been a co-investigator in numerous clinical trials in urology and uro-oncology and published on innovative surgical techniques and immuno-oncological approaches in kidney, bladder and prostate cancer. He is an examiner for the European Board of Urology and a member of the Swiss Medical Association, European Urological Association, Swiss Urological Society and American Urological Association.

    About Versameb

    Versameb AG is a private biotechnology company focused on the discovery and development of innovative RNA-based drugs for the modulation of protein expression, including the ability to influence multiple therapeutic targets simultaneously, in a controlled manner , with molecular construction and cell targeting. Situated at Basel and fully operational as of 2018, the company is led by an experienced science and management team with proven expertise in drug discovery and development, from lab to patient. Versameb’s proprietary technology platform, VERSagileoptimizes the application of functional RNA in different disease contexts – making RNA medicable in new therapeutic areas that others have not been able to solve.

    The pipeline includes lead candidate programs in stress urinary incontinence (SUI) and solid tumors. Versameb is working on a first in-human/proof-of-concept clinical study while advancing its platform. You can find more information about Versameb on www.versameb.com as well as on LinkedIn.

    SOURCEVersameb

    The researchers feed the worms a natural plant extract; watch them get bigger, live 40% longer — ScienceDaily

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    A research team from Louisiana State University’s Department of Biological Sciences, led by Assistant Professor Adam Bohnert, has published a landmark study linking better metabolic health – achieved through a natural plant extract – and longer life in C.elegans, commonly called roundworms. Although worms and humans don’t appear to have much in common, the researchers say there’s good reason to assume the findings could be replicated in humans, as the study relies on previous work on metabolic health in mice, conducted at LSU’s Pennington Biomedical Research Center. under the direction of Professor Jacqueline Stephens.

    “The reason this study made so much sense to do on the worms is that the worms only live about three weeks, so within a month or two we had definitive results,” said LSU student Bhaswati Ghosh. and lead author of the published study.

    Bohnert and Stephens’ research teams are interested in studying the effects of Artemisia scoparius, a natural plant extract of a particular type of wormwood native to Asia. Made from its leaves, the extract was fed to worms in various doses in Bohnert’s lab. The treated worms that received the highest dose and the second highest dose showed an almost immediate improvement in their metabolic health. Not only did the treated worms live up to 40% longer than the untreated control group, but they also grew in size and somewhat slowly, as their increased body mass made them harder to move. But the worms have also become healthier and more resilient. It was easier for the treated worms to handle the stress. Additionally, the researchers found that Artemisia scoparius helps convert unhealthy fat stores into healthy fat stores in the body.

    This study adds to previous work by Bohnert and LSU Assistant Professor Alyssa Johnson on how dietary changes influence aging at the cellular level. Now it appears Artemisia scoparius can also activate many pro-longevity pathways in the body and effectively activate several genes involved in the process of lifespan regulation.

    “Until recently, it was unclear how aging could be altered by diet, or how essential metabolic signaling pathways influence longevity,” Bohnert said. “What we were able to show is that a natural extract can come in and influence these pathways the same way a genetic mutation would.”

    The study positions aging as non-deterministic and under our control.

    “Mostly, it gives us a therapeutic perspective,” Bohnert said. “We know that age is the main risk factor for many diseases, such as cancer and cardiovascular disease, but if you think of aging as a treatable disease, you can actually treat several diseases at once.”

    While the longest-lived worms were fed Artemisia scoparius by the time they reached reproductive maturity, or adulthood, Bohnert’s team also observed significant effects in worms first treated in middle age. Instead of a 40% increase in lifespan, these worms still managed to live about 20% longer.

    The study offers a first insight into how Artemisia scoparius could change aging and longevity. It also reinforces the link between metabolic health, fat regulation and longer lifespan.

    “Usually people think of fat as ‘bad,’ but in these cases it looks good and actually promotes longevity,” Bohnert said. “Artemisia scoparius could have exciting potential as a dietary supplement.”

    “Also, just because an organism is small, big, and slow doesn’t necessarily qualify it as unhealthy,” Ghosh added. “These phenotypes must be considered in the full context of other parameters, including lifespan.”

    There are currently no recommendations for humans to take Artemisia scoparius as a supplement or any indication of what an effective and safe dosage might be. Researchers have studied several types of extracts from related plants and have only observed positive effects on fat regulation and longevity with Artemisia scoparius. common wormwood, Wormwood Artemisiaused as an ingredient in the alcoholic drink absinthe, is moderately toxic and was not included in the study.

    This work was supported by a pilot grant from Pennington Biomedical’s NIH-funded Botanical Dietary Supplement Research Center. The study was published on February 15, 2022 in Gerontology journals.

    With increasing investment in wind energy, geotechnics

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    LONDON, 23 Feb. 28, 2022 (GLOBE NEWSWIRE) — According to The Business Research Company’s research report on the geotechnical services market, increasing investment in wind energy is expected to propel the growth of the geotechnical services market in the future. The technique of using the wind to generate mechanical energy or electricity is called wind power. This requires the use of geotechnical exploration and data analysis approaches particularly suited to managing risks at different phases of project development. For example, according to the U.S. Department of Energy, wind power accounted for $24.6 billion in 2020 investment in the United States. The U.S. offshore wind pipeline grew 24% year-over-year, with 35,324 MW in various stages of development. Hence, increasing investment in wind energy is driving the growth of the geotechnical services market.

    Demand for a sample of the world geotechnical services market report

    The size of the global geotechnical services market is expected to grow from $1.92 billion in 2021 to $2.10 billion in 2022 at a compound annual growth rate (CAGR) of 9.6%. The market growth is mainly driven by businesses resuming operations and adapting to the new normal while recovering from the impact of COVID-19, which previously led to restrictive lockdown measures involving social distancing , remote working and closing business activities. which resulted in operational difficulties. The geotechnical services market is expected to reach $2.70 billion in 2026 at 6.4% CAGR.

    Technological advancements are gaining popularity among geotechnical services market trends. Technological progress is the discovery of knowledge that advances technology. In July 2021, Ryder Geotechnical Limited, a UK-based geotechnical services provider, launched its new geotechnical data analytics solution, Hadrian Cloud Services. Hadrian is an analysis and visualization tool that allows users to easily interact with and query geotechnical data and provide detailed design. It also offers hassle-free geotechnical insight through intuitive controls, speeds up responsive, data-driven design decisions, and helps streamline the offshore construction project.

    Key players in the geotechnical services market include AECOM, AMEC Engineering, Arup Group, Bechtel Group, CH2M HILL, Fugro, Gardline Limited, Geoquip Marine Group, HDR Inc, Jacobs Engineering Group, Kiewit Corporation, Stantec, Tetra Tech, Turner Construction and WSP. Global.

    The global geotechnical services market is segmented by product type into underground urban space engineering, slope and excavation engineering, soil and foundation engineering; by wired, wireless networking technology; by application in municipal engineering, hydraulic engineering, bridge and tunnel engineering, mining engineering, marine engineering, national defense engineering, building construction, etc.

    North America was the greater region in the Geotechnical Services Market in 2021. Regions covered in the Geotechnical Services Market report are Asia-Pacific, Western Europe, Eastern Europe, North America, America South, the Middle East and Africa.

    Global Geotechnical Services Market Report 2022 – Global Market Size, Trends and Forecasts 2022-2026 is part of a series of new reports by The Business Research Company that provide geotechnical services market overviews, analyzes the geotechnical services market geotechnical services and forecast market size and growth for the overall market, geotechnical services market segments and geographies, geotechnical services market trends, geotechnical services market drivers, geotechnical services market restraints, revenue, profiles and market shares of leading geotechnical services market competitors in over 1,000 industry reports, covering over 2,500 market segments and 60 geographies.

    The report also gives an in-depth analysis of the impact of COVID-19 on the market. The reports are based on 150,000 datasets, extensive secondary research and proprietary insights from interviews with industry leaders. A highly experienced and expert team of analysts and modellers provide market analysis and forecasts. The reports identify key countries and segments for opportunities and strategies based on market trends and key competitor approaches.

    Not the market you are looking for? To verify some ssimilar Marlet intelligence reports:

    Global Wind Power Generation Market Report 2020 – By Connectivity (On-Grid, Off-Grid), By End User (Industrial, Commercial, Residential)

    Global Heavy Construction & Civil Engineering Market Report 2022 – By Type (Utility System Construction, Highway, Street & Bridge Construction), By Organization Size (Large Enterprise, Small & Medium Enterprise ) – Global Market Size, Trends and Forecast 2022-2026

    Global Mining Machinery and Equipment Market Report 2021 – By Product Type (Underground Mining Machinery, Surface Mining Machinery, Drills & Crushers, Crushing, Pulverizing & Screening Equipment, Processing Machinery minerals), by type of function (transport, processing, excavation), by Application (coal, ore, metal), growth and change COVID-19

    Want to know more about The Business Research Company?

    The Business Research Company is a market intelligence firm that excels in business, market and consumer research. Located around the world, it has consultants specializing in a wide range of industries, including manufacturing, healthcare, financial services, chemicals and technology.

    The most comprehensive database in the world

    The Business Research Company’s flagship product, Global Market Model, is a market intelligence platform covering various macroeconomic indicators and measures in 60 geographies and 27 industries. The Global Market Model covers multi-layered datasets that help its users assess gaps between supply and demand.

    
    

    Is Omicron bringing us closer to herd immunity against COVID?

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    Experts say the highly transmissible variant – or any other variant – is unlikely to lead to herd immunity.

    “Herd immunity is an elusive concept and does not apply to the coronavirus,” says Dr. Don Milton of the University of Maryland School of Public Health.

    Herd immunity occurs when enough of a population is immune to a virus that it is difficult for the germ to spread to those who are not protected by vaccination or previous infection.

    For example, herd immunity against measles requires about 95% of a community to be immune. Early hopes of herd immunity against the coronavirus have faded for several reasons.


    The first is that antibodies developed from available vaccines or past infections decline over time. While vaccines offer strong protection against serious illnesses, the decline in antibodies means it’s still possible to get infected, even for those who are boosted.

    Then there is the huge variation in vaccinations. In some low-income countries, less than 5% of the population is vaccinated. Rich countries are grappling with vaccine hesitancy. And young children are still not eligible in many places.

    As the virus spreads, it mutates, helping the virus to survive and giving rise to new variants. These mutants — like omicron — can better evade the protection people have from vaccines or previous infection.

    Populations are moving towards “collective resistance,” where infections will continue, but people have enough protection that future spikes won’t be as disruptive to society, Milton says.

    Many scientists believe that COVID-19 will eventually become like the flu and cause seasonal epidemics, but not huge outbreaks.

    ___

    The AP answers your questions about the coronavirus in this series. Submit them to: [email protected] Learn more here:

    Can you contract COVID for a long time after an omicron infection?

    How many times can I reuse my N95 mask?

    When am I contagious if I am infected with omicron?

    EV Battery Tech announces optimal site developments and

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    Vancouver, BC, Feb. 22 2022 (GLOBE NEWSWIRE) — Extreme Vehicle Battery Technologies Corp. (the “Company” Where “VE Battery Technology”) (CST: AC DC) (OTCQB: CRYBF) is pleased to announce developments within its wholly-owned cryptocurrency mining subsidiary Optimal CP Inc. (“optimal”) for the company’s inaugural bitcoin mining facility and general company updates.

    Optimal expects the initial tranche of 100 ASIC miners to be delivered to its facility in mid-March and will be commissioned in the first mining enclosure over the next four to eight weeks.

    Following the commissioning of this initial tranche of 100 ASIC miners, the company’s goal is to add an average of 500kW per month of ASIC capacity over the next six months, which should result in capacity additional mining of 3,500 kW with a total hashrate of around 100 petahash. In total, the Company expects mining capacity of approximately 12 bitcoins per month to be in place by the end of Q3 2022.

    Optimal’s experienced team continues to make developments on time and on budget as we build this new cash flow block chain vertical in our portfolio,said EV Battery Tech CEO Bryson Goodwin.

    Optimal has retained the services of an Alberta-based electrical contractor with experience in the supply and commissioning of mining enclosure systems to begin the supply and delivery of its first mining enclosure systems in in a timely and cost effective manner.

    Completion of this process will allow Optimal to begin the phased construction and commissioning of its first mining facility. The facility should be best suited to Optimal’s ambitions for its initial crypto production and expansion of this facility as future levels of state-of-the-art ASIC machines continue to arrive.

    In addition to advancing the crypto mining vertical, the company continues to advance in its other blockchain division and marketing efforts. Some notable developments include:

    • The Company continues to advance the development of the Smart Miner. The collaboration between IONiX Pro Battery Technologies (“IONix Pro”) and the energy saving of the renewable bond base (“Dressing gown2”) is working to develop the first carbon-negative mining device. Dressing gown2 has already placed an order for the first 10,000 miners to deploy in its first ROBe2 Ecosystem development.
    • Development of theClever OrderThe app continues as the Company prepares for beta testing of the app. The Smart Command app allows users to monitor and control their Energy Storage System (ESS) products as well as the ability to pay for electric vehicle (EV) charging using cryptocurrency.
    • The company engaged IAM Ventures Inc. for CAD$150,000 to assist with the company’s marketing efforts, including analysis, development and creation of content for all marketing materials, email marketing, generation and maintenance of landing pages and the use of an influencer network. to help the Company increase brand awareness.
    • The company and IONiX Pro continue to work with Daymak Inc. to develop custom battery systems for their Avvenire EV and Light Electric Vehicle (LEV) line using EV Battery Tech’s patented BMS and proprietary blockchain technology. The first prototype using the IONiX Pro battery system was unveiled in December 2021. https://www.youtube.com/watch?v=ZEipnUOEdHo

    Our blockchain asset portfolio continues to progress on all fronts. As we get closer and closer to anticipated revenues from our mining operations, we continue to develop our long-term vertical markets as we believe will have a disruptive force in their respective Market segments, concluded Mr. Goodwin.

    On behalf of the company,

    Bryson Goodwin
    Chief Executive Officer

    About Extreme Vehicle Battery Technologies Corp.

    Extreme Vehicle Battery Technologies is a blockchain and battery technology company with revolutionary, patented Battery Management Systems (BMS) designed to meet the growing demand for scalable and intelligent solutions for the rapidly growing electric vehicle (EV) markets. ) and energy storage solutions (ESS). The company is committed to helping global recycling solutions by providing recycling initiatives using their technology to analyze and fully refurbish used batteries.

    Contact numbers and emails  

    For more information about the Company, please visithttps://www.evbattery.tech.
    For more information about the company’s products, please visithttps://www.ionixpro.com.
    For investor inquiries, please contact (236) 259-0279 or emailin[email protected]
    For product or sales inquiries, please contact (236) 266-5174 or email[email protected].
    All communications are handled by AlphaOne Media Group Inc.

    About Optimal CP Inc.

    Optimal CP is a company focused on meeting the growing demand for profitable cryptocurrency infrastructure in North America. Optimal’s focus on integrating its mining facilities with power generation facilities in Alberta, and using state-of-the-art operating techniques, will allow it to achieve a high degree of financial and long-term operational certainty that can provide some of the cleanest and lowest cost mining operations in the world.

    Forward-looking statements

    The information in this press release includes certain information and statements about management’s views on future events, expectations, plans and prospects that constitute forward-looking statements. These statements are based on assumptions subject to risks and uncertainties. Forward-looking statements and information can be identified by the use of words such as “expects”, “intends”, “is expected”, “potential”, “suggests” or variations of these words or expressions, or statements that certain actions, events or results “may”, “could”, “should”, “would”, “could” or “will” be taken, occur or be achieved. Forward-looking statements in this press release include, but are not limited to, statements relating to: Optimal’s expectation of delivery of the initial tranche of 100 ASIC miners and their commission in the first mining enclosure; the Company’s expectation of a 500 kW per month increase in ASIC capacity; the Alberta-based electrical contractor began procurement and delivery of Optimal’s first mining enclosure systems in a timely and cost-effective manner; finalizing the process for Optimal to begin construction and phased commissioning of its first mining facility; the expectation that the facility will best suit Optimal’s ambitions; the continued advancement of the Smart Miner; development of “Smart Command”; the Company’s commitment to IAM Ventures Inc.; and continued work with Daymak Inc., . Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee that the expectations of any forward-looking statement will prove to be correct. Except as required by law, the Company disclaims any intention and undertakes no obligation to update or revise any forward-looking statements to reflect actual results, whether as a result of new information, future events, changes in assumptions, changes in factors affecting these forward-looking statements. – statements seeking or otherwise. Other risk factors are discussed in the Company’s MD&A for the year ended January 31, 2021.

    The CSE (operated by CNSX Markets Inc.) has neither approved nor disapproved of the contents of this press release.

    WPI Researcher Min Wu Receives $450,000 NSF CAREER Grant to Mathematically Model Plant Cell Wall Growth | News

    0

    Min Wu, a researcher at Worcester Polytechnic Institute (WPI), received a $450,000 CAREER grant from the National Science Foundation (NSF) to develop mathematical models describing how secretions and mechanical forces shape the growth of elongated plant cells.

    The five-year project will focus on mathematical modeling of filamentous cell wall growth, which could lead to insights into plants and fungi that impact agriculture and human health, Wu said, assistant professor in the Department of Mathematical Sciences.

    “How filamentous-walled cells grow is poorly understood, and it is difficult to observe and measure biological activity with experimental approaches alone,” Wu said. “Mathematical models can fill this knowledge gap. . The models could lead to a better understanding of how plant root hairs enter the soil for moisture and nutrients and how disease-causing fungi might be attacked.

    Cell filaments such as moss cells in the juvenile stage maintain their growth at the tip and through a process known as exocytosis. During exocytosis, materials inside a cell cross the cell membrane and deposit deposits outside the cell.

    Wu will develop two mathematical models to describe cellular activity and growth-related forces. A model will define how secretions from inside a cell and mechanical forces on cell walls influence the surface shapes of cell walls. A second model will define how patterns of novel cell wall materials in elongated cells regulate cell wall thickness under mechanical pressure. Wu will validate his models by comparing the predicted secretion profiles with experimental measurements.

    “The fundamental question is how does a cell surface grow without changing shape,” Wu said. “The models will allow us to mathematically simulate cell wall growth and describe how exocytosis gives rise to the growth pattern of the cell wall, but this project will also look at how the cell wall retains its thickness, or three-dimensional shape, as it grows.”

    The project extends Wu’s previous research, which used mathematics to analyze biological processes, such as wound healing and tumor growth. She has also modeled the development of living tissue on a large scale.

    As part of his project, Wu will work with Luis Vidali, an associate professor in the Department of Biology and Biotechnology, to validate his models. It will expand its research mentoring activities with undergraduate and graduate students, and it will create an open source teaching and learning platform called “Filaform” with courses that emphasize the connections between mathematics and biology.

    “I want to teach students that the transdisciplinary way of thinking about the world is very natural,” Wu said. “This platform will merge math and biology from a geometric perspective to encourage students to make that connection.”

    Corbevax and ZyCoV-D – Things to keep in mind before taking your children for the COVID-19 vaccination

    0
    • The Indian government has approved a second COVID-19 vaccine for children.
    • The government would accept school ID cards for childhood vaccinations.
    • Now children over the age of 12 can register for the COVID-19 vaccination.

    Disclaimer: This article should not be considered medical advice.

    The Indian government has approved a second Covid-19 vaccine for children, almost a month after the official launch of the vaccination campaign for adolescents aged 15 to 18. This measure will allow children over the age of 12 to be vaccinated against COVID-19.

    The government would accept school ID cards for the vaccination of children, therefore children without Aadhaar cards will also be able to get vaccinated.

    This comes as a sign of relief for parents who were worried about the delay in vaccinating their children. Teenagers can request the vaccination dose on the CoWin app.

    But before you take your kids to get vaccinated, these are the things you need to know.

    ZyCoV-D is needle free

    Age range: 15-18

    The Zydus ZyCov-D vaccine was the first COVID-19 vaccine – the fifth vaccine overall – to be approved in India for children. The vaccine was available for adolescents aged 15 to 18, from January 3, 2022.

    Unlike other vaccines, ZyCov-D is needle-free. It is injected using a needleless applicator called a PharmaJet which uses a narrow jet of liquid to penetrate the skin and deliver the jab.

    It is also a plasmid – a type of DNA found mainly in bacteria – that provides the spike protein of the SARS-CoV-2 virus and elicits an immune response mediated by the cellular and humoral arms of the human immune system.

    “The plasmid DNA platform also allows for the rapid generation of new constructs to deal with mutations in the virus, such as those that are already occurring,” Cadila Healthcare, the vaccine’s maker, told the government in August 2021.

    Corbevax is a COVID-19 protein subunit vaccine

    Age range: 12-18

    Corbevax is the first locally developed COVID-19 protein subunit vaccine in India, which includes parts of a virus that stimulate an immune system.

    “CORBEVAX is a ‘recombinant protein subunit’ vaccine, developed from a component of the spike protein on the surface of the virus, which helps the body mount the immune response against the virus,” Biological explained. E Limited, the manufacturer of the vaccine. .

    The vaccine was developed by Biological E Limited in collaboration with the Texas Children’s Hospital Center for Vaccine Development (Texas Children’s CVD) and Baylor College of Medicine (Baylor) in Houston, Texas.

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    Wet Scrubber Market Size and Forecast by 2029

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    New Jersey, United States,-The latest report published by Market Research Intellect presents an in-depth analysis of the global wet scrubber market. This research report assesses ever-changing market dynamics that are expected to affect the trajectory of the overall market. Analysts have studied historical market performance and compared it to current market trends, charting the trajectory. For a detailed discussion of the global wet scrubbers market, analysts have segmented the market on the basis of applications, products, and end users. The research reports have been collated using primary as well as secondary research methodologies to provide readers with a precise understanding of the ongoing development of the Wet Scrubber market.

    Analysts used Porter’s Five Forces Analysis, Study Worm Analysis, and Pestle Analysis to determine the path major vendors should follow in the coming years. The research report also includes the assessment of these vendors’ financial prospects, Wet Scrubbers market growth strategy and expansion plan during the forecast period. All the information presented in the Global Wet Scrubber Market research report has been certified by market experts.

    Get | Download a sample copy with table of contents, graphics and list of [email protected] https://www.marketresearchintellect.com/download-sample/?rid=363443

    The report includes a detailed segmentation study of the global Wet Scrubber market, in which all the segments are analyzed in terms of market growth, share, growth rate, and other significant factors. It also provides the segment attractiveness index, allowing players to inform about the profitable revenue pockets of the global wet scrubbers market. A broad assessment of the segments provided in the report enables investments, strategy, and teams to focus on the right areas of the global Wet Scrubbers Market.

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    • pollution systems

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    • Chemical and Gas Scrubbers
    • Chlorine scrubbers
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    • Others

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    Report attribute Details
    Market size available for years 2021 – 2028
    Base year considered 2021
    Historical data 2015 – 2019
    Forecast period 2021 – 2028
    Quantitative units Revenue in USD Million and CAGR from 2021 to 2027
    Segments Covered Types, applications, end users, and more.
    Report cover Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends
    Regional scope North America, Europe, Asia-Pacific, Latin America, Middle East and Africa
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    Each regional Wet Washer industry is carefully researched to understand its current and future growth scenarios. This helps players strengthen their position. Use market research to get a better perspective and understanding of the market and target audience and ensure you stay ahead of the competition.

    Based on geography, the global wet scrubber market has been segmented as follows:

      • North America includes the United States, Canada and Mexico
      • Europe includes Germany, France, UK, Italy, Spain
      • South America includes Colombia, Argentina, Nigeria and Chile
      • Asia Pacific includes Japan, China, Korea, India, Saudi Arabia and Southeast Asia

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    Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations, in addition to the goal of providing customized and in-depth research studies. range of industries including energy, technology, manufacturing and construction, chemicals and materials, food and beverage. etc Our research studies help our clients to make decisions based on higher data, to admit deep forecasts, to grossly capitalize with opportunities and to optimize efficiency by activating as their belt in crime to adopt a mention precise and essential without compromise. customers, we have provided expert behavior assertion research facilities to more than 100 Global Fortune 500 companies such as Amazon, Dell, IBM, Shell, Exxon Mobil, General Electric, Siemens, Microsoft, Sony and Hitachi.

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    Boost your immunity, but with the right mix of herbs | Chennai News

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    Concoctions, powders and mixes – all things natural have become a rage, especially so for alternative healing and immunity-boosting measures, during the pandemic. But even in nature, an overdose of anything can make a disease worse. And that’s a lesson some learn the hard way.
    Take for example the herb giloy (Tamil name “Seenthal”), which has become popular for its immunity-boosting and anti-Covid superpowers, but recent studies suggest the heart-leaved herb may be more harmful than healing. . In January, an article on giloy-induced liver damage during the Covid-19 pandemic published in Hepatology Communications records 43 cases in 13 hospitals across India.
    Lead author, hepatologist Dr Cyriac Abby Philips of the Liver Institute at Rajagiri Hospital, Kerala, said those who consumed giloy, a herbal supplement commonly used in traditional medicine systems, experienced a acute hepatitis or worsening of chronic liver disease.
    Although the Kerala State Medical Council for Indian Systems of Medicine and the Ayush Ministry have sent Dr. Philips an opinion on “tarnishing the image of traditional medicine”, but the doctor maintains that “giloy is rich in diterpenoids, which can cause immune-mediated damage”. to the liver. “Some people have made a decoction of it, while others have used the over-the-counter tablet form to protect against coronavirus. “While 85% recovered after stopping giloy, about 10% died from damage caused by using the herb,” he says.
    In Chennai, gastroenterologist Dr R Ravi from Rela Hospital, says that since the second wave of the pandemic, he has seen several cases of upper abdominal pain, ulcers, loss of appetite and nausea, which were attributed to the effects of “overconsumption of certain herbal concoctions like ‘kabasura kudineer’. When we did endoscopies, they were found to have erosions in the stomach wall,” says- he.
    There is no doubt that herbs have health beneficial and bioactive properties, says Dr. Meenakshi Bajai, Registered Dietitian, TN Government Multi Super Specialty Hospital, Chennai.
    “Culinary herbs and spices have been used to improve digestion and treat digestive disorders in Ayurvedic medicine because they are abundant in bioactive phytochemicals, many of which are alkaloids, phenolic acids and flavonoids. They have antioxidant, antimicrobial and anti-inflammatory properties. But overdoing it can be harmful. “For example, drinking more than two cups a day of lemongrass tea can cause itchy skin in people with food allergies.” Additionally, consuming large amounts of lemongrass can cause dizziness, drowsiness, dry mouth, excessive urination, increased appetite and deterioration of kidney function. “The same goes for green tea,” she says. “If you drink too much, you run the risk of liver damage and gastrointestinal discomfort. The tannins it contains may alter the therapeutic effectiveness of prescription medications.”
    Medicine is all about moderation, says Dr M Ravichandran, a professor at Government Siddha Medical College, Chennai. “At higher doses, even the nectar is toxic. During the pandemic, there was so much panic that people believed everything they read. “’Kabasura kudineer’, he says, a mixture of nine ingredients in precise proportions must be purchased from a licensed practitioner and prepared and consumed in the correct dosage.
    “About 5g of powder mixed with 200ml of water, reduced by 50ml and taken for a prescribed number of days (usually three as a preventative),” he explains. “But instead, people were drinking two glasses a day for weeks and then ending up with gastrointestinal issues. Some added other ingredients to the mix assuming it would overload the drink. We had the case of a person who thought he had bought ‘kabasura kudineer’, but when we examined the sachet, we discovered that it was a fake mixture of neem and other ingredients. “In another incident, says Dr. Ravichandran, a person was rushed to Siddha Government Hospital with abdominal pain after eating large quantities of peanut candy wrapped in betel leaves. “It was apparently on the advice of a WhatsApp attacker. Betel leaf can be a gastric irritant when taken in large amounts,” he says.
    Food safety of herbs is a priority, says Dr. Bajaj. “Deliberate, accidental, natural biological, microbial and chemical contamination of herbs or adulteration of dried or powdered herbs can produce adverse effects. ”
    The curcumin in turmeric, while known for its anti-inflammatory properties, also has another aspect, according to doctors. “Curcumin also tends to slow blood clotting, so it should be avoided by those taking blood thinners. We have had reports of internal bleeding and skin bleeding in people taking 1-2g daily of turmeric as supplement form. Turmeric also tends to absorb lead and therefore should be grown in soils that are low in lead. Therefore, care must be taken about the source of the turmeric,” says Dr. Philips.
    Anything consumed should be in consultation with a doctor, warns Dr. Ravichandran. “When we have a short circuit in the house, we rush to an electrician, but when it comes to our health, why do we go to YouTube for expert advice?”

    Charge separation imaging on titanium dioxide photoelectrocatalytic nanotube surfaces

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    Semiconductor devices harness the power of light to produce other types of energy: electrical or chemical. One of the applications of this technology is to produce hydrogen molecules from water, in a process known as the photoelectrochemical (PEC) splitting of water, as a source of ‘renewable energy.

    Photoelectrolytic cells include semiconductor electrodes, in which the hole and the electron are spatially separated when irradiated with light with an energy above a certain threshold. Charge flow initiates PEC reactions. Titanium dioxide (TiO2) nanotubes are widely used semiconductors for this purpose. However, the charge flux distribution at the surface of TiO2 tubes is unclear. Now, Marina Makarova at the University of Kanazawa and her colleagues in Japan and Europe have used an innovative technique called scanning electrochemical microscopy (SECCM) to identify this distribution.

    To first measure the success of PEC water separation, the release of oxygen (the reaction product accompanying hydrogen) was measured. Its production was further characterized by lead(II) ions added to the cell, such that lead(IV) oxide (PbO2) particles were found deposited on the walls and tops of the TiO2 nanotubes, suggesting similar electrochemical reactivity at these two sites. The research team then used SECCM to clarify the photoreactivity at the two sites at different electrode potentials.

    SECCM involves the use of a narrow pointed pipette probe to measure electrical changes at specific locations. This probe is filled with a conductive fluid called an electrolyte which sits between two charged electrodes. One electrode is immersed in the electrolyte, while the second is connected to the sample surface. Measurements were taken perpendicular and parallel to the length of the tubes to determine the differences in reactivity on the walls and top, respectively. Now the free electrons generally move along the nanotubes towards the positive electrode inside the cell. When these electrons delocalize and jump to the conductive strip, they leave behind “holes” which are just pockets of positive charge that can move around. The SECCM results showed the presence of similar electrical activity along the walls and top of the nanotubes. Since the activity at the top could be preferentially attributed to the movement of electrons, this suggested that the holes instead traveled shorter distances and moved perpendicular to the length of the tube towards the walls. This flow in a direction orthogonal to the length of the tubes explains why PbO2 deposits were also found on the walls of the tubes.

    “This information could be used to establish further correlations between photocurrent and microstructure of 1D nanostructures, and for site-specific decoration with co-catalysts or visible-light sensitive sensitizers,” the team explain. Understanding the spatial patterns of electrochemical activity is important for designing efficient and cost-effective photovoltaic cells. Additionally, a combination of oxide deposition and SECCM might be the most sensitive tool for identifying active sites.

    Figure 1. Local analysis by scanning electrochemical cell microscopy (SECCM).

    The photoelectrochemical responses of the top and sides of the TiO2 nanotube array were measured using the nanopipette. ©Takahashi, Kanazawa University

    Figure 2. Three-dimensional topographic image of the TiO2 nanotube array and local photocurrent response.

    There were no significant differences in photocurrent values ​​between the top and the side of the tube. ©Takahashi, Kanazawa University

    [Background]

    Photoelectrochemical (PEC) separation of water

    Hydrogen is increasingly becoming a cleaner and more sustainable source of energy. One method of obtaining it is the PEC splitting of water to produce hydrogen and oxygen molecules. This reaction can also be carried out industrially using a photovoltaic system coupled to an electrolyser. The PEC cell uses light to produce high-energy electrons and uses these electrons to initiate the chemical reaction that breaks up water molecules. Since semiconductors are the main source of electrons in photoelectrolytic cells, understanding their PEC properties is essential for designing optimal systems.

    Scanning electrochemical cell microscopy (SECCM)

    /Public release. This material from the original organization/authors may be ad hoc in nature, edited for clarity, style and length. The views and opinions expressed are those of the author or authors. See in full here.

    If You Have Alzheimer’s This Is When You’ll Start To Have Symptoms – Eat This, Not That

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    An estimated 5.8 million Americans are living with Alzheimer’s disease, “a progressive disease that begins with mild memory loss and can lead to loss of the ability to hold a conversation and respond to the environment.” , according to Centers for Disaster Control and Prevention. Although Alzheimer’s disease generally affects the older community, the disease can begin in the thirties. To better understand Alzheimer’s disease, eat this, not that! Health spoke to experts who explained when the signs of the disease usually begin and who is at risk of developing Alzheimer’s disease. Read on and to ensure your health and the health of others, don’t miss these Sure signs that you have already had COVID.

    Shutterstock

    Dr Elise Eifertassistant professor, gerontology program, UNC Greensboro explains, “It can be hard to tell when people with Alzheimer’s disease and related dementias realize something has changed. Early symptoms can be vague and vary from person to person. While some people notice changes in their own thinking or behavior, sometimes these signs are first noticed by those close to them.In the later stages, many people suffer from anosognosia or a lack of awareness that there are deficits. of mental function essentially affects his ability to understand and recognize the extent of his impairment.

    Dr Sam Zand, psychiatrist and chief medical officer of You’d do better adds: “Usually screened above 65, there may be an early onset in the 50s and even 40s.”

    elderly woman with an adult daughter at home.
    Shutterstock

    Dr. Verna R. Porter, MD, neurologist and director of dementia, Alzheimer’s disease and neurocognitive disorders at Providence Saint John’s Health Center in Santa Monica, California, says signs of Alzheimer’s disease include “progressive loss of working and long-term memory, confusion and disorientation, changes in the fluency of speech or writing, reduced ability to focus, impaired judgment and reasoning leading to questionable decision-making, and mood changes such as apathy, anxiety, and depression that can lead to social withdrawal.Depression, if not untreated, can exacerbate confusion and forgetfulness.

    Comforting an elderly husband with dementia
    Shutterstock

    According to Dr. Porter, “Normal age-related memory changes are very different from memory loss caused by forms of dementia, such as Alzheimer’s disease. In normal aging, forgetfulness does not interfere with the ability to continue normal daily activities. and is not necessarily cause for concern. Examples of common memory problems that can sometimes occur during normal aging include moving objects around the house, forgetting the names of less familiar acquaintances, forgetting intention to enter a room or having difficulty remembering less familiar objects. details about what you have read or past conversations. »

    RELATED: If you have a heart problem, you may need these specialists as soon as possible

    senior man with dementia talking to doctor
    Shutterstock / Robert Kneschke

    Dr. Zand says the elderly are most at risk. Age is the biggest risk factor because the brain atrophies over time. Cellular strength weakens and metabolic processes slow down with age. Those with low mental stimulation. As the old saying goes, if you don’t use it, you lose it. This is also true for neural health. Those with uncontrolled medical problems. Poor brain health is usually caused by the same factors that cause poor heart health. High blood pressure, diabetes, smoking, poor diet and lack of exercise can all accelerate the process of dementia.”

    RELATED: Sure Signs You’re Getting Omicron Now

    A group of elderly people with dementia build a tower in the retirement home from colored building blocks
    Shutterstock

    Dr. Zand says, “Stimulate your mind. Read more, find creative outlets, or learn a new hobby. Engage in stimulating conversations and pursue your interests. Eat well. “

    RELATED: #1 Sign that you have one of the “deadliest” cancers

    Elderly hispanic man with dementia trying to get dressed
    Shutterstock

    “Globally, an estimated 50 million people suffer from dementia; 70% of these cases are caused by Alzheimer’s disease, making it the most common neurodegenerative disease causing dementia,” explains Dr Porter. “The terms dementia and Alzheimer’s are distinct from each other, in that dementia is an umbrella term that describes symptoms resulting from mental decline severe enough to interfere with normal daily activities and functioning; in contrast Alzheimer’s disease is a condition that causes dementia.” AAnd to protect your life and the lives of others, do not visit any of these 35 places where you are most likely to catch COVID.

    Investors alarmed as streaming services lose their magic touch | netflix

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    The end of the pandemic-fueled home entertainment boom that drove record growth for Netflix and its rivals has revealed a disturbing truth: the streaming revolution has peaked.

    The market faces a perfect storm as, after a decade of easy conversions, streaming companies experience dramatically slower growth and growing competition fueling an unsustainable content war, just as stretched household budgets entice consumers to start to reduce entertainment services.

    Continued global lockdowns have provided the ideal conditions for stratospheric growth. Netflix added a single-year record of 37 million subscribers in 2020, and newcomer Disney+ hit 100 million in 16 months, a feat its rival took a decade to achieve. Excited investors sent the market values ​​of both companies to all-time highs late last year.

    Netflix came down to earth last month, forecasting just 2.5 million new subscribers worldwide in the first quarter, its worst start to the year in more than a decade, and confirming that last year it added the fewer subscribers since 2015. Growth, has wiped out almost $300bn (£220bn) from the two giants’ combined market value since last year’s highs.

    Gal Gadot and Dwayne Johnson in Netflix’s big-budget Red Notice.

    Netflix has traditionally acted as a bellwether for the industry and its worrying slowdown in growth – on the heels of its self-proclaimed strongest content slate ever, with records squid game, red notice and Do not look At the top – raises questions about the future of cutting-edge streaming. MoffettNathanson analysts, longtime Netflix skeptics, said the predictions were “worrying” for the rest of the industry.

    Netflix’s once-revolutionary binge-watching model, the source of a lot of headaches for traditional TV companies, is proving to be a nightmare for the bottom line. The company will increase its content spending to around $19 billion this year, and there’s an additional $23 billion on its balance sheet for long-term content costs, plus $14.8 billion in long-term debt.

    Disney, which also owns sports operation ESPN and streaming service Hulu as well as its Marvel, Pixar, Star Wars and Disney film businesses, is spending $33 billion on content this year.

    Netflix has ditched the 30-day free trials popular with binge-watchers, and finds that even its huge spend isn’t enough to keep customers coming back, with many unsubscribing after watching big-budget hits.

    squid game? It’s been so last quarter,” analyst Michael Nathanson said in a note to investors last month after the streaming giant’s shares suffered their biggest drop in a decade. “the witcher? Done on New Years Eve! “.

    Alan Ritchson as Jack Reacher in a scene from Amazon's Reacher.
    Alan Ritchson as Jack Reacher in a scene from Amazon’s Reacher series. Photograph: Keri Anderson/AP

    The new trend, used by Disney+ and Amazon’s Prime Video, is to release episodes of hit shows every week, to extend the life of content and prevent subscribers from canceling after consuming a few must-watch hits. Last year, Apple dropped its attractive offer of free one-year access to its streaming service with the purchase of an Apple device.

    Netflix, and later Amazon, were nearly a decade ahead, but now that traditional media giants are vying for a share of streaming spending, the market is severely overcrowded.

    America’s biggest media groups, from Disney-owned Comcast and Sky, to WarnerMedia, ViacomCBS and Discovery, will spend about $140 billion on content this year, with a focus on streaming services. Globally, content spending is expected to exceed $240 billion, according to Ampere Analysis, which will add pressure to retain subscribers and gain new ones.

    “Everyone started to feel the heat,” said Dominic Sunnebo of the Kantar research group. “In addition to a wave of new, well-funded subscription services, there is now also an acceleration of low-cost or even free ad-supported services. Netflix suddenly isn’t so cheap anymore.

    However, with the wealthier populations of the United States, Europe, and Australia mostly devoid of potential subscribers, providers must accept that not all customers are financially equal.

    In high-potential markets, such as India, consumers are unable or unwilling to pay high prices for services, which means price competition is fierce and subscriber growth leads to increases in much lower income.

    Globally, Disney+’s average monthly revenue per subscriber is just $4.12, as around 37% of its 118 million base comes from its ownership of the low-cost Indian service Hotstar. In December, Netflix had to cut its standard price in India by nearly a quarter to $6.60, and its mobile-only offering to less than $2; in the US and UK, its most popular plan costs $15.49 and £9.99 respectively.

    Newer services such as HBO Max are showing relatively strong initial growth, however. And Disney+, which disappointed investors in November when its last quarter results showed the lowest number of new subscribers since its launch, staged a remarkable recovery last week, beating Wall Street expectations to nearly 130. million subscribers at the end of last year.

    “For now, Disney is defending its position, but it’s not the walkover you might expect from a company with a content cabinet already full of blockbusters,” said analyst Sophie Lund. -Yates of Hargreaves Lansdown.

    Shares of Disney jumped nearly 10% as investors breathed a sigh of relief, hoping the golden days of streaming growth aren’t over yet.

    Brendan Hunt, Cristo Fernández and Jason Sudeikis in Apple TV's Ted Lasso.
    Brendan Hunt, Cristo Fernández and Jason Sudeikis in Apple TV’s Ted Lasso. Photograph: Colin Hutton/AP

    The new golden age of TV is proving too positive in some ways, with the overload of choice starting to cause streaming fatigue among consumers. Analysis of the nine major streaming services available in the UK, including ITV Hub, All4 and BBC iPlayer, as well as US subscription services, found 125,000 hours of content. Given that the typical Brit watches around three hours of television a day, it would take 86 years to see it all.

    “The market has become a lot more crowded in recent years and it’s not going to support many more services at this point,” said Richard Broughton, analyst at Ampere. “Consumers now have more services than they could possibly need.”

    It’s an unlikely scenario, but a viewer who wanted to sign up for streaming services to cover all the major entertainment and sporting events – from Sky, BT and Virgin to Amazon, Disney and Netflix, with a little ‘Ad-free ITV Hub+ and specialist streamers like reality TV service Hayu – and pay the BBC license fee, would need to spend around £2,000 a year, excluding the cost of broadband.

    There are signs that consumers are becoming more selective about the number of services they want to manage and pay for. Kantar found that a fifth of German consumers who signed up for a new subscription video-on-demand service in the last three months of last year canceled one of their existing services.

    “Planned cancellation increases exponentially when people exceed three services,” Sunnebo said. “Consumers are not going to continue to spend indefinitely: there is a ceiling and this ceiling is getting closer and closer. I don’t think we’ve peaked in terms of viewing yet, but we’re getting closer in terms of what people are willing to pay. »

    Include These 5 Foods In Your Diet That Boost Immunity

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    Since the start of the COVID-19 pandemic, people have come to understand a lot about their body’s ability to fight off a dreaded virus like COVIID-19. From the day people started contracting the virus, the whole debate has revolved around the human body’s immune response and ways to boost it.

    Although scientists have now successfully developed the vaccine against the virus, that does not mean it will be effective against a similar future threat. Thus, it is advisable to start strengthening our immune system by natural means in order to protect us not only from an epidemic but also from common diseases.

    You don’t have to search for a miraculous herb found in the mountains, but certain foods used daily can do wonders for our long-term immune system.

    We have listed some of the readily available foods that will give you that much-needed immune boost.

    Garlic

    Apart from its pungent taste and smell, garlic has a lot to offer when it comes to health. Garlic is already a common home remedy for preventing illnesses like the common cold, which obviously suggests that it works well for our immune system. Experts claim that the high concentration of sulfur compounds in garlic may be responsible for its ability to boost our immunity.

    Spinach

    Popularly used in the Indian diet, spinach has always been associated with strength. However, this leafy vegetable is packed with antioxidants and carotene, which greatly increases our body’s ability to fight infections. It is advisable not to overcook spinach in order to take advantage of its benefits for the immune system.

    Almonds

    Nuts like almonds are packed with nutrients like vitamin E. This fat-soluble vitamin effectively helps our immune system fight infections caused by bacteria and viruses. Moreover, these nuts are also high in protein, riboflavin, magnesium, and zinc, making them one of the healthiest snacks.

    Red peppers

    Surprisingly, red bell peppers contain three times more vitamin C than any other fruit or vegetable. They also contain a significant amount of beta-carotene which strengthens the immune system. Being a powerful antioxidant, vitamin C helps the body fight disease through antibodies.

    Broccoli

    Broccoli is another superfood rich in nutrients like vitamin A and vitamin C. Experts believe that the phytochemicals found in broccoli are effective in weaponizing the immune system. Moreover, broccoli also contains antioxidants like lutein and sulforaphane which help keep diseases at bay by boosting immunity.

    Read all the latest Assembly news, breaking news and live updates here.

    Potassium Tracking: Tech Ideas to Try

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    Staying on top of your potassium needs and incorporating them into your diet are important aspects of managing hyperkalemia.

    But managing your potassium intake and level also requires staying hydrated and regularly taking medications and other over-the-counter medications that help support things like kidney and heart health.

    To help you keep track of all the moving parts, you might want to consider incorporating a few tech tools or gadgets into your daily routine. These include diet apps, medication reminders, and water bottles that let you know when it’s time to drink.

    But before we go over the ins and outs of what’s available, let’s start by looking at potassium, including what it is, what it does, and how much you need each day.

    Potassium’s primary role is to help maintain normal cell function, making this essential mineral a vital player in your body’s functioning.

    For example, adequate levels of potassium contribute to the proper functioning of the heart and kidneys, muscle contraction, nerve transmission and the maintenance of normal blood pressure.

    Potassium is often discussed with sodium, which is responsible for maintaining fluid levels outside of cells. It is essential to address the relationship between the two minerals because our body needs more potassium than sodium to function properly.

    However, the average American diet is quite the opposite, according to the Harvard TH Chan School of Public Health.

    According to National Institutes of Health Office of Dietary Supplements.

    Too much potassium is generally not a risk for people with healthy kidneys. But if you have kidney disease or use certain medications that cause impaired urinary potassium excretion, you are at risk of developing hyperkalemia.

    Potassium is naturally present in many foods, including fruits, vegetables, beans, legumes, nuts and some dairy products. It is also available as a dietary supplement.

    the recommended daily intake of potassium depends on your age and gender. For example, adult men need 3400 milligrams (mg) and adult women 2600 mg.

    If you have a health condition that requires a different potassium intake, be sure to follow your doctor’s recommendations.

    Now that we’ve covered why it’s important to keep tabs on your potassium intake, it’s time to review some tools to help you track potassium while supporting your overall health.

    1. Stopwatch

    If you want a complete food and fitness tracking app that also records biometrics and health data, give Stopwatch to try.

    This app tracks up to 82 micronutrients, logs meals, exercise, and biometrics, provides dietary support, and displays valuable graphs and reports that show you how nutrients like potassium and biometrics correlate over time .

    Plus, it syncs with Apple Health and Samsung Health, letting you keep all your health and medical data in one place.

    What sets Cronometer apart from its competitors is the ability to set minimums and maximums for certain nutrients, such as potassium. With the premium (paid) version, you also get a nutrition score that gives you an idea of ​​your nutrition in certain categories.

    For potassium, you can look up your data from the Electrolyte Nutrition Score, which also shows calcium, magnesium, and sodium.

    The stopwatch is available for iOS and Android.

    2. DecideRegime

    The DecideDiet is a smartphone app that lets you scan a barcode or enter a food item you plan to eat.

    The app will rate the sodium and potassium content, then rate the food by color: green, yellow, or red. In general, users are advised to eat at least 75% of their food in the green category and stay away from items that get a red rating.

    The app was designed by a nephrologist and assistant professor at the UConn School of Medicine to help people with chronic conditions like kidney or heart disease manage their diet according to medical recommendations.

    DecideDiet is available for iOS and Android.

    3. HidrateSpark PRO Water Bottle

    We could all use a little help drinking enough water throughout the day. With a HidrateSpark PRO water bottle, you get a water bottle that not only keeps your H2O cold for up to 24 hours, but also reminds you when it’s time to drink.

    Here’s how it works: The bottle has an LED smart sensor “puck” around the bottom of the container that lights up when it’s time for a drink. This smart water bottle connects the bottle sensor via Bluetooth to an app on your smartphone that keeps track of how much water you drink. The app tracks every sip to keep your daily goal up to date throughout the day.

    The HidrateSpark PRO is available in stainless steel or Tritan plastic. In addition to PRO, HidrateSpark also has TAP, which updates your water intake on the app when you tap your smartphone on the bottle label.

    4. Medisafe

    The Medisafe Medication Reminder app is like a virtual pill organizer that allows you to store information about all your medications and dosage details.

    Plus, it reminds you when it’s time to take any of your medications and sends notifications when your prescriptions are running low. You will also receive an alert whenever any of your medications should not be used together.

    Although not specifically a potassium tracker, a medication reminder can help you manage prescriptions for any health condition.

    Medisafe is available for iOS and Android.

    5. MyNetDiary

    the The MyNetDiary app is a complete diet solution for tracking calories, food, exercise, and water. Additionally, it is equipped with the ability to set targets and goals related to nutrients and health. You can also set reminders and notifications and search hundreds of recipes.

    With the premium subscription, you can customize and set nutrition goals for things like potassium and sodium. You can log into the app throughout the day and view a personalized diet dashboard that lets you quickly monitor your intake and compare it to your goal.

    The premium version also has tools to support tracking medications, symptoms, test results, and more.

    MyNetDiary is available for iOS and Android.

    6. Potassium Tracker

    The American Kidney Fund’s Potassium Tracker is a weekly diary that allows you to record how much potassium from food enters your body each day. It also has a place to record when you take a potassium binder if your doctor or healthcare team recommends taking one.

    The Potassium Tracker is a form you can download and fill out on your computer or print and save throughout the day. Although it’s a little less technologically advanced than some of the other options, it’s a nice tool for people looking for a paper-based tracker.

    Using tech tools like apps, water bottles, and medication reminders are just a few ways to track your potassium intake and stay on top of your nutrient needs.

    That said, if you have any questions about your general health or concerns related to a specific condition, be sure to speak with your doctor or other healthcare professional.

    12 Science-Based Health Benefits of Bananas, According to a Dietitian

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    Whether you’re sinking into banana bread during quarantine or tossing them into your morning smoothies, you’re probably pretty familiar with bananas. They’re an easy staple fruit to keep on your counter (right next to apples and oranges, of course), and they taste great whether you eat them on their own or add them to your favorite recipes. like those breakfast yogurt bowls.

    But buying the perfect band can create headaches. How to choose the most mature? Some people prefer to buy them when they are green and leave them to ripen at home, while others go straight for the already spotted ones.

    “If it’s something you want to eat right away, definitely get something that’s perfectly yellow,” she says. Rebecca Boova, MS, RD, LDN. But, she adds, there’s no harm in choosing a slightly green or slightly brown bouquet — it all depends on how you prefer to eat them.

    Green bananas have a higher starch content. As they brown, these starches turn into sugar, Boova explains. So the browner they are, the sweeter they will be. No matter how you prefer them, they all pack a nutritional punch.

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    You already know they’re packed with potassium, but there are a dozen (literally!) reasons why cracking that yellow skin is a great idea. Here are all the surprising health benefits of bananas and the research behind them, according to a registered dietitian.

    How does the nutrition of a banana compare?

    A medium banana is packed with protein, carbs, and more. Here are the highlights, according to the USDA.

    • calories: 105
    • Fat: 0.39g
    • Saturated fat: 0.04g
    • Carbohydrates: 27g
    • Sodium: 1mg
    • Sugar: 14g
    • Fiber: 3g
    • Protein: 1g

        So what are the health benefits of bananas?

        You already know that fruits like bananas are great to add to a healthy diet. But there are more than a few reasons why bananas are a cut above the rest:

        1. Their potassium can reduce the risk of stroke.

          Most people need about 4,700 milligrams of potassium per day, says Valerie Agyeman, RD. A banana contains about 10% of the recommended daily intake, or about 470 milligrams. Potassium is a multifunctional mineral, but one of its superpowers is the ability to reduce the risk of stroke, she adds. Potassium improves blood flow and makes arteries less stiff, which can reduce the risk of stroke by up to 20% in women who don’t have high blood pressure, a study in the study has found. Stroke Diary after tracking the potassium intake of more than 90,000 women over the age of 11.

          2. Potassium can also help lower blood pressure.

          The potassium in bananas can help keep your blood pressure low, says Boova. It relaxes the walls of your blood vessels, which lowers your blood pressure (and that peak, aka systolic, number), according to Harvard Medical School. As a reminder, your blood pressure reading consists of two numbers. The systolic measures the pressure in your arteries when your heart is beating, and the diastolic (bottom number) measures your blood pressure when your heart is resting.

          3. The fiber in bananas can help relieve constipation and diarrhea.

          Bananas can help you stay regular. The fiber in the fruit, along with resistant starch (a type of carbohydrate), is known for its ability to remedy both constipation and diarrhea by making your stool firmer and moving it along your bowels. .

          4. Fiber also regulates your gut health.

          Even if your toilet habits are normal, the fiber in bananas is still great for your gut health, says Boova. A study review within the review Cell host and microbe found that fiber replenishes your gut microbiome with all the microbes you need to keep everything going, so peel it off.

          5. The prebiotics in bananas also stimulate your gut.

          You’ve heard of probiotics, but prebiotics are just as important. “It’s like food for the probiotics to help it thrive,” says Agyeman. Prebiotics feed the bacteria in your digestive system, while probiotics are a kind of those bacteria. All of this contributes to a super healthy gut microbiome.

          6. Their vitamin C can help fight disease and improve skin health.

          You can support immunity and take care of your skin when you get into a banana, Agyeman says. Your body needs vitamin C to generate collagen, which helps heal wounds and protects against aging, according to the National Institutes of Health. It’s also a game-changer for your immune system, as vitamin C plays a role in keeping your white blood cells working efficiently.

          7. Their antioxidants and phytonutrients decrease your risk of contracting chronic diseases.

          Fortunately, bananas contain both. “They’ll promote wellness, help you avoid getting sick, and also help lower your risk of different chronic diseases, like heart disease, kidney disease, and diabetes,” Boova said. Both prevent cell damage, which can completely mess up your body and lead to disease.

          8. Carbohydrates make bananas a good source of energy.

          You need energy to function and your body needs carbohydrates to produce energy. Their high carb content makes bananas a great source of energy, even if you fry them, a study found in the Journal of Human Nutrition and Food Science. So if you’re feeling lazy, try snacking on a banana at midday and adding a handful of nuts for a well-balanced snack, Agyeman recommends.

          9. Their vitamin B6 content can help relieve stress and anxiety.

          Bananas are high in vitamin B6, which can help regulate or even boost your mood. “It can help increase those feel-good hormones,” Agyeman says, such as serotonin. The vitamin is actually involved in the creation of several neurotransmitters, like serotonin and dopamine.

          10. Their vitamin A content may support healthy skin and other bodily processes.

          Bananas are also high in vitamin A, which is great for skin health. In case you didn’t know, vitamin A is also known as retinol, which you probably know from your skincare products. Vitamin A helps fight sun damage, which can break down collagen. It is also involved in creating the lining of several mucous membranes, including your gastrointestinal tract, according to the University of Rochester.

          11. Bananas are rich in iron, which can fight anemia.

          Research also shows that bananas contain a lot of iron. This makes it an excellent choice for anyone with low iron levels, including people with anemia, a mineral your body needs to grow, develop and properly produce hemoglobin which carries oxygen in your body. the whole body.

          12. And it’s the perfect post-workout snack.

          Since they’re so full of electrolytes, including potassium, Agyeman says bananas are ideal post-workout. “Enjoying it as a post-workout snack will aid recovery by restoring the body’s muscle glycogen stores,” she explains. “The potassium it provides will help replenish what has been lost through sweating.”

          Basically, there is no reason do not throw a bunch in your shopping cart the next time you go grocery shopping.

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          Crypto holders are closing in on brokerage account owners

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          Research firm Morning Consult recently published their quarterly report and reveal some interesting data on crypto adoption in the United States. The company’s “The State of Consumer Banking and Payments” study attempts to provide insight into the new dynamics, attitudes and relationships between consumers and their banks and payment providers.

          Related Reading | ProShares Bitcoin ETF hits AUM milestone, breathes life into CME

          The research firm based its findings on 50,000 survey interviews conducted in the Americas, Europe and the Asia-Pacific region. The firm also conducted a survey in December 2021 of a representative sample of 2,200 American adults.

          Among their key findings, Morning Consult claimed that 2022 will see another crypto boom as these digital assets continue to be adopted. In this sense, the company said that owners of digital assets are not necessarily abandoning the legacy financial system, but “working with more” traditional payment providers.

          As seen below, the report revealed that crypto owners are growing and have recently overtaken other traditional investment and savings vehicles, such as certificates of deposit and Robo-investment accounts. advise. Owners of digital assets made up 24% of respondents and are close to the 31% who said they own a brokerage account.

          The latter allows US citizens to invest in stocks and access other securities regulated by the US Securities and Exchange Commission. The focus of crypto owners on equity investors represents a significant shift in the United States and could be an indicator of the future of the fledgling asset class.

          Source: Morning Consult, The State of Consumer Banking and Payments.

          Crypto is taking over the world, Latin America the friendliest region

          The United States is far from the only region to have experienced a boom in the adoption of digital assets. Singapore, China and Spain also saw significant increases on these conditions alongside the Latin America region. Morning Consult claimed the following on their discovery of digital asset adoption in other parts of the world highlighting how

          Nearly 1 in 4 consumers (24%) in our recent global survey reported owning a cryptocurrency per household, up 2 percentage points from July. Latin American countries still have some of the highest rates of cryptocurrency ownership, but European nations of Germany, Spain, and the United Kingdom have increased significantly over the past six months.

          Additional data provided by the report indicates that only 19% of respondents are satisfied with their bank, 17% with their credit card company, 17% with their digital bank and 13% with their credit union. This, along with the data provided above, suggests the potential start of a trend that could favor cryptocurrencies in the long run.

          The report revealed that younger generations are more inclined to own digital assets, with Bitcoin ranking as one of the fastest growing brands of 2021. As seen below, millennials and adults in Gen Z with an income above $100,000 per year are the dominant groups in terms of crypto ownership.

          Crypto survey
          Source: Morning Consult, The State of Consumer Banking and Payments.

          Related Reading | PayPal and Venmo will charge flat fees for crypto transactions under $200

          At press time, Bitcoin is trading at $41,112 with a loss of 6.11% on the daily chart.

          Crypto
          BTC with moderate losses on the daily chart. Source: BTCUSD Tradingview

          Appeals Court Says Deputy BSO Maintained Your Ground Immunity for Battery

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          A screen capture from a video of the teardown by an BSO officer of 15-year-old Delucca Rolle at the Tamarac Town Center Plaza on April 18, 2019

          By Dan Christensen, FloridaBulldog.org

          A state appeals court today upheld a Broward judge’s decision to dismiss a misdemeanor battery charge against BSO Sgt. Gregory LaCerra for his role in the pepper spraying and removal of a teenager in Tamarac in April 2019 because the officer was complying with the “Hold Your Ground” law.

          Thursday’s unanimous decision in the high-profile case, which also upheld Broward County Court Judge Jill Levy’s ruling to deny former deputy BSO Christopher Krickovich immunity, was handed down by a West Palm Beach Fourth District Court of Appeals three-judge panel.

          LaCerra still faces trial later this year on two misdemeanor charges of tampering with records and conspiracy to tamper with records. Co-defendant Krickovich is charged with assault, falsification of records and conspiracy to falsify records.

          BSO Sheriff Gregory Tony fired Krickovich in December 2019 for slamming 15-year-old Delucca Rolle’s head into the curb. Tony rejected the recommendation of BSO’s Professional Standards Committee that no disciplinary action should be taken against Krickovich.

          Attorney Eric Schwartzreich, who handled the appeal with co-lawyer Sheila Zolnoor, said they were “delighted” but “not terribly surprised” that the appeals court upheld Judge Levy’s rulings.

          BSO Sergeant. Gregory LaCerra, right, and former BSO deputy Christopher Krickovichkrick

          “There was a lot of pressure to bring these charges. I always thought it was a political decision and these charges should never have been made,” Schwartzreich said.

          The case attracted media attention due to videos of the scene that afternoon at the Tamarac Town Center Plaza. According to Levy’s factual findings, for several years there had been “an increase in violence in the square and calls to the police department about students participating in fights, disorderly conduct, robberies and to other criminal activities”. There was a standing order for BSO MPs to be in the square between 2:30 and 3:30 p.m. when pupils were leaving school.

          BSO DEPUTY TESTIMONIES

          A number of MPs and business owners testified to the chaotic and at times violent conditions in the square.

          On April 18, 2019, police were called by a woman who said she saw between 200 and 300 children, some of whom were fighting. LaCerra and Krickovich arrived at what LaCerra said was a scene of “utter chaos.” The two deputies got out of their cars and “ordered the crowd to disperse,” Levy wrote.

          As officers attempted to arrest another teenager, Gary Dierusil, for trespassing at McDonald’s the day before. Dierusil’s phone fell out of his pocket and someone reached down to pick it up when BSO Deputy LaCerra pushed it away, landing at Rolle’s feet. A crowd was gathering and LaCerra gave a “legal” order warning people to stay away or they would be pepper sprayed. Rolle, a 15-year-old student from nearby Taravella High School, bent down to grab the phone and LaCerra pushed him away, throwing him off balance. “When Delucca [Rolle] regained his balance, the Court finds that Delucca leaned over and stabbed his body, and he had a look of anger on his face. The officer sprayed him, then grabbed his backpack and pushed him to the ground,” the judge wrote.

          Krickovich testified that he needed to help LaCerra and climbed onto Rolle, using his hands to push his head to the ground as Rolle resisted. The judge concluded that Rolle’s testimony about what happened was “less than credible”.

          Judge Levy, however, determined that BSO Deputy Krickovich’s use of non-deadly force was not “objectively reasonable” – a finding upheld by the appeal panel.

          Printable, PDF and email version

          Oncology Pharma Expands Feasibility Studies and Data

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          SAN FRANCISCO, CA / ACCESSWIRE / February 17, 2022 / Oncology Pharma Inc. (OTC PINK: ONPH) – Oncology Pharma, Inc. (“The Company”) wishes to expand on a previously announced press release that included formulation results and technology data licensed with NanoSmart Pharmaceuticals, Inc. demonstrating the characteristic of time release which is expected to improve the safety and localization profile of potential lead candidate formulations.

          The active pharmaceutical ingredient, dactinomycin is an actinomycin antibiotic belonging to a class of polypeptide antitumor antibodies. It inhibits transcription by binding to DNA at the transcription initiation complex and preventing RNA chain elongation by RNA polymerase. Dactinomycin has been used alone and in combination with other drugs to treat a wide range of cancers. Specifically, it has demonstrated clinical benefit for the treatment of pediatric and adult sarcomas and is used regularly as part of standard treatment regimens in clinical practice for the treatment of Ewing’s sarcoma.

          The benefits of lipid nanoparticle drug delivery are well understood. In addition to sequestering toxic drugs from healthy tissue, the small particle size (diameter range of 100 nm to 400 nm) allows passive accumulation of the drug at tumor sites. Passive accumulation occurs because tumor-associated blood capillaries have enlarged “pores” between lining endothelial cells and nanoparticles are able to pass through these “leaky” capillaries and enter the interstitial fluid space within tumor mass. Additionally, conjugation to polyethylene glycol (PEG) prevents the nanoparticle from being recognized and detoxified by the liver.

          Oncology Pharma, Inc. has authorized and funded the first feasibility studies to date for this technology from NanoSmart and intends to commercially develop, distribute and use this product and continue studies so that it can put this product to market with the goal of initially focusing on the pediatric market. The Company believes that the pediatric market is underserved and this gives Oncology Pharma a pioneering edge in this critical market and enables Oncology Pharma to be a strong player in this well-deserved market.

          Described below are the results of the first studies we have discussed before:

          • Initial formulations
            • Tested for drug incorporation (visual): >95% drug incorporation.

          • 50% remaining after 3 hours (better than drug-free formulation).
          • However, the formulation showed aggregation after several days in 4ohC storage. This is not optimal for formal development, but more favorable solutions have been found with further testing.
          • Formulation of the A-1 series
            • Tested for drug incorporation (spectrophotometer – quantitative measurement) – 100% drug incorporated.

          • However, the formulation showed aggregation after several days in 4ohC storage.
          • Formulation of the A-2 series
            • The preparation showed overnight aggregation at 4ohC, could not be filtered through a 0.22 µm membrane filter.

          • Decided to switch to natural oil over hydrogenated oil to increase amount of drug incorporation and to reduce aggregation (natural oil seems to aggregate less than hydrogenated oil in storage).
          • Formulation series B-1 (natural oil)
          • Attempt to filter through a 0.22 µm filter. Filter clogged quickly, indicating heavy aggregation after formulation (prior to storage).
          • Formulation of the B-2 series
            • Dilution and minor modification of formulation B-1, modification and extrusion 10X.

          • 100% drug incorporation (visual).
          • Aggregation still visible during storage at 4 o’clockohC (approx. 50%) – still possible to filter through a 0.22um filter.
          • After further research, it appears that repeated extrusion can impart additional energy to the nanoemulsion causing the nanodroplets to clump together. Also, an ice bath was not used during this preparation, which may be a factor.
          • Formulation of the B-3 series
          • Formulation B-2 was extruded 3x through 400/200/100 nm membranes at room temperature.
          • Formulation B-3 filtered through a 0.22 µm filter without clogging (see photo next slide).
          • Increasing the amount of glycerol added to Formulation B-3 did not improve the formulation.
          • 37-day drug release studyohVS :
            • 70% remaining after 1 hour, 35% remaining after 3 hours, 5% remaining after 6 hours. It is desirable to improve on this, but it is achievable as a sustained release formulation.
            • Submit split samples for physical characterization and initial analytical method validation.

          The proprietary nanoemulsion under development also has the new potential to be stable during storage for an extended period. This contrasts with most lipid nanoparticle formulations which typically have a very short shelf life once formulated. The nanoemulsion formulation can likely be used for a wide range of lipophilic (i.e. non-water soluble) cancer drugs, thereby expanding the potential for licensing additional drug formulations using this same platform technology. -form, with each new drug being safer and more effective than the underlying drug formulation currently on the market.

          Progress continues to be made on feasibility testing and initial data collection of nanoemulsion formulations for dactinomycin. Early work continues to show promise with formulations demonstrating a satisfactory level of nanoemulsion loading and dactinomycin retention. Studies to assess the physical characterization of the formulations, as well as quantitative performance measures (eg storage stability, release time, etc.) are ongoing.

          ABOUT ONCOLOGY PHARMA, INC.

          ONCOLOGY PHARMA, INC. (OTC PINK: ONPH) (the “Company”) is currently engaged in the research and development of therapies for oncology and prides itself on having a world-class advisory board that keeps the Company at the forefront of technology development in cancer research, biotechnology and healthcare.

          ABOUT NANOSMART PHARMACEUTICALS, INC.

          NanoSmart® Pharmaceuticals is a California-based private company that develops nanoparticle-based drug delivery platforms, including the use of antinuclear antibodies (ANA) to enable targeted drug delivery of existing drug therapies to areas of necrosis present in virtually all solid cancerous tumors.

          FORWARD-LOOKING STATEMENTS

          Certain of the matters discussed in this announcement contain forward-looking statements that involve significant risks and uncertainties in the Company’s business that may cause actual results to differ materially from those anticipated by the statements made herein. These risks and uncertainties include risks relating to licensing agreements and joint ventures, including the need to negotiate definitive agreements for the relationship; the possible inability to realize the expected benefits of business relationships and the costs of financing such business relationships. Other risks and uncertainties related to the Company include, among others, current negative operating cash flow and a need for additional financing to fund our operating plan; the terms of any other financing, which may be highly dilutive and may include onerous terms; unexpected operating costs and deficits, and lower-than-expected sales and revenues; the uncertain willingness and ability of customers to adopt new technologies and other factors that may affect future market acceptance; unfavorable economic conditions; adverse results of any legal proceedings; the volatility of our operating results and financial condition; failure to attract or retain qualified senior management, including sales and marketing personnel; our ability to establish and maintain the proprietary nature of our technology through the patent process, as well as our ability to potentially license to others patents and patent applications necessary to develop products; the Company’s ability to implement its long-term business plan for various applications of its technology; the Company’s ability to enter into agreements with all necessary marketing and/or distribution partners and with all strategic or joint venture partners; the impact of competition; obtaining and maintaining all necessary regulatory approvals applicable to applications of the Company’s technology; growth management; and, other risks and uncertainties. It is not a solicitation to buy or sell securities and does not purport to be an analysis of the financial condition of the Company.

          CONTACTS:

          For more information, please contact Oncology Pharma at:

          One Sansome Street, Suite 3500
          San Francisco, California 94104
          Phone: 415-869-1038
          Fax: 415-946-8801
          website: www.oncologie-pharma.com
          email: [email protected]

          THE SOURCE: Oncology Pharma Inc.

          See the source version on accesswire.com:
          https://www.accesswire.com/689228/Oncology-Pharma-Expands-on-Feasibility-Studies-and-Data

          Mining for Miracles Eyes 2022 Completion of $3.385 million fundraising goal to establish a Cellular and Regenerative Medicine Center (CRMC) at BC Children’s Hospital

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          British Columbia Children’s Hospital Foundation

          CRMC will tap into the power of personalized medicine to help stop cardiac arrest in children before it strikes.

          Mining for Miracles Launches 2022 Campaign

          Premier John Horgan (middle) meets BC Children’s Hospital patient Airie Vivancos Udatsu (bottom right) with his father Amos, mother Keiko and brother Kian, Karla Mills (bottom left ), Mining for Miracles Co-Chair and Co-Chair Vice President, Project Development, Teck Resources, Jelena Puzic (top right), Mining for Miracles Co-Chair and Director, Geoscience Services, Teck Resources, and Lindsay Turner (top right) left), Associate Director, Corporate Partnerships, BC Children';  s Hospital Foundation today to launch the 2022 Mining for Miracles campaign.

          Premier John Horgan (middle) meets BC Children’s Hospital patient Airie Vivancos Udatsu (bottom right), along with his father Amos, mother Keiko and brother Kian, Karla Mills (bottom left), co-chair and Vice President of Mining for Miracles, Project Development, Teck Resources, Jelena Puzic (top right), Co-President and Director of Mining for Miracles, Geoscience Services, Teck Resources, and Lindsay Turner (top left), Associate Director , Corporate Partnerships, BC Children’s Hospital Foundation today to launch the Mining for Miracles 2022 Campaign.

          VANCOUVER, British Columbia, Feb. 2022 (GLOBE NEWSWIRE) — Mining for Miracles, BC’s longstanding mining industry fundraising campaign for the BC Children’s Hospital Foundation, launched its 2022 campaign today with Premier John Horgan, in support of BC Children’s Center for Cellular and Regenerative Medicine (CRMC) at the hospital, the first of its kind in Western Canada.

          “Mining for Miracles continues to demonstrate how the women and men who work in BC’s mining industry contribute to the strength and resilience of families and communities in our province,” said Premier Horgan. “It’s just one of the many ways the resource industry strengthens our province.”

          In 2022, Mining for Miracles is launching the final leg of its campaign to fulfill its commitment, made in 2020, to create the CRMC, a $3.385 million initiative. CRMC will give BC Children’s clinicians the tools to better understand the genetic cause of cardiac arrhythmias so they can provide the best possible care to BC children. This will result in better diagnoses, the identification of optimal treatments and, eventually, cures, improving and saving the lives of children across the province and beyond. In the future, the CRMC could also be used to provide answers for the thousands of children living with other life-changing conditions, such as diabetes, cancer, bowel disease and epilepsy.

          “Through this initiative, we are taking a giant step towards improving health care for children in British Columbia,” said Dr. Shubhayan Sanatani, Division Chief of Cardiology at BC Children’s Hospital. “This center will use personalized medicine in ways we have not imagined before.”

          “We receive incredible support for the annual Mining for Miracles campaign from the thousands of women and men who work in the mining industry. In 35 years, we’ve raised over $35 million to support children’s health through initiatives like Pie Throw,” said Karla Mills, Co-Chair of Mining for Miracles and Vice President, Project Development at Teck.

          “Together, we are ensuring that the children of our province have access to world-class health care,” added Jelena Puzic, Co-Chair of Mining for Miracles and Director of Geoscience Services at Teck.

          As a new addition to the 2022 campaign, reflecting diversity and inclusion in the mining community, the Mining for Miracles team also introduced a new mascot – Betty the Miner. Buddy and Betty will continue to be Mining for Miracles ambassadors at various events across the province during the campaign..

          About Mining for Miracles
          For more than 30 years, the BC mining community has worked together through Mining for Miracles to help improve the quality of health care for children in our province. Through its support of facility construction, innovative research and the acquisition of specialized medical equipment at the hospital, Mining for Miracles helps keep BC Children’s Hospital at the forefront of excellence in pediatric care. Industry donations have had a tremendous positive impact on the health and well-being of BC children, families and communities. will take place over three action-packed days starting Tuesday, June 7, 2022. Fundraising ends Thursday, May 19. Follow @Mining4Miracles on social media or visit www.miningformiracles.ca for more Support information. Look. Make a donation.

          About BC Children’s Hospital Foundation

          BC Children’s Hospital is the only hospital in the province dedicated exclusively to the care of children and is one of the few pediatric medical centers in Canada with a world-class acute care facility, research institute , a mental health facility and a rehabilitation center, all on a single campus. BC Children’s leading experts provide a level of specialized expertise, innovative therapies and child-centered care found nowhere else in the province, including for the sickest and most seriously injured. At the BC Children’s Hospital Foundation, our vision is that every child is healthy and able to achieve their hopes and dreams. The generosity of donors fuels our ability to help defeat childhood illnesses and address the biggest health challenges facing children today. Please follow us at @bchf or visit bcchf.ca for more information.

          BACKGROUND INFORMATION

          Why is the creation of the CRMC so important?

          • Each year, approximately 50,000 Canadians, including children, will die suddenly from cardiac arrest.

          • Ten percent of children with heart rhythm disorders are at high risk of sudden cardiac arrest – a condition in which the heart suddenly and unexpectedly stops and, if not treated within minutes, is deadly.

          • There are 1,000 families followed by the BC Inherited Heart Rhythm Disorder Program, a group of cardiology specialists, as well as medical genetics which identifies, screens and supports people in the province affected by inherited heart rhythm disorders that put them at risk of a sudden heart attack. Stop.

          • Health care is increasingly using genetics to determine why diseases occur. CRMC will give BC Children’s clinicians the tools to better understand the genetic cause of cardiac arrhythmias so they can provide the best possible care to BC children.

          • Currently, to find the appropriate treatment options to prevent cardiac arrest, doctors must determine through trial and error which combination of cardiac arrhythmia medications is right for each child.

          • With just ten drops of blood, CRMC researchers will be able to create a “disease in a dish” where they can generate and study the beating heart cells of a specific child.

          • By studying the cells in the lab, researchers can determine if children are at high risk for sudden cardiac arrest and help determine the best treatment options.

          How BC Children’s CRMC will transform pediatric cardiac care

          • The CRMC will be the first of its kind in Western Canada

          • CRMC has the potential to avoid years of uncertainty and reduce potential risks and side effects of ineffective drug options. British Columbia’s children need CRMC so they can receive a more accurate diagnosis and tailored treatment options.

          • The future vision of CRMC is to expand beyond childhood cardiac arrhythmias and apply this advanced technology to improve care for children living with other conditions, such as diabetes, cancer, bowel disease and epilepsy.

          • BC Children’s has the clinical and scientific expertise to be a leader in pediatric cellular and regenerative medicine, but it needs the infrastructure and equipment to do so.

          A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/56e064f4-ea98-455c-8104-520e41897879

          CONTACT: CONTACT INFORMATION For more information please contact: Karla Mills Mining for Miracles Co-Chair 604.699.4618 Jelena Puzic Mining for Miracles Co-Chair 604.699.4022 Lindsay Turner Associate Director, Corporate Partnerships BC Children's Hospital Foundation 604.449.6323

          Altering Lung Blood Type Increases Potential of Universal Organs for Transplants

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          Iit was 4 a.m. on a damp night in St. Catharines, Ontario, and Elizabeth Ostrander couldn’t breathe. Chronic obstructive pulmonary disease, complicated by pneumonia, was suffocating her, doctors told her that day in 2016. If she hadn’t gotten to the hospital when she did, she would have been dead, Ostrander recalls. She was in her early fifties.

          She would spend the next five years clinging to an oxygen tank, the ropes tangling around her as she slept. The incurable disease worsened until she had only 25% of her lung capacity left. It was so hard to breathe that she could barely haul groceries from her car to her kitchen, let alone be the “avid camper” she once was. She had to stop working and was placed on the waiting list for a lung transplant. When the Covid-19 pandemic hit, she said to herself, “I will never have my lungs.

          She finally did, on November 13, 2021, but it took almost two years of waiting and three false alarms.

          advertising

          Ostrander was in the same situation as many people awaiting transplants. His blood type, B positive, did not match many donor organs, and an incompatible transplant would be catastrophic and deadly. But new research suggests that this barrier could disappear if donor organs were treated with special enzymes that made them compatible with recipients of any blood type.

          “This research is truly a game-changer in organ transplantation,” said Aizhou Wang, lead author of a paper published Wednesday in Science Translational Medicine. “For modern transplant medicine, matching is always part of the criteria when trying to find the right organ for a recipient.”

          advertising

          And blood type is always one of the first considerations that limits which organs a patient can receive, she said. A hospital might have a donor organ, and it’s healthy, it’s the right size for the patient, and it’s geographically close, but if it’s an incompatible blood type, the recipient’s immune response would destroy the organ. within the first 48 hours.

          This mismatch, determined by a network of immune system foot soldiers on the surface of red blood cells and blood vessels, is a problem for all three major blood types: A, B, and O. For patients with blood type O, who cannot receive an organ from another donor O, their risk of dying while waiting for a transplant is 20% higher than for those with other blood types. Blacks and Latinos are more likely than whites to have type O blood.

          In the fall of 2018, Wang sat down with Marcelo Cypel, his supervisor and a lung transplant specialist at the Toronto General Hospital Research Institute. They were looking for a project that Wang could focus his postdoctoral research on, and a corner of the scientific world was abuzz with enzymes. Specifically, people were talking about the work done by Stephen Withers at the University of British Columbia. His team had discovered a new pair of enzymes in the human gut that could change blood type from A to O – and do it extremely well, far more efficiently than any other similar enzyme previously found.

          The enzymes move like a pair of sharp scissors, carefully shearing a sugar called GalNAc from the A antigens that line the surface of red blood cells, as well as cells in the lungs, until they resemble blood type O. This transformation, Withers realized, could neutralize any conflict that may arise when warring antigens and antibodies meet during an incompatible organ transplant. In Cypel and Wang, Withers found researchers eager to explore this hypothesis.

          Their research shows proof of concept: the lungs of a type A donor could be treated with the enzymes for a few hours and emerge with the cellular appearance of a blood type O. And, the treated lungs were not damaged when they came into contact with O blood plasma during a transplant simulation. “Like camouflage,” Cypel said. The antibodies “will no longer recognize cells as being of a different blood type”.

          About 85% of people have blood type A or O, so engineering organ compatibility between the groups would greatly expand transplant options for these patients, Cypel said. If doctors could remove ABO blood type matching entirely from the equation, it would remove a major logistical hurdle and get organs to the patients who need them more quickly.

          “He has the potential – and I would underline ‘potential’ – to expand the donor pool significantly. And we have to think of any way to do that, given that there is still significant mortality on the lung transplant waiting list,” said David Weill, former director of the lung transplant program at the ‘Stanford University.

          Despite a marked increase in organ donations over the past decade, the demand for lung transplants is often unmet, according to Annual Report of the Organ Procurement and Transplantation Network. More than 20% of patients on the waiting list for donor lungs wait longer than a year.

          Each year, “hundreds of patients die while waiting for lung transplants due to lack of availability of matching organs,” said Nirmal Sharma, medical director of the lung transplant program at Brigham and Women’s Hospital.

          A thoracic surgeon, Cypel was one of the researchers who developed ex vivo lung perfusion (EVLP), a method of keeping the lungs at body temperature in an incubator that mimics the environment of the human body. EVLP has also proven to be an effective way to treat less healthy lungs and test their performance in the human body. After trying the enzymes on human red blood cells and aortas, Cypel’s multidisciplinary Canadian research group used EVLP to treat human lungs and then expose them to O blood plasma. It was a clever workaround which came out of necessity. The researchers couldn’t go the usual route – from small animal (rodent) models that were easy to control, to large animals and then to humans – because there is no comparable list of blood types in animals.

          “I had never thought of using the technology of these devices in this way. In other words, I knew all about the type of treatment you can do to the organs while they are on the devices. I didn’t know not that we could change ABO compatibility,” said Weill, who sits on the board of TransMedics, creator of a competing organ storage machine.

          Cypel is founder and shareholder of Traferox Technologies, which develops alternative methods of lung storage, including an EVLP machine. He is also a consultant for Lung Bioengineering and inventor of a patent for the use of these sugar-cutting enzymes to alter blood types in human organs.

          The main limitations of the study stem from the fact that the treated lungs were not implanted in a real person, several lung transplant specialists told STAT. Passing O blood plasma through EVLP can trigger an interaction comparable to what would happen in the human body. But the body’s immune system is much more complex in real life and could present additional challenges.

          “It’s still isolated plasma. It’s not related to an actual recipient who has active bone marrow, may have active antibody production because T-cells and B-cells may be activated,” said Matthew Bacchetta, chairman of the Department of Thoracic Surgery at the Vanderbilt University Medical Center.

          The next step will be to test this organ treatment against the full arsenal of tools a human body uses to destroy the unknown. Additionally, the enzyme haircut is not permanent; antigens, like hair, reappear on cell surfaces at some point, raising questions about whether the body might have a negative response to an incompatible transplant sometime after the initial 24-hour post-transplant window. Wang, the lead author, agrees that more research is needed.

          “We recognize that we are only suppressing the antigen, not the body machinery that makes those antigens,” Wang said. “So over time we expect them to gradually grow back. But how fast? We are currently trying to study this.

          For people like Ostrander, who waited two years for new lungs, the universal organs would make a huge difference – giving them back years of their life. “It would have changed my whole life,” she said. “I could have done more back then instead of being so limited.”

          Correction: An earlier version of this story misrepresented the status of a patent for the use of sugar-cutting enzymes in the new research.

          Aircraft Solid State Power Controller (SSPC) Market Expected to Grow 9.3% During 2022-2027

          0

          RAIPUR, India, February 16, 2022 /PRNewswire/ — Stratview Research, a Leader market research cabinet launched a report on Aircraft Electrical Solid State Power Controller Market which provides in-depth analysis of market dynamics, current and emerging trends, industry forecasts and competitive landscape.

          Click here to get the free sample pdf: https://www.stratviewresearch.com/Request-Sample/2459/aircraft-electrical-solid-state-power-controller-SSPC-market.html#form

          How is the report useful?

          The report has great utility for key decision makers and strategists in terms of accurate market insights, future growth opportunities, and key success factors.

          Most importantly, the report analyzes the possible impact of COVID-19 on the market dynamics, which provides cushion against the uncertain business environment and helps streamline resources and investment decisions fruitfully.

          What are the main market drivers?

          According to the report, the Aircraft Electrical Solid State Power Controller market is driven by multitude of factors, some of which are given below:

          • Faster operation and high life expectancy compared to contactors and circuit breakers.
          • Long-term stable demand for commercial aircraft.

          The report also includes growth rate estimates based on the intensity of drivers and restraints and provides users with several graphical illustrations of key information.

          Aircraft Electrical Solid State Power Controller Market Segmentation:

          Stratview Research has segmented the market in the following 4 ways that meet the market data needs of multiple stakeholders across the industry value chain.

          • Phase type (Single-phase and Three-phase)
          • Aircraft type (Commercial aircraft, regional aircraft, general aviation, helicopter, military aircraft and UAV)
          • Type of adjustment (Original Equipment and Aftermarket)
          • Region (North America, Europe, Asia Pacificand Rest of the world).

          Aircraft Electrical Solid State Power Controller Market Overview

          Market trends by Phase type:

          On the basis of phase type, the aircraft electrical SSPC market is categorized into single-phase and three-phase systems.

          Between the types of system, the three-phase system should remain the dominant segment market during the forecast period as these systems require less assembly time and can transmit more power at lower cost.

          Market Trends by AAircraft type:

          Likewise, based on aircraft type, the market is segmented into commercial aircraft, regional aircraft, general aviation, helicopters, military aircraft, and UAVs.

          Of these aircraft types, commercial aircraft is expected to remain the dominant segment as well as the fastest growing market during the forecast period.

          Commercial aircraft have come under immense pressure due to several setbacks including the grounding of the B737Max in 2019 followed by the onset of the pandemic

          Despite short-term market difficulties, long-term demand is believed to remain sustainable. Boeing, in its 2021-2040 outlook, estimates that 43,610 commercial and regional aircraft should be delivered in the next 20 years, ensuring good demand in the years to come.

          General aviation and military aircraft are other market segments likely to generate significant demand for SSPC in the coming years.

          Which region offers the best opportunity and growth?

          At the regional level, North America should remain the largest market for aircraft electrical SSPCs over the forecast period. This is mainly due to the massive use of aircraft for regional, commercial and military applications in the region. In addition, regional investments in military aircraft (fighter jets and helicopters) are the largest in the world.

          In parallel, Asia Pacific is also likely to create significant market opportunities in the coming years, driven by the expected rebound in air passenger traffic coupled with the opening of assembly plants in the region, mainly in China, Japanand India.

          Impact of COVID-19 on Aircraft Electrical Solid State Power Controller Market

          COVID-19 has brought an instant halt to many industries around the world. Lockdown norms in several countries quickly affected the global economy by affecting supply chain, production and market demand. The direct and indirect impacts of the pandemic have been integrated into this report.

          To learn more about the impact of covid-19, get a free sample report here:

          https://www.stratviewresearch.com/Request-Sample/2459/aircraft-electrical-solid-state-power-controller-SSPC-market.html#form

          Who are the best market players?

          After in-depth analysis of the market, the experts have listed down few key players and discussed the company profiles of the players below –

          • GE Aviation
          • Safran Group
          • Collins Aerospace (Raytheon Technologies Corporation)
          • TransDigm Group, Inc.

          What deliverables will you get in this report?

          – In-depth analysis of the Aircraft Electrical Solid State Power Controller market.

          – Detailed market segmentation.

          – Analysis of the competitive landscape.

          – Historical, current and future market size analysis.

          – Industry trends, technologies and advancements.

          – Growth and operating strategies adopted by key players.

          – Potential segments/regions offering promising growth.

          – Geographical presence of key players.

          Related reports that might be helpful:

          1. Avionics and Radio Testing Market

          2. Aircraft circuit breakers market

          About Us –

          Stratview Research is a global market research company that offers reliable market reports, market entry strategies, strategic growth advice, and more. Market experts compile high-quality market information to help users gain granular level clarity on current business trends and expected future developments. Stratview Research also offers report customization. Contact the analysts to customize the given report according to your priority/requirement.

          Stratview Research has also launched “Composites”, an online portal that offers free thought leadership reports, white papers, market report summaries and more for the composites and related industries, worth $20,000 every year.

          Click here to register (free of charge): https://www.stratviewresearch.com/composites/sign-in

          Connect with the team of –

          Stratview Search
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          SOURCE Stratview Research

          7 Easy Detox Water Recipes to Boost Your Immunity and Overall Health

          0

          Leading an unhealthy lifestyle with erratic sleep patterns, poor eating habits, non-existent work-life balance, and ever-increasing stress levels makes us all want to take a break to cleanse and detoxify our body, mind, and soul. soul from time to time. . Let’s talk about detox water.

          What if we told you that the most powerful yet overlooked secret to detox, weight loss, and glowing “glass” skin isn’t the latest workout routine you discovered on YouTube or a keto diet? impossible, but… water? It’s true. Plain water can flush toxins from your kidneys and liver, boost your metabolism, and help shed that stubborn belly fat you just can’t seem to get rid of.

          We know the internet is obsessed with fanciful claims about water and its magical health benefits that can even turn a frog into a prince, but hear us out. We’re stepping up a gear and using something even better than water: Detox Water!

          What is detox water?

          Detox water is basically plain drinking water combined with healthy superfoods like berries, grapefruit, lemon, fresh ginger, and more to create a concoction that revitalizes you, aids weight loss, and reduces physical and mental fatigue.

          It not only improves your mood, but also your gastrointestinal health and metabolism, among other health benefits.

          Fruits like berries, grapefruits, apples, including their peels, pulp, and fiber, are made up of compounds that blast fat and ward off disease in a delicious way. Why stick to plain drinking water when you can easily replace it with all-natural detox drinks that will help relieve bloating and boost your immune system?

          Although our bodies are naturally programmed to get rid of accumulated toxins by organs like the kidneys and liver which eliminate them via bodily fluids, large amounts of additional toxins are absorbed through pollution and exposure to preservatives and to pesticides through the food we eat.

          These can eventually penetrate deep into the tissues and cells of the body, slowly hampering our physical and mental abilities, leading to compromised immunity and disease.

          Since detox water is made simply by infusing flavor, as opposed to juicing or blending, it essentially becomes a nearly calorie-free beverage. This is what makes it a popular drink for detox diets like “lemon detox” or “main cleanse”.

          Detox water is thus regularly included in weight-loss plans, in particular to replace drinks rich in sugar such as sodas and fruit juices with preservatives. Plus, they taste way better than plain water and will get you down to your daily needs in no time.

          Get inspired by these 7 best detox water recipes below

          Ginger with pink salt and lemon mint water

          Image credit: Mikhail Nilov/Unsplash

          Add 2 inches of fresh ginger root, 2-3 thick wedges of lemon or lemon juice, and freshly crushed mint leaves to a jar of water and sprinkle a generous pinch of Himalayan pink salt, while stirring the whole thing.

          Let this mixture steep overnight or at least 4-5 hours to create a drink that fights stomach bloating, sore throats and aids digestion and immunity.

          Our star ingredient, fresh ginger, has a long history of use in various forms of traditional and alternative medicine as it is a natural colon rinse with anti-inflammatory properties known to reduce nausea and related issues. to the intestine. It also helps fight joint and muscle pain, inflammation, and cholesterol levels, among other impressive health benefits.

          Orange pomegranate cinnamon detox water

          orange cinnamon
          Image credit: Shameel Mukkath/Pexels

          This is a cozy winter-themed detox drink. Yes, you have the right to pretend it’s mulled hot wine instead of a healthy drink while you’re at itbut it will be delicious either way!

          Add 2 cinnamon sticks to a jar of drinking water mixed with lightly crushed pomegranate seeds and a few slices of orange, and let sit and steep overnight.

          Fruit and cinnamon are a great way to incorporate some sweetness into your drink without the extra calories that other sugary additives provide.

          Pomegranates have great antioxidant properties which are beneficial for healthy teeth, skin and hair as well as keeping diseases at bay.

          Oranges are packed with essential vitamins, especially vitamin C, and minerals that help keep your body healthy.

          watermelon aloe vera water

          aloe vera detox water
          Image credit: Pisauikan/Unsplash

          How can we add Following water hydration? With watermelon and aloe vera, of course. One of the best kept secrets for weight loss, aloe vera juice has been a winner in Ayurvedic medicine for ages.

          Aloe vera juice includes health benefits that can help balance your digestive system and reduce bloating.

          Watermelon is also packed with nutrients, vitamins, and beneficial plant compounds shown to have anticancer effects and positively impact your overall digestive and cardiovascular health.

          Simply mix drinking water with a few pieces of freshly cut watermelon, aloe vera pulp or juice and consume it fresh after a few hours as refreshment.

          Detox water mint cucumber lemon

          Lemon cucumber mint drink
          Image credit: Shameel Mukkath/Pexels

          This trio of lemon, cucumber, and mint, packed with vitamin C, hydrating, and digestive-boosting benefits respectively, will naturally suppress your mid-day hunger pangs and binge-eating sessions.

          It will help you lose weight and keep your skin glowing with its silica, vitamins and antioxidants.

          Infuse together 3-4 wedges of fresh lemon or lime with mint leaves and cucumber slices and drink it in the morning to start your day on a healthy and refreshing note.

          Ayurvedic herbal tea with honey and turmeric

          turmeric honey detox tea
          Image credit: Valeria Boltneva/Pexels

          This detox recipe is a superb blend of antioxidants such as Ayurveda-approved turmeric (haldy) garnished with spices such as ginger and black pepper or even cayenne pepper if you like a little spiciness, with honey. Even a few sprigs of this infused detox water will help flush out toxins and soothe your upset stomach, among a host of other health benefits.

          Turmeric is an ancient Indian spice that has become a worldwide sensation thanks to its healing properties. We’re looking at you Starbucks Turmeric latte aka good old haldi doodhyou are not fooling anyone!

          This detox tea will help you lose weight and digest, boost immunity and liver health. Its endotoxins will also reduce the risk of catching colds, flu and other infections. It’s safe to say that the health benefits of detox water are much needed at times like these.

          Super Lime Chia Rosemary Drink

          Lime chia rosemary
          Image credit: Tamara Velazquez/Pexels

          While lime or lemon are calming and purifying veterans, chia seeds are the big detox daddies. They can balance blood sugar, help with weight loss, keep cravings at bay, and even help keep your body hydrated throughout the day.

          Since they expand up to 10 times their size when in liquid form, once consumed they will help you feel full and fight overeating.

          Packed with nutrients, omega-3 fatty acids, antioxidants, and fiber, this drink will also prevent inflammation and keep your immunity high.

          Very berry detox water

          very berry water
          Image credit: Alex Azabache/Pexels

          You’ll find it remarkably easy to knock down a bottle (or three) of this detox water. Blackberries and strawberries are known for their high antioxidant qualities and fiber content. This bay good detox water is the best way to enjoy a delicious drink with a hint of natural sweetness while boosting your immunity.

          Slice and add 3-4 fresh strawberries, a handful of blueberries or whole blackberries to a mason jar of drinking water and let sit overnight. This detox water will add great flavor and variety to your healthy drinks.

          Berries are natural antioxidants and packed with vitamins and minerals that fight cell damage. Need we say more?

          (Main and featured image credit: Huizeng Hu/Getty Images)

          This story first appeared on Prestige Malaysia.

          Leadership role for junior WRHS Jardine serves ice hockey team well

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          HOLDEN — Winning a captaincy as a junior in high school is a rare touch in any sport, but not so much when the honor is passed to Wachusett Regional High junior ice hockey co-captain Dennis Jardine.

          Jardine checks all the boxes for ideal qualities in a team model. Leadership by example, a hard worker with an almost impeccable understanding of the game, and the ability to inspire and demonstrate confidence are just some of the attributes he possesses. While assembling his 2021-22 roster, WRHS college ice hockey head coach Matt Lane barely blinked when he selected Jardine, a 5-foot-11 forward. of Holden, for a role as co-captain of the team. Lane never looked back on the decision.

          “Dennis is a great boy and a talented hockey player,” Lane said. “He’s led our team in scoring since the very first game and continues to be our leading scorer with 7 goals and 7 assists for 14 points in 11 games. He is also an excellent captain, leading by example on and off the ice. He’s a straight kid in the classroom and he’s still our hardest working player in practice.

          “Since I was young, I have always tried to lead by example as my parents taught me,” Jardine said. “Working hard is the best way to show people around you that you care, not just in sports, but also in the classroom and in life. Hard work goes a long way.

          The commitment to the game came early for Jardine and his teammates, with whom he became close on and off the ice. It was a progression spanning a decade or more that saw his skills and maturity shine where they are today.

          Being able to get out of his back door and practice on the ice whenever he wanted also helped.

          “I had done some ‘learning to skate’ before that, but it was definitely a slow start,” he said. “When I had a few years under my belt, we built an ice rink in our back yard, which we’ve had for a few years now. To start, I remember skating with a chair in front of me.

          “I started playing the Lakers (youth hockey), a team from Lake Ave. (Worcester), then I moved to the Crusaders for two or three years. And then I started playing for the NorthStars. This is where I really started to get better. My coach there was Guy LaRose, who played in the NHL, and he taught us some really good things there. I played for them for nine years and really improved. This year I moved to the Railers (U-16 travel team) and we won the state championship. After the school season is over, we travel to Michigan for the Nationals.

          “Over time, I fell in love with the game and I have to give my coach (LaRose) a lot of credit. He coached us with a lot of emotion and taught us the right way to play. I worked hard, and that, plus the coaching, really gave me a passion for the game.”

          The playoffs, which were sorely missed a season ago due to the pandemic, return at the end of the team’s regular season schedule. The team must hit a record .500 to earn a spot, and getting there will be a battle until the end, as the team was 4-6-1 at The Landmark press time. Jardine knows this 2021-2022 squad is capable of getting the job done. He also acknowledges that playing in front of sparse crowds (due to COVID-19) has not been an optimal situation.

          “We’ve been really close in a lot of games, and it seems like every night we end up fighting instead of the other team beating us,” he said. “Everyone comes together in terms of conditioning, skill and everyone really trusts each other. I think things are falling into place and we’re going to turn things around.

          “The playoffs are motivation to work hard in practices, and the extra work is a reminder that the extra sprints can help motivate your team and get you ready for games. Our goal is to win a championship and represent our school. This is the motivation we have in mind.

          “I didn’t play a lot my first year, and last year we didn’t have any fans (due to COVID). There was a bit of nervous energy, but after the first two games, the things started to settle, and now it’s just a habit. Sometimes it’s a little discouraging not having our school there to cheer us on. On the nights you don’t feel it, you can draw from energy in the crowd, but you have to realize that you are playing for your teammates and not the crowd because you know that when it counts, your teammates will put it all on the line for you.”

          Jardine, a member of the National Honor Society, is unquestionably proud of his status as captain and the responsibility of representing his school and the community. He knows this is special, especially following in the footsteps of other standout players who have come before him.

          “Wearing the Wachusett uniform means a lot, especially knowing the people who came before us who put it on every game like we do,” he said. “It’s very important to know that your school depends on you and all the teachers at the school, especially the coaching staff, who have played for the school in the past. You want to continue the legacy.

          View Selected Smart Windows for 100 Hood Park Drive, Part of Trademark’s New Life Science Initiative… | News

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          BOSTON and MILPITAS, Calif., Feb. 15 10, 2022 (GLOBE NEWSWIRE) — View, Inc. (NASDAQ: VIEW) (“View”), the leader in smart building technology, announced that its smart windows will be installed at 100 Hood Park Drive, an office and seven-story labs that will be a key part of Hood Park, a multi-building life science and technology center being developed by Trademark in Charlestown, Boston. Trademark Partners is transforming the former HP Hood dairy into an urban campus with office and laboratory workspaces, modern residences and street-level retail. View Smart Windows is expected to be installed in all Hood Park office buildings as the sprawling campus continues to expand.

          Designed for life science companies with over 150,000 square feet of flexible lab space, 100 Hood Park Drive will be fully equipped with View Smart Windows, creating a healthier, more productive environment filled with natural light and offering a view of Boston.

          View Smart Windows transforms buildings into responsive environments that automatically adjust to control heat and glare without the need for blinds. This is especially useful in life science buildings, where sterile working environments and alert, healthy scientists are critical to success. Blinds act as a reservoir of dust and germs that can contaminate sensitive materials and block shorter wavelength sunlight that disinfects surfaces. View Smart Windows eliminates these issues, while providing privacy to protect intellectual property and enabling a greater variety of workspace configurations, including those with workstations directly in front of windows.

          “We are thrilled to bring the benefits of View Smart Windows to tenants at 100 Hood Park Drive,” said Mark Rosenshein, partner at Trademark Partners. “Boston is rapidly becoming one of the world’s leading life sciences markets. We designed the entire Hood Park campus to optimize occupant health, comfort and productivity, helping our tenants attract the best talent to the area. The health benefits of increased access to natural light and exterior views made View Smart Windows a logical choice for the Hood Park project.

          View Smart Windows provides significant health benefits by reducing the incidence of eye strain and headaches by more than 50%. A recent study found that employees working in rooms with View Smart Windows slept 37 minutes longer each night, scored 42% better on cognitive tests, and were 14% more productive than those working in equivalent rooms with windows and windows. ordinary blinds. View Smart Windows also reduces lighting and HVAC energy consumption by up to 20%.

          “The life sciences industry is booming, and smart, healthy and sustainable workspaces are key to attracting and retaining top talent,” said Brian Klansky, Vice President of View. “View continues to show significant traction in the industry and is excited to partner with Hood Park and Trademark Partners to accelerate innovation in Boston.”

          SMMA served as architect and Lee Kennedy Company as general contractor for 100 Hood Park Drive. Newmark is the rental agent.

          About View View is the leader in smart building technologies that transform buildings to improve human health and experience, reduce energy consumption and carbon emissions, and generate additional revenue for building owners. View Smart Windows uses artificial intelligence to automatically adapt to outdoor conditions, eliminating the need for blinds and increasing access to natural light. Every View installation includes a cloud-connected smart building platform that can easily be extended to improve indoor cellular coverage, enhance building security, and redesign the occupant experience. View is installed and designed in more than 90 million square feet of buildings including offices, hospitals, airports, educational institutions, hotels and multi-family residences. For more information, visit: www.view.com.

          About Hood Park Hood Park is an innovative adaptive reuse of a former industrial site located in Boston’s vibrant Charlestown neighborhood. The 20-acre campus is licensed for 1.8 million square feet of development and currently has a range of uses including life sciences, residential, retail, entertainment, office and multiple spaces open. For more information, please visit: www.HoodPark.com.

          About Trademark Partners Trademark Partners is a WBE-certified real estate development and project management consulting firm based in Boston, MA. Trademark specializes in complex permitting, design and construction projects involving residential, laboratory/office, retail and hotel projects in New England and the South East regions. For more information, please visit: https://www.trademark.boston.

          Contacts: For Investors: Samuel Meehan View, Inc. [email protected] 408-493-1358

          For media: Tom Nolan Great Ink Communications [email protected] 908-392-0333

          A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/799327c7-8703-495e-88ec-2eb105c5858f

          Copyright 2022 GlobeNewswire, Inc.

          Group of doctors sue UC Davis over Elon Musk-funded monkey research

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          Elon Musk's Neuralink has teamed up with UC Davis to experiment on monkeys.  Now a group of doctors is suing.

          Elon Musk’s Neuralink has teamed up with UC Davis to experiment on monkeys. Now a group of doctors is suing.

          TNS

          A group of doctors has filed a lawsuit against UC Davis with the US Department of Agriculture, alleging that a primate research program funded by Elon Musk violates animal welfare law.

          The Physicians’ Committee for Responsible Medicine alleges in its complaint that the National Center for Primate Research at UC Davis in California – which received more than $1.4 million from Musk’s Neuralink company to conduct experiments – failed to provide the dying monkeys with sufficient veterinary care, used an unapproved substance called “Bioglue” which destroyed parts of the monkeys’ brains, and failed to ensure the psychological well-being of the monkeys in the experience, according to a statement released by the group.

          The group is suing in Yolo County Superior Court to force the university to release videos and photographs of the monkeys used in the experiments.

          “UC Davis may have handed over its state-funded facility to a billionaire, but that doesn’t mean it can evade transparency requirements and violate federal animal welfare laws,” Jeremy said. Beckham, the committee’s advocacy coordinator, in a statement. “Documents reveal monkeys had their brains mutilated in shoddy experiments and left to suffer and die. It’s no mystery why Elon Musk and the university want to keep the photos and videos of this horrific abuse hidden from the public.

          In response to the lawsuit, UC Davis released a statement acknowledging that there was a collaboration with Neuralink that ended in 2020.

          A UC Davis spokesperson said in a statement that the research protocols were carefully reviewed and approved by the campus Institutional Animal Care and Use Committee, and that UC Davis staff provide veterinary care, including round-the-clock monitoring of animals.

          “We strive to provide the best possible care for the animals in our care. Animal research is strictly regulated, and UC Davis follows all applicable laws and regulations, including those of the U.S. Department of Agriculture, which conducts regular inspections, and the NIH Office of Laboratory Animal Welfare. UC Davis’ animal care program, including the California National Primate Research Center, is accredited by AAALAC International, a nonprofit organization,” said UC Davis spokesperson Andy Fell. in a press release.

          Fell said UC Davis fully complied with the California Public Records Act in responding to the Physicians Committee for Responsible Medicine’s request for records.

          “Indeed, additional material has been provided to the (committee) since the conclusion of the research agreement with Neuralink,” Fell said in a statement to The Sacramento Bee.

          In response to media coverage of the USDA complaint, Neuralink released a statement thus, saying that, “It is important to note that these accusations come from people who oppose any use of animals in research. Currently, all new medical devices and treatments must be tested on animals before they can be ethically tested on humans. Neuralink is not unique in this regard. At Neuralink, we are absolutely committed to working with animals in the most humane and ethical way possible. »

          Related Sacramento Bee Stories

          Andrew Sheeler covers California’s unique political climate for the Sacramento Bee. He covered crime and politics from the interior of Alaska to the oil patch of North Dakota to the rugged coast of southern Oregon. He attended the University of Alaska Fairbanks.

          Keto Diet May Reduce Damage From Traumatic Brain Injury | Health

          0

          Eating a ketogenic diet appears to be beneficial after traumatic brain injury, according to an international study led by Tel Aviv University.

          Traumatic brain injury, which affects some 10 million people each year, can cause physical, cognitive, behavioral and emotional damage and is also a risk factor for diseases such as Alzheimer’s disease and Parkinson’s disease.

          The study indicates that a keto diet improves spatial and visual memory, reduces brain inflammation, causes less neuronal death, and slows the rate of cellular aging in injured brains.

          The study was led by Professor Chaim (Chagi) Pick, director of TAU’s Sylvan Adams Sports Institute and a member of its Sagol School of Neuroscience, and Ph.D. student Meirav Har-Even Kerzhner, dietitian and brain researcher . The results were published in Scientific Reports.

          Har-Even Kerzhner explained that a ketogenic diet aims to mimic a fasting state. Carbohydrates such as bread, sugar, cereals, legumes, pastries, and even fruit are significantly limited, while high-fat foods such as meat, fish, eggs, avocado, and butter are encouraged.

          The diet increases the production of ketone bodies, energy-generating molecules produced in the liver when it breaks down fat. The blood carries these ketone bodies to the brain.

          This diet has been used for nearly 100 years to treat children with epilepsy and more recently has become popular for weight loss.

          In the study, conducted on mice with brain damage, researchers found that a ketogenic diet significantly improved their brain function compared to a control group fed a standard diet.

          The results were unequivocal, Pick said.

          “These findings could open the door to further research that will give hope to people with traumatic brain injury and their family members.”

          Researchers from New Jersey and Florida participated in the study.

          This story first appeared on Israel 21C.

          10 easy ways to increase your metabolism and lose weight

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          Metabolism describes all the chemical reactions that occur in your body that keep it alive and functioning well. It refers to the cellular process that turns food into energy, and particular proteins in the body control these chemical reactions.

          The word metabolism can easily be confused with the term metabolic rate, the amount of calories you burn. Having a high metabolism means you burn more calories and lose weight faster. Here are ten easy ways to boost your metabolism:

          1. Replace sugary drinks with water

          Those who drink water instead of high sugar drinks are lose weight better and keep it off, according to Harvard Health. These sugary drinks contain calories that accumulate throughout the day, while the water is calorie-free and hydrating. Even if you only replace one to three cups with plain water, you might see improvements. Water is also satiating.

          Some sources indicate that drinking more cold water may help boost your metabolism. An older study published in The Journal of Clinical Endocrinology and Metabolism found that the energy expenditure results are negligible. Cooling the water before drinking produced less than 5% energy expenditure in 60 minutes.

          2. Eat more protein

          When you eat, your metabolism reacts. The thermic food effect (TEF) refers to the increase in calories needed to process nutrients from a meal. Proteins cause the greatest increase in TEF from 20 to 35% compared to carbohydrates and, therefore, increases your metabolic rate. Protein can also keep you full longer.

          3. Do high-intensity interval training (HIIT)

          High Intensity Interval Training (HIIT) engages the body in intense, rapid bursts of aerobic and resistance workouts. This variety of activity at fast and intense levels can help you burn fat by increasing your metabolic rate, which persists for hours after activityaccording to a 2021 systematic review published in Opinion on Obesity.

          A HIIT workout can last anywhere from 10 to 30 minutes. You can try anything, like dancing, sprinting, cycling, or jumping rope at a fast, intense pace for 30 seconds, then a few minutes at a slower, more relaxed pace. The number of repetitions usually ranges from four to six. Including HIIT workouts in your exercise routine could help you avoid weight plateauing.

          4. Lift heavier things

          Fat is less metabolically active than muscle. Your metabolism goes down when you lose weight, if you are sedentary. However, lifting weights can help combat this drop and build muscle. Resting energy expenditure is 60-75% of the calories you burn every day, according to Harvard Health. This is the rate at which you burn calories after a workout.

          If you can’t make it to the gym, start slowly at home by taking the time to revamp your closet or pantry. According to the Washington Post, the calories you burn doing chores can fight weight gain at home. And remember to lift with your legs, not your back.

          5. Stand up more often

          Sitting has too often been called “the new smoking” because both are linked to higher rates of obesity, increased blood pressure and other risk factors for chronic diseases. Sitting too long can also harm your mental health.

          Standing burns eight more calories per hour than sitting, according to Harvard Health, walking burns a lot more. A good rule of thumb is to avoid sitting for intervals longer than 40 minutes. Invest in a standing desk or consider a treadmill or bike under the desk to keep your legs moving. Although standing doesn’t burn many calories, variations between sitting and standing throughout the day are better for your health.

          6. Drink green tea

          Can green tea speed up weight loss? Drinking green tea will not help you lose weight, but it may help slight increase in your metabolic ratereports NPR.

          A 2012 meta-analysis published in Cochrane reviewed 15 weight loss studies and three weight maintenance studies involving green tea consumption and found it had an effect, albeit small. The weight loss benefits of green tea may be applicable to certain subsets of the population.

          However, green tea has antioxidant effects which are helpful in fighting free radicals and increasing oxygen in your bloodstream. These antioxidants could have a beneficial effect on helping your muscles recover after a workout.

          7. Eat spicy foods

          A 2017 study published in the International Journal of Food Science and Nutrition found that chilli (peppers) can improve insulin control, helping with weight management. Chilli decreases energy expenditure by activating brown adipose tissue. The researchers also noted that this discovery had positive effects for the treatments of diabetes, obesity and cardiovascular disorders.

          Bell peppers also contain capsaicin which can boost your metabolism. The McCormick Science Institute reports that red bell pepper may increase satiety and improve your metabolism and energy.

          8. Get plenty of rest

          Did you know that a lack of sleep can influence insulin resistance as well as your blood sugar? Pennsylvania State University reports that sleep deprivation can hurt your metabolism and contribute to weight gain. Longer exposure to short periods of sleep may increase the risk of obesity and other chronic diseases. However, missing several hours of sleep over several days can also affect your metabolism.

          It takes time for your system to get back to its basal metabolic rate, and catching up on sleep over the weekend is not the answer. Take the time to develop a bedtime routine and between seven and nine hours of sleepthe recommended amount of sleep for adults.

          9. Drink coffee

          Normal caffeine consumption can increase energy expenditure, increase resting metabolic rate by 3-11% for lean and post-obese people, according to an older study published in The American Journal of Clinical Nutrition. Interestingly, this effect may diminish with age and is more effective in young adults.

          Caffeine boosted fat burning closely 29% in lean women and 10% in obese womenreported an older study published in The Journal of American Physiology, Endocrinology, and Metabolism.

          10. Use coconut oil

          Use coconut oil as your primary cooking fat because it contains many medium-chain fats in place of the saturated and long-chain fats found in other cooking oils. Medium chain fats can boost your metabolism and help with weight losswhile potentially reducing obesity-related risk perimeters, according to a 2020 study published in Food and function.

          Simple lifestyle changes can help boost your metabolism, like including more green tea in your diet and HIIT in your workout routine. A higher metabolic rate can help you maintain a healthy weight and provide you with more energy over time.

          In-depth research of global CD40 ligand market, industry statistics 2022

          0

          the CD40 Ligand Market The report covers the entire global market scenario including key players, their future campaigns, preferred vendors, market shares along with historical data and price analysis. It continues to offer key details on changing dynamics to generate market improving factors. Its objective is to rationalize the company’s costs. You can also find interest and expense points on current income here. The best thing about the CD40 Ligand market report is the provision of guidelines and strategies followed by major market players. The investment opportunities in the market that are highlighted here will go a long way in moving the business forward. Knowing the current market situation is the most important thing discussed here to help major players survive in the deadly market.

          This CD40 Ligand market study describes the economic catastrophe caused by the covid-19 outbreak, which has affected all sectors of the business. A major global economic loss has occurred due to various industrial closures and loss of income. A high degree of information is offered here to assess the market situation.

          Get Sample Full PDF Copy of Report: (Including Full TOC, List of Tables & Figures, Chart) @ https://reportsglobe.com/download-sample/?rid=109775

          The authors of the report draw up an encyclopedic assessment of the most important regional markets and their evolution in recent years. Readers are provided with accurate facts and figures on the CD40 Ligand market and its important factors such as consumption, production, revenue growth, and CAGR. The report also shares gross margin, market share, attractiveness index, and value and volume growth for all segments studied by analysts. It highlights key developments, product portfolio, markets served and other areas depicting business growth of major companies profiled in the report.

          The report has been prepared using the latest primary and secondary research methods and tools. Our analysts rely on government documents, white papers, press releases, reliable investor information, financial and quarterly reports, and public and private interviews to gather data and information about the market in which they operate.

          Key Players Covered in the CD40 Ligand Markets:

        1. Biogene, Inc.
        2. XL-protein GmbH
        3. ImmuNext, Inc.
        4. Bristol-Myers Squibb Company
        5. Targovax AS
        6. eTheRNA Immunotherapies SA
        7. MedImmune, LLC
        8. Juno Therapeutics Inc.

          CD40 Ligand Market Split By Type:

        9. ISF-35
        10. CHARGE-700
        11. MEDI-4920
        12. MegaCD40L
        13. Others

          CD40 Ligand Market Split By Application:

        14. Hepatitis B
        15. Bladder cancer
        16. Liver cancer
        17. Ovarian cancer
        18. Others

          The CD40 Ligand market report has been segregated into distinct categories such as product type, application, end-user, and region. Each segment is rated based on CAGR, participation, and growth potential. In the regional analysis, the report highlights the potential region, which is expected to generate opportunities in the global Keyword Market in the coming years. This segment analysis is sure to prove to be a useful tool for readers, stakeholders, and market players to get a complete picture of the global Keyword Market and its growth potential in the coming years.

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          Scope of CD40 Ligand Market Report

          ATTRIBUTES

          The description

          ESTIMATED YEAR

          2022

          YEAR OF REFERENCE

          2021

          FORECAST YEAR

          2022 to 2028

          HISTORICAL YEAR

          2020

          SECTORS COVERED

          Types, applications, end users, and more.

          REPORT COVER

          Revenue Forecast, Business Ranking, Competitive Landscape, Growth Factors and Trends

          BY REGION

          North America, Europe, Asia-Pacific, Latin America, Middle East and Africa

          Geographic segment covered in the report:

          The CD40 Ligand report provides information about the market area, which is divided into sub-regions and countries/regions. In addition to the market share in each country and sub-region, this chapter of this report also contains information on profit opportunities. This chapter of the report mentions the market share and the growth rate for each region, country and sub-region during the estimated period.

          • North America includes the United States, Canada and Mexico
          • Europe includes Germany, France, UK, Italy, Spain
          • South America includes Colombia, Argentina, Nigeria and Chile
          • Asia Pacific includes Japan, China, Korea, India, Saudi Arabia and Southeast Asia

          Goals and Objectives of CD40 Ligand Market Research

          • Understanding the CD40 Ligand opportunities and advancements determines the market strengths, along with the key regions and countries involved in the market growth.
          • Study the various segments of the Ligand CD40 market and the dynamics of Ligand CD40 in the market.
          • Categorize CD40 Ligand segments with increasing growth potential and assess the futuristic segment market.
          • To analyze the most important trends related to the different segments which help to decipher and convince the Ligand CD40 market.
          • Check region-specific growth and development in the CD40 Ligand Market.
          • To understand the key CD40 Ligand market stakeholders and the competitive image value of the CD40 Ligand market leaders.
          • To study the key plans, initiatives, and strategies for the development of the CD40 Ligand Market.

          The study thoroughly examines the profiles of major market players and their key financial aspects. This comprehensive business analysis report is useful for all new and existing participants when designing their business strategies. This report covers KEYWORD production, revenue, market share and growth rate for each key company and covers the breakdown data (production, consumption, revenue and market share) by regions, type and applications. CD40 Ligand historical distribution data from 2016-2021 and forecast for 2022-2028.

          Ask questions about personalization at @ https://reportsglobe.com/need-customization/?rid=109775

          Some highlights from the table of contents:

          1 Presentation of the report

          2 Market Trends and Competitive Landscape

          3 CD40 Ligand Market Segmentation by Types

          4 CD40 Ligand Market Segmentation by End Users

          5 Market Analysis by Major Regions

          6 Product Commodity CD40 Ligand Market by Major Countries

          7 North America CD40 Ligand Landscape Analysis

          8 Europe CD40 Ligand Landscape Analysis

          9 Asia-Pacific CD40 Ligand Landscape Analysis

          10 Latin America, Middle East and Africa Landscape Analysis of CD40 Ligand

          11 Profile of Key Players

          How Reports Globe is different from other market research providers:

          The creation of Reports Globe has been underpinned by providing clients with a holistic view of market conditions and future possibilities/opportunities to derive maximum benefit from their business and assist in decision making. Our team of in-house analysts and consultants work tirelessly to understand your needs and provide the best possible solutions to meet your research needs.

          Our team at Reports Globe follows a rigorous data validation process, which allows us to publish publisher reports with minimal or no deviation. Reports Globe collects, separates and publishes over 500 reports each year covering products and services in many areas.

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        19. 90 minutes of exercise after vaccination can provide additional immune support

          0

          Researchers at Iowa State University have found that 90 minutes of light-to-moderate intensity exercise directly after a flu or COVID-19 vaccine can provide additional immune support.

          In the recently published study, participants who cycled on a stationary bike or took a brisk walk for an hour and a half after receiving a jab produced more antibodies over the following four weeks compared to participants who sat down or continued their daily routine. post-immunization. The researchers found similar results when they conducted an experiment with mice and treadmills.

          Antibodies are essentially the body’s “seek-and-destroy” line of defense against viruses, bacteria, fungi, and parasites. Vaccines help the immune system learn to identify something foreign and respond by strengthening the body’s defenses, including increasing antibodies.

          “Our preliminary results are the first to demonstrate that a specific time frame can enhance the body’s antibody response to the Pfizer-BioNtech COVID-19 vaccine and two influenza vaccines,” said kinesiology professor Marian Kohut. , lead author of the article published in the Journal Brain, Behavior and Immunity.

          The researchers said the study results could directly benefit people with a range of fitness levels. Almost half of the participants in the experiment had a BMI in the overweight or obese category. During 90 minutes of exercise, they focused on maintaining a pace that kept their heart rate around 120 to 140 beats per minute rather than distance.

          In the study, researchers also tested whether participants could achieve the same increase in antibodies with just 45 minutes of exercise. They found that the shorter workout did not increase participants’ antibody levels. Kohut said the research team could test whether 60 minutes is enough to generate a response in a follow-up study.

          Why the boost?

          As to why prolonged light-to-moderate intensity exercise might improve the body’s immune response, Kohut said there could be several reasons. Exercise increases blood and lymph flow, which helps immune cells circulate. As these cells move through the body, they are more likely to detect something foreign.

          Data from the mouse experiment also suggested that a type of protein (i.e. interferon alpha) produced during exercise helps generate virus-specific antibodies and T cells.

          But much more research is needed to answer the whys and hows. There are so many changes that occur when we exercise – metabolic, biochemical, neuroendocrine, circulatory. So there is likely a combination of factors contributing to the antibody response that we found in our study.”


          Professor Marian Kohut, lead author of the article

          Researchers continue to follow the antibody response in participants six months after vaccination and have launched another study that focuses on the effects of exercise on people who receive booster shots.

          Postdoctoral researcher Tyanez Jones, graduate assistant Jessica Alley, and Justus Hallam, a graduate student at the time of the study, co-authored the recently published paper with Marian Kohut. Kohut said the research team also received a lot of help from undergraduate students, including students from the ISU Science Bound Scholars program.

          Source:

          Journal reference:

          Hallam, J. et al. (2022) Exercise after influenza or COVID-19 vaccination increases serum antibodies without increased side effects. Brain, behavior and immunity. doi.org/10.1016/j.bbi.2022.02.005.

          Gardening Etcètera: Agriculture NPK: Is that all there is to plant nutrition? | Local

          0

          CINDY MURRAY

          As most of us know, the three main macronutrients essential for plant nutrition are nitrogen, phosphorus and potassium, or NPK. These are the nutrients needed in the greatest quantities and the ones that most often limit plant growth. For decades, farmers and gardeners have grown food crops by supplying these nutrients every year, often based on soil testing.

          Agronomists have long recognized that there are other nutrients necessary for optimal plant growth. Farmers and gardeners add them when they are aware that a nutrient is lacking, but a whole systems approach to building the soil rather than just supplying what is limited can provide better yields and healthier soils.

          To understand how a systems approach benefits soil biology and health, we need to know that plants undergo a natural biochemical sequence of nutrient uptake and metabolism. Only the supply of NPK often bypasses certain vital links in the chain.

          This biochemical sequence begins with the absorption of boron, in the form of boric acid or borate, by the roots of each plant. Boron plays a major role in sap pressure, which is vital in transporting nutrients and nutrients throughout the plant.

          People also read…

          The second link begins with boron stimulating the root system to secrete sugars into the soil. Sugars stimulate the growth of beneficial microorganisms, which in turn convert silicates (a form of silicon) into silicic acid.

          The third link is ensured by silicic acid inducing the absorption of calcium, organic nitrogen, magnesium, phosphorus and potassium by capillarity. Silicon can also provide some resistance to plant diseases, promote strong stems and improve vegetable crop yields.

          The role of calcium in plant nutrition is to strengthen cell walls and membranes and to support good soil structure. But calcium has low mobility in plants, causing some plants like tomatoes and squash to show deficiency symptoms (blood end rot) even when the soil contains adequate amounts. The key to increasing calcium mobility to all parts of a plant is to keep the soil evenly moist throughout its root system.

          Calcium then brings nitrogen into the sequence by binding to it. Now the plant is able to form DNA, undergo cell division and make proteins like chlorophyll.

          Magnesium is a crucial component of chlorophyll, which absorbs energy from sunlight through photosynthesis. Equally important, magnesium is also a phosphate transporter.

          Phosphorus helps convert sunlight into energy. It is also a vital element in the transfer of energy, including the energy needed to extract the carbon atom from the carbon dioxide molecule to make sugars.

          Finally, potassium transports sugars to nourish the whole plant.

          As the plant nutrition sequence unfolds, actinomycete bacteria and mycorrhizal fungi break down clay and humus, providing the perfect medium for nitrogen fixation and other beneficial microbes. In response, the roots exude more microbe-beneficial sugars. If you were to see a small mass of these plant roots, you would see them as dense, fine, and intricately branching. However, soils heavily treated with nitrogen, phosphorus, and potassium do not exhibit these attributes, as inorganic NPKs induce saline soil conditions inhibiting actinomycetes and mycorrhizae.

          Additionally, soils rich in inorganic NPKs inhibit the microbial growth necessary for boron to begin the process, so the entire nutrient sequence may never catch up. High levels of nitrogen and phosphorus can also block calcium uptake, making the plant calcium deficient.

          I believe the lesson we learn from studying this biochemical sequence is how to feed our soils rather than just feed our plants. The best way to do this is to incorporate abundant organic matter like compost into our gardens every year. Other practices may include using cover crops and/or applying mulch to the surface. All of these promote the growth of beneficial fungi, bacteria, protozoa, nematodes and earthworms.

          We are fortunate to reside in northern Arizona, where all the minerals necessary for plant growth are found naturally in our soils, but we may need to replenish nitrogen or other elements each year. Soil testing is the best way to tell us which nutrients and micronutrients are lacking in our fields and flowerbeds.

          Once we take these steps, the nutritional biological sequence can come alive, ultimately rewarding gardeners and farmers with bountiful harvests.

          Cindy Murray is a biologist, co-editor of Gardening Etc. and Master Gardener Coconino with Arizona Cooperative Extension.

          Beyond the usual debate, there is also the all-too-human Savarkar

          0

          Vinayak Damodar Savarkar is often considered a non-human subject. Many of his followers and supporters revere him as a deity, while some of his detractors and antagonists see him as evil incarnate – a monster. Both are incorrect.

          Conversely, I support something quite banal: Savarkar was human. I think Savarkar would have preferred this cropping.

          But before any reader misunderstands my point, let me explain.

          While I was recently teaching the writings of Mohandas Karamchand Gandhi for one of my undergraduate classes, it occurred to me that there were a lot of writings on the diseases and health issues of Gandhi as part of an effort to think about Gandhi’s humanity, but nothing comparable exists in the Savarkar literature. Scholars are only too aware of the difficulties of writing about figures like Gandhi and Savarkar who occupy a larger-than-life status in public culture. Interpreting them as human subjects and discussing their vulnerabilities and frailties is often met with suspicion and dismay.

          Gandhi made his body a subject of political protest and self-inflicted wounds through his fasts on public display, while discussing everyday issues of illness and health as part of his interpretation of modernity. Savarkar’s life circumstances and politics followed a completely different trajectory, particularly as a political prisoner in the Andamans.

          Unsurprisingly, Savarkar had a lot to say about what it meant to be Human. These ideas informed his conceptualizations of ‘Hindu’ and ‘Hindutva’ which need to be seen as central to his political thinking.

          In its key text The essence of Hindutva (1923), Savarkar argues that blood is what makes us human. He further argues that our humanity is tied to our sexuality, particularly when he notes that “sexual attraction has proven more powerful than the commandments of all the prophets put together.”

          Our ability to speak also made us human – an observation with which linguists would later agree. Most important was Savarkar’s assertion that violence is a key feature of human nature.

          by Savarkar work is replete with analyzes that all humans are violent, including Hindus. To emphasize this assertion, Savarkar added that Ahimsah (non-violence) was contrary to being human. In fact, he argued that supporters of nonviolence should suffer a cruel and brutal death. AT to be human was to recognize oneself as a violent being. Only Hindus who understood the human condition would be up to the task of inflicting violence in the name of humanity. This interpretation was Savarkar’s gift to the Hindutva-go awaywho have embraced this essence of being Hindu.

          Savarkar also wrote about suffering as part of the human condition. He explained that Hindus had mourned for millennia as victims of invasions. While the early invaders, such as the Greeks, Huns, Sakas and Kushanas, had been conquered or assimilated by the Hindus, and the later Europeans, such as the Portuguese and the British, had been forced out of India , the Hindus had continued to suffer at the hands of the Muslims. Yet if suffering was a part of being human, there was no endgame to Savarkar’s argument. The only remedy was for the Hindus to seek what he called “justifiable revenge” in permanent warfare.

          Today’s Hindutvago away echo this assertion by declaring that they are in a thousand year war against Muslims, confirming that violence remains essential to being a Hindu.

          VD Savarkar. Photo: savarkarsmarak.com

          Savarkar’s writings also provide insight into his personal suffering. While accounts of his difficult time as a prisoner in the Andaman Cellular Jail are well known in this context, what is often overlooked are the physical and mental illnesses he experienced throughout his life. As French theorist Roland Barthes points out in his autobiography, writing about life means writing about the body, its anatomy, its illnesses, its distress. Yet I realize that talking about Savarkar’s health is walking a fine line in the eyes of Savarkar’s followers and critics. Savarkar’s humanity cannot simply be reduced to a discussion of his illnesses.

          At a seminar, I once discussed that Savarkar’s body weight had dropped to 95 pounds as he had been ill for over a year in the cell prison. This was around the time he was writing petitions asking to leave the Andamans. He also wrote a letter to his brother Narayan Damodar Savarkar asking for his help as he was unsure whether he would survive the malarial climate and a long illness.

          An audience member was very upset and accused me of trying to “humanize” Savarkar. He could not be redeemed as a human, I was told.

          One of the criticisms philosopher Hannah Arendt faced in her reporting on the 1961 trial of German Nazi leader Adolf Eichmann was that she spent too much time discussing his health and appearance. Arendt went further, saying that Eichmann reflected “the banality of evil.” She was excoriated for suggesting that Eichmann was just plain ordinary: a human, not a demon. Even the most brutal killers can look unremarkable or pathetic when they’re powerless, old, or sick.

          For Arendt, it was Eichmann’s banality that offered a window into his evil deeds. The challenge Arendt faced, and it is also relevant in writing about Savarkar, is: When is it no longer possible to write about a human subject as a human?

          Savarkar presents a different kind of banality when talking about illnesses. Tuberculosis, bronchitis, pneumonia, malaria and dysentery are all mentioned in his writings. He frequently commented on the depression and suicidal tendencies of fellow cell prison inmates. He shamed these people for considering suicide as he considered it an effeminate form of death. A male death was one that involved killing an enemy on the battlefield before dying. It was an act of verata and bravery which Savarkar aspired to, but was never realized.

          Savarkar’s own experiences with angst are never fully discussed in his writings. There are delusions to psychic breaks at various times in his life, including in childhood. The best documented moment took place shortly after the execution of Madanlal Dhingra in 1909.

          Almost every biographer – from Dhananjay Keer to Jaywant Joglekar to Harindra Srivastava – has written about how Savarkar broke down physically and mentally. Savarkar was distraught as he felt his political project had failed. He had nowhere to live in London and felt completely alienated. He believed he was constantly being followed.

          Savarkar arrived in the coastal town of Brighton to stay with Niranjan Pal, the son of nationalist Bipin Chandra Pal. In an essay published in the maharatta (1938), Niranjan Pal described Savarkar’s fragile state at the time, noting that he sat by the seashore and “cried like a child”.

          Hindu Mahasabha group photo.  Standing - Shankar Kistaiya, Gopal Godse, Madanlal Pahwa, Badge Digambar.  Seated - Narayan Apte, Vinayak D. Savarkar, Nathuram Godse, Vishnu Karkare.  Credit: Flickr

          A group photo of the Hindu Mahasabha. Standing – Shankar Kistaiya, Gopal Godse, Madanlal Pahwa, Badge Digambar. Seated – Narayan Apte, Vinayak D. Savarkar, Nathuram Godse, Vishnu Karkare. Photo: Flickr/File

          According to Pal, it was at this time that Savarkar apparently composed his famous poem “Sagaras”, a work which reflected his existential crisis. A line that Savarkar repeats throughout the poem is, “My soul is so tormented.” Each stanza ends with this sentence. He describes being trapped and overwhelmed by darkness. He asks the ocean to bring him back to Bharat Mata. Hindutva-go away have interpreted this poem as representing Savarkar’s devotion to the motherland as a patriot and a nationalist. Psychic breakdown and suicidal thoughts do not appear in these analyses.

          Savarkar’s condition worsened and he was no longer able to take care of himself. He also developed bronchitis and pneumonia. He was sent to Mendip Hills Sanatorium in Wells, Somerset, where he was placed in the care of Dr David Chowry Muthu, a tuberculosis specialist who had published articles in British medical journals discussing the links between mental health and lung problems.

          Dr. Muthu was a visitor to Shyamji Krishnavarma’s India House, where Savarkar resided for some time in London. It is possible that he and Savarkar met earlier. In fact, the cost of staying at the sanitarium was paid for by Krishnavarma. Dr. Muthu would later become Ramanujan’s doctor when the mathematician fell ill at Cambridge University. Details of Savarkar’s stay at the sanatorium are not well documented. It is also unclear whether Savarkar’s other reason for being sent to Wells was to receive treatment at nearby Mendip Hospital specializing in psychiatric care.

          We know that Savarkar left Wells prematurely because he learned he could be arrested. He eventually made his way to Paris, where he continued to need help from friends.

          Harindra Srivastava explains that he had interviewed Balarao Savarkar, Savarkar’s personal secretary. Balarao told something about Savarkar that had never been revealed before.

          Once, when Savarkar was living in Bombay, he asked Balarao to accompany him to the sea. He explained that he was “going into the sea for good”.

          Balarao was puzzled and asked Savarkar to explain what he meant. Savarkar apparently declared that he no longer wanted to live. Balarao convinced Savarkar to abandon any plans for suicide, saying there was a lot of work to be done for the cause of Hindutva.

          Savarkar suffered from physical and mental health issues throughout his life. This is by no means an extraordinary revelation. The fact that Savarkar condemned other suicidal people as effeminate provides important insight into his own experiences of suicidality.

          Throughout his writings he regularly blamed effeminate Hindus for the problems of all Hindus. If only Hindu men had expressed their masculinity throughout history, Hindus would not have fallen victim to foreign invaders, especially Muslims.

          Savarkar left us an interpretation of the human condition that reflects his own subjectivity. The nom de guerre ‘Veuh attached to his name by his admirers reflects a hagiographic interpretation of Savarkar.

          There was another side to him that shows him as all too human.

          Vinayak Chaturvedi is an associate professor in the Department of History at the University of California, Irvine. His forthcoming book Hindutva and violence: VD Savarkar and the politics of history will be published by Permanent Black in India and SUNY Press in the United States.

          If you know someone – a friend or family member – who is at risk of suicide, please contact them. The Suicide Prevention India Foundation maintains a list of phone numbers they can call to talk confidentially. Icall, a counseling service run by TISS, maintained a crowdsourced list of therapists across the country. You can also take them to the nearest hospital.

          Engagement of SLAMF7 overactivates macrophages in acute and chronic inflammation

          0

          Submission History

          Has received: October 15, 2020

          Accepted: January 20, 2022

          Thanks

          We thank F. Zhang, I. Korsunsky, and S. Raychaudhuri for advice on bioinformatics analysis; M. Gurish and G. Keras for their assistance in patient recruitment and specimen processing; W. Apruzzese for helpful discussions; J. Toska for his help with Western transfers; and patients for their participation. Screening was performed at the BWH Human Immunology Center. We thank the members of the AMP RA/SLE Phase 1 network for their contributions.

          Funding: This work was supported by NIH NIAID P01AI148102, NIH NIAMS P30 AR070253, and the Accelerating Medicines Partnership (AMP) in Rheumatoid Arthritis and Lupus Network. AMP is a public-private partnership (AbbVie Inc.; Arthritis Foundation; Bristol-Myers Squibb Company; Foundation for the NIH; GlaxoSmithKline; Janssen Research and Development, LLC; Lupus Foundation of America; Lupus Research Alliance; Merck Sharp & Dohme Corp. ; National Institute of Allergy and Infectious Diseases; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Pfizer Inc.; Rheumatology Research Foundation; and Sanofi and Takeda Pharmaceuticals International Inc.) created to develop new ways to identify and validate targets promising biologics for diagnosis and drug development. Funding for AMP was provided by NIH grants (UH2-AR067676, UH2-AR067677, UH2-AR067679, UH2-AR067681, UH2-AR067685, UH2-AR067688, UH2-AR067689, UH2-AR067690, UH2-AR067691 , UH69-44 , and UM2-AR067678). DPS was supported by NIH NHLBI T32 Institutional Training Grant HL007627 and NIH NIAMS K08 AR075850.

          Author’s contributions: Conceptualization: DPS, DAR and MBB Methodology: DPS, HNN and EG-R. Formal analysis: DPS and YJ Survey: DPS, HNN and EG-R. Resources: DPS, EG-R., AHJ, AFC, JKL, GSD, PB, BEE, JSC, EMM, JAS, and DJT Data curation: DPS Writing—original draft: DPS Writing—revision and editing: DPS, HNN, EG -R., YJ, AHJ, AFC, JKL, GSD, PB, BEE, JSC, EMM, JAS, DJT, DAR, EYK and MBB Visualization: DPS Supervision: MBB Project administration: DAR and MBB Acquisition financing: DPS and MBB

          Competing interests: The authors declare that they have no competing interests. Accelerating Medicines Partnership and AMP are registered service marks of the US Department of Health and Human Services.

          Availability of data and materials: RNA-seq of sorted monocyte populations with high and low expression of SLAMF7 is available from NCBI GEO GSE185508. RNA-seq of monocyte-derived macrophages stimulated in vitro is available from NCBI GEO GSE185509. All other data necessary to evaluate the conclusions of the article are present in the article or the supplementary documents.

          Individual members of the AMP RA/SLE Phase 1 Network are listed in alphabetical order: Jen Anolik, William Apruzzese, Joan M. Bathon, Ami Ben-Artzi, David L. Boyle, Brendan Boyce, S. Louis Bridges, Vivian Bykerk, Kevin Deane, Edward DiCarlo, Laura Donlin, Tom Eisenhaure, Andrew Filer, Gary S. Firestein, Lindsy Forbess, Susan Goodman, Ellen Gravallese, Peter K. Gregersen, Joel Guthridge, V. Michael Holers, Diane Horowitz, Laura Hughes, Judith James, James Lederer, Arthur Mandelin, Mandy McGeachy, Larry Moreland, Nir Hacohen, Harris Perlman, Costantino Pitzalis, Soumya Raychaudhuri, Christopher Ritchlin, Bill Robinson, Jennifer Seifert, PJ Utz, Kevin Wei, Fan Zhang.

          The false eyelashes market is expected to grow by 5.5% in 2020-2026

          0

          RAIPUR, India, February 11, 2022 /PRNewswire/ — Stratview Research, a Leader market research firm launched a report on false eyelashes market which provides in-depth analysis of market dynamics, current and emerging trends, industry forecasts and competitive landscape.

          Click here to get the free sample pdf:

          https://www.stratviewresearch.com/Request-Sample/1235/false-eyelashes-market.html#form

          How is the report useful?

          The report has great utility for key decision makers and strategists in terms of accurate market insights, future growth opportunities, and key success factors.

          Most importantly, the report analyzes the possible impact of COVID-19 on the market dynamics, which provides cushion against the uncertain business environment and helps streamline resources and investment decisions fruitfully.

          What are the main market drivers?

          According to the report, the false eyelashes market is driven by a multitude of factors, some of which are noted below:

          • The growing popularity of personalized and unique looks among people.
          • The easy availability of materials like rubber, polymers or acrylic materials, used in the manufacture of false eyelashes.

          The report also includes growth rate estimates based on the intensity of drivers and restraints and provides users with several graphical illustrations of key information.

          Fake eyelashes Market segmentation :

          Stratview Research has segmented the market in the following 4 ways that meet the market data needs of multiple stakeholders across the industry value chain.

          • type of product (Bands, Cluster/Accent, Individual and Others)
          • Type of constituent (Natural, Synthetic)
          • Distribution channel type (Online, convenience stores and hypermarkets and supermarkets)
          • Region (North America, Europe, Asia Pacificand rest of the world)

          Fake eyelashes Market overview

          Market trends by product type

          Based on product type, the market is segmented into band, cluster/accent, individual and others. Strip false eyelashes are estimated to account for the bulk of the market. The growth is attributed to their outstanding popularity among people, owing to their easy and quick wearing modes. These eyelashes are so user-friendly that they do not require any professional help and also come in different designs, which makes the whole lash line so beautiful. In addition, it is estimated that individual false eyelashes will experience a significant growth rate in the next five years. These lashes are available in simple and flared shapes, giving a natural yet dramatic look in the eyes of the consumer. Unlike strip lashes, this requires expert help because each lash or group of lashes must be applied individually.

          Market Trends by Constituent Type

          On the basis of constituent type, the market is segmented into natural and synthetic. Synthetic is estimated to hold the largest market share, being the leading segment in the coming years. These eyelashes are made of rubber, polymers or acrylic material, and are shinier, shinier, giving a more dramatic look. These lashes are available in a variety of thicknesses, curls, lengths, styles, hold curls appropriately, and are also inexpensive, making them the dominant segment of the market. Furthermore, the natural eyelashes segment is estimated to register a steady growth rate over the forecast period, owing to their soft texture, making them similar to natural eyelashes and ease of use during regular use. . These eyelashes are made from mink hair, human hair, sable hair or silk, and are lightweight and flexible compared to their counterparts.

          Market trends by type of distribution channel

          Based on the type of distribution channel, the market is segmented into online, convenience stores, hypermarkets and supermarkets. Convenience stores held the largest market share in 2019, and includes pharmacies, department stores and specialty stores. Majority of false eyelash users are very specific as to what shape and material they want to have that is why they usually prefer to buy them from stores rather than online merchants as they also get the help experts giving them the most suitable recommendations according to the taste of the consumer and an explanation of the application of the product. On the contrary, the online channel is estimated to be the fastest growing segment over the forecast period owing to its increasing popularity among consumers due to the convenience it offers. They also offer massive discounts on different occasions over the course of a year, making the products appealing to consumers, fueling the growth of the market over the next five years.

          Which region offers the best opportunity and growth?

          At the regional level, North America is estimated to represent the majority of the market due to the presence of a large number of manufacturers in the United States during the forecast period. Factors such as growing influence of TV, movie actors and social media, and permanent eyelashes which can last about two to three weeks are gaining popularity and are expected to accelerate the demand for the products in the regional market during of the forecast period. Furthermore, Asia Pacific is estimated to be the fastest growing region in the coming years, with China, India, South Koreaand Philippines being the major countries with the highest awareness of developing trends and beauty products in the regional market during the forecast period. Europe is also expected to offer substantial growth opportunities over the forecast period.

          Impact of COVID-19 on false eyelashes Marlet

          COVID-19 has brought an instant halt to many industries around the world. Lockdown norms in several countries quickly affected the global economy by affecting supply chain, production and market demand. The direct and indirect impacts of the pandemic have been integrated into this report.

          To learn more about the impact of covid-19, get a free sample report here:

          https://www.stratviewresearch.com/Request-Sample/1235/false-eyelashes-market.html#form

          Who are the best market players?

          After in-depth analysis of the market, the experts have listed down few key players and discussed the company profiles of the players below –

          • Eyelashes
          • Ardell lashes
          • Blink Lash Store
          • emma eyelashes
          • GIANNI LASHES
          • eyelash house
          • Lemer Lashes
          • Qingdao LashBeauty Cosmetic Co., Ltd.
          • Royal Korindah
          • XIZI eyelashes

          What deliverables will you get in this report?

          – In-depth analysis of the false eyelashes market.

          – Detailed market segmentation.

          – Analysis of the competitive landscape.

          – Historical, current and future market size analysis.

          – Industry trends, technologies and advancements.

          – Growth and operating strategies adopted by key players.

          – Potential segments/regions offering promising growth.

          – Geographical presence of key players.

          Related reports that might be helpful:

          1. liquid eyeliner market
          Liquid Eyeliner Market, by Type (High Quality, Medium Quality, Low Quality), Distribution Channel (Online, Offline) and Region – COVID-19 Impact Analysis and Forecast to 2026.

          2. eyelash extensions market
          The global eyelash extensions market report is segmented by product (strips, cluster/accent, individual, others), by constituent (natural, synthetic), by distribution channel (online, convenience stores, hypermarkets and supermarkets) and by region.

          About Us –

          Stratview Research is a global market research company that offers reliable market reports, market entry strategies, strategic growth advice, and more. Market experts compile high-quality market information to help users gain granular level clarity on current business trends and expected future developments. Stratview Research also offers report customization. Contact the analysts to customize the given report according to your priority/requirement.

          Stratview Research has also launched “Composites”, an online portal that offers free thought leadership reports, white papers, market report summaries and more for the composites and related industries, worth $20,000 every year.

          Click here to register (free of charge): https://www.stratviewresearch.com/composites/sign-in

          Connect with the team of –

          Stratview Search
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          SOURCE Stratview Research

          Herbs, spices, fruits and other immune boosters straight from your kitchen

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          As we continue to brave the pandemic, particularly the Omicron variant of the coronavirus, the focus remains on health and immunity. Instead of buying things from pharmacies, people are again relying on home remedies and objects found in the kitchen.

          It’s no secret that Indian cuisines have a plethora of products that can boost immunity and help the body recover from illnesses faster. Vandana Juneja, expert lifestyle coach at GOQii, says our kitchens are full of all sorts of readily available and very effective ingredients to boost our immunity. She lists them here; continue reading.

          Spices

          “The essential spices are turmeric, cinnamon, black pepper, cumin seeds, fennel seeds, fenugreek seeds, ginger, garlic, etc. etc., or boil various concoctions and drink them as herbal tea,” says Juneja.

          * Turmeric – Rich in curcumin, the spice is the best immunity-boosting ingredient, as well as being helpful in many inflammatory conditions. It can be added to various dishes, but the best way to consume it is in hot milk or by mixing it with lemon and water as a drink.

          *Ginger- Ginger is considered the best immunity booster in Ayurveda; it cures many digestive disorders. It can be eaten raw or added to various recipes and masala tea.

          *Garlic- It is the most popular ingredient used in Indian dishes, due to its many medicinal properties. The best way to consume it is to have a clove of garlic (lightly crushed) on an empty stomach with water. The ideal time is early in the morning.

          These super spices can boost your health. (Photo: Getty/Thinkstock)

          * Cinnamon – It has antiviral, antibacterial and antifungal properties. The ingredient also contains antioxidants with anti-inflammatory effects that protect your body from disease. It also helps lower high blood pressure, improve gut, lower risk of type 2 diabetes and lower blood sugar. One can use the sticks or the powder and mix them in tea, dishes, lukewarm water or desserts.

          * Black pepper – Black pepper is an important spice due to its antioxidant, antimicrobial and gastroprotective properties. You can add it to curds, sprinkle on salads or in tea.

          * Cumin – Cumin contains compounds called flavonoids that act as antioxidants and have shown benefits in preventing cancer, heart disease, and blood pressure. It is also beneficial in weight loss, has antibacterial properties and improves digestion. It can be used as a seasoning in whole seeds or in powder form. Soaking a teaspoon overnight and having it in the morning is beneficial.

          Herbs

          *Tulsi- It has purifying properties that help fight respiratory illnesses, fever and other infections by boosting natural immunity. You can consume the leaves or make a juice and mix it with honey to relieve coughs, colds and mild fever.

          * Curry leaves – Curry leaves are high in antioxidants and high in vitamins and minerals like calcium and iron. They can be added in whole leaves in dishes or in chutneys; drink the juice of the leaves or boil them and consume the water.

          * Mint leaves – Mint leaves are a good source of several nutrients, especially vitamin A and antioxidants. They are used in chutneys, sauces, tea or detox water.

          citrus fruits

          Citrus fruits are rich in vitamin C, which helps increase the production of white blood cells that help fight infections. Oranges, lime, lemon, guava are examples. Out of these, amla/Indian gooseberry has the highest vitamin C content. Consume amla whole, extract its juice or add it to chutneys.

          herbs and spices, immunity boosters, cooking immunity boosters, home remedies, healthy eating, dairy, citrus, diet, Indian Express news Seasonal vegetables are excellent sources of vitamins and minerals. (Photo: Getty/Thinkstock)

          Seasonal vegetables

          Seasonal vegetables are excellent sources of vitamins and minerals, especially green vegetables like spinach, fenugreek leaves, mustard greens, etc., which are rich in vitamin C. They are also rich in antioxidants and beta-carotene, which can increase infection-fighting ability. of our immune system.

          Dairy

          Nutrients in dairy products play an important role in immunity, and every household consumes these products daily – milk, curd, ghee, paneer, cheese, etc. They are rich in vitamins A and D, protein, zinc and selenium and help boost immunity. Vegans can replace them with almond milk, soy milk, oat milk, coconut milk, etc.

          Nuts and seeds

          Nuts and seeds are rich in key immunity-boosting nutrients, such as vitamin E and omega-3 fatty acids, certain B vitamins and minerals, and should be consumed daily. The best way is to soak them for 5-6 hours and then eat them, or dry roast them or even make a trail mix and eat them at snack time.

          📣 For more lifestyle news, follow us on Instagram | Twitter | Facebook and don’t miss the latest updates!

          Announcement of Ornellaia 2019 “Il Vigore” and the 14th edition of Vendemmia d’Artista

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          The vigor of the vines interpreted through the visual brilliance of the artists Nathalie Djurberg and Hans Berg

          New York, NY, February 10, 2022 – Ornellaia, one of the world’s iconic wine estates, is delighted to unveil Il Vigore (“Vigor”), Artista’s latest Vendemmia dedicated to Ornellaia 2019 and described by Estate Director Axel Heinz: “’Il Vigore ‘ is the strength of good vine growth. It is the active vigor of mind and body. It is the character of a wine that captivates the senses and projects flavor into a natural landscape of energy, power, strength and vitality. The flavors, aromatic nuances and body of the wine transport it to a spiritual dimension, where the power of nature is at the center of the experience. The 2019 vintage served as an inspiration, characterized by highly variable conditions interspersed with cold spells and humidity and long periods of heat and drought. After a changeable spring and an almost perfect summer, the lower temperatures at the end of September gave wines of great finesse and aromatic abundance. It is a powerful, mysterious and intriguing wine, the first sip of which does not reveal all its facets, but envelops the palate, curious to grasp its myriad nuances.

          Artista’s Vendemmia project was born from this inspiration to celebrate each year the uniqueness of each season. Some of these exquisite labels will be up for sale at Sotheby’s online auction scheduled for October 5-19.and, 2022 before being delivered to happy collectors. Since 2019, profits have been donated to the Solomon R. Guggenheim Foundation to support the innovative Mind’s Eye program.

          Jamie Ritchie, Global Director of Sotheby’s Wine, explains: “Vendemmia d’Artista d’Ornellaia is a pioneering project, which involves the combination of wine and art to support charities. This month of October will be our 14th collaboration with the estate on this exceptional project. When we started this adventure, we had no idea that it would lead to a multitude of charitable projects in the world of wine. Our customers around the world always look forward to the opportunity to participate in the auction and purchase unique bottles, knowing that they are supporting a worthy cause that facilitates access to art for blind and visually impaired people. . The association between the extraordinary wines of the estate and the visual brilliance of the participating artists has proven to be an irresistible couple, which will shine this year for the 2019 vintage, “Il Vigore”, with the creations of Nathalie Djurberg and Hans Berg. .”

          The chosen artists have based their work on the theme of metamorphosis, the cycles of nature and its transformation, as well as the relationship between man and the earth. These concepts are expressed in a project that evolves from the design developed for the 750 ml and 3 liter labels to the sculptures for the large 6 liter and 9 liter formats.

          The finger, represented on the 750 ml label, which leaves an imprint on the earth, is a beautiful representation of wine, which arouses curiosity and the desire to gradually reveal itself before leaving a tangible imprint in a long tasting. In the glass, connoisseurs discover the energy that nature gives to plants and to man, but in particular to the region that expresses itself like blood: the blood of “Il Vigore”.

          Estate winemaker Olga Fusari describes the 2019 Ornellaia as “having a deep ruby ​​red color, with a rich bouquet of intriguing spicy and balsamic notes, including aromas of black pepper, sage and herbs. wine is full-bodied and vibrant on the palate, filling the palate with its dense, elegant tannins, and ending with a lingering and wonderfully refreshing finish.

          The sums collected within the framework of the Vendemmia d’Artista project make it possible to extend the program to all the museums of the Guggenheim constellation (New York, Venice, Bilbao). “Ornellaia’s generosity has enabled the expansion of Mind’s Eye, connecting participants around the world through virtual programs,” said Richard Armstrong, director of the Solomon R. Guggenheim Museum and Foundation. “Our learnings over the past three years have enabled the Guggenheim to increase accessibility to both the location and the artworks through multi-sensory exploration. We are grateful for Ornellaia’s continued support.

          Giovanni Geddes da Filicaja, CEO of Ornellaia Estate, is also delighted to state that “Since introducing Vendemmia d’Artista in 2009, we have donated over $2 million to charity. It is extremely gratifying to see the project expand internationally and to know that the work we do empowers blind and visually impaired people to experience contemporary art through the senses.

          About Ornellaia –

          The name Ornellaia is synonymous with fine winemaking and an authentic expression of the beauty of Tuscany. The estate is located along the Tuscan coast, a short distance from the medieval town of Bolgheri and the iconic cypress lined approach. Ornellaia Bolgheri DOC Superiore and Ornellaia Bianco are the best wines of the estate, followed by the second wine Le Serre Nuove dell’Ornellaia, Le Volte dell’Ornellaia and the white Poggio alle Gazze dell’Ornellaia. In just over thirty years (Ornellaia’s first vintage dates back to 1985), the team’s dedication, along with the optimal soil and microclimate, has garnered critical acclaim and public acclaim in Italy and abroad.

          About Artista’s Vendemmia

          Artista’s Ornellaia Vendemmia project celebrates the exclusivity of each new Ornellaia vintage. Each year, beginning with the release of Ornellaia 2006 in May 2009, a contemporary artist creates a site-specific artwork and a set of limited-edition labels, inspired by a word chosen by the estate’s director, Axel Heinz, to describe the personality of the new vintage.

          An artist-designed label appears on one of the six 750ml bottles in each case of Ornellaia. As in previous years, the project includes a limited edition of 111 large format bottles (100 Jeroboams – 3 litres, 10 Imperiales – 6 liters and 1 Salmanazar – 9 litres) numbered and personally signed by the artist. Each year, a selection of these bottles are auctioned off by Sotheby’s and the proceeds are donated to the Solomon R. Guggenheim Foundation’s Mind’s Eye program.

          About the “Mind’s Eye” program

          The “Mind’s Eye” program, created by the Guggenheim Department of Education, helps blind or visually impaired visitors experience art using all of the senses. This approach promotes the development of creative impressions, emotional connections and memories, the perception of which endures over time. As in art, the appreciation of good wine requires the involvement of all the senses. It is this common idea that led Ornellaia to support the development of this particular program. Donations collected through Artista’s Ornellaia Vendemmia project allow the Solomon R. Guggenheim Foundation to continue the activities of the “Mind’s Eye” program aimed at disseminating the model to other artistic institutions, ensuring that its excellence continues to guide museum programming for the benefit of blind and visually impaired people around the world.

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          Cellarity Expands Leadership Team to Continue Evolution of Breakthrough Platform to Code Biology and Purposefully Create New Medicines

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          CAMBRIDGE, Mass.–(BUSINESS WIRE)–Cellarity, a life sciences company founded by Flagship Pioneering to code and simulate human biology to reinvent the way we create medicines, today announced the expansion of its leadership team with three appointments keys. As Chief Scientific Officer, Laurens Kruidenier, Ph.D., will lead the continued evolution of Cellarity’s platform and pipeline and oversee cross-functional integration across all aspects of computation, drug creation and optimization. . As Chief People Officer, Anna O’Driscoll will lead the development of human resources and talent development strategies to enable Cellarity’s rapid growth and make the company a preferred place to work for talent. As Senior Vice President and Head of Data and Software Engineering, Parul Doshi will lead the development of a state-of-the-art and scalable data infrastructure to support the entire drug creation and development process. .

          “We are building a transformative company and bringing together a strong team of people with proven track records to make things happen,” said Fabrice Chouraqui, Ph.D., CEO of Cellarity and CEO-Partner at Flagship Pioneering. “Laurens is not only an exceptional translational scientist, with experience and successes that advance primary research into clinical-stage programs, he is also a team and business builder, helping to integrate and make evolve drug discovery platforms.”

          Dr Chouraqui continued, “Anna brings deep experience in developing talent and leadership in the biotech industry, and is known for her passion for positively impacting the employee experience. Parul not only brings a extensive expertise in data infrastructure across the entire pharmaceutical value chain, from preclinical and clinical operations to technology operations and commercialization, but also practical expertise in software engineering. I am delighted that these great leaders have joined us at this pivotal moment as Cellarity grows our team, advances key programs and develops a pipeline of important new therapies.

          Cellarity has developed unique capabilities to code biology and computationally model the changes that occur between health and disease to design breakthrough medicines. Cellarity’s transformative approach to drug creation goes beyond an individual molecular target to understand the complex biological web of cellular changes that underlie disease onset and progression. Built at the confluence of systems biology, single-cell data and machine learning, the Cellarity platform leverages a more comprehensive view of cell biology to create drugs with purpose. Since all disease originates from a disorder at the cellular level, Cellarity’s approach can be applied to virtually any disease and uncovers new biology and treatments that are unlikely to be found through discovery. target-based.

          “Despite the enormous strides made by the industry in advancing medical treatments, most diseases have no cures, and there are thousands of conditions that lack treatments,” said Dr Kruidenier. “I am impressed with Cellarity’s drug creation engine, which goes beyond the single target and encompasses the full complexity of human disease. I look forward to working with the team to realize the truly transformative nature of the Cellarity platform and to advance new drugs in various therapeutic areas into the clinic to address a wide range of patient needs.

          Laurens Kruidenier, Ph.D., Scientific Director

          Dr. Kruidenier has over 25 years of experience in frontier research, both in academia and in the life sciences industry and a track record of success in drug discovery and development, leading research programs towards clinical studies and integrating teams and technologies. for growth and scale. Prior to joining Cellarity, Dr. Kruidenier was Chief Scientific Officer (CSO) at Prometheus Biosciences, a precision medicine company in the area of ​​immune-mediated diseases. At Prometheus, he helped grow the company from an early-stage Cedars-Sinai-spin-out startup to a Nasdaq-listed platform-focused holding company with three active Phase 2 clinical trials. , he served as Vice President of Discovery at Second Genome, where he was responsible for a portfolio of microbiome programs and Head of Gastrointestinal Immunology Research at Takeda Pharmaceuticals, where he was responsible for development global discovery research and commercial development strategy in inflammatory bowel disease. Earlier in his career, Dr. Kruidenier held various positions in different discovery units at GlaxoSmithKline, where he led preclinical teams and drug discovery projects in immuno-inflammation, epigenetics and protein degradation. He completed his post-doctoral training at the University of London and holds an M.Sc. in medical biology from the University of Utrecht and a Ph.D. in mucosal immunology from Leiden University. His research has resulted in multiple publications in leading scientific journals, including Nature.

          Anna O’Driscoll, Director of Human Resources

          Ms. O’Driscoll has over a decade of human resources experience and was most recently vice president of human resources at Alnylam Pharmaceuticals, where she held positions spanning R&D, sales, corporate functions, learning and development and employee relations as Alnylam. has grown from a research organization to a leading biotechnology company. Prior to Alnylam, she was responsible for talent strategy and process at Shire and the human resources leadership development program at Johnson & Johnson. Ms. O’Driscoll holds an MBA from the Institute of Chartered Financial Analysts and a BA in Marketing and Languages ​​from Dublin City University.

          Parul Doshi, Senior Vice President, Head of Data and Software Engineering

          Ms. Doshi has over twenty years of experience in information technology (IT) and software engineering and was most recently head of IT and digital for Takeda’s Vaccines division. She has spent the past 16 years at Takeda, in roles of increasing seniority across multiple divisions of the company. In particular, she led the computer programs to launch the NINLARO oncology products® and ALUNBRIG® as well as the consolidation of the Vaccines Business Unit in Cambridge, Massachusetts and the integration of ARIAD Pharmaceuticals after the acquisition. Prior to Takeda, Ms. Doshi worked as a developer at Patni Computer Systems, serving large companies such as Fidelity Investments and LEGO.®. Ms. Doshi holds an MBA in Information Technology and Finance from Savitribai Phule Pune University and a BSc in Economics and Applied Statistics from the University of Rajasthan.

          About the winery

          Cellarity’s mission is to fundamentally transform the way medicines are created through the development of the first complete digital battery. Founded by Flagship Pioneering in 2017, Cellarity has developed unique capabilities combining high-resolution data, single cell technologies and machine learning to code biology, model interventions and purposefully design breakthrough medicines. By focusing on the cellular changes that underlie disease rather than a single target, Cellarity’s approach uncovers new biology and treatments and applies to a wide range of disease areas. The company currently has ongoing programs in the areas of metabolic disease, hematology, immuno-oncology and respiratory disease. The company raised $123m in a Series B funding round with contributions from funds and accounts managed by Blackrock, Baupost Group, Banque Pictet on behalf of their clients and eight other investors alongside of Flagship Pioneering. For more information, visit www.cellarity.com.

          About Flagship Pioneering

          Flagship Pioneering designs, creates, resources and grows best-in-class bioplatform companies to transform human health and sustainability. Since its launch in 2000, the company has, through its Flagship Labs unit, applied its unique hypothesis-driven innovation process to create and foster more than 100 scientific projects, generating a total value of more than 140 billions of dollars. To date, Flagship has deployed more than $2.6 billion in capital for the creation and growth of its pioneering companies, as well as more than $19 billion in follow-on investments from other institutions. The current flagship ecosystem comprises 42 transformative companies, including Axcella Health (Nasdaq: AXLA), Codiak BioSciences (Nasdaq: CDAK) Denali Therapeutics (Nasdaq: DNLI), Evelo Biosciences (Nasdaq: EVLO), Foghorn Therapeutics (Nasdaq: FHTX), Indigo Ag, Kaleido Biosciences (Nasdaq: KLDO), Moderna (Nasdaq: MRNA), Omega Therapeutics (Nasdaq: OMGA), Rubius Therapeutics (Nasdaq: RUBY), Sana Biotechnology (Nasdaq: SANA), Seres Therapeutics (Nasdaq: MCRB) and Sigilon Therapeutics (Nasdaq: SGTX).

          This Group Of NUS Students Has Some Pretty Interesting Inventions That Can Potentially Change The World – Mothership.SG

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          Imagine this: you have just graduated from Junior College, a polytechnic or an International Baccalaureate program, and you are studying courses to further your education.

          There are many factors to consider when choosing your degree: your interests, eligibility, strengths, and possible careers in the future.

          Perhaps one of the considerations you may want to look into is the accomplishments of alumni, research staff, as well as academic members of the department.

          The Department of Materials Science and Engineering (MSE) at the National University of Singapore (NUS) has a long list of interesting inventions and achievements that could prove useful in changing the world in the future. .

          Harvesting water from the air for agriculture

          NUS MSE students and faculty members are not afraid to get their hands dirty to come up with solutions creatively.

          For example, the conversion of water from thin air.

          Yes, apparently you can with a newly developed copper-based hydrogel created by Department Assistant Professor Tan Swee Ching.

          Dubbed “SmartFarm,” the hydrogel has the ability to absorb moisture from the air and convert it to water.

          The water is then used for an autonomous irrigation system without manual intervention.

          The SmartFarm is powered by solar energy and the hydrogel is used to absorb moisture from the air at night when the relative humidity is higher.

          The water is then released in the morning when exposed to the sun for irrigation.

          One gram of hydrogel releases approximately 2.24 grams of water in one hour.

          Not only could the hydrogel convert water from the air, but the water quality is judged to be drinkable according to the standard of the World Health Organization.

          This invention is not only applicable on Earth.

          The hydrogel was also tested in Hawaii’s Space Exploration Analogue and Simulation (HI-SEAS), a remote facility on Hawaii’s Mauna Loa volcano designed to simulate long-duration missions to the Moon and Mars.

          Tan used the hydrogel to control humidity in small experimental greenhouses to support crops of edible micro-green sunflower plants and mountain cress for astronauts on missions.

          The experiments showed that hydrogels offer a potential low-cost, low-weight, and low-energy solution for growing crops in self-contained farms in space.

          Bringing HOPE to Glaucoma Patients

          In addition to trying to solve real-world problems, NUS MSE also offers human-centered inventions aimed at easing the burden of those in need.

          NUS MSE graduate student Yu Kelu invented an award-winning invention after seeing how his father had to endure long hours in the hospital just to have his eyes checked for glaucoma.

          In collaboration with Benjamin Tee, associate professor in the department, Yu and his team succeeded in inventing a solution that allows patients to self-test in the comfort of their own home.

          Their invention won the James Dyson Prize in 2021 – the first time a team from Singapore has won the prize since its debut 17 years ago.

          the Home E-skin eye pressure sensor (HOPES) is designed for safe, accurate, painless and low-cost intraocular pressure (IOP) monitoring at home.

          IOP refers to the fluid pressure in the eye.

          Traditionally, measure IOP can be quite intimidating.

          Patients’ eyes are anesthetized using numbing drops, and a small amount of non-toxic dye is then placed in the eye.

          After which, an ophthalmologist will place the patient’s head in a slit lamp and a small tip will gently touch the surface of the eye and the pressure measurement will be taken.

          With HOPES, this daunting procedure may soon be a thing of the past.

          It uses a combination of electronic skin sensor (e-skin) and artificial intelligence (AI) technology to measure IOP.

          The device consists of a glove with fingertip sensors that are linked to a mobile app.

          Users only need to touch their eyelids with the glove.

          The sensors will then capture dynamic pressure information from the user’s eye and process it through machine learning algorithms to calculate eye pressure.

          Plant-derived biopolymer for surgical adhesions

          Plant-based diets are all the rage now, but this invention has nothing to do with food or diet.

          In medical terms, adhesions are fibrinous bands of internal scar tissue that cause tissues and internal organs that are usually separated to stick together.

          More than 90% of patients develop peritoneal adhesions following their first laparotomya surgical procedure that makes small incisions through the abdominal walls.

          As a result, they might suffer from small bowel obstruction, infertility, and pain in the pelvic region.

          An academic from NUS MSE managed to find a way to overcome this problem by using a plant-based biopolymer.

          Ng Wei-Beng, an associate professor in the department who is also an alumnus of the department, identified anti-fibrinolytic characteristics in a unique plant-derived biopolymer.

          Ng is also CEO and Founder of Sporogenics Pte Ltd.

          The naturally occurring biopolymer contains bioactive ingredients that can attenuate the cellular mechanism and fibrogenesis signaling pathway to treat post-surgical adhesions.

          It can be harvested and made into a film (for open surgery) or a sprayed gel (for keyhole surgery).

          Preclinical studies of the biopolymer in animals have shown promising results.

          It dramatically reduces post-surgical adhesions by over 90%.

          They plan to start their first human clinical trials in 2022.

          Nobel Prize-winning physicist joins NUS MSE

          NUS MSE students and researchers can also interact and learn from a Nobel Laureate, which many current students and faculty appreciate.

          Konstantin Novoselov joined NUS MSE as Emeritus Professor of Materials Science and Engineering in April 2019.

          He was also knighted by the Queen of England.

          Novoselov is the first Nobel laureate to join NUS.

          MSE is the only department in the College of Design and Engineering at NUS with a Nobel Laureate.

          Novoselov was the youngest winner of the Nobel Prize in Physics since 1971 and the youngest since 1992.

          Novoselov and Professor Andre Geim received the Nobel Prize in 2010 for their discovery of the two-dimensional material graphene.

          Graphene is considered one of the most exciting materials for technological research.

          It is tested in desalination filters to produce clean drinking water, in batteries, new generation LED bulbs and solar cells.

          At NUS MSE, Novoselov leads a research group focused on advanced materials.

          The group aims to discover interesting combinations of materials that can behave as smart sensors and microcomputing devices.

          Lab visits and virtual roadshows

          Of all the inventions and discoveries listed, NUS MSE has a good mix of science (physics, chemistry, biomedical) and engineering.

          The top-ranked department in the global ranking offers a multidisciplinary program that incorporates new elements such as innovation, entrepreneurship, data science, artificial intelligence and intellectual property for materials innovation in its curriculum.

          In this regard, NUS MSE is suitable for students interested in science and willing to apply this knowledge to real-world applications.

          Graduates of the program can have multiple career opportunities as the program prepares them for careers in research, industry and even entrepreneurship.

          If you want to know more about NUS MSE, you can leave your details on its admission microsite.

          You will receive personalized updates on the program via your email.

          You also have the opportunity to visit the laboratories of NUS MSE and learn more about the program and the research they pursue.

          You will also be able to attend virtual roadshows on current topics concerning MSE.

          Follow and listen to our podcast here

          Top images courtesy of NUS MSE.

          This sponsored article from the NUS Department of Materials Science and Engineering prompted the author to read scientific research articles.

          I’m vaxxed, boosted and just got Covid-19. Can I relax now?

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          At the start of the pandemic, recovery from coronavirus infection was perhaps cause for cautious optimism: if you were lucky enough to bounce back from Covid-19, you had some level of immunity. Over time, research confirmed this, although it also showed that immunity wanes, so recovering from the virus was not a one-off affair. So how should vaccinated people think about their immunity after recovering from a breakthrough infection?

          After an outbreak of omicron that infected hundreds of thousands of people a day in the United States – including many people who had breakthrough cases – some wonder if the combination of vaccination and infection, known under the name of hybrid immunity, will offer a kind of long-lasting protection. Is this contact with the virus sufficient to justify relief and a return to life without pandemic precautions? Vox spoke to experts to help advise new recoveries.

          What does a Covid-19 infection do for my immunity?

          Immunity is defined as your body’s ability to protect you from disease when you are exposed to bacteria, viruses, parasites, or fungi. immunity can help protect you from infection in the first place, and if you are infected, it can prevent you from feeling sick or protect you from serious symptoms. Depending on the type of infection, this type of protection can last for months, years or even a lifetime. For example, once a person has recovered from measles, they are immune for life and will not get it again. But most illnesses are not one and finite. Immunity to Covid-19 can last for months, but it weakens over time and the exact duration is still under investigation.

          Everyone’s body and immune system react differently to the viruses they encounter. Unlike vaccines, which deliver a standard size and formula to large populations, “having a Covid infection is a very non-standardized thing,” says Theodore Bailey, chief of the division of infectious diseases at Greater Baltimore Medical Center. (Even though everyone’s immune system reacts differently to the same dose of vaccine — someone might have severe side effects and others might have none — the shots themselves are standardized.)

          If you’ve tested positive for Covid-19, it’s unclear how much of the virus you’ve been exposed to, how well it’s managed to reproduce in your body, and how committed your immune system is to fighting it. . It is therefore difficult to know to what extent you will also be protected. “One person’s infection is not someone else’s infection,” Bailey says.

          Studies show that before omicron arrived, recovering from Covid-19 infections made people much less likely to get infected again – at least for several months. But omicron seemed to behave differently: a non-peer-reviewed study conducted during the omicron wave in England found that omicron has the potential to evade immunity from past infection or two doses of vaccine. Similarly, another non-peer-reviewed Danish study found that omicron was able to evade immune responses in both vaccinated and unvaccinated people (although a small South African study showed that infection with omicron could protect against delta, which now includes a small minority of cases in the United States).

          For vaccinated people who get sick, breakthrough infections boost immunity, according to a December study. “People who have had both the disease and the vaccination have much higher antibody levels than people who have just recovered and have not been vaccinated,” says William Schaffner, professor of infectious diseases at Vanderbilt. University Medical Center. “And higher antibody levels are associated with longer duration of protection.” If you have recently recovered from Covid-19 and are not vaccinated, Schaffner advises getting vaccinated to take advantage of this protective combination.

          Is it safe to go to restaurants and bars after a Covid-19 infection?

          It’s extremely unlikely that you’ll be re-infected with the same variant within a month or two of recovering from Covid-19, Bailey says. A scientific review of published research on immunity to Covid-19 has suggested antibody levels begin to decline three months after a previous infection. However, when you gain immunity to one variant, you don’t necessarily gain immunity to the others: it’s possible to be quickly reinfected by omicron after recovering from the delta. So a breakthrough infection is not permission to live like it’s 2019.

          Because there will always be a risk of reinfection, Bailey suggests thinking about immunity in the weeks following recovery much like airbags in a car. Airbags protect drivers from serious injury, but risky behavior like texting, speeding or reckless driving negates the benefits of the airbag. Something similar is true for post-infection immunity: Antibodies offer protection, but persistent high-risk activities — like unmasking in a crowded bar — increase the risk of reinfection.

          That’s not to say recently recovered people don’t have any leeway. They just have to decide how much risk they are willing to tolerate. In the first few months after infection, most healthy vaccinated people who aren’t immunocompromised have a low risk of serious reinfection, Bailey says, meaning they can move around the world knowing that a visit to the gym won’t kill them.

          “They have a similar level of risk to other things we tolerate,” like highway driving, Bailey says. “So doing things like going to restaurants, potentially traveling, becomes something safer, and it’s even safer if you wear masks as much as you can and you’re not really going to do things. at very high density like a rave or a mosh pit.These things will further increase your risk.

          What other fun activities can I do safely now, and what precautions are needed?

          If you’re planning on getting on a plane or attending an indoor sporting event, Bailey says to make sure you always take precautions, such as masking up and avoiding crowds as best you can. “Even though I have my airbag, I’m still going to put on my seatbelt, I’m still going to pay attention to traffic,” he says. “As I take on this additional level of risk, I consider what else I can do in my immediate environment to limit the unnecessary elevation of risk.”

          Schaffner agrees that recently recovered people should always be wary of crowds and should continue to mask up indoors. “It’s not recommended that they be reckless and say, ‘Okay, I got a release card, I can do whatever I want,'” he says. If you decide to go on vacation after illness, be sure to continue testing and masking, especially if you’re visiting an elderly grandparent or immunocompromised friend during or after your trip, advises Schaffner.

          Although Schaffner says it’s unlikely in the short term that you’ll pick up an infection and spread it, it’s still possible. The more time passes after you recover, the more likely it is that you can be reinfected and spread the virus. The CDC continues to recommend that anyone who tests positive self-isolate, even if they are asymptomatic.

          The risk of future variants should make people a bit more cautious about post-infection behavior, Schaffner says. When a new variant emerges, the world may face another round of wait-and-see uncertainty about how well vaccination, protection from previous infection, and hybrid immunity hold up against the mutated virus.

          Ultimately, the activities you decide to participate in after recovering from Covid-19, Schaffner says, comes down to the level of risk you’re willing to bear. “If you are 72 and have diabetes, everything is at risk. That’s what I would tell all my patients,” he says. “If you’re 28 and otherwise perfectly healthy and have recovered, the first thing I would ask you is, ‘Are you vaccinated? These people can go out. But because nothing is “safe” or comes without risk, he recommends everyone wear masks in indoor environments.

          As cases go down, the overall risk will also go down: less virus in the community means less chance of catching it and spreading it. On top of that, you can probably breathe a sigh of relief for a few weeks after infection, as long as you continue to avoid unnecessary risks, like crowded dance floors, and mask up around your vulnerable loved ones and anyone outside your household.

          Research reveals why more black women are dying of breast cancer

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          Credit: Unsplash/CC0 public domain

          New research from Sanford Burnham Prebys has revealed significant molecular differences between white and black women’s breast cells that help explain why black women experience higher breast cancer mortality. The results, published on February 8 in the journal Therapeutic advances in medical oncologysuggest that modifying current diagnostic and treatment strategies could help reduce the disparity.

          “How each human responds to cancer treatment is influenced by many internal and external factors unique to us,” says Svasti Haricharan, Ph.D., assistant professor at Sanford Burnham Prebys. “The scientific community needs to face this and invest time and money to understand it, because everyone deserves care that is as tailored to their molecular makeup as possible.”

          Haricharan and her team found significant differences between white and black women in how DNA repair genes are expressed, both in healthy breast tissue and in estrogen receptor positive (ER+) tumors. ), which is one of the most common forms of breast cancer. These molecular differences also corresponded to changes in the growth rate of breast cancer cells.

          “What we see here is a tangible molecular difference in how these cells repair damaged DNA – a critical factor in cancer development – which affects how cells grow and reproduce in tumors,” explains Haricharan.

          Black women with breast cancer: Worse outcomes, less research

          Black people have the highest cancer death rate of any racial or ethnic group. Among black women, breast cancer accounts for about a third of all cancer diagnoses, with ER+ breast cancer being the most common. Black women with ER+ breast cancer are 42% more likely to die from the disease than white women, and while there are lifestyle and socioeconomic factors that contribute to this disparity, such than access to health care, they are not enough to fully explain the difference. .

          “Society has internalized the narrative that lifestyle factors are to blame for racial differences in health outcomes, so most scientists don’t look at molecular-level differences between people,” says Haricharan. “It also makes sick people feel like they’re somehow at fault for the way they live their lives. Now we see it’s so much more complicated than that.”

          A barrier to fully exploring disparities between white and black women with breast cancer is the historical lack of data on non-white patients.

          “Black women are severely underrepresented in virtually all patient tumor datasets, so many past breast cancer findings only accurately reflect what happens to white women,” Haricharan says. “We hope our research will highlight the need to more closely study cancer in different racial and ethnic groups and improve outcomes for historically marginalized patients.”

          Black women’s cells repair DNA differently

          DNA repair is a fundamental part of normal cellular function, regulating processes throughout the cell and helping them recover from errors that occur naturally during DNA replication or in response to external factors. like stress. Unlike healthy cells, cancer cells often acquire genetic changes that prevent them from repairing DNA, which can make these cells resistant to treatment.

          “We have already seen how defects in DNA repair lead to resistance to treatment in breast cancer. But until now, there were no studies to measure how much this differs in women. black versus white women or what explains this difference,” Haricharan said. .

          To fill this gap, the researchers examined both healthy and tumor tissue from 185 black women and compared them to samples from white women. They found that eight genes fueling DNA repair are expressed differently in black women. They also found consistent molecular differences in cellular signals controlling cell growth rate.

          Notably, these differences were not limited to cancer cells — even healthy tissue showed a different gene expression pattern in black women compared to white women.

          “It’s so important because if normal tissue is different at the molecular level based on race or ethnicity, then everything we understand about how each of us responds to cancer treatment will also be different.” , adds Haricharan.

          Towards better precision medicine

          The study demonstrates how precision medicine for ER+ breast cancer could be quickly and easily improved by taking ancestry into account when prescribing treatments. Specifically, the findings suggest that black women may benefit from early treatment with CDK inhibitors, a class of drugs that help prevent cancer cells from multiplying by blocking biochemical signals called cyclin-dependent kinases (CDKs). .

          Current clinical guidelines for the use of CDK inhibitors suggest that they should only be used after seeing progress in standard hormone therapy, which means that for some women, at the time they receive CDK inhibitors, their disease has progressed too far. The team found that there are significantly higher levels of one type of CDK in the tumor tissue of black women, suggesting that at least a subset of black women could benefit from earlier treatment. with CDK inhibitors.

          “It’s something we can act on immediately, because helping these women is less about finding a new drug and more about changing the schedule of treatments we already have,” says Haricharan.

          In a broader sense, the study highlights the critical need for more inclusive biomedical research that understands and respects the need to represent each patient’s unique biology when building datasets and formulating research. hypotheses to be tested in the laboratory.

          “The more we look for differences between groups, the more we’re going to find,” says Haricharan. “We need to build better datasets so that we can stop viewing what we observe in white people as the default of all biology, which creates fundamental inequality in biomedical progress.”


          Why Black Women Need Cervical Cancer Screening


          More information:
          Aloran Mazumder et al, The landscape of DNA damage repair in black women with breast cancer, Therapeutic advances in medical oncology (2022). DOI: 10.1177/17588359221075458

          Supplied by Sanford Burnham Prebys

          Quote: Research reveals why more black women are dying from breast cancer (February 8, 2022) Retrieved February 8, 2022 from https://medicalxpress.com/news/2022-02-reveals-black-women-die-breast.html

          This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

          Frontier Medicines Announces Renowned Physician Scientist

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          SOUTH SAN FRANCISCO, Calif., Feb. 08 2, 2022 (GLOBE NEWSWIRE) — Frontier Medicines Corporation, a precision medicine company seeking to unlock the proteome to advance breakthrough therapies against otherwise untreatable pathogen targets, today announced Piro Lito, MD, Ph.D. ., associate member and attending physician at Memorial Sloan Kettering Cancer Center (MSK), has joined its Scientific Advisory Board.

          “We are thrilled to have Dr. Lito join our Scientific Advisory Board, comprised of industry leaders in oncology, drug development and discovery research,” said Chris Varma, Ph.D., Co-Founder, President and CEO. from Frontiers. “Dr. Lito is a world-renowned physician-scientist who studies KRAS mutations and their impact on intracellular signaling and cellular function. We look forward to working with him as we move our core program, a dual KRAS inhibitor inactive and activatedG12Ctowards the selection of clinical candidates.

          Dr. Lito’s research focuses on proteins that stimulate cancer cell growth with the goal of uncovering the fundamental processes that govern tumor biology and identifying new therapies that prolong survival and improve quality of life for patients. with cancer. Specifically, his research has made several key contributions in the effort to better understand KRAS-induced cancers and to develop therapies that directly target mutant KRAS. Dr. Lito’s lab also examines the heterogeneity that exists within tumor cells and combines single-cell sequencing methods with biosensor technologies to map how different tumor populations respond to treatment, which could lead to a understanding of variable responses to cancer treatment. Dr. Lito obtained his Ph.D. in biochemistry and molecular biology and his medical degree from Michigan State University. He completed his residency in internal medicine at Beth Israel Deaconess Medical Center at Harvard Medical School and his fellowship in medical oncology at MSK. Dr. Lito is board certified in internal medicine and medical oncology.

          Dr Lito added: “Frontier aims to develop drugs targeting some of the most important proteins for cancer cell growth and has the potential to impact cancer care. We know that KRAS periodically switches between enabled and inactive states. Blocking these two states could constitute an important innovation in the care of patients whose tumors harbor a KRAS mutation. I look forward to collaborating on these programs.

          About Frontier Medicines
          Frontier Medicines is a precision medicine company that has launched a powerful discovery and development platform designed to generate drugs against pathogenic proteins previously considered unmedicable. The company deploys its technologies in chemoproteomics, covalent drug discovery and machine learning to potentially develop breakthrough drugs for genetically defined patient populations, starting with cancer. Frontier is advancing its proprietary precision drug portfolio against key cancer drivers. The main program of the company is focused on KRASG12C and is distinctive in that it targets the direct inhibition of activated and inactive forms of KRASG12C. This KRAS mutation is most commonly found in patients with non-small cell lung, colorectal, and pancreatic cancers. For more information on how Frontier is boldly advancing science to defeat disease, visit www.frontiermeds.com and follow us on LinkedIn and Twitter.

          Frontier Medicines Media:
          [email protected]

          Food Testing Equipment Market Trends by 2022-2028

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          Understand the influence of COVID-19[feminine sur le Marché des équipements de test alimentaire avec nos analystes surveillant la situation à travers le monde. Demander maintenant

          Aperçu du marché des équipements de test alimentaire | 2022 – 2028

          Le marché mondial des équipements de test alimentaire couvre des informations explicites concernant le taux de développement, les estimations du marché, les moteurs, les limites, la demande future et les revenus au cours de la période de prévision. Le marché mondial des équipements de test alimentaire se compose de données accumulées à partir de nombreuses sources primaires et secondaires. Ces informations ont été vérifiées et validées par les analystes de l’industrie, fournissant ainsi des informations importantes aux chercheurs, analystes, gestionnaires et autres professionnels de l’industrie. Ce document aide en outre à comprendre les tendances du marché, les applications, les spécifications et les défis du marché.

          Le rapport sur le marché mondial des équipements de test alimentaire propose une étude de recherche de haute qualité, éprouvée et de grande envergure pour fournir aux acteurs des données précieuses pour prendre des décisions commerciales éclairées. Les chercheurs et analystes ont fourni une analyse approfondie de la segmentation du marché en fonction du type, de l’application et de la géographie. Le rapport met également en lumière le paysage des fournisseurs, pour informer les lecteurs de l’évolution de la dynamique du marché.

          Obtenez un échantillon PDF de ce rapport @ https://www.marketreportsinsights.com/sample/22623

          Grandes entreprises :
          Gilson Company, Bruker, Intertek, Research International, Qiagen, Thermo Fisher Scientific, Bio-Rad, 3M Food Safety, Ametek, Neogen, Marshfield Food Safety, Laboratoires Fort Richard, Nuaire

          Les statistiques de marché mondiales, régionales et autres, y compris le TCAC, les états financiers, le volume et la part de marché mentionnés dans ce rapport, peuvent être facilement invoquées à la lumière de leur haute précision et de leur authenticité. Le rapport fournit également une étude sur la demande actuelle et future du marché mondial des équipements de test alimentaire.

          Les principaux types de marché sont :
          q-PCR
          d-PCR

          Les principales applications du marché sont :
          Aliments
          Agriculture
          Autre

          Pour une remise instantanée, cliquez ici https://www.marketreportsinsights.com/discount/22623

          Analyse régionale pour le marché des équipements de test alimentaire

          Amérique du Nord (États-Unis, Canada et Mexique)
          L’Europe  (Allemagne, France, Royaume-Uni, Russie et Italie)
          Asie-Pacifique (Chine, Japon, Corée, Inde et Asie du Sud-Est)
          Amérique du Sud (Brésil, Argentine, Colombie, etc.)
          Le Moyen-Orient et l’Afrique (Arabie saoudite, Émirats arabes unis, Égypte, Nigéria et Afrique du Sud)

          Méthodologie de la recherche

          Le rapport a été consolidé à l’aide de trois méthodologies de recherche. La première étape s’articule autour de recherches primaires et secondaires exhaustives, qui comprennent une vaste collection d’informations sur le marché mondial des équipements de test alimentaire et le marché parent et pair. L’étape suivante consiste à valider la taille du marché, les estimations, les conclusions et les hypothèses avec des informations plus précises provenant d’experts du secteur. Le rapport obtient une estimation complète de la taille du marché à l’aide d’approches ascendantes et descendantes. Enfin, le rapport obtient l’estimation du marché de tous les segments et sous-segments à l’aide de procédures de triangulation des données et de répartition du marché.

          Table des matières

          Présentation du rapport : L’aperçu du rapport comprend l’étude de la portée du marché, les principaux acteurs, les segments et sous-segments de marché, l’analyse du marché par type, application, géographie et les chapitres restants qui éclairent l’aperçu du marché.

          Exécutif : Le rapport résume les tendances et les parts de marché des équipements de test alimentaire, l’analyse de la taille du marché par région et par pays. Dans l’analyse de la taille du marché par région, une analyse de la part de marché et du taux de croissance par région est fournie.

          Profils des joueurs internationaux : Cette section présente également quelques des principaux acteurs opérant sur le marché mondial des équipements d’analyse des aliments, en fonction de divers facteurs tels que l’aperçu de l’entreprise, les revenus, l’offre de produits, le ou les développements clés, les stratégies commerciales, l’analyse des cinq forces de Porter et l’analyse SWOT.

          Étude régionale : Les régions et pays mentionnés dans cette Les études de recherche ont été étudiées en fonction de la taille du marché par application, produit, acteurs clés et prévisions du marché.

          Joueurs clés: Cette section du rapport sur le marché des équipements de test alimentaire explique les plans d’expansion de les principaux acteurs, l’analyse des investissements, le financement, les dates de création des entreprises, les revenus des fabricants et les régions desservies.

          Obtenez le rapport complet @ https://www.marketreportsinsights.com/industry-forecast/global-food-testing-equipment-market-growth-2021-22623

          Enfin, l’étude de marché sur les équipements de test alimentaire fournit essentiel des informations sur les principaux défis qui vont influencer la croissance du marché. Le rapport fournit en outre des détails généraux sur les opportunités commerciales aux principales parties prenantes pour développer leur activité et générer des revenus dans des secteurs verticaux précis. le rapport aidera les entreprises existantes ou à venir sur ce marché à examiner les différents aspects de ce domaine avant d’investir ou de développer leurs activités sur le marché Équipement de test alimentaire.

          Nous contacter:
          Aperçu des rapports de marché
          [email protected]



          Juror Scott Peterson will receive immunity

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          The juror at the heart of allegations of misconduct by Scott Peterson in her quest for a new trial will be granted immunity before testifying on February 25.

          Stanislaus County District Attorney Birgit Fladager said Monday she intends to grant immunity and will prepare a document if Richelle Nice invokes the Fifth Amendment, as her attorney had announced.

          The issue was one of about 20 discussed at a motion hearing ahead of an evidence hearing beginning Feb. 25 and continuing through early March. Superior Court Judge Anne-Christine Massullo will decide within 90 days of the conclusion of the hearing whether to overturn Peterson’s conviction for the murders of his wife Laci and their unborn son Conner.

          Peterson’s attorney alleges Nice – identified in court documents as juror 7 – lied during the jury selection process for Peterson’s 2004 trial when she wrote on a questionnaire that she had never been victim of a crime or involved in a trial.

          They claim she wanted so badly to judge him, “in part to punish him for hurting her unborn child – a crime she personally suffered when (an attacker) threatened her life and that of her unborn child.”

          Nice was pregnant in 2001 when she got a restraining order — a kind of lawsuit — against her then-boyfriend’s former girlfriend for harassing and threatening them. Additionally, the previous year, the same boyfriend had been arrested on domestic violence charges in an incident that named her as a victim.

          Prosecutors argue the questionnaire asked if she had ever been tried and Nice did not understand that a restraining order is a type of trial. Regarding the domestic violence incident, Nice filed a statement describing the incident as a “heated argument.” She said it was her then-boyfriend, not her, who called the police and she did not see herself as a victim.

          It is this statement, should her testimony deviate from it, that makes her vulnerable to a potential perjury charge, according to her attorney.

          During Monday’s hearings, there were also questions about whether a book Nice co-wrote, letters she wrote to Peterson on death row, or things she said to other people , all after the trial, could be presented as evidence of his alleged bias.

          “Events that occurred after the verdict in this case are not helpful to this investigation and are not relevant,” the prosecution wrote in its motion. They asked the court “to exclude all attempts by (Peterson’s attorneys) to obtain post-verdict media interviews, pseudo-documentaries, alleged re-enactments, post-verdict letters allegedly written by Juror 7, etc.”

          Peterson’s attorney responded that Nice “has literally been in dozens of media interviews about his involvement in the case. She took the extraordinary step of entering into a lengthy correspondence with Mr. Peterson while he was on death row…(and) made numerous statements about her role in the case.

          They said the district attorney “carried the heavy burden of proving no harm…the question is not when those statements were made, but what those statements are.”

          Judge Massullo said there may be valid reasons why Peterson’s lawyers want to present certain information that came out after juror number 7 completed her questionnaire.

          She said it would be premature to rule anything out now and the prosecution could raise objections when hearing evidence.

          Other issues were tracked until a hearing scheduled for February 17, such as who can testify remotely or wear a face shield instead of a mask and who can be present in court. Many of these issues could change as the state’s current mask mandate is due to expire on February 15.

          Modesto Bee Related Stories

          Erin Tracy covers criminal justice and breaking news. She started working at the Modesto Bee in 2010 and previously worked at newspapers in Woodland and Eureka. She graduated from Humboldt State University.

          Jacobs Acquires Mobility Analytics Leader StreetLight Data, Inc

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          StreetLight’s on-demand analytics transform transportation and infrastructure solutions, enabling smarter, more impactful investments

          DALLAS, February 7, 2022 /PRNewswire/ — Jacobs (NYSE: J) today announced the acquisition Street Lighting Data, Inc. (“StreetLight”), a mobility analytics pioneer that uses its vast data and machine learning resources to shed light on mobility, empowering users to solve complex transportation problems. The addition of StreetLight accelerates Jacobs’ strategy by growing its end-to-end digital solutions portfolio and focusing on ESG, while adding high-growth, highly recurring revenue software businesses that deliver significant value to its customers and the communities they serve.

          Jacobs Logo (PRNewsfoto/Jacobs)

          StreetLight applies proprietary processing technology to location data from millions of mobile devices, connected vehicles, IoT sensors and geospatial databases to measure multimodal travel patterns – and makes it available through its SaaS (Software as a Service) online StreetLight InSight®. Designed for smart cities and the transportation industry, the on-demand software provides industry-targeted analysis tools to support critical infrastructure planning, investment, and policy decisions.

          “The past two years have accelerated structural changes in human mobility, infrastructure and supply chain planning, which have resulted in increased investment from governments and businesses around the world. We also see a need critical of data-driven planning to meet carbon emissions targets, address energy transformation and advance social equity through infrastructure investments,” said Jacobs President and CEO Steve Demetriou. “There is a global need for solutions that help us better understand the movement of people, goods and services while addressing broader societal challenges, and our acquisition of StreetLight reinforces our leadership in this rapidly growing field.

          StreetLight’s suite of powerful analytics enables all major transportation verticals to make much more informed investment decisions while measuring critical impacts. Offering more than a modern alternative to traditional measurement methods with months of lead time and limited scope, the company’s technology has enabled industry to solve complex problems, such as planning electric vehicle networks in forecasting future demand, recommending optimal traffic pattern improvements and helping to ensure equitable access to transportation.

          “We chose Jacobs because they truly share our mission and recognize the importance of StreetLight’s digital innovation in adapting their own core practices to the needs of a changing industry,” said StreetLight’s CEO. Laura Schewell. “They have the global scale to rapidly accelerate customer decision-making at a pivotal time for infrastructure investment and its impact on climate and society.”

          StreetLight has a long history of supporting transportation agencies at the federal, state, regional and municipal levels, transportation engineering and consulting firms, and private enterprises spanning the new mobility, automotive, transport and transport sectors. ‘IoT and utilities. The company’s metrics informed transportation analyzes in all states and provinces of the North America.

          Demetriou continued, “We constantly seek to add value for our shareholders, create transformative solutions for our clients and make a positive difference within our communities. Like Jacobs, StreetLight is purpose-driven and shares our commitment to creating a more connected and sustainable society. world.”

          One of the growth accelerators of Jacobs’ new strategy is centered about data solutions aligned with high growth markets with increasing margin profiles. Building on its strong foundation of existing data technologies and capabilities, the company also recently acquired BlackLynx, a provider of cutting-edge edge computing, hybrid cloud and collection automation technologies. industry serving the intelligence, defense and critical infrastructure sectors. Jacobs’ portfolio of data and technology investments will be leveraged in tandem to create expanded market penetration, growth opportunities and solutions for its customers.

          For more information on the StreetLight acquisition, visit the Investor Relations page on Jacobs.com.

          Advisors

          Centerview Partners served as exclusive financial advisor to Jacobs, and Fried, Frank, Harris, Shriver & Johnson LLP served as legal advisor to Jacobs. Raymond James served as exclusive financial advisor to StreetLight Data and DLA Piper served as legal advisor to StreetLight Data.

          About Jacob

          At Jacobs, we strive today to reinvent tomorrow by solving the world’s most critical problems for thriving cities, resilient environments, critical outcomes, operational advancements, scientific discovery and advanced manufacturing, transforming ideas abstracts into world-transforming realities. for real. With $14 billion in revenue and a talent force of approximately 55,000 people, Jacobs provides a full range of professional services, including consulting, technical, scientific and project delivery services for the public and private sector. Visit jacobs.com and connect with Jacobs on Facebook, instagram, LinkedIn and Twitter.

          About StreetLight

          StreetLight is a pioneer in using big data analytics to help transportation professionals solve their biggest problems. By applying proprietary machine learning algorithms to more than four trillion spatial data points over time, StreetLight measures various travel patterns and makes them available on demand through its mobility SaaS platform, StreetLight InSight.®. Whether identifying sources of congestion, optimizing new infrastructure, planning self-driving vehicles, or improving the location of outdoor advertising and commercial facilities, StreetLight powers more than 10,000 global projects each month. Visit streetlightdata.com for more information.

          Forward-looking statements

          Certain statements contained in this press release constitute forward-looking statements as defined in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and such statements are intended to be covered by the safe harbor provided by the same. Statements made in this release that are not based on historical fact are forward-looking statements. Examples of forward-looking statements include, but are not limited to, statements regarding our expectations regarding the future growth of StreetLight Data and the expected benefits of the acquisition. We base these forward-looking statements on management’s current estimates and expectations as well as competitive, financial and economic data currently available. Forward-looking statements, however, are inherently uncertain. There are a variety of factors that could cause actual business results to differ materially from our forward-looking statements, including, but not limited to, our ability to execute our technology-driven strategy, competition from existing and future competitors in the markets in which StreetLight Data operates, the level and timing of federal and state transportation funding, uncertainty over data protection and data privacy regulations, Jacob’s ability to achieve the cost savings and synergies contemplated by the proposed transaction on schedule and to successfully integrate the business while retaining key personnel, as well as general economic conditions and the impact of the COVID-19 pandemic, including the emergence and spread of variants of COVID-19, and the related reaction of governments to global market conditions and regional and corporate affairs. For a description of certain additional factors that may arise that could cause actual results to differ from our forward-looking statements, see the discussions contained in Section 1 – Business; Item 1A – Risk Factors; Item 3 – Legal Proceedings; and Item 7 – Management’s Discussion and Analysis of Financial Condition and Results of Operations in our most recently filed Annual Report on Form 10-K, as well as in the company’s other filings with the Securities and Exchange Commission. The company is under no obligation to update any forward-looking statements after the date of this press release to conform to actual results, except as required by applicable law.

          For press/media enquiries:
          Kerrie Sparks
          214.583.8433

          For investors:
          Jonathan Doros
          817.239.3457

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          SOURCE Jacobs

          Several studies illustrate the widespread damage caused by COVID-19

          0

          Typically, whatever a person’s condition, COVID-19 makes it worse. But COVID-19 also causes certain conditions or is implicated in their early onset. Type 1 diabetes and Parkinson’s disease are prime examples. Now researchers report that the SARS-CoV-2 virus can also cause fetal inflammation, even when the placenta itself is not inflamed.

          Nardhy Gomez-Lopez and his colleagues from Wayne State University, editing in Nature Communication, reported the link between the virus and fetal inflammation. The group also noted that pregnant women who were infected with the SARS-CoV-2 virus during pregnancy had a higher risk of serious illness resulting from the virus, as well as a higher risk of premature delivery, stillbirth and preeclampsia.

          Researchers examined 23 pregnant women, 12 of whom tested positive for COVID-19. Of these, eight were asymptomatic, one had mild symptoms and three had severe symptoms. Comparing those with COVID-19 to those without infection, researchers noted changes in antibodies, immune cell types, and inflammatory markers in maternal blood, umbilical cord blood, and placental tissues among the COVID-19 group. 19, whether the mothers were symptomatic or not. or asymptomatic.

          Specifically, mothers with COVID-19 grew fewer T cells, developed antibodies against SARS-CoV-2 that were found in umbilical cord blood, and had more cytokines (specifically IL-8, IL -15 and IL-10) in their blood – regardless of symptoms.

          “We found that in pregnant mothers who contract the virus, SARS-CoV-2 induces a fetal immune response even in the absence of placental infection or symptoms in the newborn,” Gomez-Lopez said in a declaration. Their babies had an inflammatory response that was evidenced by higher levels of IL-8, even though the fetus did not have COVID-19. Similarly, although the SARS-CoV-2 virus was not present in the placentas, the placentas of the infected mothers had altered ratios of immune cell types.

          Although this study suggests that placental infections associated with COVID-19 are rare, pregnant women are at increased risk of hospitalization, need for mechanical ventilation, admission to intensive care and preterm delivery, but not mortality. , the researchers noted.

          “The potential long-term effects of this inflammatory process on infants require further study,” Gomez-Lopez said.

          In other research late last year, Slav A. Semerdzhiev and his colleagues at the University of Twente in the Netherlands showed, in vitro, that the SARS-CoV-2 virus causes early-onset Parkinson’s disease. the articlePosted in ACS Chemistry Neurosciences, explained that this occurs when the N protein of SARS-CoV-2 interacts with a neuronal protein called α-synuclein, which then accelerates the formation of amyloid fibrils. These fibrils are a defining feature of Parkinson’s disease.

          In this study, previously reported in BioSpace, aggregation started as early as 9 a.m. and usually peaked at around 20 a.m., depending on the concentration (which ranged from 0.1 μM to 1 μM) of protein N injected into the 10 mM NaCl sample. Without the presence of the SARS-CoV-2 virus, aggregation began at 240 hours and peaked around 280 hours. This rapid acceleration of the formation of multiprotein complexes and their aggregation into amyloid fibrils indicates that “protein N facilitates the formation of a core critical for aggregation,” the researchers concluded.

          By mid-2021, it had become clear that the SARS-CoV-2 virus was also causing – and not accelerating – type 1 diabetes. newly diagnosed diabetic patients were at greater risk of death from COVID-19 than known diabetics.

          the National Institutes of Health cited two studies in which people developed type 1 diabetes after acute COVID-19 infections. As these studies have reported, the SARS-CoV-2 virus can kill pancreatic beta cells (which produce insulin), alter their productivity and/or reprogram them.

          Their knowledge shows that the SARS-CoV-2 virus infects beta cells more frequently than other cells. The infection is linked to the interaction of the virus with neuropilin, which is found in greater abundance on the surface of pancreatic beta cells than on other pancreatic cells. Blocking the interaction between SARS-CoV-2 and neuropilin prevented the virus from infecting beta cells, and thus prevented people who contracted COVID-19 from also developing diabetes.

          Xuming Tang’s study of Weill Cornell Medicine and colleagues, published in Cell metabolism in 2021 detected the SARS-CoV-2 viral antigen in pancreatic beta cells taken from autopsy specimens of people who contracted COVID-19. “Several types of pancreatic islet cells were susceptible to SARS-CoV-2,” the researchers pointed out, but the presence of neuropilin on beta cells made them particularly susceptible. Such infection led to cellular stress and induction of chemokines. As a result, beta cells expressed less insulin but more alpha and acinar cell markers. Consequently, some of the beta cells produced glucagon (which raises blood sugar) rather than hypoglycemic insulin.

          Further analysis showed that the virus induced elF2 pathway-mediated beta cell transdifferentiation. This change in cell fate could be reversed with trans-Built-in stress response inhibitor (trans-ISRIB), they found, after testing about 400 FDA-approved drugs. Trans-ISRIB…decreased polyhormonal level in a dose-dependent manner, they wrote, and blocked beta-cell transdifferentiation upon SARS-CoV-2 infection. “Additionally, genes associated with cellular stress were down-regulated.”

          Another studyby Chien-Ting Wu and colleagues, all from Stanford University, published in Cell metabolism, also reported infection via interactions of the virus with neuropilin. He further found that infecting cells cultured in the lab with the SARS-CoV-2 virus induced apoptosis such that the cells simply died.

          What these studies and others show is that COVID-19 is more than a respiratory or lung disease. It not only affects many areas of the body, but also plays a role in causing other seemingly unrelated conditions. Therefore, despite the increasingly mild symptoms of some recent variations, COVID-19 should still be taken seriously.

          Can we beat aging? Jeff Bezos tries

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          Jeff Bezos is on a mission to defeat aging. He comes from recruited Hal Barron from GlaxoSmithKline to help lead Altos Labs, the ambitious new anti-aging company with billions in investment. So what does science really say about this? Could we beat aging?

          Aging is not just a change in the way we feel or look, aging happens at the cellular level. In a culture dish in the laboratory, adult skin cells divide about 50 times before stopping. But a newborn’s skin cells can divide 80 or 90 times. And on the other hand, the cells of an old person divide only around twenty times.

          Aging is also evident in our genes. Our genetic material is changed over time – chemicals can be attached that alter which genes are turned on or off. These are called epigenetic changes, and they accumulate with age. Another type of change takes place at the ends of the DNA of our cells. Repeating segments of DNA called telomeres act like the plastic tip of a shoelace, preventing twisted coils of genetic material from fraying at the ends or tying themselves together. But these telomeres get shorter every time a cell divides. We don’t know if short telomeres are just a mark of aging, like gray hair, or part of the process by which cells age.

          Cells, chromosomes and telomeres

          To stay alive and keep dividing, immune cells stop shortening their telomeres when they multiply, just like cancer cells. This is likely a contributing factor to their apparent immortality. Drugs that stop telomerase from working also show promise against cancer (although cancer cells can develop resistance).

          Biggest question

          Since aging has such a profound effect on our cells and genes – the effects mentioned here are just a few examples – a much larger question arises: why is this happening? Why do we age?

          Aging was once thought to occur for the continued evolution of species. In other words, the evolution of a species requires a renewal of individuals. However, a problem with this idea is that most life on Earth never reaches old age. Most animals are killed by predators, disease, weather, or starvation. Thus, a built-in limit to an animal’s lifespan may not be evolutionarily important.

          Another view is that aging is just a side effect of damage that accumulates over time that is caused by metabolism or exposure to ultraviolet light from the sun. We know that genes are damaged with age, but there is no evidence that this directly causes aging. Another possibility is that aging may have evolved as a defense against cancer. Since cells accumulate genetic damage over time, they may have developed a process to not linger too long in the body, in case that damage eventually turns a cell into cancer.

          As we age, certain cells in the body enter a state called senescence, in which a cell stays alive but stops dividing. Senescent cells accumulate in the body throughout life – particularly in the skin, liver, lungs and spleen – and have both beneficial and harmful effects.

          They are beneficial because they secrete chemicals that help repair damaged tissue, but over a long period of time, as the number of senescent cells increases, they can disrupt the normal structure of organs and tissues. These cells could be an underlying cause of many of the problems we associate with aging. Mice in which senescent cells were cleared were profoundly retarded to show signs of aging.

          We can describe much of what happens during aging at the level of what physically happens to our genes, cells and organs. But the fundamental question of why we age remains open. In all likelihood, there is more than one correct answer.

          Of course, no one knows if Bezos’ company can succeed in helping to extend the human lifespan. But what is clear is that in studying aging, exciting new discoveries are inevitable. Never listen to someone who says the big questions have already been answered. As I recently detailed in a book on new technologies and the human body, The secret bodyI am convinced that spectacular breakthroughs will profoundly change the human experience in the century to come.

          This article is republished from The conversation under Creative Commons license. Read it original article.

          The Week in Business: A Strong Employment Report

          0

          The economy added 467,000 jobs in January despite record levels of coronavirus cases, the Labor Department reported on Friday. Employers continued to add jobs at about the same pace as in December. The quirks of the data make January’s employment figures particularly difficult to interpret accurately, and the labor force has shrunk, suggesting that Omicron may have kept some people from looking for work. But economists said the strong jobs report was a good sign. “Clearly, something is different about this push,” said Julia Pollak, chief economist for career site ZipRecruiter.

          Meta’s stock price fell on Thursday after the company reported weak quarterly results a day earlier, wiping more than $230 billion from the market value of Facebook’s parent company and triggering Wall’s worst fall ever. Street in almost a year. It was the largest one-day wipeout in history, according to Birinyi Associates, a research firm. Some of the troubling signs for Meta include its first-ever drop in user numbers for its flagship app and new competition from TikTok. He also reported that Apple’s recent changes to its privacy tools, which allow iPhone users to be untracked by advertisers, could cost the company $10 billion in ad sales this year. And Meta’s main effort to build a business outside of its current advertising model, its pivot to the Metaverse, is also costing the company a lot of money. The division that builds devices to access these virtual worlds, such as virtual reality goggles, lost $10 billion last year.

          Jeff Zucker resigned as president of CNN on Wednesday after failing to disclose a consensual relationship with one of the network’s top executives. Mr. Zucker was one of the most powerful leaders in America’s media and television industries. His resignation comes as CNN parent WarnerMedia is set to spin off from AT&T and partner with Discovery in a $43 billion deal, and its new streaming service by subscription – intended to compensate for a decline in cable subscriptions – should start in a few weeks.

          On Thursday, the Department of Labor will report on the price increase in January. In December, the Consumer Price Index, an important gauge of inflation, rose at its fastest pace since 1982. A United Nations report last week showed global food prices soared , and Starbucks said it would raise prices again this year, citing inflation as one of the reasons. Federal Reserve officials said Monday they would move quickly rather than gradually to cool the economy. The Fed is expected to start raising interest rates in March.

          One of the key factors behind the rapid rise in inflation is a supply chain crisis that has caused shortages of everything from computer chips to kitchen appliances. But even if central banks around the world try to cool the economy with higher interest rates and less support, supply chains are unlikely to return to normal anytime soon. Many of the delays were caused by aging infrastructure, labor shortages, outdated technology and a lack of warehouse space – systemic issues that have built up over years that would be difficult to resolve quickly.

          The Beijing Winter Olympics kicked off on Friday and will run until February 20. For the Games’ official broadcaster, NBC, producing the event could be more difficult than even the Tokyo Olympics, which last year drew the lowest viewership of any summer game. since 1988. China’s Covid-19 restrictions will keep most sports commentators, as well as the hosts of NBC’s “Today” and “NBC Nightly News,” in the United States. In the past, broadcasts have moved to Olympic host cities and provided a boost in ratings. In addition to the challenges of Covid-19, NBC will have to manage a political aspect of what is generally feel-good entertainment. President Biden announced a diplomatic boycott of the Olympics because of human rights abuses in China, and House Republicans recently asked NBC executives what influence the Chinese government would have on the network’s broadcast.

          The national debt exceeded $30 trillion for the first time. Tesla has recalled cars equipped with its fully autonomous driving software to disable a feature that allowed them to drive through intersections without stopping. And TurboTax will allow users to deposit tax refunds into crypto accounts.

          Paving the way for renewable energy in Sri Lanka

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          In line with President Gotabaya Rajapaksa’s political manifesto “Prospects for Prosperity and Splendor”, the government has taken steps to accelerate the energy transition from thermal to large-scale renewable energy. Sri Lanka plans to produce 70% renewable energy sources by 2030, doubling our current share of 35% renewable energy in electricity generation. This requires an additional 11,000 MW of clean renewable energy capacity leading to annual electricity generation of 21,000 GWh with an investment of USD 10 billion.

          With the goal of achieving 70% electricity generation from renewable energy resources, sustainable energy development programs have been boosted in the country. The Sustainable Energy Authority of Sri Lanka (SLSEA), which falls under the Ministry of State responsible for the development of solar, wind and hydropower projects, has taken initiatives to develop an implementation framework of the sustainable energy development program.

          The development of renewable energies brings a multitude of advantages to the country. It is necessary to seek indigenous energy resources. By improving electricity generation capacity based on renewable energy, Sri Lanka can increase the share of indigenous energy. Improving energy security is a key aspect to consider in developing the energy sector and increasing the share of indigenous energy.

          Larger scale projects

          Renewable energy development projects have been implemented in a range from 1 MW to 10 MW. Through the implementation of larger-scale projects such as 100MW or more, it is possible to attract high-end companies investing in renewable energy in the world to Sri Lanka, where they could have the most technologies. sophisticated at the most competitive prices. This type of international investment will be a boon to the overall economy of the country.

          SLSEA is taking steps to streamline renewable energy development programs. Steps are being taken to identify suitable land and locations to develop different renewable energy sources such as solar, wind and biomass in different parts of the country.

          President Gotabaya Rajapaksa instructed renewable energy power generation promotion agencies including SLSEA to come up with proper plans to supply electricity from renewable energy sources to villages remote, as it is also not economical and practical to supply electricity through the national power grid under the circumstances. .

          SLSEA has embarked on a project to facilitate the implementation of projects through the use of renewable energy sources in off-grid power systems. Under this initiative, technical assistance is being provided for the networking of rural hydropower plants through a pilot project in the villages of Meemure, Udagaldebokka and Galamuduna, which are isolated settlements in the Divisional Secretariat Division of Minipe in Kandy district.

          Photovoltaic solar systems

          Electricity is supplied to the villages of Galamuduna, Udagaldebokka and Medakelle under this program using solar photovoltaic systems with mini-grid battery storage systems. Technical assistance is also being provided to develop rural hydropower plants in the remote Kalukandawa village of Palindanuwara. In addition to rural electrification based on renewable energy, interventions are underway to target rural households, such as the start-up of solar-powered water pump supply activities for agrarian families in Rajangane and the supply of small-scale solar kits for school children in remote villages and photovoltaic solar street lights. fixed in public places.

          President SLSEA Eng. Ranjith Sepala told the Sunday Observer that residents of Medakele, Galamuduwa and Udagaldebokka face difficulties without basic infrastructure to access mainly roads, electricity, healthcare, education and marketing facilities. . Given the location of these three villages, it is not possible to supply electricity from the national grid to this area where around a hundred families live due to the high cost involved.

          “According to our estimates to supply electricity from the national grid in this region, it costs at least 200 million rupees. But thanks to the innovative centralized off-grid system, the total cost is around Rs 56 million. There are 38 schoolchildren in the three villages, who walk around 16 km up and down daily to school along ramshackle gravel roads through the wildlife-haunted jungle. The villagers encounter many difficulties in obtaining marketing facilities for their production of pepper, kurakkan, maize, bee honey and Kithul honey. These inconveniences and difficulties will be alleviated once the village electrification program is completed,” said the SLSEA Chairman.

          He said that to achieve the goal of 70% renewable energy from the national grid by 2030, there will be electricity generation such as 4800 MW and 3500 MW from solar and electricity. wind energy between 2022 and 2030.

          The level of electrification of the country has reached almost 100%, where almost all localities accessible by the national electricity network are supplied with electricity on the grid. To achieve full island-wide electrification, it is planned to supply electricity to rural localities far from the grid using off-grid electricity systems based on renewable energy, as this offers a more economical solution. for these locations in relation to the expansion of the national electricity grid. Grid.

          Electrification programs

          The three rural electrification programs using solar energy will be implemented in the Hasalaka Divisional Secretariat area by SLSEA. Solar power is generated using 25 kW capacity solar photovoltaic systems installed at a central location in the village, where battery packs are also installed for energy storage at the same location.

          All households in the village are connected to the centralized power supply system via an alternating current network, where the supply of electricity within 24 hours every day is ensured by using the energy stored in the batteries for the night-time electrical needs of the households. It meets their energy needs for lighting, television and other essential needs, which greatly increases people’s living standards, especially by providing improved lighting solutions with LED lamps. for children’s studies.

          According to the chairman of SLSEA, the electricity supply system has an integrated energy management system using smart metering methods, which provides an optimal solution for the efficient use of solar electricity. A rechargeable card is provided to each dwelling, which functions as the activation system for the power supply of each dwelling used in conjunction with the smart meters installed in the houses.

          At the beginning of the month, the card is activated for a predetermined number of electricity units, and the owner must manage his electricity consumption within the particular limit. If exceeded, he has to recharge it by paying at a higher rate, and therefore households are encouraged to use their electricity at optimal levels across the system.

          Pilot projects

          These three projects are being implemented by SLSEA as pilot projects to demonstrate an autonomous energy supply system managed by smart metering systems. Based on the results of these projects, it will be possible to provide similar electrical systems with more sophisticated inputs for household electrification using renewable energy and energy management systems based on smart meters in the way the most effective.

          The initiative will provide an attractive solution for rural electrification using off-grid systems based on renewable energy, and by replicating it, it will be possible to achieve full electrification of the country in a short time.

          As part of the National Accelerated Renewable Energy Supply Programme, construction works for the Moragolla and Broadlands hydropower plants are in full swing. The Moragolla Power Station is the final element of the hydropower generation projects under the Mahaweli Ganga Diversion Scheme, while the Brodlands Hydropower Project is the final stage of the Laksapana Power Station Complex. The power generation capacity of the two plants is 66 MW.

          The Sustainable Energy Authority of Sri Lanka is the main government organization involved in the development of renewable energy. It is an organization promulgated by Law No. 35 of 2007. The government is strongly committed to the development of renewable energies. SLSEA develops investment-ready power park projects using solar and wind power in the 100 MW capacity range.

          Siyambalanduwa Project

          The Siyambalanduwa 100MW solar power project, which is a model energy park project being the first of its kind, will generate 148 GWh of clean energy per year, which will lead to a reduction in greenhouse gas (GHG) emissions of 147,542 tons. The project consists of a solar park and a 27 km 132 KV transmission line in one package.

          The Pooneryn 100 MW wind project and the Mannar 100 MW wind project will be commissioned soon. Pooneryn is one of the most attractive renewable energy sites in the country with 240 MW of wind power and 150 MW of solar power. Some 100 MW of wind energy will be harnessed in the first phase as a first model wind energy park with all initial studies and regulatory approval available to the investor.

          The Pooneryn 100MW wind project will initially generate 370 GWh of clean energy per year, resulting in a reduction in GHG emissions of 265,732 tonnes. The 100 MW Mannar Wind Project has the highest wind potential in the country with over 300 MW estimated. The first phase of wind energy development with a capacity of 100 MW has been implemented by the CEB with an estimated annual electricity production of 400 GWh. A feasibility study and an environmental impact study are being carried out by SLSEA and CEB for the second phase.

          The project will generate 380 GWh of energy per year, resulting in a reduction of 270,350 tonnes of GHG emissions.

          Proposed renewable energy projects

          Renewable energy resource allocation and project facilitation processes continued over the past year with significant progress in registering tendered solar energy projects with the SLSEA and issuing energy permits for them. . Some 101 projects have been registered and 89 energy permits have been issued for one MW projects and provisional approval has been given for 81 projects with a capacity of 57 MW under the 150 solar tender. MW at the end of October last year.

          Apple Watch 7 vs. Fitbit Sense: Which smartwatch should you buy?

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          Should you buy the Apple Watch 7 or the Fitbit Sense? The answer to this question depends on what you are looking for in a smartwatch. Although the two are considered two of the best smart watches you can buy, each offers unique advantages (and disadvantages).

          On the one hand, the Apple watch 7 is exclusive to iPhone users, while the Fitbit Sense is both iOS compatible and one of the best smartwatches for android. There’s a big difference in cost, too: Apple’s latest smartwatch starts at $399, while the Fitbit Sense starts at $299.

          Both smartwatches support a number of health tracking features, as well as communication tools to stay connected from your wrist. Users can also download selected third-party apps on the Apple Watch 7 and Fitbit Sense, including most best workout apps and best productivity apps.

          Here’s everything you need to know before choosing between the Apple Watch 7 and Fitbit Sense.

          Apple Watch 7 vs. Fitbit Sense: Features Compared

          Apple watch 7 Fitbit Sense
          Starting price $399 $299
          Sizes 41mm, 45mm 40.5mm
          Display Size/Resolution 1.9 inches, 484 x 396 pixels (45mm) 1.58 inches, 336 x 336 pixels
          Cellular option Yes No
          Raincoat Up to 50 meters Up to 50 meters
          Permanent display Yes Yes
          Voice assistants Siri Alexa, Google Assistant
          Battery life 18 hours 6 days
          Mobile payments Yes (Apple Pay) Yes (Fitbit Pay)
          Color options Silver, Black, Green, Blue, Red Silver, Graphite, Gray
          Special features ECG, SpO2, heart rate alerts, fall detection, compass, always-on altimeter ECG, EDA, skin temperature sensor, heart rate alerts, SpO2

          Apple Watch 7 vs. Fitbit Sense: Price

          The Apple Watch 7 and Fitbit Sene have a price difference of $100, depending on which Apple Watch model you want to get. Apple’s flagship smartwatch starts at $399 but goes up to $529 for the 44mm model with Cellular. And that’s before considering high-end materials like stainless steel or titanium.

          That said, the best Apple Watch deals and the best Fitbit deals can help you get discounts on either model. We’ve noticed that the Fitbit Sense savings are generally more impressive, but if you know how to trade in your Apple Watch, you can put the value of an older model down to a Series 7.

          Apple Watch 7 vs. Fitbit Sense: Design

          The Apple Watch 7 and Fitbit Sense share a similar rounded square look, instead of the circular face preferred by the Samsung Galaxy Watch 4the best samsung watch overall and a notable alternative to the two smartwatches we’re comparing.

          Apple watch 7

          (Image credit: future)

          We think Apple’s Watch has a more recognizable look thanks to its nearly bezel-less design. Not only is the Apple Watch 7 screen about 20% larger than the Apple Watch 6‘sand Apple WatchSE‘s, but with a narrow 1.7mm bezel, the new Apple Watch 7 sizes look bigger without making the smartwatch bulkier.

          Fitbit Sense review

          (Image credit: Tom’s Guide)

          The Sense, on the other hand, has a uniform chassis — it has no buttons. While the Apple Watch 7 retains a protruding digital crown, the Fitbit Sense has a capacitive touch zone for navigation. Sleek sides make the Sense a little more fashionable than the sporty Apple Watch 7. While both watches come in a variety of colors and metallic finishes, you can pick the one that best suits your style.

          Apple Watch 7 vs. Fitbit Sense: Health tracking and fitness features

          The Apple Watch 7 and Fitbit Sense both have built-in GPS, which means you don’t need to have your phone in range to track runs or other outdoor adventures. If outdoor running or biking is your thing, you might want to check out the best gps watches Where best running watches we tested instead, but you’ll still find accurate GPS tracking with the models in discussion.

          When it comes to tracking your fitness goals, these smartwatches take distinct approaches. The colorful Apple Watch is ringing Set daily thresholds, while Fitbit’s Activity Zone Minutes monitors how much time you spend in the fat-burning, cardio, or max heart rate zones during exercise each week. Fitbit Daily Readiness Score also tracks your recovery needs, a feature the Apple Watch is still missing.

          Apple Watch Activity Rings

          (Image credit: future)

          Apple Watch 7 and Fitbit Sense can count your steps, read your SpO2 levels and nudge you to move. Each also has FDA-approved ECG sensors, which can alert wearers that they have atrial fibrillation (AFib), a life-threatening condition where the heart beats rapidly and irregularly. Likewise, both devices also feature heart rate sensors, which can be used for a number of things outside of fitness. For example, the Sense uses the heart rate sensor to monitor sleep, although you can still use one of the best sleep apps for sleep tracking, too.

          Fitbit Sense review

          (Image credit: Tom’s Guide)

          Two sensors that the Sense lacks in the Apple Watch are a skin temperature sensor and an EDA (electrodermal activity) sensor. The EDA sensor can track the amount of electricity passing through sweat onto the skin; it’s a way to tell if you’re under a lot of stress. The watch will then guide you through some de-stressing activities and also suggest things you can do to avoid or alleviate stress.

          When you get the Fitbit Sense, you’ll have the option to subscribe to Fitbit Premium, which costs $9.99 per month or $79.99 per year. The subscription service offers personalized sleep insights and more, as well as workout plans, based on your health data. Meanwhile, the Apple Watch 7 completes Apple Fitness Plusthe company’s exercise service that costs the same as Fitbit Premium.

          Apple Watch 7 vs. Fitbit Sense: Smartwatch Features

          As it was designed as a smartwatch first, the Apple Watch 7 is overall better than the Sense for smartwatch-y functions. Like all best apple watch models, the Series 7 receives annual software updates. He is currently spinning watchOS 8, which features new workout types, a new mindfulness app, and expanded virtual key support. The Apple Watch 7 also has all the best apple watch apps including a built-in map and compass, so you can use it to navigate unfamiliar places. You will also find a QWERTY keyboard for typing texts on the Series 7.

          Apple Watch 7 Keyboard

          (Image credit: future)

          While you can change the watch face on both the Apple Watch 7 and the Fitbit Sense, only the Apple Watch lets you further customize these faces with whatever complications you want. Fitbit has some great watch faces that focus on specific health-tracking features, though.

          Both watches also have some form of NFC mobile payments, which comes in handy when you’re on a run without your wallet and want to grab a bottle of water. It’s also useful if you’re trying to avoid touching things in public places. Both watches support offline playlists, notification mirroring and the ability to answer calls, although the Apple Watch can only answer calls via a designated cell number or iPhone, while the Sense can only answer calls from one of the best Android phones.

          Fitbit Sense review

          (Image credit: Tom’s Guide)

          When it comes to voice assistants, it’s Siri versus Alexa and Google Assistant. As you’d expect, the Apple Watch has Siri built in, while the Fitbit Sense has Alexa and Google Assistant. You can use voice assistants to ask questions, initiate communications, or control the best smart home devices (as long as they are compatible.)

          Apple Watch 7 vs. Fitbit Sense: Battery life

          There’s no competition between the Apple Watch 7 and Fitbit Sense’s battery life. The Fitbit Sense boasts an excellent 6-day battery life, far exceeding the Apple Watch 7’s 18 hours. You need to charge the Apple Watch almost every day, while the Sense can easily survive a weekend no more juice.

          Apple Watch 7 vs. Fitbit Sense: Which should you buy?

          In this Apple Watch 7 vs Fitbit Sense comparison, we concluded that the Sense leads in terms of price, health sensors, and battery life. If you’re looking for the more fitness-focused option, the Fitbit Sense is probably the way to go, as it does more in this area, including recovery tools and stress monitoring.

          However, if you’re looking for a more comprehensive smartwatch, the Apple Watch 7 is the better choice, as it has more robust tools like LTE connectivity and annual software updates. However, you need an iPhone to use it, while the Fitbit Sense works with Android and iOS devices.

          If you’re looking for similar choices at a lower price, check out our guide to the Apple Watch SE vs. Fitbit Versa 3. You might also want to consider the Galaxy Watch 4 we mentioned earlier – our Apple Watch 7 vs. Galaxy Watch 4 and Galaxy Watch 4 vs. Fitbit Sense confrontations offer additional guidance.

          NMN for Longevity: What Doctors Know So Far

          0
          OWhen it comes to living a longer, healthier life, you probably know the basics: research indicates that diet, exercise, and modulating your stress levels are key to adding quantity. and quality to your time here on Earth. Yet, every day, scientists and researchers are looking for new sources of longevity. Over the past few years, a small but compelling body of research has discovered that nicotinamide mononucleotide (NMN – not to be confused with M&M’s), a molecule found naturally in all living things, may show promise for increasing your life expectancy. of life. If right now you are thinking: Molecules? Cellular processes? What? Do not worry. In front, doctor of functional medicine Frank Lipman, MDgives us 411.

          NMN is a form of vitamin B3 that occurs naturally in all living things, says Dr. Lipman. It is a precursor of nicotinamide adenine dinucleotide (NAD), which is one of the most abundant and crucial coenzymes in your cells, says Dr. Lipman. In other words, NMN becomes NAD through a series of chemical processes, and NAD helps your cells function properly. “When it comes to anti-aging, we talk about sleep, exercise, and diet, but cellular aging, or the deterioration of cellular function, is one of the hallmarks of aging,” says Dr. Lipman. NAD levels decline with age, and research even indicates that humans lose about half middle-aged. He adds that other factors such as stress, poor diet or stagnation can also slow down the process.

          It is important to note that NAD research is still new: first human clinical trial of NMN happened less than 10 years ago. However, if you’re wondering how, specifically, NAD can increase lifespan, science tells us a few things. First, there is evidence to suggest that NAD can help the body repair neuronal stress or stress that occurs in brain neurons in animals tested. This indicates that NMN may protect the brain against memory loss. Scientific research also suggests that NAD may increase endurance and build muscleand extend life by improving mitochondrial functions. But again, it’s worth remembering that the vast majority of this research has been done on mice, so take it as a grain of salt for now.

          One of NMN’s biggest disappointments? Dr. Lipman says you can’t really rely on food to fill you up on a daily basis (like you would eat, say, an orange if you wanted vitamin C). While NMN is naturally present in broccoli, edamame and cabbage, these foods contain traces. And while some people take NMN in supplement form, Dr. Lipman points out that how easily these supplements are absorbed is still unclear. “I’ve been in the supplement world for so long. [Supplement companies] always say it contains X, but whether it is absorbed is another story,” he explains. Research will likely continue on NMN for decades to come, so stay tuned. tips that have years of data behind them.

          Oh hi! You sound like someone who loves free workouts, discounts on top wellness brands, and exclusive Well+Good content. Subscribe to Well+our online community of Wellness Insiders, and unlock your rewards instantly.

          Liquid Argon Market Growth, Segments, Revenue, Manufacturers and Forecast Research Report

          0

          Global Liquid Argon Market was valued at USD 3036.49 Million in 2021 and will grow with a CAGR of 3.46% from 2021 to 2027.

          Global Liquid Argon Market 2022 By Manufacturers, Regions, Type and Application, the forecast to 2027 has been published by Reporthive.com and combines in-depth insights on overseas markets with a specific perspective on the industry in question. The Global Liquid Argon Market report assesses the business status and potential of major regions from the perspective of key players and application/end-user industries. The latest Liquid Argon Market report is a description of the end-to-end analysis of this business vertical and includes extensive industry insights, relating to critical parameters such as the most recent market trends, revenue current, market share, market size, periodic deliverables and earnings estimates for the forecast period.

          A brief overview of the performance of the Liquid Argon market over the forecasted period has been given in the report. Further, details about the driving aspects influencing the market dynamics along with the growth rate that the industry is expected to witness over the forecast period have been provided. Moreover, the Liquid Argon market report also provides a summary of the challenges by which this vertical is defined, in conjunction with the growth opportunities of which this business space is a remnant.

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          Liquid Argon Market Competition by Top Manufacturers/Key Player

          Company A, Company B, …

          Global demand for the liquid argon market is expected to register strong development driven by consumption in major developing markets. More growth opportunities will present themselves between 2022 and 2027 than a few years ago, which signifies the rapid pace of change.

          Impact of COVID-19:

          The Liquid Argon Market report analyzes the impact of Coronavirus (COVID-19) on the Liquid Argon industry. Since the outbreak of the COVID-19 virus in December 2019, the disease has spread to nearly 180 countries around the world, with the World Health Organization declaring it a public health emergency. The global impacts of the coronavirus disease 2019 (COVID-19) are already starting to be felt and will significantly affect the liquid argon market in 2022.

          COVID-19 can affect the global economy in 3 main ways: by directly affecting production and demand, by creating supply chain and market disruptions, and by its financial impact on businesses and financial markets .

          Market studies by type:

          Pure category
          High Purity Grade
          Ultra pure quality

          Market study by applications:

          Welding and cutting
          Semiconductor industry
          Photovoltaic industry
          Melting

          Competitive landscape

          The report begins with a market overview and then moves on to growth prospects for the Liquid Argon market. The report covers the details resulting from the analysis of the targeted market. Liquid argon includes a general successful system, containments and global disclosures of past information as well as present and future needs that may concern development. The report provides specific data on the main factors that are impacting the growth of the fuels market.

          The Liquid Argon Market report covers the manufacturers data including shipment, price, revenue, gross profit, service record, trade distribution, etc., this information helps the consumer to know the competitors better. This report also covers all regions and countries in the world, which shows a regional development status, including business sector size, volume and value, as well as price data.

          Research methodology :

          This research study involves the extensive use of primary and secondary data sources.

          width=606

          The research process involves the study of various factors affecting the industry, including government policy, market environment, competitive landscape, historical data, current market trends, technological innovation, technologies to upcoming and technical advancements in related industry; and market risks, opportunities, market barriers and challenges.

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          The report provides information about the following pointers:

          Market penetration: Comprehensive information on product portfolios of major Liquid Argon market players.

          Competitive Evaluation: In-depth assessment of market strategies, geographic and business segments of major market players.

          Product Development/Innovation: Detailed information on upcoming technologies, R&D activities and product launches in the market.

          Market development: Comprehensive information on emerging markets. This report analyzes the market for various segments across geographies.

          Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the Liquid Argon market.

          Table of Contents Highlights:

          Chapter 1 Introduction:

          The Liquid Argon Research Job Report provides a compact introduction to the global market. This segment provides reviews of major participants, an overview of the Liquid Argon industry, insights for key areas, financials, and various challenges facing the Liquid Argon market. This section depends on the scope of the study and reporting guidelines.

          Chapter 2. Liquid Argon Market Scope of the Current Report:

          This is the second most important chapter that covers market segmentation with definition of Liquid Argon. It characterizes the entire scope of the Liquid Argon report and the various functions described therein.

          Chapter 3. Liquid Argon Market Dynamics and Key Indicators:

          This chapter contains key elements that focus on drivers [includes increasing global Liquid Argon frequency and increasing investment in Liquid Argon]main constraints of the market [high cost of Liquid Argon]Opportunities [emerging markets in developing countries] and details emerging trends [consistent innovation of newer Screening Products] Development challenges and influencing factors identified in this latest report.

          Chapter 4. Liquid Argon Market Type Segments:

          This Liquid Argon Market report demonstrates the market development for different product types presented by prominent organizations.

          Chapter 5. Application Segments of Liquid Argon Market:

          The analysts who authored the report have fully assessed the commercialization of key applications and exercised future freedoms.

          Chapter 6. Geographical Analysis of Liquid Argon Market:

          Each provincial market is deliberately examined to understand its current and future development, improvement and demand situation for that market.

          Chapter 7. Liquid Argon Market Impact of COVID-19 Pandemic on Global Liquid Argon Market:

          7.1 North America: Overview of COVID-19 Impact Study 2022-2027

          7.2 Europe: Provides comprehensive information on COVID-19 Impact Study 2022-2027

          7.3 Asia-Pacific: Potential impacts of COVID-19 (2022-2027)

          7.4 Rest of the world: assessment of the impact of the COVID-19 pandemic

          Chapter 8. Manufacturing Profiles of Liquid Argon Market:

          Leading Liquid Argon Market players are identified in the report based on their market size, market served, products, applications, regional development, and other variables.

          Chapter 9. Liquid Argon Market Estimation Analysis:

          This chapter contains price analysis by region and various forecasts.

          Chapter 10. North America Liquid Argon Market Analysis:

          This chapter provides an assessment of the Liquid Argon product sales in major countries of United States and Canada, along with a detailed segmental view of these countries for the forecast period 2022-2027.

          Chapter 11. Latin America Liquid Argon Market Analysis:

          The major countries of Brazil, Chile, Peru, Argentina and Mexico are rated for Liquid Argon delivery.

          Chapter 12. Europe Liquid Argon Market Analysis:

          The Liquid Argon Market analysis report contains information on the supply, demand and sales of Liquid Argon in Germany, France, Great Britain, Spain, BENELUX, Scandinavia and Italy.

          Chapter 13. Asia-Pacific ex-Japan (APEJ) Liquid Argon Market Analysis of Liquid Argon Market:

          The countries of Greater China, ASEAN, India, Australia and New Zealand are assessed, and the assessment of Liquid Argon sales in these countries is covered.

          Chapter 14. Middle East and Africa (MEA) Liquid Argon Market Analysis:

          This chapter focuses on the Liquid Argon market scenario in GCC countries, Israel, South Africa and Turkey.

          Chapter 15. Liquid Argon Market Research Methodology

          The chapter on research procedure contains the accompanying primary realities,

          15.1 Coverage

          15.2 Documentary research

          15.3 Primary research

          Chapter 16. Conclusion…….

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          Two New Omega-3 Index Studies Explore Benefits for Immunity and Cell Membrane Integrity in Healthy People

          0

          February 3, 2022, Sioux Falls, SD: Two pivotal studies showcasing the Omega-3 Index were recently published in the journal Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). The first discussed the relationship between the Omega-3 Index and red blood cell (RBC) distribution width (a measure of cellular integrity) and the second explored the relationship between the Omega-3 Index and a balanced immune system.

          Both studies observed benefits associated with higher blood levels of omega-3s (EPA+DHA) in healthy people, which helps provide support for establishing Dietary Reference Intakes (DRIs) for healthy people. EPA and DHA.

          The omega-3 content of erythrocyte membranes, i.e. the omega-3 index, is a stable biomarker of the long-term intake of omega-3 EPA and DHA. And fatty acids sequestered in red blood cell membranes have been known for decades to contribute to structural integrity and affect signaling pathways.

          The deformability of RBC cells (i.

          “We used red blood cell distribution width (RDW), measured routinely in hematology labs, as the biomarker of interest, as it is a standard way to assess the size heterogeneity of cells. red blood cells, which is related to the proper deformability of the cell membrane,” said Michael McBurney, PhD, FCNS-SCN, FASN, lead author of this paper, and consultant scientist with the Fatty Acid Research Institute (FARI).

          “Although the RDW is used clinically to diagnose anemia, it has recently been shown to also predict the risk of death from several diseases – namely, cardiovascular, SARS-COV-2, sepsis, lung disease and cancer. . Instead of sick people, however, we chose to study healthy people. Why?” he said. “Because we wanted to determine if red blood cell EPA+DHA levels were associated with red blood cell structure and function in non-disease states.”

          The researchers in this study did indeed find a relationship. In 25,485 people with no signs of inflammation or anemia, a higher Omega-3 Index was still significantly associated with a lower (i.e., better) RDW. And while their observation does not prove that omega-3 fatty acids lower RDW, it does strengthen the case for establishing DRIs for EPA+DHA in a healthy population.

          The second study delved deeper into the relationship between the Omega-3 Index and the immune system. The human immune system is made up of innate and adaptive components. The innate component consists of cells that engulf injured and diseased human cells and bacteria that have invaded the body. This digestive action of innate immune cells such as neutrophils (N) and natural killer cells prevents enzymes and acids from being released by dead or dying cells that can damage adjacent healthy cells.

          The adaptive system, on the other hand, is made up of memory cells, i.e. lymphocytes (L) or T and B cells, with the learned ability to attack cells expressing certain markers, for example those infected by viruses. Cells forming tissues and organs, as well as immune cells, can release signaling molecules, e.g. stimulate the creation of new immune cells).

          The neutrophil to lymphocyte ratio (NLR) measures the balance between the innate and adaptive immune system. The NLR is also a biomarker of systemic inflammation and, like the RDW, predicts a higher risk of death from many chronic diseases. A normal NLR is around 1 to 3, with a score above 6 indicating mild stress and above 9 indicating severe illness.

          “As previously stated, DRIs are for the general healthy population only. Since one of our long-term goals at FARI is to generate scientific support for EPA+EPA DRIs, we also limited this study to healthy individuals. In other words, excluding people with active inflammation [C-reactive protein (CRP) > 3mg/L – the threshold for acute inflammation] we tried to minimize the risks for critics to claim that our findings were related to the disease,” McBurney explained.

          In this study of 28,871 healthy, non-inflamed individuals, researchers observed inverse associations between the Omega-3 Index and the NLR, i.e. the higher the Omega-3 Index, the more the NLR is weak. This was especially evident in people with an Omega-3 Index below 6.6% (an ideal Omega-3 Index is considered to be 8% or higher). In these people, the NLR clearly increased when the Omega-3 index fell; but above an index of 6.6%, the NLR remained relatively stable.

          McBurney pointed out that the relationship observed in healthy people suggests that blood levels of EPA + DHA play a role in maintaining a quiescent and balanced immune system, and therefore provides evidence for a relationship between the nutrients. and structure/function in healthy people. However, even when people with evidence of chronic inflammation (ie, CRP > 3 mg/L) were included, the relationship still held.

          “The NLR paper may be particularly important because most nutritional immunity studies measure circulating levels of inflammatory molecules, i.e. markers of inflammation, making these findings related to disease,” McBurney said, adding, “This is a report of association between nutrient status and cell-based immune function/balance in healthy people.

          “These two reports associating a high omega-3 index with low (i.e. healthier) levels of two new biomarkers – RDW and NLR – help us understand a little better why omega-3 fatty acids are good for us,” said William S. Harris, PhD, FASN, lead author of both studies and president of FARI.

          /Public release. This material from the original organization/authors may be ad hoc in nature, edited for clarity, style and length. The views and opinions expressed are those of the author or authors. See in full here.

          Relationship between SARS-CoV-2 neurotropism and Alzheimer’s disease

          0

          In a recent study published on bioRxiv* preprint server, researchers assessed the neurotropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its impact on patients with coronavirus disease 2019 (COVID-19) with and without neurological disorders as Alzheimer’s disease.

          Study: SARS-CoV-2 invades cognitive centers in the brain and induces Alzheimer-like neuropathology. Image Credit: Solarisys/Shutterstock


          Fund

          The ongoing COVID-19 pandemic has resulted in over 380 million confirmed SARS-CoV-2 infections worldwide. In addition to respiratory manifestations, SARS-CoV-2 also causes neurological abnormalities with an occurrence rate of 85% in people with Alzheimer’s.

          Most patients with COVID-19 present with neurological symptoms such as headache, anosmia and hypogeusia before the manifestation of respiratory symptoms. Additionally, the long-term sequelae of COVID-19 range from mild cognitive impairment to dementia.

          A recent study demonstrated the presence of SARS-CoV-2 in the olfactory mucosa and its neuronal projections of a patient infected with COVID-19. Furthermore, additional pathways of SARS-CoV-2 entry have been proposed, for example via the compromised blood-brain barrier (BBB) ​​in conditions such as autism and Alzheimer’s disease, but a sufficient evidence of infected immune cells remains absent.

          Taken together, although the major factors promoting SARS-CoV-2 cellular entry have been found in neurons, sufficient information regarding the phenotypes of infected neurons and the neurotropism of SARS-CoV-2 is not yet available.

          About the study

          In the current study, the team of researchers investigated the potential neurotropic characteristics of SARS-CoV-2 in COVID-19 patients with Alzheimer’s disease, autism, dementia, and those without any comorbid conditions. The control group for the study consisted of non-COVID patients with the aforementioned comorbidities.

          Immunohistological staining and double immunohistological labeling (DAB) of SARS-CoV-2 spike (S) protein in brain tissues of age-matched study and control groups were performed to determine the presence of the SARS-CoV-2 in brain regions. Furthermore, the development of Alzheimer-like phenotype and exacerbation of Alzheimer-like phenotypes in SARS-CoV-2 were determined using β-amyloid (Aβ) and phospho-tau (pTau) immunohistochemistry. and immunofluorescence analysis with thioflavin staining of Aβ of brain tissue samples. SARS-CoV-2 genomic ribonucleic acid (RNA) in samples was analyzed using RNAscope on the spot hybridization.

          Results

          The results indicated that SARS-CoV-2 invaded the lower frontal cortices of five COVID-19 patients: one subject with frontotemporal dementia (FTD), one with Alzheimer’s disease, two with autism and one. healthy subject without any comorbid condition by infecting neurons and several other cells of the cerebral cortex.

          The cortices of the two young autistic COVID-19 patients demonstrated the presence of p-Tau tangles. Manifestations such as cellular Aβ accumulation and plaque formation, neuroinflammation, tauopathy, senescence, ferroptosis, necroptosis and apoptosis in COVID-19 patients indicated that SARS-CoV-2 ameliorates or induces neuropathology similar to Alzheimer’s disease.

          Mature SARS-CoV-2 infected neurons were derived from inducible pluripotent stem cells (iPSCs) of age-matched healthy COVID-19 patients and those with Alzheimer’s disease via the enzyme receptor converting angiotensin 2 (ACE2) and a facilitator named neuropilin-1 (NRP1), but SARS-CoV-2 did not infect immature neurons.

          Furthermore, SARS-CoV-2 triggered an Alzheimer’s-like cellular program in iPSC-derived neurons from healthy COVID-19 patients and enhanced Alzheimer’s phenotypes in neurons from iPSCs from patients with AD. Alzheimer’s.

          A list of 24 genes was identified from groups infected with simulated and healthy neurons infected with Alzheimer’s SARS-CoV-2, which activated infection pathways induced by viruses and bacteria. In neurons of Alzheimer’s disease patients infected with COVID-19, SARS-CoV-2 enhanced and reduced the expression of 25 up-regulated genes and 34 down-regulated genes, respectively, by several-fold. Thus, SARS-CoV-2 worsens Alzheimer’s conditions through altered gene expression, elevated neuroinflammation, and other neurological processes in neurons of Alzheimer’s patients.

          Moreover, the silencing of the three main underexpressed genes in human primary neurons, named CryAA2, PSG6 and GJA8, by SARS-CoV-2 resulted in the conversion of healthy human neurons into Alzheimer-like neurons during COVID-19. .

          conclusion

          Study findings showed that SARS-CoV-2 penetrated the cognitive centers of COVID-19 patients, resulting in Alzheimer’s-like phenotypes in those without any underlying conditions, and exacerbated the neuropathology of Alzheimer’s in patients with Alzheimer’s and autism. Furthermore, SARS-CoV-2-infected neurons derived from iPSCs demonstrated the pathological hallmarks of neurological disorders, including neurotropism and induction or amelioration of Alzheimer’s disease in COVID patients and convalescents. -19. The 24 overlapping genes identified from Alzheimer’s neurons without SARS-CoV-2 and healthy neurons with SARS-CoV-2 were potential mediators of infectious Alzheimer’s etiology in SARS-CoV infection -2.

          BBB leakage is thought to be the primary central nervous system (CNS) entry route for SARS-CoV-2 in autistic patients, as no evidence of SARS-CoV-2 infected immune cell infiltration in autistic brains was observed in the current study. The study findings were in line with that of previous studies suggesting manifestations of neurodegenerative characteristics in the brain of COVID-19 patients. Further research is needed to illustrate the mechanism by which SARS-CoV-2 caused Alzheimer-like phenotypes.

          *Important Notice

          bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be considered conclusive, guide clinical practice/health-related behaviors, or treated as established information.

          Two members of Google’s Ethical AI group leave to join Timnit Gebru nonprofit

          0

          Two members of Google’s Ethical AI group have announced their departure from the company, according to a report by Bloomberg. Principal investigator Alex Hanna and software engineer Dylan Baker will join Timnit Gebru’s nonprofit research institute, Distributed AI Research (DAIR).

          In one post announcing his resignation on MediumHanna criticizes the “toxic” work environment at Google, and draws attention to a lack of representation of black women within the company.

          “Before Timnit was hired, Google Research management had never hired a black woman as a researcher,” says Hanna. “At a town hall around Googlegeist (Google’s annual workplace climate survey), a high-level executive remarked that there had been such a low number of black women in the Google Research organization that they couldn’t even present a point estimate of those employees’ dissatisfaction with the organization, lest management risk anonymizing the results.

          Gebru, the former co-head of Google’s AI Ethical research group, was fired by the company in 2020 after he co-wrote a research paper that drew attention to the potential risks of models of large-scale language, a concept similar to that Google Search employs. The search giant fired another AI ethics researcher, Margaret Mitchell, for her involvement in Gebru’s paper soon after.

          While the company’s diversity report last year showed an overall increase in the number of black employees it hired, there was still an increase in the number of women of color leaving the company. company – at the time of the report’s publication, black women made up 1.8% of Google’s workforce. And in December, the California Department of Fair Employment and Housing (DFEH) launched an investigation into Google’s treatment of black female workers.

          “We appreciate the contributions of Alex and Dylan – our research into Responsible AI is extremely important, and we continue to expand our work in this area in accordance with our AI Principles,” the Google spokesperson said, Brian Gabriel, in a statement emailed to The edge. “We are also committed to building a business where people of different opinions, backgrounds and experiences can do their best and show up for each other. »

          Natural immunity vs vaccination in people previously infected with COVID-19

          0

          Although prior infection and vaccination have been found to significantly protect against COVID-19 infection, vaccination in previously infected individuals only provided additional protection against symptomatic COVID-19 among those who received the vaccine several months after the initial onset of the disease. These findings were published in Clinical infectious diseases.

          To assess the need for vaccination in people previously infected with COVID-19, researchers conducted a retrospective cohort study among people employed at the Cleveland Clinic in Ohio. Participants with at least 1 positive test result for COVID-19 infection were considered previously infected. The primary outcome was time to COVID-19 infection. Researchers analyzed the cumulative incidence of COVID-19, symptomatic COVID-19, and COVID-19 hospitalizations for 1 year after COVID-19 vaccines became available in the United States.

          At the end of the study, 4,718 (9%) and 36,922 (71%) of a total of 52,238 enrolled participants had respectively been previously infected or vaccinated against COVID-19 infection. Of all participants included in the study, 7851 (15%) became infected with COVID-19 during the study period, of which 4675 (60%) had symptomatic infections and 133 (1.7%) had to be hospitalized. Among participants infected with COVID-19 during the study period, 4,936 (63%) and 2,915 (37%) were infected within 11 months before or within one month after first detection of the variant Omicron in the United States, respectively. Of note, the cumulative incidence of COVID-19 infection increased significantly in unvaccinated participants without prior COVID-19 infection.


          Continue Reading

          The researchers analyzed the results in a Cox proportional hazards regression model and found that prior infection and vaccination were independently associated with a significantly reduced risk of incident COVID-19 infection. Among participants without prior COVID-19 infection, vaccination was associated with a significant decrease in the risk of a COVID-19 incident both in the period before the emergence of Omicron (relative risk [HR], 0.26; 95% CI, 0.24-0.28) and time after Omicron emergence (HR, 0.48; 95% CI, 0.44-0.53). In patients who were previously infected with COVID-19, the researchers noted that vaccination was not associated with a significant decrease in the risk of a COVID-19 incident nor in the period before (HR, 0.78 95% CI, 0.31-1.96) nor after emergence. of the Omicron variant (HR, 0.77; 95% CI, 0.53-1.12). Among participants with prior COVID-19 infection, in the periods before and after the emergence of the Omicron variant, vaccination was associated with a significantly decreased risk of symptomatic COVID-19 (RR, 0.60; CI 95%, 0.40-0.90 versus HR, 0.36; 95% CI, 0.23-0.57, respectively).

          Based on further analysis of the results, the researchers estimated that the duration of protection against COVID-19 infection conferred by natural immunity in unvaccinated participants was 1 year or more for the period before the emergence of Omicron.

          Limitations of the study included a lack of routine testing among asymptomatic participants, as those previously infected who remained asymptomatic were potentially misclassified as previously infected. Additionally, the study included no children, few older adults, and only a small number of immunocompromised participants, so the results may not be generalizable to other patient populations.

          According to the researchers, “both previously infected people and those who [have] vaccinated are substantially protected against COVID-19 infection, but protection against natural and vaccine-induced immunity declines over time and is inherently less potent against the Omicron variant. They concluded that “prior infection should be considered in COVID-19 vaccination recommendations.”

          Reference

          Shrestha NK, Burke PC, Nowacki AS, Terpeluk P, Gordon SM. Need for vaccination against COVID-19 in people who have already had COVID-19. Blink Infect Dis. Published online January 13, 2022. doi: 10.1093/cid/ciac022

          NorthSea Therapeutics initiates Phase 1 trial of SEFA-6179, targeting the orphan indication of liver disease associated with intestinal failure

          0
          • Preclinical studies have demonstrated the beneficial effects of SEFA-6179 in preventing the development of parenteral nutrition-induced cholestasis and liver damage associated with intestinal failure-associated liver failure (IFALD)

          • SEFA-6179 is NST’s third program to enter the clinic

          • NST strengthens its position as a multi-asset clinical development company targeting the first orphan indication with high unmet medical need

          AMSTERDAM, February 02, 2022–(BUSINESS WIRE)–NorthSea Therapeutics BV, (“NST”), a biotechnology company developing new and innovative strategies for the treatment of NASH and other metabolic diseases, today announces that it has launched a phase 1 study with SEFA-6179 in adult subjects, targeting the initial orphan indication for the treatment of IFALD.

          IFALD is a multifactorial condition characterized by the development of hepatic inflammation, cholestasis and steatosis in patients with intestinal failure and/or short bowel syndrome. It occurs after prolonged use of total parenteral (intravenous) nutrition. The development of liver fibrosis, which can progress to cirrhosis and liver failure, is a major concern for patients with this disease. No approved drug treatment exists for this population.

          The SEFA-6179 Phase 1 clinical trial is being conducted in the UK and is expected to enroll approximately 90 healthy participants. The study is a randomized, placebo-controlled, single dose and multiple ascending dose trial evaluating the safety, tolerability and pharmacokinetics of SEFA-6179. Final results are expected in the third quarter of 2022 and will support the initiation of a global phase 2 study in patients with IFALD, which is expected to start in the first quarter of 2023.

          Professor Palle Bekker JeppesenHead of the Department of Intestinal Insufficiency and Liver Diseases at Rigshospitalet Copenhagen, said: “SEFA-6179 showed a broad therapeutic effect on key biomarkers of liver injury as well as improvements in liver histology in several preclinical models. The availability of oral therapy could optimize the management of this hepatic disease with a high medical need. It could provide significant clinical benefit to patients on long-term parenteral nutrition at high risk of IFALD.

          NST has a library of structurally modified fatty acids (SEFAs) which are all new chemical entities with unique and differentiated physicochemical properties and biological targets.

          Rob de Ree, CEO of NST, commented: “The initiation of this trial is a key step in NST’s journey to becoming a multi-asset company with a strong clinical SEFA pipeline. We are delighted to develop our first candidate for an orphan indication, in particular for an indication where patients currently have no therapeutics. choices available.”

          SEFA-6179 is a novel, highly potent, orally administered, synthetic medium-chain fatty acid analog. The molecule directly targets the liver and has demonstrated robust treatment of cholestasis, steatosis and fibrosis in several preclinical models. The unique pharmacological properties of SEFA-6179 facilitate intestinal absorption, which is essential to ensure optimal drug absorption in patients with intestinal failure and short bowel syndrome. Unlike natural fatty acids, NST’s SEFAs are designed to prevent rapid utilization as an energy source, allowing for optimal drug exposure.

          NST also has two other SEFA programs in the clinic:

          • The company’s lead product icosabutate recently completed enrollment in its Phase 2b study in NASH. Last year, NST released strong interim results, and first results are expected in the first quarter of 2023.

          • SEFA-1024 is being developed for dyslipidemia. The phase 1 study is expected to be completed in the second quarter of 2022.

          -Ends-

          About Intestinal Failure Associated Liver Disease (IFALD)

          IFALD is a multifactorial condition in patients with bowel failure and/or major resection. It is characterized by the development of hepatic inflammation, cholestasis and steatosis. It has been shown to be associated with prolonged administration of parenteral nutrition. Patients with IFALD are often asymptomatic in the early stages, but progress to increased liver biochemistries, steatosis, and fibrosis. This can eventually lead to liver failure, transplant, and death if left untreated. There is a clear medical need for treatment options for patients and there are currently no approved treatments for IFALD.

          About SEFA-6179

          SEFA-6179 is a novel, highly potent synthetic medium-chain fatty acid (MCFA) analog. MCFAs are rapidly taken up by passive diffusion rather than receptor-mediated transport, but are rapidly metabolized. SEFA-6179 was designed to maintain the ease of transport to the liver and into cells that is characteristic of unmodified MCFAs, while providing enhanced pharmacological effects by avoiding rapid metabolism.

          SEFA-6179 treatment completely prevented severe cholestasis and the development of fibrosis in piglets with liver damage due to intravenous (parenteral) (IP) nutrition. SEFA-6179 also prevented the pronounced increase in liver injury markers in mice receiving parenteral nutrition in combination with an inflammatory stimulus (endotoxin). Additionally, SEFA-6179 significantly reduced the number of myofibroblasts, the main collagen-producing cell in the liver, in addition to liver inflammation and steatosis in mice with established fibrosis.

          The ability of SEFA-6179 to target multiple pathogenic components of IFALD, in addition to its oral dosing potential, highlights its potential to become a highly effective drug for the treatment of NP-induced liver disease as well as other indications of potential liver disease.

          About NorthSea Therapeutics

          NorthSea Therapeutics BV (NST) is a Dutch biotechnology company specializing in the development of structurally modified fatty acids (SEFAs) for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic disorders.

          NST licensed the rights to its lead compound, icosabutate, and a SEFA library from Pronova BioPharma Norge AS (now part of BASF), which developed Lovaza® (American brand, Omacor brand® in Europe), a successful cardiovascular drug. Icosabutate has been shown to be safe and effective in two previous Phase 2 clinical studies for the treatment of hypertriglyceridemia and mixed dyslipidemia and is currently in clinical development for NASH. The ICONA Phase 2b trial of icosabutate in patients with biopsy-confirmed NASH is expected to complete in the first quarter of 2023.

          Two additional SEFAs are in clinical development: SEFA-1024 is in phase 1 to be developed for patients with severe hypertriglyceridemia, and SEFA-6179 is in phase 1 development for the orphan indication IFALD (Intestinal Failure Associated Liver Disease) .

          NST is headquartered in the Netherlands with a presence in Norway and the United States and is backed by Ysios Capital, Forbion Growth, Forbion Ventures, venBio partners, Novo Seeds, Sofinnova Investments, BGV, NSV and Hercules Capital.

          To learn more about us, visit: www.northseatherapeutics.com

          See the source version on businesswire.com: https://www.businesswire.com/news/home/20220202005072/en/

          contacts

          NorthSea Therapeutics BV
          Rob de Ree (CEO)
          Email: [email protected]
          Tel: +31 356993000

          Instinctive Partners (Media)
          Melanie Toyne-Sewell / Agnes Stephens / Katie Duffell / Grace Rutter
          Email: [email protected]
          Tel: +44 20 7457 2020

          Mesoblast Appoints Dr. Eric Rose as Chief Medical Officer

          0

          NEW YORK, 01 Feb. 10, 2022 (GLOBE NEWSWIRE) — Mesoblast Limited (Nasdaq:MESO ASX:MSB), the world leader in allogeneic cellular medicines for inflammatory diseases, is pleased to announce the appointment of Dr. Eric Rose as the company’s Chief Medical Officer (CMO). Dr. Rose has served as Non-Executive Director of Mesoblast since 2013. In his new role as a key executive, Dr. Rose brings to Mesoblast an extensive record of excellence in clinical development and successful interactions at the highest levels with key regulatory bodies. , industry, and government stakeholders including the U.S. Food and Drug Administration (FDA), National Institutes of Health (NIH), and Biomedical Advanced Research and Development Authority (BARDA).

          Dr. Rose is a highly respected medical scientist who focuses on clinical research, drug discovery, biodefense and health policy. A world-renowned heart surgeon and scientist, Dr. Rose led Columbia’s Presbyterian Heart Transplant Program from 1982 to 1992 and made history in 1984 when he performed the first successful pediatric heart transplant. From 1994 to 2007, he was chairman of the department of surgery at Columbia University and chief surgeon at Columbia Presbyterian Medical Center in New York. During this time, his leadership of the NIH-supported Randomized Evaluation of Mechanical Circulatory Support in Heart Failure (REMATCH) program resulted in the first FDA approval of an implantable left ventricular assist device for long-term circulatory support. , spawning a whole new industry. Dr. Rose continues to serve as a non-executive director of the leading implantable cardiovascular device company, ABIOMED.

          From 2007 to 2011, Dr. Rose served on the National Biodefense Science Board which advises the US Secretary of Health and Human Services on biodefense, influenza and emerging diseases. In 2007, he was named Chairman and CEO of SIGA Technologies where he oversaw the development of the first US-approved antipoxviral drug, TPOXX for the treatment of smallpox. Dr. Rose played a key role in getting the drug approved by the FDA in 2019, and he was responsible for securing contracts with BARDA under which the US government bought 1.7 million courses of TPOXX for more than US$1 billion in Strategic National Stock (SNS).

          Dr. Rose said, “I really look forward to being an integral part of Mesoblast’s leadership team at such a crucial time in the company’s history. Having seen first hand at board level the enormous potential of our technology to achieve remarkable clinical results in the most refractory inflammatory conditions, I feel privileged to be able to contribute in a more comprehensive way to help guide our therapies. through the final but crucial stages of regulatory approval and commercialization.

          Mesoblast Chief Executive Officer, Dr. Silviu Itescu, thanked outgoing Chief Marketing Officer, Dr. Fred Grossman, for his significant contributions, particularly regarding the regulatory progress of remestemcel-L in children with acute graft disease against steroid-refractory host (SR-aGVHD) and its role in pivoting society to acute respiratory distress syndrome COVID-19. Dr. Grossman will continue to provide support to the Society in an ongoing advisory role.

          Dr Itescu said, “We are delighted to have Dr Rose stepping into the critical position of Chief Marketing Officer of Mesoblast at such an important time in the company’s development. He is a world renowned physician with extensive marketing experience and a proven track record in successfully navigating products through the FDA in addition to his extensive network across government, regulatory agencies and the pharmaceutical industry.

          About the mesoblast
          Mesoblast is a world leader in the development of allogeneic (ready-to-use) cellular drugs for the treatment of serious and life-threatening inflammatory diseases. The Company has leveraged its proprietary mesenchymal lineage cell therapy technology platform to establish a broad portfolio of late-stage product candidates that respond to severe inflammation by releasing anti-inflammatory factors that counteract and modulate multiple effector arms of the immune system, leading to a significant reduction in the damaging inflammatory process.

          Mesoblast has a strong and extensive global intellectual property portfolio with protection extending to at least 2041 in all major markets. The company’s proprietary manufacturing processes produce industrial-scale, cryopreserved, ready-to-use cellular drugs. These cell therapies, with defined pharmaceutical release criteria, should be readily available to patients worldwide.

          Mesoblast is developing product candidates for distinct indications based on its remestemcel-L and rexlemestrocel-L stromal cell technology platforms. Remestemcel-L is being developed for inflammatory diseases in children and adults, including steroid-refractory acute graft-versus-host disease and moderate to severe acute respiratory distress syndrome. Rexlemestrocel-L is being developed for advanced chronic heart failure and chronic low back pain. Two products have been commercialized in Japan and Europe by Mesoblast licensees, and the Company has established commercial partnerships in Europe and China for certain Phase 3 assets.

          Mesoblast has offices in Australia, the United States and Singapore and is listed on the Australian Securities Exchange (MSB) and Nasdaq (MESO). For more information, please visit www.mesoblast.com, LinkedIn: Mesoblast Limited and Twitter: @Mesoblast

          Forward-looking statements
          This press release contains forward-looking statements relating to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that could cause our results, levels of activity, performance or actual achievements differ materially from any future results. , the levels of activity, performance or achievements expressed or implied by such forward-looking statements. We make such forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 and other federal securities laws. Forward-looking statements should not be construed as guarantees of future performance or results, and actual results may differ from the results anticipated in such forward-looking statements, and the differences may be material and adverse. Forward-looking statements include, but are not limited to, statements regarding: the initiation, timing, progress and results of preclinical and clinical studies of Mesoblast, as well as Mesoblast’s research and development programs; Mesoblast’s ability to advance product candidates, enroll in and complete clinical studies, including multinational clinical trials; Mesoblast’s ability to advance its manufacturing capabilities; the timing or likelihood of regulatory filings and approvals (including resubmission BLA), manufacturing activities and product marketing activities, if any; the commercialization of Mesoblast’s product candidates, if approved; regulatory or public perceptions and market acceptance surrounding the use of stem cell therapies; the possibility that Mesoblast’s product candidates, if approved, may be withdrawn from the market due to adverse events or patient deaths; the potential benefits of strategic collaboration agreements and Mesoblast’s ability to enter into and maintain established strategic collaborations; Mesoblast’s ability to establish and maintain intellectual property in its product candidates and Mesoblast’s ability to successfully defend against alleged infringement; the scope of protection that Mesoblast is able to establish and maintain for the intellectual property rights covering its product candidates and technology; estimates of Mesoblast’s expenses, future revenues, capital requirements and additional financing requirements; the financial performance of Mesoblast; developments regarding Mesoblast’s competitors and industry; and pricing and reimbursement of Mesoblast’s product candidates, if approved. You should read this press release, together with our risk factors, in our latest reports filed with the SEC or on our website. Uncertainties and risks that may cause Mesoblast’s actual results, performance or achievements to be materially different from those that may be expressed or implied by such statements, and accordingly, you should not place undue reliance on such forward-looking statements . We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future developments or otherwise.

          Release authorized by the general manager.

          For more information please contact:

          What is a brain? For Yale authors, conversation brings new clarity

          0

          For a new booktwo Yale researchers and a colleague from Oxford take a new approach to exploring the interrelated complexities of the brain: they talk about it.

          In “Body, Brain, Behavior: Three Views and a Conversation,” co-authored by Tamas Horvath and Joy Hirsch of Yale School of Medicine, and Zoltán Molnár, professor of developmental neuroscience at Oxford University, the three researchers each share a traditional chapter related to their disciplines: endocrine physiology, social neuroscience and developmental neuroscience. But the connection of the chapters is a series of transcripts of weekly conversations they held for two years.

          Although initially intended to help them shape their individual chapters, the conversations ended up helping each of the authors understand the perspectives of others and see where their disciplines and research areas intersect. They decided to include the conversations in the hope that they would be as enlightening for readers as they were for themselves.

          Horvath is the Jean and David W. Wallace Professor of Comparative Medicine, Professor of Neuroscience, and Professor of Obstetrics, Gynecology, and Reproductive Sciences. Hirsch is Elizabeth Mears and House Jameson Professor of Psychiatry, Professor of Comparative Medicine and Professor of Neuroscience.

          Horvath and Hirsch recently sat down with Yale News to discuss the book and what it reveals about the human brain. The interview is edited for length.

          You each contributed a chapter to the book. What did your chapters cover?

          Joy Hirsch: I’m a systems neuroscientist, which means I look at the brain in terms of the large-scale neural circuitry that underlies behavior. I don’t look at the brain from a cellular or molecular perspective, but I look at the mechanisms inside the brain and how they relate to cognition.

          The main methodology of systems neuroscience has been functional MRI neuroimaging, and over the past three decades we have gained incredible insights into the brain systems that underlie various cognitive behaviors. However, conventional neuroimaging methods do not interrogate the brain systems that underlie natural interpersonal interactions because only one brain can be studied at a time from inside the bore of a scanner. In other words, the neural systems that underlie living communicative behaviors, the social brain, cannot be studied by conventional methods, leaving a huge void in our knowledge of the brain and behavior.

          We have developed an alternative technology called functional near-infrared spectroscopy for the new purpose of imaging the brains of two people simultaneously during natural interactions. My chapter is about what we have learned from these new approaches. It is the beginning of a new “science of two” that builds on our conventional techniques and our understanding of cognition, but extends it in the new direction of dynamic social interactions.

          Tamas Horvath: My view is that the brain does not exist in isolation and should not and never has. And that if you want to understand the brain, you really have to understand how it integrates with the rest of the body and how information from the rest of the body is fundamentally crucial to the functioning of different parts of the brain.

          One of the things I emphasize from my point of view is that the trajectory that neuroscience has taken over the past hundred years may not be the right paradigm to look at brain function, because the Majority of efforts have been to try to understand how the brain works from inside the brain. We take a different approach by saying that information from the brain, from the body – from the liver, from your fat, from your gut, from your muscles, etc. – play a crucial role in the orchestration of events in the brain. For example, to better understand schizophrenia, one must understand how these brain-periphery communications are orchestrated. And we argue that these processes are relevant and critical to all complex normal and maladaptive behaviors and brain functions.

          How did the idea of ​​including your conversations come about?

          Hires: Tamas presented our project to Zoltán in the hope that he could help us write this book. I didn’t know Zoltán and he didn’t know our ideas, so we had to start conversations around our topics. We ask a big question for all of us: what is a brain? Tamas has the idea that the brain is everything in the whole body that connects to it. My idea is that a brain is only half of a fundamental social unit. Zoltán’s idea is that the brain is a magnificent control system that develops through millions of years of evolutionary adjustments. We had a lot to tell each other.

          These three points of view do not easily come together. However, the conversations began to guide our thinking, and connections between our research areas began to emerge. It was so exciting. We soon realized that it was our relatively “unplugged” conversations that led us to the intersections between these fundamental disciplines of neuroscience. We thought that if we recorded these conversations, they would guide us in the development of our chapters. This turned out to be wrong. However, in the end, we realized that the conversations had inspired and guided us in our understanding of how to think about the larger ideas that brought our disciplines together.

          Horvat: And to be respectful of each other’s ideas instead of pontificating that the truth lies in the way I Look at this. And I think that’s one of the key things about this process is that nobody knows. And I think the more we talk about it, the more we will be able to understand, from different angles.

          It’s really the conversational component that made us conceptualize our individual components and our overall view of neuroscience. So the conversational component was really what I think got us on the path to where we could actually do this book. They really stimulated us, made us think about things in a different way.

          Who is the audience for this book and what do you hope they take away from it?

          Horvat: I think this will mostly benefit people who want to learn more about neuroscience, physiology, and disease. For example, students, whether they are in high school, graduate school, or medical school.

          Hires: This book transcends the specific disciplines of neuroscience and focuses on the mechanisms of interaction as a spark of creativity. He endorses conversation as a scientific tool that we can take seriously. Very often, scientists give credence to the random chat they had at the water cooler. “I had this brilliant idea when I ran into my friend, and we just sat down, and we drew these things on a napkin, and now here’s this beautiful scientific discovery.” What is retained is the end result and perhaps the memory of the water fountain moment, but the actual mechanism by which the idea was generated is left out.

          What we have done in this book is to shine a spotlight on the value of conversation in science to find connections between different approaches and topics. I hope that by sharing our conversations on our particular topics, we will encourage our readers from all disciplines and at all stages of the academic ladder to do the same, and ultimately energize our collective thinking.

          Plant-based meat market size worth $24.8 billion by 2030: Grand View Research, Inc.

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          SAN FRANCISCO, February 1, 2022 /PRNewswire/ — The World vegetable meat market size is projected to reach $24.8 billion by 2030, according to a new report from Grand View Research, Inc.. The market is expected grow at a CAGR of 19.3% from 2022 to 2030. Rising adoption of vegan lifestyle and diet by health conscious consumers in traditionally meat consuming developed economies is expected to drive the market over the forecast period.

          Main information and conclusions of the report:

          • The plant-based sausage segment is expected to grow at a CAGR of 20.4% during the forecast period. Shifting consumer inclination towards plant-based diets and increasing consumption of sausages in retail channels due to their taste, texture and convenience are expected to drive demand for products worldwide
          • The soybean products segment accounted for more than 48.3% of revenue share in 2021, due to its high protein content and high popularity
          • The rising trend of vegan diet in European countries has pushed the demand for plant-based meat products in the region. Conversely, the UK is known for being progressive in providing a variety of fresh, high quality food products to its population and is associated with housing the largest vegan populations across the world.
          • In June 2020Starbucks, in conjunction with Impossible Foods Inc., has introduced the Impossible Breakfast Sandwich to its menu at most of its locations in the United States. The sandwich is made with plant-based sausage, and was launched as Starbucks’ sustainability initiatives to address growing consumer interest in plant-based options

          Read the 140-page market research report, “Plant-Based Meat Market Size, Share, and Trend Analysis Report by Source (Soy, Peas, Wheat), By Product (Burgers, Patties, Sausages), by Type (Chicken, Pork, Beef), By End User, By Storage, Forecast By Region & Segment, 2022 – 2030“, published by Grand View Research.

          Growing consumer concern over animal welfare and greenhouse gas emissions created by the distinguished practices of the meat industry is driving the market. Celebrity recommendations for vegan/vegetarian diets are expected to increase demand for meat alternatives in the global market. Moreover, the launch of new products by the manufacturers similar to meat in terms of flavor, texture, color and taste increases the demand for the products.

          Plant-based meat is mainly consumed in the Hotel/Restaurant/Café (HORECA) sector. Key industry companies are working with fast food outlets and restaurant chains to drive adoption of their products. For example, fast-food establishments such as Burger King, MacDonald’s and Subway are launching new vegan meat products to capitalize on an industry dominated by health-conscious customers.

          Plant-based burgers are expected to show steady growth over the next few years due to growing consumer concerns about conventional meat products in the wake of the coronavirus pandemic. Plant-based burgers are known to be low in gluten and fat, making them popular among health-conscious people.

          Market segmentation :

          Grand View Research has segmented the global plant-based meat market based on source, product, type, end-user, storage, and region:

          • Plant-Based Meat Sources Outlook (Revenue, USD Million, 2017 – 2030)
          • Plant-Based Meat Products Outlook (Revenue, USD Million, 2017 – 2030)
            • Burgers
            • Sausages
            • Patties
            • Nuggets, fillets and cutlets
            • Lands
            • Others
          • Plant-Based Meat Type Outlook (Revenue, USD Million, 2017 – 2030)
            • Chicken
            • Pork
            • Beef
            • Fish
            • Others
          • Plant-Based Meat End-User Outlook (Revenue, USD Million, 2017 – 2030)
          • Plant Based Meat Storage Outlook (Revenue, USD Million, 2017 – 2030)
            • Chilled Vegetable Meat
            • Frozen Vegetable Meat
            • Shelf-stable vegetable meat
          • Plant-Based Meat Regional Outlook (Revenue, USD Million, 2017 – 2030)
            • North America
            • Europe
              • UK
              • Germany
              • France
              • Italy
              • The Netherlands
            • Asia Pacific
              • China
              • Japan
              • Australia & New Zealand
            • Central & South America
            • Middle East & Africa

          List of Plant-based Meat Market Key Players

          • Beyond meat
          • Impossible Foods Inc.
          • Maple Leaf Foods (Country Roast and Maple Leaf)
          • Vegetarian Butcher
          • Conagra, Inc. (Gardein Protein International)
          • Kellogg NA Co. (MorningStar Farms)
          • Quorn
          • Amy’s Kitchen, Inc.
          • Tofurki
          • Gold&Green Foods Ltd.
          • powered by the sun
          • VBites Foods Limited
          • Kraft Foods, Inc.
          • Lightlife Foods, Inc.
          • Trader Joe’s
          • Yves Veggie Cuisine (Le Hain-Céleste Canada, ULC)
          • Marlow Foods Ltd. (Cauldron)
          • Ojah B.V.
          • move mountains
          • Eat JUST Inc.
          • LikeMeat GmbH
          • Good point
          • OmniFoods
          • No bad foods
          • DR. Praeger’s Reasonable Foods

          Check out more studies related to herbal foods and supplements, published by Grand View Research:

          • Herbal Protein Supplements Market – The global herbal protein supplements market size was valued at $5.35 billion in 2020 and is projected to grow at a compound annual growth rate (CAGR) of 8.6% from 2020 to 2028. The growth of the market can be attributed to the growing consumer awareness regarding the nutritional values ​​of herbal products. botanicals such as low sodium and high amino acids.
          • Vegetable drinks market – The global plant-based beverages market size was valued at $22,859.4 million in 2020 and is expected to grow at a compound annual growth rate (CAGR) of 14.3% from 2021 to 2028. Rising health concerns have forced consumers to change their preference for vegan foods and beverages.

          Browse Grand View Research coverage on the Global processed and frozen food industry.

          About Grand View Research

          Grand View Research, a US-based market research and consulting firm, provides syndicated and custom research reports and consulting services. Checked in California and whose head office is at San Francisco, the company has more than 425 analysts and consultants, adding more than 1,200 market research reports to its extensive database each year. These reports offer in-depth analysis of 46 industries in 25 major countries around the world. Using an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and assess upcoming opportunities.

          Contact:

          Sherry James
          Corporate Sales Specialist, United States
          Grand View Research, Inc.
          Phone: +1-415-349-0058
          Toll Free: 1-888-202-9519
          E-mail: [email protected]
          The Web: https://www.grandviewresearch.com
          Follow us: LinkedIn | Twitter

          SOURCEGrand View Research, Inc.

          Doctors wonder if COVID herd immunity is possible – WISH-TV | Indianapolis News | Indiana Weather forecast

          0

          INDIANAPOLIS (WISH) — The United States may be on the verge of putting COVID-19 behind us.

          But with overwhelmed hospitals, the pace just isn’t fast enough. Experts say we need something called herd immunity

          According to the Mayo Clinic, herd immunity is defined as “when a large portion of the community becomes immune to a disease, making the spread of disease from person to person unlikely.”

          As a result, the whole community becomes protected, not just the immunized people. The marker is expressed as a percentage. So what percentage are the health authorities aiming for?

          News 8 turned to Dr. Paul Driscoll of Franciscan Health to weigh in.

          “Part of the difficulty is that no one really knows what level we need to reach to have a community of herd immunity,” Driscoll said. “When the pandemic started, they were talking about maybe 60-65% of the population. But then when some of the other variants came out, they bumped it up from 85% to 90%.

          If so, we’re not even close. The latest report from Our World Data shows that 76% of people have at least one dose of vaccine, 64% are fully vaccinated, but only 27% are boosted. More and more evidence shows that boosters are necessary because the protection decreases rapidly. Several studies show that antibodies decline at around six months or less.

          Currently, 53% of Hoosiers are fully vaccinated.

          Microgrid project using vanadium redox flow battery – pv magazine USA

          0

          “Weather conditions are increasingly threatening the continuity of essential services that our customers expect and deserve from us, which is one of the many reasons why we are so focused on innovation and technology,” said Caroline Winn, CEO of SDG&E. “Developing breakthrough solutions such as zero-emission microgrids is essential not only to minimize disruption, but also to support the transition to a cleaner, safer and more reliable energy grid of the future. »

          Different from more common stacked lithium-ion battery cells, VRF batteries consist of reservoirs of liquid electrolytes and pumps that charge and discharge electrons to the grid. According to the U.S. Department of Energy, VRF technology has several advantages, including the potential for storing MWh of energy in simple designs, the ability to discharge energy for up to 12 hours at a time, and the fact that VRF batteries do not present a fire hazard. and use no highly reactive or toxic substances, can sit idle for long periods of time without losing storage capacity, and more. Disadvantages include the fact that VRBs generally have lower energy densities than other battery types (although increased energy density would help reduce costs and expand applications), the current draw of Standby can result in power loss, the technology’s small operating temperature window requires the use of air conditioning systems which can result in significant power losses, and the cost of the vanadium electrolyte.

          During the pilot, the batteries charged when solar power was abundant and discharged during peak hours to meet demand.

          The microgrid demonstration project was completed late last year and included two successful tests. One was a seamless transition in which customers suffered no loss of power when transferred to the microgrid for electric service. The other was a black boot, where microgrid operators established and maintained service after a total power outage. Customers suffered a momentary outage before being transferred to the microgrid, which operated in island mode separated from the power grid. The microgrid provided energy service as expected, even on cloudy days when solar power generation was not optimal.

          SDG&E began operating America’s first large-scale microgrid in 2013 in Borrego Springs and is currently in the process of upgrading it to run on 100% renewable energy. The utility is building four additional microgrids and is on track to integrate approximately 145 MW of utility-owned energy storage with the local grid in 2022.

          14 drug discovery startups to watch, according to top VCs

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          2021 was the year drug development startups in Europe shifted into a different gear. They raised $1.6 billion – nearly three times the 2020 figure – as VCs backed a some startups with large checksincluding huge funding rounds for companies like owkin and Exscientia, while BenevolentAI agreed to Europe largest transaction ever by Spac.

          Investors are beginning to sense the opportunity to leverage AI to develop new drugs and treatments, spurred by pandemic-driven digitalization and increasingly favorable regulatory conditions in Europe. Pharmaceutical megaliths have also started paying attention to startups in the space, and earlier this month Exscientia got a huge $5.2 billion contract with Sanofi.

          But which early stage startups do investors have on their radar heading into 2022? Sifted asked five VCs which (non-portfolio) companies they were monitoring.

          Antoine Papiernik, Chairman and Managing Partner of Sofinnova Partners

          Papiernik’s portfolio includes biotechs Mnemo Therapeutics, Noema Pharma and Tissium

          Nucleoma therapy

          Nucleome Therapeutics decodes the dark matter of the human genome to discover new ways to treat disease. The dark matter genome contains more than 95% of disease-linked genetic variants and its value remains untapped, representing a significant opportunity for drug discovery and development.

          Lifted: N / A
          Based: 2019
          Last round: N / A
          The head office : Oxford, United Kingdom

          Proxygen

          Proxygen develops therapies for cancer and other life-threatening diseases by reprogramming cellular proteins with special drugs called molecular glue degraders. Molecular glue degraders are considered one of the most promising therapeutic innovations of recent decades due to their potential to pave the way for targeting proteins known to be key drivers of disease.

          Lifted: N / A
          Based: 2020
          Last round: Grant, February 2020
          The head office : Vienna, Austria

          Stage biotechnology

          Scenic Biotech is at the forefront of the discovery of genetic modifiers for drug intervention. Its innovative platform, Cell-Seq, enables a comprehensive overview of genetic modifiers for many different disease phenotypes to select the best targets.

          Lifted: $7.2 million
          Based: 2017
          Last round: €3.1 million grant, June 2020
          The head office : Amsterdam, Netherlands

          Therapeutic Hemab

          It is an emerging biotechnology company that develops new treatments for rare and underserved bleeding disorders.

          Lifted: $55 million
          Based: 2019
          Last round: $55 million, Series A, July 2021
          The head office : Copenhagen, Denmark

          TreeFrog Therapeutic

          TreeFrog Therapeutics is developing a technology that enables the mass production and differentiation of stem cells. Its technology platform provides an end-to-end, scalable solution that dramatically improves the quality of therapeutic cells and reduces treatment costs.

          Lifted: $85.8 million
          Based: 2018
          Last round: €3.5 million grant, December 2021
          The head office : Bordeaux, France

          Julia Hawkins, General Partner of LocalGlobe

          Hawkins portfolio includes Oxford Nanopore biotech, AccuRx health platform and Yulife wellness app

          Julia Hawkins, General Partner of LocalGlobe

          BioCorteX

          BioCorteX applies AI to design new therapies, improving current drugs by hacking into the microbiome (genetic information). This team may have found a way to make the microbiome therapeutic opportunity addressable and scalable.

          Its founders, Nik Sharma and Mo Alomari, believe that BioCorteX-enhanced therapies based on drug-microbiome interactions will usher in a new era in pharmaceuticals. For example: resistant cancers can be treated by modifying the microbiome of patients before chemotherapy.

          BioCorteX has already developed four AI engines that produce a flywheel effect delivering multiple potential therapeutics. These engines have already produced and validated 100,000 previously unknown drug-microbiome interactions.

          Lifted: undisclosed
          Based: 2021
          Last round: undisclosed
          The head office : London, UK

          Therapeutic Charm

          The startup’s founder, Laksh Aithani, started his first AI venture in college, before becoming a machine learning engineer at Exscientia working on the development of the predictive modeling platform.

          Charm is powered by DeepMind’s AlphaFold, an AI system that has been trained on the sequences and structures of 100,000 proteins, mapped by scientists around the world. Today, AlphaFold can predict the structure of a protein just by its amino acid sequence.

          The startup relies on AlphaFold to develop small molecule therapeutics targeting pathogenic proteins whose 3D structure is unknown.

          Lifted: undisclosed
          Based: 2021
          Last round: undisclosed
          The head office : London, UK

          Tanel Ozdemir, life sciences investor at AlbionVC

          Ozdemir’s portfolio includes biotechnology Epsilogen, Quell Therapeutics and PanAngium Therapeutics

          Tanel Ozdemir, life sciences investor at AlbionVC

          Enara Organic

          Enara is a cancer immunotherapy and vaccine company spun off from leading UK research institutions including the University of Oxford and Cardiff University. The startup is taking an intriguing platform approach to developing next-generation T-cell receptor-based therapies and vaccines that fight cancer by targeting a previously inaccessible repertoire of antigens on tumors.

          The company is backed by investors such as SV Health and RA Capital, and has already signed a partnership agreement with pharmaceutical company Boehringer Ingelheim.

          Lifted: $17.5 million
          Based: 2016
          Last round: $17.5 million Series A, November 2019
          The head office : Oxford, United Kingdom

          Catherine Boule, managing partner at Karista

          Boule’s portfolio includes health technologies Incepto Medical, Acticor Biotech and Tissium

          Catherine Boule, managing partner at Karista

          Alderaan Biotechnology

          This startup is developing high-potential treatments for cancer patients. His programs relate to the elimination of regulatory T cells and the hyper-activation of natural killer cells in the tumor microenvironment – ​​both of which are emerging as new immunotherapy modalities.

          Lifted: $22 million
          Based: 2017
          Last round: €18.5m Series A, January 2020
          The head office : Paris, France

          Osivax

          Osivax is developing a universal influenza vaccine for current and future influenza infections. One candidate is in phase 2a clinical development and the startup is leveraging the same technology for the development of a universal vaccine against all existing and emerging coronavirus infections.

          Lifted: $49.6 million
          Based: 2017
          Last round: €15 million grant, July 2020
          The head office : Lyon, France

          Aboleris Pharma

          The startup develops new immunomodulators for immune-mediated diseases. The company has two programs: a monoclonal antibody that will soon reach the Phase 1 clinical stage and the cytokine IL-34. These novel treatments offer exciting new approaches for patients at risk for graft-versus-host disease (GVHD) or those with autoimmune diseases.

          Lifted: €2.5 million
          Based: 2019
          Last round: €2.5 million seed, Nov 2020
          The head office : Nantes, France

          Michael Treskow, Partner at Eight Roads

          Treskow’s portfolio includes drug discovery startups Owkin and biotechs Insilico Medicine and Silexon

          Michael Treskow, Partner at Eight Roads

          LabGenius

          The startup has an interesting comprehensive approach to protein discovery, starting with the field of inflammation, using unsupervised learning AI.

          Lifted: $28.7 million
          Based: 2012
          Last round: $15 million, Series A, October 2020
          The head office : London, UK

          Nuclear

          Nucleai supports drug development with AI-based image analysis of pathology data to discover predictive biomarkers.

          Lifted: $11.5 million
          Based: 2017
          Last round: $6.5 million, Series A, July 2020
          The head office : Tel Aviv, Israel

          causality

          Causaly keeps scientists abreast of information in publicly available research, helping them understand what has already been discovered and tested, and what remains unknown.

          Lifted: $22.9 million
          Based: 2018
          Last round: $17 million, Series A, May 2021
          The head office : London, UK

          Kai Nicol-Schwarz is a journalist at Sifted. He covers health tech and community journalism, and tweets from @NicolSchwarzK

          Science already explains the link between cancer and obesity

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          Published on 01/30/2022 20:00

          Obesity increases the risk of many types of cancer. This knowledge has been reinforced in recent years by several epidemiological studies. But unlike other factors, like smoking, most people and even doctors aren’t aware of the relationship. Finding out how excess fat contributes to tumor formation can help prevent and develop new drugs.

          More than 200 types of cancers are already known, and so far science has discovered the link between obesity and 13 types of diseases, such as diseases of the liver, thyroid, ovaries, kidneys, pancreas, stomach, esophagus and gallbladder. The list also includes cancers of the tissues surrounding the brain and spinal cord (meningioma), leukemia (multiple myeloma), colorectal cancer, cancer of the breast (postmenopause), and cancer of the endometrium (the tissue that lines the ‘uterus).

          Concern over the relationship between obesity (increasing worldwide) and disease has led to the emergence of institutions such as the World Health Organization (WHO), the National Cancer Institute (NCI) , in the United States, and the National Cancer Institute. (Inca.), in Brazil, to warn of the need for prevention.

          With the decline in the number of smokers, obesity tends to become the most important preventable factor in the genesis of cancer, according to the American Society of Clinical Oncology (ASCO).

          A study published this month in the journal Nature Communication It offers a new explanation for putting this puzzle together. According to the work, cellular adaptation to obesity is subject to palmitic acid derived from lipids.

          This adaptation results in changes in stem cells that become carcinogenic rather than forming healthy tissue. The study was conducted by transplanting breast tumor cells into 223 patients. “Obese people are more likely to develop cancer, and when this happens the tumors seem to be more aggressive,” says Nils Hallberg of the University of Bergen in Norway, one of the authors. “This new understanding could lead to better targeted therapies for obese cancer patients.”

          “There is no doubt that obesity increases the risk of several types of cancer,” says Dr. Paulo Hoff, president of the Brazilian Society of Clinical Oncology (SBOC). “What is happening now, as the Nature Communications article explains, is a revision of assumptions,” he says.

          Early retrospective surveys (when researchers collected information about patient risk factors) found that obese postmenopausal women had a higher risk of developing breast cancer. Then other studies showed an association with liver cancer. In recent years, oncologists have noticed an increase in cases where these tumors are not caused by alcohol abuse or viral hepatitis, but by an accumulation of fat (steatosis) in the liver.

          the reasons

          “There are still mechanisms to be elucidated,” says breast specialist Renato Cagnacci, MD, of the Camargo AC Cancer Center. But there are at least three reasons why excess fat increases the risk of developing malignant cells.

          Obesity increases the amount of insulin in the body, a hormone that increases metabolism and cell multiplication, which can lead to tumors. Adipose tissue also produces female hormones (estrogen and progesterone), which are a risk factor for breast cancer, especially in obese postmenopausal women.

          The third important factor is chronic inflammation. Obesity leads to the production of certain cytokines (proteins secreted by cells) which leave a person in a permanent inflammatory state, increasing the risk of cancer. “The World Health Organization estimates that around 20% of all cancers are linked to obesity,” says Kagnashi.

          Despite the evidence accumulated in recent years, ignorance of the subject persists. “Most clinicians still tend not to consider obesity as a risk factor for cancer,” says Hof, an oncologist. “That has to change.”

          protection

          Obesity also appears to increase the risk of tumor recurrence. Epidemiological studies suggest that women who are obese or who gain weight after treatment have a higher risk of recurrence. The explanation, again, lies in high estrogen levels. “We always advise patients undergoing treatment to maintain a healthy lifestyle, lose weight and be physically active,” says Kagnashi.

          To this end, the artist Leila Maria de Sequeira Garcia, 64, has reorganized her habits. She was never skinny, but she weighed over 130 kg during treatment for breast cancer. “One day I looked in the mirror and decided to conquer a new body,” he said. Lost 47 kg in three years. “On my own, I changed my diet to reduce fat, sugar and soda,” says she, who emerged from cancer treatment more than 10 years ago. “Today I feel better, but I want to lose another 5 kg for breast reconstruction surgery,” she says.

          determinants

          Most of the evidence linking obesity to an increased risk of cancer comes from large cohort studies, the type of observational study that aims to analyze the incidence of a particular disease in a predefined population. Data from observational studies can be difficult to interpret. Despite these limitations, there is consistent evidence that high amounts of body fat increase cancer risk, according to the US National Cancer Institute.

          In 2016, the World Health Organization’s International Agency for Research on Cancer (IARC) analyzed evidence from more than a thousand studies on the subject and concluded that the absence of excess fat body reduces the risk of cancer. The work was published in the New England Journal of Medicine.

          “Cancer is a multifactorial disease. It is difficult to determine the cause in a specific person,” said oncologist Ronaldo Corre of the Inca Organization for Prevention and Control. “In about 90% of cases, the causative agent is lifestyle behavior or environmental exposure.”

          According to Corrêa, no study has evaluated the relative risk of being overweight in a Brazilian population. The researcher explains that many surveys conducted around the world do not only analyze obesity ranges.

          They include all kinds of extras in the same package. They are: one category of overweight and three categories of obesity, classified by body mass index (BMI).

          This definition of excess weight has contributed to 1.8% of cancer cases in Brazil, according to an estimate published last year by Correa and his colleagues in the scientific journal PLOS 1. According to the Inca, 5% of Postmenopausal breast cancer cases are attributable to excess fat. . In the body.

          “It’s not uncommon for three institutions to report different values,” says Correa. “It’s based on population survey data that the researchers used.”

          small tires

          “What increases the risk of cancer is obesity (a BMI greater than 30), not just being slightly overweight,” said Paulo Hoff. “If a person has a spare wheel, it does not mean that he is at an increased risk of suffering from the disease.”

          The trend is that in the coming years, the number of cancer cases attributable to excess fat will increase.

          The increase in overweight, which already affects 57.5% of Brazilians, is worrying, since the trend is that they continue to gain weight and become obese. Getting an overweight person to lose weight is more difficult than preventing a normal weight person from becoming an overweight person.

          “Adopting a healthy lifestyle as a preventative factor is a simple thing that most people can strive for,” says breast specialist Kagnashi.

          The value of benefits is enormous. Log information. State of Sao Paulo.

          3 Reasons to Ditch All My Individual Stocks for Index and Mutual Funds

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          • When I first started investing, I only bought a bunch of individual stocks, which resulted in low returns.
          • I think I’m going to ditch all of my individual stocks in favor of mutual and index funds.
          • I hope it makes investing less time consuming, diversifies my portfolio and improves my returns.
          • Learn more about Personal Finance Insider.

          I spent most of my 20s making lots of financial mistakes, from ignoring my retirement fund to racking up debt. A few years ago I was able to stabilize my finances and that’s when I decided it was time to invest.

          Without much knowledge or strategy, I decided to buy a handful of individual stocks. I invested in companies of which I was a consumer and in companies that I thought had a promising future. Although it seemed like a good idea at the time, buying these individual stocks made my investment strategy long and not as profitable as I would like.

          Index funds and mutual funds, which put your money in securities like stocks, bonds and short-term debt securities, often offer higher returns.

          According to The balancein 2021, mutual funds in seven categories averaged an annual return of 11.54%, which is far more than the returns I’ve made on individual stocks.

          As I reassess my finances in 2022, here are three reasons I’m considering ditching all of my individual stocks in favor of indices or mutual funds.

          1. My individual approach to actions was haphazard

          I was so excited to enter the world of investing that I just took a large sum of money and used it to start buying stocks. I bought stocks in companies that I thought were promising and companies that I was a loyal consumer of. While this approach may work for some, it hasn’t led to the best returns.

          Instead, picking index funds or mutual funds — even some that encompass the companies I bought individual stocks in — might be a better strategy for boosting returns, because success doesn’t rest only on one company.

          2. I want more variety with my investments

          From the moment I started investing in stocks, I knew the importance of having a variety of categories and companies for my portfolio. In the end, I found that I mostly invest in technology companies, because those are the companies I know best.

          One of the benefits of putting money in mutual funds or index funds is being able to have a more diversified portfolio. You can choose funds based on company size or categories like the S&P 500


          index fund

          emerging markets or an international equity fund.

          3. I don’t have time to manage my stocks

          Over the years I have purchased shares in over 15 companies. Although I’m often tempted to leave the money in the market and not check them out, I’ve seen for myself why that’s a bad idea.

          Once, one of the companies I invested in went bankrupt and I lost all my money because I didn’t pay attention to the news or sell the stock fast enough.

          Since I’m still new to investing, managing my stocks requires a few hours of research per week and requires me to make daily decisions about when to buy and sell stocks. Index or mutual funds do not require as much research and time.

          Ultimately, I want to spend less time thinking about which stocks to buy and which to sell. Instead, I want to spend about an hour a month looking at my index or mutual funds, and a few hours a quarter deciding which new funds I should invest in.

          I hope this approach makes investing less time-consuming and provides greater returns.

          innate, adaptive and booster immunity

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          Update with Professor Lorenzo Dagna, Head of the Immunology, Rheumatology, Allergology and Rare Diseases Department at San Raffaele Hospital in Milan

          How the immune system in front of vaccine and to sickness? Is the protection induced by the disease infection really stronger and more durable than that induced by the vaccine? A third or fourth dose of the severe disease vaccine covid after a few months of the previous one, they can weaken the immune system? In the era of generalized medicine, where the Sars-CoV-2 coronavirus pandemic has seen many ordinary citizens take an interest in scientific issues, the immune system, the main ally of our health and our lives, has returned to the center of the debate. Between no vax, maybe vax and yes vax the nuances are the most diverse. And it’s good to take stock of what we know so far based on the data. Starting from how the immune system works.

          Immune system: innate immunity –

          It may come as a surprise, but the outpost of immune system consists of the the skin, give him mucous membranes, sweat, mucus, sebum. These physical barriers are the first filter between us and potentially pathogenic external agents. Beyond the skin, immunities can be of two types:innate or non-specific immunity headaptive or specific immunity. “The immune system it is the result of the evolution of hundreds of thousands of years. After the defense barriers like the skin, the body has specialized cells that eat germs, and they always do it the same way: if they encounter a substance or something that is perceived as dangerous, they try to destroy it, most often ‘to eat it’. These cells represent the innate immune system, explain to Official asset Professor Lorenzo Dagna, Head of the Department of Immunology, Rheumatology, Allergology and Rare Diseases at IRCCS San Raffaele Hospital in Milan and Associate Professor of Internal Medicine at Vita-Salute San Raffaele University. “In the case, for example, where we receive a scratch and a bacterium penetrates under the skin, thus overcoming the first external barrier, the cells of the innate immune system and try to destroy it. It is a very rapid and non-specific immune response, valid immediately for everything with which we come into contact”, underlines the immunologist. But the non-specificity of the innate immune response is not total: “We used to believe so. However, the latest data show that evolution has led to an innate immunity that “learns”, so to speak, albeit in a less sophisticated way than adaptive immunity”.

          Immune system: adaptive immunity –

          But to differentiate between innate and adaptive immunity it’s not just the specificity of the response. An important role is played by the Memory. “After the first response given by innate immunity, we have that ofadaptive immunity, Which one is hyperspecific against bacteria, viruses or in general the pathogen responsible for the attack. And this second immunity has a fundamental characteristic: it is endowed with Memory – emphasizes Professor Dagna -. So when we encounter the same antigen again, the immune response will not arrive in weeks, but in days.”

          The importance of memory cells for the immune response –

          Just there immune system memory is the one on which I vaccineswhich stimulate a response to the infection in order to make the immune system how to react in the event of an attack by the same virus. “While when we first encounter a substance we have to develop specific cells against it, on the second encounter these cells will already be present in the immune system as memory cells and they will still have the information for the response to that antigen. Therefore, our immune system will already be prepared for defense – explains Dagna -. The immunological memory is operated by vaccines. One administers the antigen which causes the immune reaction but which is unable to cause the disease, although the substance administered is very similar to that which causes the disease. In this way, it is possible to trigger protection against the disease without giving its effects”.

          Why disease infection gives a stronger response than vaccine infection (but not always practical) –

          It must be said to be honest that if the vaccine is able to “teach” our body the immune response to an infection, it may be less strong than the immune response triggered by sickness. “It is absolutely likely that a natural infection could give a larger memory-like response than that generated by a vaccine. Unfortunately, this is not a guarantee of long-term protection. For example, several data suggest that at least in some people who have become ill with covid over time there is a slow but gradual loss of protective immunity against the virus same. And the same phenomenon was also observed in vaccinated subjects. This despite what is observed in other diseases, where once the vaccine or disease you are protected forever or at least for several years”, explains Professor Dagna.

          Immune system, vaccine and booster –

          Hence the need to vaccine reminders against severe forms of covid. And some will say: at this stage, why should you get vaccinated, if vaccination does not provide long-lasting protection? “A single dose of vaccine it may not be enough to protect us from a reinfection by analogy with the fact that it is possible to fall ill again after having contracted Covid – recalls the immunologist -. This happens because in such subjects the virus (or the vaccine) was unable to generate a lasting response. Administer multiple doses of vaccinewhile not eliminating the risk of reinfection, it reduces the risk of developing serious illness. Not getting vaccinated puts you at risk of getting sick (or getting sick again) from the natural disease, associated with extraordinarily higher risks (even for a second infection) than those associated with vaccination.”

          Covid vaccine: what is the frequency of reminders? –

          “As a matter of principle, the vaccines they all work the same way, but the duration of protection – explains Professor Dagna – depends from one vaccine to another and the type of immune response evoked. In the case of Covid vaccines it has been found that one or two doses, especially in fragile subjects, are insufficient to guarantee protection of adequate duration. For this reason, it was necessary to administer a third dose or booster, which is of crucial importance especially in frail, elderly or immunocompromised patients. To this day, on the contrary, as they also claim WHO and EMA – emphasizes Professor Dagna – there is no data to support the usefulness of any other fourth dose of vaccine in the general population, while we assess whether this could make sense in fragile populations. It is important to remember that no data indicates a possible danger of repeated and frequent vaccinations, but if a general benefit linked to this practice is not demonstrated, it will make no sense to propose it. I remind you that there are parts of the world, like in Africa, which are still waiting for the first dose of vaccine and perhaps our attention should also be on these people”.

          wri: Civic organization and irg sign memorandum of understanding for climate action plan in Nashik | Nashik News

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          Nashik: A Memorandum of Understanding was signed on Friday between the Nashik Municipal Corporation (NMC) and the World Resource Institute (WRI) for the Nashik Climate Action Plan, in the presence of the state’s Minister of Environment, Aditya Thackeray.
          The Minister said that if citizens, experts and NGOs are involved in planning the development of cities, sustainable development must be achieved by minimizing damage to nature. The minister also said that as part of the exercise, GIS mapping of every tree in Nashik city and the rural belt will be carried out, which will help keep an eye on trees and plan development works. .
          Thackeray, who also holds the tourism portfolio, said efforts are underway to make Nashik a tourist district and a meeting will be held soon for the development of adventure, religious and health tourism.
          Commissioner Kailas Jadhav said the action plan is being prepared to achieve carbon neutrality in the city by 2035 and carbon surplus by 2050, for which, the WRI – which receives funds under CSR will prepare the roadmap for the company which would be executed only with the participation of people.
          The action plan proposes maximum uses of electric vehicles, the use of renewable energy sources, finding the right balance between the available resources of water, air, soil, energy and their optimal use. “Optimum use of energy can be sought by using more cycles and the availability of footpaths than the NMC will take in due course. But it is important that people use the system provided by the NMC,” Jadhav said.

          The #1 Best Smoothie to Slow Aging, Dietitians Say – Eat This, Not That

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          You’ve probably seen the commercials or advertisements in magazines with celebrities promoting the latest anti-aging serums. Maybe you’ve even splurged on some products yourself. But as we all know, there is no magic elixir that will completely reverse the inevitable effects of aging.

          However, there are several ingredients you can incorporate into your diet that can help with the aging process. And what better way to do that than by blending them into a refreshing smoothie?

          According to our medical expert board members Tammy Lakatos Shames, RDN, CDN, CFT and Lyssie Lakatos, RDK, CDN, CFT, also known as The Nutrition Twins, the best anti-aging smoothie is a wild blueberry chai protein smoothie.

          Packed with nutrients, this drink covers several bases when it comes to looking and feeling younger. Read on to discover the benefits of each ingredient. And for more anti-aging tips, check out The 5 Best Lifestyle Habits That Will Make You Feel Young, According To Science.

          Courtesy of Wild Blueberries

          There’s a reason these little blue gems have been popularized as “superfruits.” Blueberries are revered for their powerful antioxidant content, and wild blueberries go even further. Despite their small size, they contain twice as many antioxidants and 33% more healthy anthocyanins (a type of flavonoid) than regular blueberries.

          “All that antioxidant power is a big deal when it comes to keeping skin looking young, because antioxidants scavenge free radicals that damage and age skin,” say the Nutrition Twins.

          These antioxidants are known to help reduce inflammation, which in turn prevents some of the cell damage that naturally occurs with age.

          Vegan pea protein powder in a white ramekin next to a whole pea pod
          Shutterstock

          Protein is essential for the production of collagen, which helps keep skin supple, elastic and youthful. Nutrition Twins’ go-to ingredient for this smoothie is pea protein powder, but that can also be substituted with chickpeas. Legumes like pea protein and chickpeas are also great sources of plant-based protein and fiber, so they help keep you full, which can ultimately help with weight loss.

          While these protein sources help look younger on the outside, like blueberries, their anti-inflammatory properties also fight aging on the inside, say The Nutrition Twins.

          ground cinnamon
          Shutterstock

          Spices are celebrated for their plethora of health benefits, and this chai spice blend is full of them. Cinnamon, ginger, and cardamom not only enhance the flavor of the smoothie, but they also contain powerful antioxidants that fight inflammation and protect cells against diseases such as Alzheimer’s disease, heart disease, and cancer.

          While the spice trio actively works to defend and repair cells in the body, cinnamon also plays a particularly notable role in lowering blood sugar.

          “Continued high blood sugar levels are likely to react with proteins in the body like collagen and can lead to loss of elasticity, premature wrinkles, and can create dark spots or ‘age spots'” , say The Nutrition Twins.

          Related: 33 Best Foods for Glowing Skin Without Blemishes

          nutrition twins blueberry chai protein smoothie
          Courtesy of The Nutrition Twins

          Ready to whip up this delicious and healthy anti-aging concoction? Here is what you will need:

          • 2/3 cup frozen wild blueberries
          • 1/2 small banana
          • 1 scoop (20 grams) plain pea protein powder (or flavor like vanilla)
          • 1/2 cup unsweetened almond milk
          • 1/4 teaspoon ground cinnamon
          • 1/4 teaspoon ground ginger
          • 1 pinch ground cardamom
          • 3 ice cubes

          Optional add-ins for your smoothie may include water (to thin the smoothie to your desired thickness), 1/4 tsp ground turmeric (for added antioxidant/anti-inflammatory effect), 1-2 drops liquid stevia (for extra sweetness if your banana isn’t very ripe or you want a bit more sweetness when using unflavored protein powder)

          To substitute canned chickpeas, omit the protein powder and substitute 1/2 cup unsalted canned chickpeas, drained and rinsed.

          For more information on healthy eating, see 10 easy recipes to lower your cholesterol.

          New treatment helps frogs regenerate limbs with functioning nerves in just 18 months

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          Our body connects us to the world. When people lose parts of their bodies to traumatic illness or injury, they often feel like they’ve lost a part of who they are, or even suffer a loss. grief similar to the loss of a loved one.

          Their sense of personal loss is justified because unlike salamanders or sarcastic comic book characters like dead Pool, adult human tissues generally do not regenerate – the loss of a limb is permanent and irreversible.

          Where is it?

          Although there have been significant advances in prosthetic and bionic technologies to replace lost limbs, they cannot yet restore the sense of touch, minimize the feeling of phantom pains, or match the capabilities of natural limbs. Without reconstructing the limb itself, a person will not be able to feel the touch of a loved one or the warmth of the sun.

          We are researchers in regenerator and development biology and biomedical genius.

          Our recent study in the journal Scientists progress showed that just 24 hours of a treatment we designed is enough to regenerate fully functional, touch-sensitive limbs in frogs.

          Start regeneration

          Early in development, the cells that will eventually become limbs and organs organize themselves into specific anatomical structures using a set of chemical, biomechanical and electrical signals.

          When looking at ways to regenerate limbs, we thought it would be much easier to have cells repeat what they had already done early in development. So we looked for ways to trigger the “build what was normally here” signal for cells at the site of a wound.

          However, one of the main challenges is figuring out how to create an environment that encourages the body to regenerate itself instead of forming scars.

          Although scars help protect injured tissue from further damage, they also alter the cellular environment in ways that prevent regeneration.

          Some aquatic animals like the axolotls have mastered regeneration without scar formation. And even at the beginning of human development, the amniotic sac provides an environment that can facilitate regenerative mechanisms.

          We hypothesized that developing a similar environment could undo scar formation at the time of injury and allow the body to reactivate dormant regenerative signals.

          To implement this idea, we developed a wearable device consisting of a silk hydrogel as a way to create an isolated chamber for regeneration by blocking other signals that would direct the body to develop scarring or undergo other processes. We then loaded the device with a cocktail of five drugs involved in normal animal development and tissue growth.

          We chose to test the device using African clawed frogs, a species commonly used in animal research that, like humans, does not regenerate limbs in adulthood.

          We strapped the device to a leg stump for 24 hours. We then removed the device and observed how the site of the lost limb changed over time.

          Over the course of 18 months, we were amazed to find that the frogs were able to regenerate their legs, including finger-like projections with significant regrowth of nerves, bones and blood vessels.

          The limbs also responded to light pressure, meaning they regained the sense of touch and allowed the frog to resume normal swimming behavior.

          Frogs that received the device but without the drug cocktail had limited limb regrowth without much functional restoration.

          And frogs that weren’t treated with the device or the drug cocktail didn’t regrow their limbs, leaving stumps numb to touch and functionally impaired.

          Interestingly, the limbs of frogs treated with the device and the drug cocktail were not perfectly reconstructed. For example, bones were sometimes fragmented. However, the incompleteness of the new member tells us that other key molecular signals may be missing and many aspects of treatment can still be optimized.

          Once these signals are identified, adding them to drug treatment could potentially completely reverse limb loss in the future.

          The future of regenerative medicine

          traumatic injury is a leading cause of death and disability among Americans. And the loss of a limb following a serious injury is the most frequent source of lifetime disability.

          These traumatic injuries are often caused by automobile accidents, sports injuries, side effects of metabolic diseases such as diabetes, and even battlefield injuries.

          The ability to decode and reawaken dormant signals that allow the body to regenerate parts of itself is a transformative frontier of medical science.

          Beyond the regrowth of lost limbs, the regeneration of heart tissue after a heart attack or brain tissue after a stroke could prolong life and significantly increase its quality. Our treatment is far from ready for use in humans, and we only know that it works when applied immediately after injury.

          But discovering and understanding the signals that allow cells to regenerate means that patients may not have to wait for scientists to truly understand all the intricacies of building complex organs before they can be treated.

          To make a person whole means more than simply replacing his limb. It also means restoring their sense of touch and their ability to function. New approaches in regenerative medicine are now beginning to identify how this might be possible.

          Michel Levin, a biology teacher, Tufts University; David Kaplan, professor of biomedical engineering, Tufts University, and Nirosha Murugan, assistant professor of biology, Algoma University.

          This article is republished from The conversation under Creative Commons license. Read it original article.

          Company Overview, Analytical Assessment and Future Scope Analysis 2027 Yotrio Corporation, Brown Jordan, Agio International, DEDON – The Oxford Spokesperson

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          The latest document issued by MarketQuest.biz title Global outdoor furniture and accessories market from 2021 to 2027 suggests a comprehensive review of the market that covers various product defining factors, market segmentation has taken care of numerous parameters and hence the landscape of existing vendors. The document assesses the possibilities and current situation of the market, providing an overview and update of the relevant segments engaged in the global Outdoor Furniture and Accessories Market for the anticipated duration of 2021-2027.

          A unique research technique has been used to perform a comprehensive analysis of the Global Outdoor Furniture and Accessories Market growth and draw conclusions about the future growth prospects of the industry. This method combines primary and secondary research, allowing analysts to ensure the accuracy and reliability of their findings.

          DOWNLOAD A FREE SAMPLE REPORT: https://www.marketquest.biz/sample-request/85518

          The market is fragmented into the following geographic segments:

          North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia, Italy and rest of Europe), Asia-Pacific (China, Japan, Korea, India, South Asia- East and Australia), South Asia America (Brazil, Argentina, Colombia and rest of South America), Middle East and Africa (Saudi Arabia, United Arab Emirates, Egypt, South Africa and rest of Middle East and Africa)

          The following application types are covered in the report:

          Specialized stores, Hypermarkets, E-tailers, Others,

          The study will help stakeholders gain better knowledge of the market impulse and provide data on key market drivers, bottlenecks, challenges, and opportunities. The study also examines the market segmentation and wide range of profitable opportunities available in the industry. The study covers the following types of products:

          Outdoor Furniture & Accessories, Outdoor Grilles & Accessories, Patio Heaters,

          Profiling of the following major vendors has been provided:

          Yotrio Corporation, Brown Jordan, Agio International, DEDON, KETTAL, Gloster, The Keter Group, Linya Group, Tuuci, MR DEARM, HIGOLD, Artie, Llyod/Flanders, Rattan, Emu Group, Barbeques Galore, COMFORT, Fischer Mobel GmbH, Royal Botania, Homecrest Outdoor Living, Hartman, Trex (Polyx Wood), Treasure Garden, Patio Furniture,

          ACCESS THE FULL REPORT: https://www.marketquest.biz/report/85518/global-outdoor-furniture-and-accessories-market-2021-by-company-regions-type-and-application-forecast-to-2026

          The entire market is illustrated focusing on scope, production, production value, loss/profit, supply/demand and import/export. It also contains information on strategic collaborations. A thorough assessment based on the market segment will be helpful in improving business development. This report also offers SWOT assessment, investment feasibility assessment, and investment return assessment.

          Report customization:

          This report can be customized to meet customer requirements. Please contact our sales team ([email protected]), who will ensure that you get a report tailored to your needs. You can also get in touch with our executives at +1-201-465-4211 to share your research needs.

          Contact us
          mark the stone
          Business Development Manager
          Call: +1-201-465-4211
          E-mail: [email protected]
          The Web: www.marketquest.biz

          Novel Prime and Spike Vaccine Strategy Leverages Existing Immunity Generated by Primary COVID-19 Vaccination

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          Scientists at Yale University, USA, recently developed an intranasal spike-stimulating vaccine that induces robust mucosal immunity in the airways, in addition to boosting pre-existing systemic immunity generated by vaccination with mRNA. In partially immunized mice, the vaccine can completely prevent infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study is currently available on the bioRxiv* preprint server.

          Study: Unadjuvanted intranasal vaccine booster elicits robust protective mucosal immunity against sarbecoviruses. Image Credit: Haris MM/Shutterstock

          Fund

          Currently approved vaccines against coronavirus disease 2019 (COVID-19), including mRNA-based and adenoviral vector-based vaccines, have shown over 85% efficacy in preventing SARS- CoV-2 and symptomatic COVID-19. These vaccines are also able to prevent viral transmission to some extent. However, some recent studies have shown that vaccine immunity may decline over time. The emergence of new viral variants is another potential cause of declining vaccine immunity.

          Most COVID-19 vaccines are administered intramuscularly, which is very favorable for inducing potent systemic antibodies. However, this route of administration is not optimal for inducing adequate mucosal immunity at the site of infection, i.e. the respiratory tract. For complete prevention of viral transmission, strong mucosal immunity is necessary.

          In the current study, scientists evaluated the immunogenicity and protective efficacy of a vaccination strategy that includes systemic priming with an mRNA-based COVID-19 vaccine (Pfizer/BioNTech) followed by stimulation intranasally with a SARS-CoV-2 spike protein without adjuvant.

          Mucosal and systemic immunity

          The SARS-CoV-2 spike protein used for intranasal stimulation was modified with a C-terminal T4 fibritin trimerization motif and proline and alanine substitutions in the furin cleavage site. These modifications were made to increase the stabilization and immunogenicity of the spike protein.

          Mice were primed with the Pfizer vaccine intramuscularly, followed by an intranasal boost 14 days after the primary vaccination. Mucosal immune responses were assessed 7 or 14 days after booster vaccination.

          The results revealed that the prime-spike vaccination scheme could induce potent mucosal and systemic anti-spike IgG and IgA antibodies in mice. Induction of binding antibody levels was significantly correlated with mucosal and systemic neutralizing titers. Moreover, the strong response of tissue-resident memory B cells induced by spike vaccination in the lungs. However, immunization with only a spike boost was insufficient to induce a robust antibody response.

          Similar to humoral immunity, a strong induction of tissue-resident memory CD4+ and CD8+ T cells was observed in the lower and upper respiratory tract after primary vaccination. Importantly, the prime-spike vaccination given three months apart showed a similar ability to induce strong humoral and cellular immunity at both mucosal and systemic levels.

          In addition to the recombinant spike protein without adjuvant, the immunogenicity of a spike protein encoding encapsulated polyplex mRNA was investigated in the study. The results revealed that polyplex-encapsulated spike booster vaccination could induce humoral and cellular immunity of similar intensity as spike booster vaccination without adjuvant.

          Protection against severe SARS-CoV-2 infection

          A low-dose primary vaccination schedule was used to mimic the decline in vaccine efficacy in the study. Mice immunized with the low-dose (prime) Pfizer vaccine received intranasal spiking without adjuvant or polyplex (boost) spiking 14 days after the primary vaccination. These mice were then challenged with wild-type SARS-CoV-2.

          The results revealed that both boosting regimens could induce strong humoral and cellular immune responses in mice with suboptimal primary vaccination. Additionally, both booster regimens showed high protective efficacy against severe SARS-CoV-2 infection in terms of preventing body weight loss and mortality and reducing lung viral load and disease. .

          The study also compared the immunogenicity of the prime–spike vaccination regimen with the Pfizer prime–Pfizer boost vaccination regimen. The results revealed that intranasal spike stimulation and intramuscular mRNA stimulation (Pfizer) can induce comparable immune responses in mice primed with the Pfizer vaccine.

          Cross-reactive immunity

          The effectiveness of the intranasal booster strategy in inducing cross-reactive immune responses was assessed in the study. To this end, mice primed with the Pfizer vaccine were intranasally administered a non-adjuvanted heterologous SARS-CoV spike protein. The results revealed that the tested prime-boost vaccination regimen is able to induce robust mucosal immunity against SARS-CoV spike as well as stimulate neutralizing antibodies against SARS-CoV-2 spike.

          Significance of the study

          The study describes the immunogenicity of a new vaccination strategy in which the Pfizer COVID-19 vaccine was used for the primary intramuscular immunization, and a SARS-CoV-2 spike without adjuvant was used for the immunization of intranasal recall. As highlighted in the study, this novel vaccination strategy can induce strong mucosal and systemic immunity in mice, which is sufficient to protect against lethal SARS-CoV-2 infection.

          *Important Notice

          bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be considered conclusive, guide clinical practice/health-related behaviors, or treated as established information.

          Juvenile prison explores how to pay for renovations | Winchester Star

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          WINCHESTER — Inaugurated in 1997, the regional prison for minors needs a new roof, an HVAC system and energy and lighting upgrades.

          At their bi-annual meeting on Thursday, members of the prison service heard a speech from a national company on overseeing improvements. Founded in 1909 in San Francisco, ABM Building Services has annual revenue of $5 billion and 100,000 employees, according to its website. The company’s offices include locations in Alexandria and Richmond, and ABM has managed projects in Virginia involving prisons, municipal buildings and schools.

          “We’re a big company, but we’re very local,” Frank LeBlanc, account executive at ABM’s Alexandria office, told members of the authority. “We guarantee energy savings based on the renovations we carry out for the entire building.”

          On October 13, ABM conducted a free appraisal of the 32-bed prison located at 145 Fort Collier Road in Frederick County, officially known as the Northwestern Regional Juvenile Detention Center. It serves Winchester as well as Clarke, Frederick, Page, Shenandoah and Warren counties and is currently home to nine miners. The assessment included examining the HVAC system, lights and roof. ABM estimated annual savings of approximately $14,000 ($10,600 electrical, $3,400 operating). The prison’s annual energy costs are approximately $40,000.

          If the company’s promised savings have not been met at the end of a 15-year contract, ABM regional manager Whitley Blake said he would pay the jail the unsaved amount. However, Blake said ABM projects have generally exceeded energy savings estimates. ABM would also negotiate optimal energy rates with the utility company.

          Blake estimated that replacing the prison’s 40,000 square foot roof would cost around $200,000. He recommended that the new roof be fitted with solar panels installed by the prison’s utility company, which would be responsible for installation and maintenance. Other suggestions included replacing all fluorescent lights with LED lights, better insulation, computerizing many building functions, and better water conservation. Some of the improvements could be paid for with federal stimulus funds, according to ABM infrastructure financing specialist Christina Sheriff.

          If prison officials agree to a letter of intent with ABM, the sheriff said the company would conduct a three-month ‘investment grade audit’ to provide a more detailed analysis of savings from building improvements. .

          “What we showed you today is superficial,” she told members of Authority. “What we want to address in our full audit is really getting a full assessment of the financial impact and the technical impact that we can have with you.”

          Shenandoah Authority member Evan Vass said a local business could do a similar assessment and charge a one-time fee. He said it could save the prison more money and expressed concern about a 15-year contract.

          “After 15 years you have to be married to them,” said Vass, who is the Shenandoah County administrator. “Sometimes you need a divorce.”

          Mary Blowe, representing Winchester, and Robert T. Williamson, representing Frederick County, agreed. “I’ve been through this many times in my career and I still don’t see the savings,” said Blowe, assistant city manager for Winchester.

          “They’re going to profit from everything we do here,” said Williamson, a former Frederick County sheriff. “If we can do the same and take advantage of it and keep it all, it’s better in our pockets than in theirs.”

          Superintendent Erin K. Maloney said she invited ABM to make the proposal because the company had a good reputation. Maloney, who has worked at the prison since it opened and was named superintendent in 2013, said the opportunity to complete a major renovation project with no upfront cost was attractive. She said staff had been proactive in maintaining the buildings, but a long-term construction plan was needed.

          “Five, 10, 15 years later, it would be great to have a clean, clear document to hand over to the next superintendent to say, ‘Here’s what we’ve done and this is what needs to be done in the future. said Maloney, who has worked at the jail since it opened and was named superintendent in 2013. “We don’t have that right now.

          In other business, Maloney has proposed a $3.2 million budget for the 2022-23 fiscal year that begins July 1. The proposed budget is approximately $59,000 less than the current budget. The authority should meet in April or May to approve the new budget.

          3 University of Arizona professors named AAAS Fellows

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          WASHINGTON DC — Three University of Arizona professors were named AAAS Fellows by the American Association for the Advancement of Science (AAAS) on Wednesday.

          The trio are among a group of 565 scientists, engineers and innovators across all scientific disciplines to earn the distinction from AAAS, the Washington, DC-based General Science Society and publisher of the Science family of journals.

          The UA professors who earned the distinction were: Elizabeth “Betsy” Arnold, Professor of Plant Science, Carol Gregorio, Professor and Head of the Department of Cellular and Molecular Medicine, and Cecile McKee, Professor of Linguistics.

          “AAAS is proud to bestow the honor of AAAS Fellow on some of today’s brightest minds who are integral to our journey into the future,” said AAAS Chief Executive Officer Sudip Parikh. and Executive Editor of the Science family of journals. “We celebrate these distinguished individuals for their invaluable contributions to the scientific enterprise.”

          Arnold is recognized for her contributions to the field of ecology and evolution, particularly for her studies of plant microbiomes in wild and agricultural ecosystems, an AU spokesperson said.

          In 2005, Arnold began as a faculty member at UA and as curator of the university’s Robert L. Gilbertson Mycological Herbarium, a role she still holds today.

          She led an effort to digitize, expand and preserve the Gilbertson Herbarium in addition to contributing to research, teaching, mentoring, outreach and service.

          Arnold has published over 140 peer-reviewed articles and for the past five years has served as editor of Mycologia, the flagship journal of the Mycological Society of America.

          “There are millions of fungal species on Earth, but we’ve only described about 100,000,” Arnold said. “Each plant harbors tremendous biodiversity waiting to be discovered. In many cases, these fungi can be used to make new medicines or agricultural tools for sustainability.”

          Gregorio, who joined the UA faculty in 1996, is honored for her internationally recognized contributions to understanding the structure, function and disease of the heart and skeletal muscles, according to the university.

          In addition to directing the Department of Cellular and Molecular Medicine, Gregorio is Co-Director of the Sarver Heart Center, Director of the Molecular Cardiovascular Research Program, Professor of Cellular and Molecular Medicine, Associate Vice Provost for Global Health Sciences and a member of the BIO5 Institute.

          Gregorio said she loved the beauty of her science.

          “Muscles work by sliding against each other – their structure is very regular,” Gregorio said. “The same mechanisms that cause a heart to contract cause cells to move during processes such as cancer metastasis, but because the striated muscle is so well aligned, you can see and watch the muscle filaments move, which would be impossible if it wasn’t so well organised.”

          McKee is a professor in the Department of Linguistics at UA and, according to AAAS, she is recognized for: “(her) distinguished contributions to developmental psycholinguistics, particularly experimental design to demonstrate children’s knowledge of syntax, and for distinguished service in promoting public awareness of the importance of linguistic study.

          McKee’s studies have focused on children’s language development, recently focusing on how quickly and fluently they speak. McKee has also developed innovative ways to examine complex syntax in young children.

          “For much of my research, I wanted to see if children knew anything about their language that was either very rare or very complex,” McKee said. “And, so, I spent a lot of time developing new ways to engage 2-year-olds in experiments to probe their grammatical knowledge.”

          McKee added: “The reason that matters is that various contrasting theories care a great deal about this early ending. Once a child is about 3 or 4 years old, syntactically, they are pretty much done. We find that they behave like adults in some experiments.”

          For many years, McKee – often accompanied by a team of students – has been active in public engagement at K-12 schools, science and cultural festivals, including Science City at the Tucson Festival of Books and Tucson Meet Yourself.

          She has also collaborated with the Children’s Museum Tucson, as part of a UA class offering special engagement opportunities for undergraduate students.

          Reveal a mathematical secret of lizard camouflage

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          The patterns of the ocellated lizard are predictable by a mathematical model. Credit: UNIGE / Michel Milinkovitch

          The shape-shifting clouds of starling birds, the organization of neural networks or the structure of an anthill: nature is full of complex systems whose behaviors can be modeled using mathematical tools. The same is true for the labyrinthine patterns formed by the green or black scales of the ocellated lizard. A multidisciplinary team from the University of Geneva (UNIGE) explains, using a very simple mathematical equation, the complexity of the system that generates these patterns. This discovery contributes to a better understanding of the evolution of skin color patterns: the process allows for many different locations of green and black scales but still leads to an optimal pattern for the animal’s survival. These results are published in the journal Physical examination letters.

          A complex system is composed of several elements (sometimes only two) whose local interactions lead to global properties that are difficult to predict. The result of a complex system will not be the sum of these elements taken separately since the interactions between them will generate unexpected behavior of the whole. The group of Michel Milinkovitch, professor in the Department of Genetics and Evolution, and Stanislav Smirnov, professor in the Mathematics Section of the UNIGE Faculty of Sciences, studied the complexity of the distribution of colored scales on the skin of ocellated lizards.

          Labyrinths of scales

          The individual scales of the ocellated lizard (Timon lepidus) change color (from green to black, and vice versa) over the animal’s life, gradually forming an intricate labyrinthine pattern as it reaches adulthood. UNIGE researchers have previously shown that the labyrinths emerge on the surface of the skin because the network of scales constitutes what is called a “cellular automaton”. “It is a computer system invented in 1948 by mathematician John von Neumann in which each element changes state depending on the states of neighboring elements”, explains Stanislav Smirnov.

          In the case of the ocellated lizard, the scales change state – green or black – according to the colors of their neighbors according to a precise mathematical rule. Milinkovitch had demonstrated that this cellular automaton mechanism emerges from the superposition, on the one hand, of the geometry of the skin (thick inside the scales and much thinner between the scales) and, on the other hand, of the interactions between the pigment cells of the skin.

          The path to simplicity

          Szabolcs Zakany, a theoretical physicist in the laboratory of Michel Milinkovitch, joined forces with the two professors to determine whether this change in the color of the scales could obey an even simpler mathematical law. Researchers therefore turned to the Lenz-Ising model developed in the 1920s to describe the behavior of magnetic particles that possess spontaneous magnetization. The particles can be in two different states (+1 or -1) and only interact with their first neighbors.

          “The elegance of the Lenz-Ising model is that it describes these dynamics using a single equation with only two parameters: the energy of aligned or misaligned neighbors, and the energy of an external magnetic field which tends to push all particles towards the +1 or -1 state,” says Szabolcs Zakany.

          Maximum chaos for better survival

          The three UNIGE scientists determined that this model could accurately describe the phenomenon of scale color change in the ocellated lizard. More precisely, they adapted the Lenz-Ising model, generally organized on a square lattice, to the hexagonal lattice of the skin scales. At a given average energy, the Lenz-Ising model favors the formation of all the state configurations of the magnetic particles corresponding to this same energy. In the case of the ocellated lizard, the process of color change promotes the formation of all distributions of green and black scales which each time result in a labyrinthine pattern (and not lines, spots, circles or unicolor areas… ).

          “These labyrinthine patterns, which provide ocellated lizards with optimal camouflage, have been selected during evolution. These patterns are generated by a complex system, which can however be simplified into a single equation, where what matters is not not the precise location of the green and black scales, but the overall look of the end patterns,” enthuses Michel Milinkovitch. Each animal will have a different precise location of its green and black scales, but all of these alternate patterns will look different. similar (i.e. very similar “energy” in the Lenz-Ising model) giving these different animals equal chances of survival.


          How to color a lizard: from biology to mathematics


          More information:
          Szabolcs Zakany et al, Lizard skin models and Ising model, Physical examination letters (2022). DOI: 10.1103/PhysRevLett.128.048102

          Provided by the University of Geneva


          Quote: Revealing a Mathematical Secret of Lizard Camouflage (January 27, 2022) Retrieved January 27, 2022 from https://phys.org/news/2022-01-revealing-mathematical-secret-lizard-camouflage.html

          This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

          Asian stocks tumble after Fed says US rates will hike ‘soon’ | Economic news

          0

          By JOE McDONALD, AP Business Writer

          BEIJING (AP) — Asian stock markets fell by unusually wide margins on Thursday after the Federal Reserve indicated it plans to start raising interest rates soon to calm inflation.

          The Tokyo market benchmark fell more than 3%. Hong Kong and Seoul lost more than 2%.

          Wall Street’s benchmark S&P 500 lost 0.1% on Wednesday after a Fed statement said the U.S. central bank “expects it to be appropriate soon” to raise rates. Investors expect four rate hikes this year, starting in March. The Fed said monthly bond purchases that lower long-term rates by pumping money into the financial system would be phased out in March.

          “The Fed’s decision will reverberate globally, which means the era of low interest rates, ultra-low interest rates is over,” Geo Securities CEO Francis Lun said at Hong Kong. “All central banks will start fighting inflation instead of trying to stimulate the economy.

          political cartoons

          The Nikkei 225 in Tokyo fell 3.2% to 26,152.12 and the Hang Seng in Hong Kong fell 2.6% to 23,664.80.

          The Kospi in Seoul fell 2.9% to 2,630.78 after a stunning market debut for battery maker LG Energy Solutions, whose shares opened at nearly double their offer price of 300,000. won ($250) after an initial public offering that attracted 13 trillion won (nearly $11 billion). ) in offers.

          LG Energy was the world’s second-largest maker of electric car batteries behind China’s CATL in the first 11 months of last year with a market share of around 22%, according to South Korean market research firm SNE. Research. The good prospects for sales of electric vehicles reinforce the attractiveness of the company.

          The company’s shares closed at 505,000 won ($420). The stock market debut made LG Energy the second most valuable company in the country by market capitalization behind tech giant Samsung Electronics.

          Samsung shares fell 2.1% on Thursday after announcing that its operating profit for the last quarter rose more than 53% from the same period last year as it thrived during the pandemic while relying on its dual strength in parts and finished products.

          The Shanghai Composite Index was down 0.9% at 3,425.28 and Sydney’s S&P-ASX 200 was down 2% at 6,822.10.

          The India Sensex opened 1.8% lower at 56,809.30. New Zealand and Southeast Asian markets also declined.

          On Wall Street, the S&P 500 slipped to 4,349.93 after rising 2.2% ahead of the Fed’s announcement.

          The Dow Jones Industrial Average fell 0.4% to 34,168.09. The Nasdaq composite was little changed at 13,542.12, shedding a 3.4% gain earlier in the day.

          Wall Street rose immediately after the Fed statement, but major indexes gave up gains as Chairman Jerome Powell asked questions about how and when the central bank will let its balance sheet shrink after buying trillions of dollars in bonds during the pandemic. This would put upward pressure on market interest rates.

          The selloff accelerated as Powell acknowledged that the high inflation that has weighed on businesses and consumers is not getting better. This could force the Fed to become even more aggressive in raising rates and removing support from the markets.

          The last time the Fed raised rates and reduced its balance sheet at the same time was in late 2018. The S&P 500 lost almost 20%.

          “Since the December meeting, I would say the inflation picture is about the same but probably slightly worse,” Powell said. “It hasn’t improved. It probably got a little worse, and that’s the trend.

          Powell also said there was room to raise interest rates without hurting the labor market, and would not rule out the possibility that the Fed could raise short-term rates during one of its seven meetings remaining this year or opt for a larger-than-usual increase at one of them.

          The Fed’s near-zero interest rates have helped lift stock prices for nearly two years, but markets have been volatile since Powell and other officials said in mid-December that plans to Reduced economic stimulus could be accelerated to combat soaring inflation.

          In energy markets, benchmark U.S. crude fell 73 cents to $86.62 a barrel in electronic trading on the New York Mercantile Exchange. The contract rose $1.75 to $87.35 on Wednesday. Brent crude, the price base for international oils, fell 72 cents to $88.02 a barrel in London. It advanced $1.76 the previous session to $89.96.

          The dollar rose slightly to 114.67 yen from 114.55 yen on Wednesday. The euro fell to $1.1223 from $1.1254.

          Kim Tong-hyung in Seoul and Alice Fung in Hong Kong contributed.

          Copyright 2022 The Associated press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

          No Antitrust Immunity for Mushroom Co-op in Winn-Dixie Suit

          0
          By Lauren Berg (January 26, 2022, 7:31 PM EST) – A federal judge in Pennsylvania handed a victory to Winn-Dixie Stores on Wednesday, finding that even though a mushroom cooperative has changed its name, the group has none did enough to gain antitrust immunity in the supermarket company’s price-fixing lawsuit.

          U.S. District Judge Berle M. Schiller granted Winn-Dixie’s motion for summary judgment on whether Eastern Mushroom Marketing Cooperative, now called American Mushroom Cooperative, can claim antitrust immunity under the Capper- Volstead, finding that EMMC failed to meet the requirements of the law, according to the 13-page order.

          The Capper-Volstead Act grants agricultural cooperatives a limited exemption from antitrust laws if the cooperative and…

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          Nanoprobe designed to help combine lung cancer treatments

          0

          In a recent study published in the journal LangmuirResearchers have developed a novel photosensitive nanoprobe for efficient targeted drug accumulation, optimal thermal conversion efficiency, and singlet oxygen generation for photodynamic or photothermal therapy during lung cancer treatment.

          Study: A new nanoprobe for targeted imaging and photothermal/photodynamic therapy of lung cancer. Image Credit: Create Jobs 51/Shutterstock.com​​​​​​​​

          The nanoprobe consists of indocyanine green (ICG) near-infrared (NIR) photosensitive drug, porous ferric oxide (Fe3O4) nanoparticles, and a hyaluronic acid (HA) modifier

          It has also been shown to exhibit excellent ICG loading, stability in organic solvents, and specific targeting of lung cancer cells under 808nm laser irradiation.

          Photothermal and photodynamic treatment of lung cancer

          Currently, ICG is the most commonly used hydrophobic NIR photosensitive reagent in the diagnosis, treatment and early detection of tumors based on photothermal (PTT) and photodynamic (PDT) therapy.

          In PTT, ICG efficiently converts light energy into heat, while in PDT, it uses light energy to generate singlet (least excited) oxygen molecules at a specific irradiation wavelength from NIR. However, its nanoprobing and sanative applications are hampered by its several characteristics, such as instability, clumping and decomposition in polar solvents, poor tumor targeting ability and rapid wilting in plasma medium due to its low half-life 2−4 min.

          As a solution, Fe3O4 nanoparticles, which are widely used in nuclear magnetic resonance (NMR) as a contrast agent, can be chemically etched to form a porous structure and used as a drug carrier of ICG to affect specific organs, tissues or cells under the effect of a magnetic adscititious domain.

          Additionally, a major component of the extracellular matrix, HA, can be used as an ICG modifier and protective agent for the Fe/ICG complex due to its biocompatibility, biodegradability, and nature of binding to overpopulated CD44 receptors. on the surface of the mutated. cells.

          About the study

          In this study, the researchers synthesized the Fe/[email protected] complex for targeted drug delivery to lung cancer cells. First, the Fe3O4 nanoparticles of uniform size and dispersibility were synthesized from FeCl24H2O, FeCl36H2O, poly(ethylene glycol) (PEG) and dilute ammonia using the co-precipitation method at 50°C.

          After that, porous Fe3O4 nanoparticles were synthesized using ammonium acetate as an etchant, followed by ICG loading into the corresponding nanopores. Finally, the Fe/[email protected] The complex was synthesized by suspending Fe/ICG in 10 mL of deionized water containing HA (0.5 mg/mL) for several hours.

          Subsequently, the prepared nanoprobe complex was characterized and its biocompatibility, biodegradability, cellular uptake, T2-MR imaging, in vitro and in vivo processing were analyzed against cultured A549 cells.

          Fluorescence intensity inside A549 cells was quantitatively analyzed by flow cytometry after several time intervals.

          Comments

          Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) images showed that Fe/[email protected] The complex exhibited a fuzzy microstructure with a clear organic layer after ICG loading and HA modification, indicating successful loading of both materials onto the porous Fe3O4 nanoparticles.

          UV−vis analysis revealed an ICG loading of 17.6% and a temperature of 61.5°C on the Fe3O4 nanoparticles. CCK-8 and apoptosis analysis revealed that ICG had no noticeable cytotoxicity in the concentration range of 0-40 μg/mL and less than 2% apoptotic cells at the highest concentration, proving excellent biocompatibility.

          Moreover, the internal fluorescence of A549 cells incubated with Fe/[email protected] The complex with 808 nm laser irradiation was stronger than that of the pure ICG complex.

          Moreover, the intensity of the fluorescence emission directly depended on the incubation time inside the A549 cells.

          Fluorescence intensity after 12 hours of incubation was significantly higher than after 2 hours.

          In vitro analysis using cell double staining and a laser confocal microscope revealed a large number of dead cancer cells for Fe/[email protected] complex than pure ICG and pure Fe3O4 nanoparticles.

          conclusion

          In summary, the researchers in this study synthesized Fe/[email protected] complex for PTT and PDT based diagnosis and treatment of lung cancer cells such as A549 cells.

          Under laser irradiation at 808 nm, the Fe/[email protected] The complex exhibited improved incubation time-dependent fluorescence intensity, targeted imaging and killing of cancer cells, excellent biocompatibility, long-lasting drug carryover, satisfactory ICG drug loading of 17.6%, and no cytotoxicity. Thus, Fe/[email protected] The complex nanoprobe is a promising candidate for precision lung cancer phototheranostics.

          Read on: Advances in Pulmonary Drug Delivery with Nanoparticles.

          Reference

          Sun, X., Xu, Y., Guo, Q., Wang, N., Wu, B., Zhu, C., Zhao, W., Qiang, W., Zheng, M., (2022) A novel Nanoprobe for targeted imaging and photothermal/photodynamic therapy of lung cancer, Langmuir. Available at: https://pubs.acs.org/doi/10.1021/acs.langmuir.1c02434

          Disclaimer: The views expressed herein are those of the author expressed privately and do not necessarily represent the views of AZoM.com Limited T/A AZoNetwork, the owner and operator of this website. This disclaimer forms part of the terms of use of this website.

          Orlando Health Cancer Institute uses cellular immunotherapy to destroy cancer cells – Florida Trend

          0

          Cellular therapy: therapy of tumor-infiltrating lymphocytes

          Orlando Cancer Institute of Health

          After being diagnosed and treated for an aggressive form of melanoma in 2015, Toni English of Rockledge had been in remission for nearly two years. In 2017, the cancer returned to his brain, lungs and kidneys and stopped responding to treatment. English thought she had “hit the end of the road” for the treatment. She was like, “OK, now what do we do? I exhausted everything that was there.

          English consulted Dr. Sajeve Thomas, an oncologist and hematologist at the Orlando Health Cancer Institute, who suggested he enroll in a clinical trial using tumor-infiltrating lymphocyte (TIL) therapy – an approach that essentially harnesses the own a person’s immune cells to fight their cancer.

          With TIL therapy, the doctor cuts out at least a portion of the metastatic tumor, isolates killer T cells from the sample, and adds drugs to expand the cells by the billions in what Thomas calls a “clone army.” This cellular army is returned to the patient’s bloodstream via infusion, providing a more robust and sustained attack on the cancer. The treatment is administered only once during the same hospitalization.

          In the case of English, it worked extraordinarily well. In the first weeks after the treatment, her tumors shrunk considerably. More than four years later, she remains cancer-free. “The TIL cells came in and took care of all the cancer,” says English. Overall response rates in the clinical trial were favorable, with tumors shrinking or remaining stable in four out of five patients. Researchers are studying whether TIL therapy could also help treat other types of solid tumors, including head, neck, lung and cervical cancers.

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