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Pleiotropy of psychiatric and immune characteristics

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For one study, researchers sought to investigate the pleiotropy of psychiatric and immune characteristics and risk variables of predicted significance.

Genetic association analysis was performed between July 10, 2020 and January 15, 2022. GWA statistics were used in the analyzes of 14 psychiatric characteristics, 13 immune system-related phenotypes, such as allergies, auto -immune and inflammatory, and 15 risk variables. related to health-related behaviours, social determinants of health and stress response. Mendelian randomization (MR) with sensitivity analysis and multivariate correction for genetic connections of third variables was used to identify genetically associated psychiatric-immune couples. Correction for the false discovery rate (Q value P values. A data-driven method was used, without any pre-planned hypotheses being tested.

There were 44 genetically associated psychiatric-immune pairings found, with 31 positive associations (most commonly including asthma, Crohn’s disease, hypothyroidism, and ulcerative colitis) and 13 negative correlations (most commonly involving allergic rhinitis and type 1 diabetes). For psychiatric traits, correlations with third factors were very high. Additionally, MR identified 7 associations of psychiatric phenotypes with immune-related phenotypes that were robust to multivariate adjustment, including the positive association of the psychiatric disorder phenotype cross-referenced with asthma (odds ratio [OR], 1.04; 95% CI, 1.02-1.06), Crohn’s disease (OR, 1.09; 95% CI, 1.05-1.14) and ulcerative colitis (OR, 1.09; CI at 95%, 1.05-1.14); major depression with asthma (OR, 1.25; 95% CI, 1.13-1.37); schizophrenia with Crohn’s disease (OR, 1.12; 95% CI, 1.05-1.18) and ulcerative colitis (OR, 1.14; 95% CI, 1.07-1.21); and a negative association of risk tolerance with allergic rhinitis (OR, 0.77; 95% CI, 0.67-0.92).

According to the results of the genetic association study, genetic responsibility for psychiatric disorders is associated with responsibility for several immune disorders, implying that vertical pleiotropy related to behavioral traits (or third correlated variables) contributes to clinical associations. observed in population-level data.

Reference: jamanetwork.com/journals/jamapsychiatry/article-abstract/2792053