Home Cellular science Runners’ plasma injections could increase brain longevity

Runners’ plasma injections could increase brain longevity



In the future, we may be able to extract the plasma from runners and gym goers around the world and inject it into others as a means of delivering the brain benefits of exercise. A new study mice indicates that such plasma transfers from young and chamois could help people with dementia.

What’s up – In the study published Wednesday in Nature, the scientists injected plasma harvested from rodents that were exercising into inactive mice. Active mice imparted many cognitive and cellular benefits from physical activity.

The effect could be reproduced in humans. Norwegian scientists are already planning A pilot study in which older people with early signs of Alzheimer’s disease will receive weekly plasma injections from healthy young people who exercise.

Co-author of the study “The population suffering from cognitive disorders is increasing every year” Miguel zurine recount Reverse. “It’s hard to find any treatment or drugs that affect the brain. If we can understand how plasma affects the brain, we can use the natural route. “

This research follows a growing body of evidence that regular exercise reduced inflammation of the brain, decreases stress hormones, and is correlated with better memory and cognitive ability. Exercise routines might even slow and mild cognitive decline in the elderly. Part of this benefit comes from the effect of exercise on plasma, which regulates body water and the mass of red blood cells to reduce inflammation.

How they did it – De Miguel and his team at Stanford University first separated mice from the same litter into two groups, one running on a hamster wheel and the other without “wheel access.” They then took “runner’s plasma” from the exercising mice and injected it intravenously into some of the sedentary mice.

“These results are very similar to the direct effects of running. “

The runner’s plasma triggered a series of healthy cellular reactions in the brains of non-practicing recipient mice, some of which were associated with reduced inflammation.

The researchers found that clusterin, a protein involved in removing cellular waste and replacing cells, was transferred from mice to mice via the injection of plasma. Once in the inactive mouse, the newly acquired clusterin bound to specific brain cells and reduced the expression of genes related to inflammation. The transfer also decreased the gene expression associated with a murine equivalent of Alzheimer’s disease.

Plasma from lab mice that had access to an exercise wheel was transferred to mice that did not.George Steinmetz / Getty Images News / Getty Images

The injected mice also performed better in tests of their cognitive abilities compared to the uninjected couch potato mice.

“In particular, these results are very similar to the direct effects of running,” the study said.

The researchers also induced an inflammatory response in the brains of some lazy mice to see if that might lessen the effects of the plasma injection, but the runner’s plasma still reversed the expression of genes that lead to the inflammation in these mice.

The authors of the study conclude:

“We show that changes in plasma resulting from aerobic physical exercise are sufficient to recapitulate the beneficial effects of exercise on neurogenesis and memory, and to reduce inflammation of the hippocampus in unexercised mice and mice with experimentally induced neuroinflammation. ”

Why is this important – It is easy to imagine a Black mirror scenario where a subclass passes every day chained to smart bikes so that they can be a source of precious, brain-stimulating plasma, available at a juice counter near you. Alternatively, athletes may be tempted to sell their plasma to the highest bidder.

These scenarios are fanciful. Scientists are more interested in developing new treatments for an aging population and a growing number of people with age-related dementia.

Over 55 million people around the world have some form of dementia, with nearly 10 million new cases each year. The disease is devastating for those affected, their families and their friends. The affected person may lose their identity, memories and motor skills. Often, they require expensive care to maintain a low quality of life. The financial, emotional and occupational burden of dementia is expected to increase dramatically as the large baby boom generation continues to age, who number to about 70 million in the United States alone.

And after – Currently, researchers at the Norwegian University of Science and Technology are recruiting people between the ages of 50 and 75 who have been diagnosed with mild cognitive impairment or early Alzheimer’s disease to receive monthly injections of ” plasma exercised ”- ExPlas, as Norwegian researchers call it – fit adults, aged 18 to 40.

That doesn’t mean there will soon be bottles of plasma from your aerobics instructor on sale at Whole Foods. This is a pilot study – a small-scale preliminary study done to show the risk, feasibility, and costs of a larger study that would more conclusively investigate the hypothesis. The pilot study is to run until 2025.

Donating plasma could one day be the key to the fight against cognitive declineGroup4 Studio / E + / Getty Images

But given the novelty of the research and the root-level mechanisms of plasma transfer, it is possible that this protocol could be used to treat other types of cognitive impairments beyond aging in the brain, explains de Miguel. . One potential use, she says, would be to use plasma to repair cognitive problems resulting from traumatic brain injury, for example.

The limits of theoretical therapy are still a mystery, she adds.

“We thought the brain was isolated from the body, but we find it is more connected than ever. [thought],” she says.

Summary: Exercise is generally beneficial for all aspects of human and animal health, slowing cognitive aging and neurodegeneration1. The cognitive benefits of exercise are linked to increased plasticity and reduced inflammation within the hippocampus, but little is known about the factors and mechanisms involved in these effects. Here we show that “runner plasma”, collected from mice that run voluntarily and infused into sedentary mice, reduces the expression of baseline neuroinflammatory genes and experimentally induced brain inflammation. Proteomic analysis of plasma revealed a concerted increase in inhibitors of the complement cascade, including clusterin (CLU). Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer’s disease. Patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU. These results demonstrate the existence of anti-inflammatory exercise factors that are transferable, target the cerebrovascular system and benefit the brain, and are present in humans who exercise.