The effects of cellular senescence on tissues in the human body – including the skin – are at the forefront of age-related disease research. And the beauty world is paying attention, as Cosmetics Business reports
Cellular senescence – defined as irreversible cell cycle arrest – is one of the frontiers of research into aging and age-related diseases.
It is a phenomenon that affects virtually all aged tissue in the human body, including our skin, and as such the subject has caught the attention of owners of beauty brands and manufacturers of cosmetic ingredients.
Around the same time last year, the Estée Lauder Companies announced that they were working with a biotech company – aptly named Atropos Therapeutics – to identify and develop chemicals that modulate senescence.
The goal of joint development would be the discovery of botanical space senomodulators for use in personal care products.
In November, meanwhile, Amorepacific published a research, in collaboration with the Department of Biological and Brain Engineering of KAIST (Korea Advanced Institute of Science and Technology), titled “Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts ”.
Additionally, in recent months, several skin-care-focused active ingredients have been launched with great fanfare around their claims to prevent skin cell senescence, modulate harmful secretions from senescent skin cells, or both.
But what exactly is cell senescence? And what are the broader implications of research on this facet of aging?
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